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| 1 | Clinical management of advanced gastric cancer: The role of new molecular drugs显示文摘Gastric cancer is the fourth most common malignant neoplasm and the second leading cause of death for cancer in Western countries with more than 20000 new cases yearly diagnosed in the United States.Surgery represents the main approach for this disease but,notwithstanding the advances in surgical techniques,we observed a minimal improvement in terms of overall survival with a significant increasing of relapsing disease rates.Despite the development of new drugs has significantly improved the effectiveness of chemothera-py,the prognosis of patients with unresectable or metastatic gastric adenocarcinoma remains poor.Recently,several molecular target agents have been investigated;in particular,trastuzumab represents the first target molecule showing improvements in overall survival in human epithelial growth factor 2-positive gastric cancer patients.New molecules targeting vascular epithelial growth factor,mammalian target of rapamycin,and anti hepatocyte growth factor-c-Met pathway are also under investigation,with interesting results.Anyway,it seems necessary to select more accurately the population to treat with new agents by the identification of new biomarkers in order to optimize the results.In this paper we review the actual'scenario'of targeted treatments,also focusing on the new agents in development for gastric cancer and gastro-esophageal carcinoma,discussing their efficacy and potential applications in clinical practice. | Ferdinando De Vita Natale Di Martino Alessio Fabozzi Maria Maddalena Laterza Jole Ventriglia Beatrice Savastano Angelica Petrillo Valentina Gambardella Vincenzo Sforza Luigi Marano Annamaria Auricchio Gennaro Galizia Fortunato Ciardiello Michele Orditura | 2014 | World Journal of Gastroenterology2014，20，40： | 12 |
| 2 | Effects of major ozonated autohemotherapy in the treatment of dry age related macular degeneration: a randomized controlled clinical study显示文摘AIM: To evaluate the effect of systemic ozonated major autohaemotherapy (O3-AHT) in patients affected by dry age related macular degeneration (AMD). METHODS: This study was a randomized, controlled clinical study. One hundred and forty patients with the diagnosis of AMD in both eyes, with the study eye presenting dry AMD and soft drusen, were randomly assigned in a 1:1 ratio to either receive 27 major ozonated autohemotherapy treatments during 12-month period, or a standardized multi-vitamin therapy. Primary outcome was the change in best corrected visual acuity (mean logMar change) between the baseline and 6 and 12 months, end point of the study. In addition, to investigate the safety of prolonged ozonated autohaemotherapy, we measured the routine haemato- chemical parameters and biochemical oxidative stress values at baseline and after 12 months treatment time. RESULTS: The mean baseline best corrected visual acuity in study eyes was 0.36 in the treatment group and 0.38 in the control group (difference not statistically significant). At the primary endpoint, 6 months post-baseline, the mean logMAR change in the treated group improved by 0.1 and the values of the control group at the same time impaired by 0.2 respect to the baseline. Four percent and twenty-five percent of eyes in the group treated with O3-AHT gained 1 or more lines after 6 and 12 months respectively compared to 0% in the eyes which received no treatment (P <0.05 at 12 months). None of the treated patients experienced a loss in visual acuity in their study eye at 6 and 12 months, compared to 16% and 40 % of patients in the control group who lost 2 lines or more at 6 months and 12 months respectively (P <0.05 treated vs control group)). Major ozonated autohemotherapy was shown to be safe and well- tolerated by the patients. Moreover, the haematochemical parameters showed a decrease in the Reactive Oxygen Metabolites (300±10.1 UCARR at 12 months compared to a baseline value of 380±10.4 UCARR, P <0.05) and an increase in Biological Antioxidant Potential plasma values (2100±34.8 micromoles/ C vitamin after 12 months compared to the baseline value of 1610±36.2, P <0.05) in the treated patients when compared to the control group. This data suggests that major ozonated autohaemotherapy may exert a role in reducing oxidative stress by endogenously stimulating the production of antioxidant molecules. CONCLUSION: The results of this study suggests that major ozonated autohaemotherapy could be a safe and effective therapeutic option for high-risk patients with dry AMD, and that a series of such treatments could improve the natural course of AMD. | Emma Borrelli Angelica Diadori Alessandro Zalaffi Velio Bocci | 2012 | International Journal of Ophthalmology(English edition)2012，5，6： | 10 |
| 3 | Peritoneal carcinosis of ovarian origin显示文摘Epithelial ovarian cancer (EOC) is the second most common genital malignancy in women and is the most lethal gynecological malignancy,with an estimated five-year survival rate of 39%.Despite efforts to develop an effective ovarian cancer screening method,60% of patients still present with advanced disease.Comprehensive management using surgical cytoreduction to decrease the tumor load to aminimum,and intraperitoneal chemotherapy to eliminate microscopic disease on peritoneal surface,has the potential to greatly improve quality of life and to have an impact on survival in ovarian cancer patients.Despite achieving clinical remission after completion of initial treatment,most patients (60%) with advanced EOC will ultimately develop recurrent disease or show drug resistance;the eventual rate of curability is less than 30%.Given the poor outcome of women with advanced EOC,it is imperative to continue to explore novel therapies. | Anna Fagotti Valerio Gallotta Federico Romano Francesco Fanfani Cristiano Rossitto Angelica Naldini Massimo Vigliotta Giovanni Scambia | 2010 | World Journal of Gastrointestinal Oncology2010，2，2： | 5 |
| 4 | Colorectal liver metastases: Current management and future perspectives显示文摘The liver is the commonest site of metastatic disease for patients with colorectal cancer,with at least 25%developing colorectal liver metastases(CRLM)during the course of their illness.The management of CRLM has evolved into a complex field requiring input from experienced members of a multi-disciplinary team involving radiology(cross sectional,nuclear medicine and interventional),Oncology,Liver surgery,Colorectal surgery,and Histopathology.Patient management is based on assessment of sophisticated clinical,radiological and biomarker information.Despite incomplete evidence in this very heterogeneous patient group,maximising resection of CRLM using all available techniques remains a key objective and provides the best chance of long-term survival and cure.To this end,liver resection is maximised by the use of downsizing chemotherapy,optimisation of liver remnant by portal vein embolization,associating liver partition and portal vein ligation for staged hepatectomy,and combining resection with ablation,in the context of improvements in the functional assessment of the future remnant liver.Liver resection may safely be carried out laparoscopically or open,and synchronously with,or before,colorectal surgery in selected patients.For unresectable patients,treatment options including systemic chemotherapy,targeted biological agents,intraarterial infusion or bead delivered chemotherapy,tumour ablation,stereotactic radiotherapy,and selective internal radiotherapy contribute to improve survival and may convert initially unresectable patients to operability.Currently evolving areas include biomarker characterisation of tumours,the development of novel systemic agents targeting specific oncogenic pathways,and the potential reemergence of radical surgical options such as liver transplantation. | Jack Martin Angelica Petrillo Elizabeth C Smyth Nadeem Shaida Samir Khwaja HK Cheow Adam Duckworth Paula Heister Raaj Praseedom Asif Jah Anita Balakrishnan Simon Harper Siong Liau Vasilis Kosmoliaptsis Emmanuel Huguet | 2020 | World Journal of Clinical Oncology2020，11，10： | 5 |
| 5 | Report on the Third IGCP-649 International Workshop on the Mayarí-Baracoa Ophiolites and Chromitites, Cuba显示文摘During April 3^(rd)–14^(th),the Third International Ophiolite Workshop of the International Geoscience Programme'Diamonds and Recycled Mantle'(IGCP-649)was successfully held in Havana,Cuba(Fig.1a).After the workshop,participants participated in a field trip to the Mayarí-Baracoa ophiolites and related chromitites | YANG Jingsui QIU Tian Angelica I.LLANES CASTRO | 2017 | Acta Geologica Sinica(English Edition)2017，91，6： | 4 |
| 6 | Role of neurotrophic factors in enhancing linear axonal growth of ganglionic sensory neurons in vitro显示文摘Neurotrophins play a major role in the regulation of neuronal growth such as neurite sprouting or regeneration in response to nerve injuries. The role of nerve growth factor, neurotrophin-3, and brain-derived neurotrophic factor in maintaining the survival of peripheral neurons remains poorly understood. In regenerative medicine, different modalities have been investigated for the delivery of growth factors to the injured neurons, in search of a suitable system for clinical applications. This study was to investigate the influence of nerve growth factor, neurotrophin-3 and brain-derived neurotrophic factor on the growth of neurites using two in vitro models of dorsal root ganglia explants and dorsal root ganglia-derived primary cell dissociated cultures. Quantitative data showed that the total neurite length and tortuosity were differently influenced by trophic factors. Nerve growth factor and, indirectly, brain-derived neurotrophic factor stimulate the tortuous growth of sensory fibers and the formation of cell clusters. Neurotrophin-3, however, enhances neurite growth in terms of length and linearity allowing for a more organized and directed axonal elongation towards a peripheral target compared to the other growth factors. These findings could be of considerable importance for any clinical application of neurotrophic factors in peripheral nerve regeneration. Ethical approval was obtained from the Regione Piemonte Animal Ethics Committee ASLTO1(file # 864/2016-PR) on September 14, 2016. | Michele Fornaro Alessia Giovannelli Angelica Foggetti Luisa Muratori Stefano Geuna Giorgia Novajra Isabelle Perroteau | 2020 | Neural Regeneration Research2020，15，9： | 3 |
| 7 | Operative Blood Loss Independently Predicts Recurrence and Survival After Resection of Hepatocellular Carcinoma显示文摘 | Steven C. Katz Jinru Shia Kui Hin Liau Mithat Gonen Leyo Ruo William R. Jarnagin Yuman Fong Michael I. D?Angelica Leslie H. Blumgart Ronald P. DeMatteo | 2009 | Annals of Surgery2009，，4： | 3 |
| 8 | Outcome After Hepatectomy for Multiple (Four or More) Colorectal Metastases in the Era of Effective Chemotherapy显示文摘 | Peter Kornprat MD William R. Jarnagin MD FACS Mithat Gonen PhD Ronald P. DeMatteo MD FACS Yuman Fong MD FACS Leslie H. Blumgart MD FACS FRCS Michael D'Angelica MD FACS | 2007 | Annals of Surgical Oncology2007，，3： | 3 |
| 9 | Occult hepatitis B virus infection among Mexican human immunodeficiency virus-1-infected patients显示文摘AIM: To determine the frequency of occult hepatitis B infection(OHBI) in a group of human immunodeficiency virus(HIV)-1+/ hepatitis B surface antigen negative(HBsAg)- patients from Mexico. METHODS: We investigated the presence of OHBI in 49 HIV-1+/HBsAg- patients. Hepatitis B virus(HBV) DNA was analyzed using nested PCR to amplify the Core(C) region and by real-time PCR to amplify a region of the S and X genes. The possible associations between the variables and OHBI were investigated using Pearson's χ2 and/or Fisher's exact test.RESULTS: We found that the frequency of OHBI was 49% among the group of 49 HIV-1+/HBsAg- patients studied. The presence of OHBI was significantly associated with the HIV-1 RNA viral load [odds ratio(OR) = 8.75; P = 0.001; 95%CI: 2.26-33.79] and with HIVantiretroviral treatment with drugs that interfere with HBV replication(lamivudine, tenofovir or emtricitabine)(OR = 0.25; P = 0.05; 95%CI: 0.08-1.05). CONCLUSION: The OHBI frequency is high among 49 Mexican HIV-1+/HBsAg- patients and it was more frequent in patients with detectable HIV RNA, and less frequent in patients who are undergoing HIV-ARV treatment with drugs active against HBV. | Ma Teresa Alvarez-Muoz Angelica Maldonado-Rodriguez Othon Rojas-Montes Rocio Torres-Ibarra Fernanda Gutierrez-Escolano Guillermo Vazquez-Rosales Alejandro Gomez Onofre Muoz Javier Torres Rosalia Lira | 2014 | World Journal of Gastroenterology2014，20，37： | 3 |
| 10 | 固相萃取和气相色谱-质谱分析酚类化合物应用简报显示文摘固相萃取为分析水中痕量化合物提供了简便的分析方法 .高分子树脂如聚苯乙烯 二乙烯基苯比常用的十八烷基和类似的硅胶基体的固相萃取吸附剂好 ,特别是对极性较大的化合物 .最近 ,安捷伦科技扩展了所提供的固相萃取产品 ,包括了聚苯乙烯 二乙烯基苯固相萃取材料AccuBondⅡ ENV小柱 ,专门用于环境应用 .本文用以前介绍的保留时间锁定气相色谱 /质谱分析方法[1 ] ,使用这种聚苯乙烯 二乙烯基苯固相萃取材料对水中浓度为1 0 μg·l- 1 的选定酚类分析能达到的准确度和精密度进行了初步论证 .固相萃取过程快速 ,缩短干燥时间 ,且只需要两种回收率指示物 (Surrogates) .小柱经优化设计 ,提高了酚类化合物的回收率 ,而其它小柱的回收率通常很低且不重复 .苯酚的回收率超过 70 % ,其它酚类化合物的回收率超过 90 % .精密度大于 5 % ,以平均绝对偏差表示的准确度 (以百分数表示 )除了 2 环己基 2 4 二硝基酚之外 ,都大于 8% .样品萃取速率高 (2 0— 2 5ml·min- 1 ) ,萃取 1L样品不到 | Angelica A Reese Harry Prest | 2003 | 环境化学2003，22，2： | 3 |
| 11 | Malignant Progression in IPMN: A Cohort Analysis of Patients Initially Selected for Resection or Observation显示文摘 | J. LaFemina N. Katabi D. Klimstra C. Correa-Gallego S. Gaujoux T. P. Kingham R. P. DeMatteo Y. Fong M. I. D’Angelica W. R. Jarnagin R. K. Do M. F. Brennan Peter J. Allen | 2013 | Annals of Surgical Oncology2013，，2： | 2 |
| 12 | Occult hepatitis B virus co-infection in human immunodeficiency virus-positive patients: A review of prevalence, diagnosis and clinical significance显示文摘The prevalence of human immunodeficiency virus(HIV) and hepatitis B virus(HBV) co-infection is high as they share similar mechanisms of transmission. The development and widespread use of highly sensitive tests for HBV diagnosis has demonstrated that a significant proportion of apparently healthy individuals with evidence of exposure to HBV continue to carry fully functional HBV DNA in their hepatocytes, a situation that predisposes them to the development of progressive liver disease and hepatocellular carcinoma. The presence of co-infections frequently influences the natural evolution of each of the participating infections present by either facilitating their virulence or competing for resources. Furthermore, the drugs used to treat these infections may also contribute to changes in the natural course of these infections, making the analysis of the impact of co-infection more difficult. The majority of studies has examined the impact of HIV on overt chronic hepatitis B, finding that co-infection carries an increased risk of progressive liver disease and the development of hepatocellular carcinoma. Although the effect of HIV on the natural history of occult hepatitis B infection(OBI) has not been fully assessed, all available data suggest a persisting risk of repeated flares of hepatitis and progressive liver disease. We describe studies regarding the diagnosis, prevalence and clinical significance of OBI in HIVpositive patients in this short review. Discrepancies in worldwide prevalence show the urgent need for the standardization of diagnostic criteria, as established by the Taormina statements. Ideally, standardized protocols for testing should be employed to enable the comparison of data from different groups. Additional studies are needed to define the differences in risk for OBI without HIV and in HIV-HBV co-infected patients with or without overt disease. | Angelica Maldonado-Rodriguez Ana Maria Cevallos Othon Rojas-Montes Karina Enriquez-Navarro Ma Teresa Alvarez-Mu?oz Rosalia Lira | 2015 | World Journal of Hepatology2015，7，2： | 2 |
| 13 | Clinical laboratory and imaging evidence for effectiveness of agarose-agarose macrobeads containing stem-like cells derived from a mouse renal adenocarcinoma cell population (RMBs) in treatment-resistant, advanced metastatic colorectal cancer:Evaluation of显示文摘Objective: The complexity, heterogeneity and capacity of malignant neoplastic cells and tumors for rapid change and evolution suggest that living-cell-based biological-systems approaches to cancer treatment are merited. Testing this hypothesis, the tumor marker, metabolic activity, and overall survival(OS) responses, to the use of one such system, implantable macrobeads [RENCA macrobeads(RMBs)], in phase I and IIa clinical trials in advanced,treatment-resistant metastatic colorectal cancer(m CRC) are described here.Methods: Forty-eight m CRC patients(30 females; 18 males), who had failed all available, approved treatments,underwent RMB implantation(8 RMB/kg body weight) up to 4 times in phase I and phase IIa open-label trials.Physicals, labs [tumor and inflammation markers, lactate dehydrogenase(LDH)] and positron emission tomography-computed tomography(PET-CT) imaging to measure number/volume and metabolic activity of the tumors were performed pre-and 3-month-post-implantation to evaluate safety and initial efficacy(as defined by biological responses). PET-CT maximum standard uptake value(SUVmax)(baseline and d 90; SUVmax ≥2.5), LDH,and carcinoembryonic antigen(CEA) and/or cancer antigen 19-9(CA 19-9) response(baseline, d 30 and/or d 60)were assessed and compared to OS.Results: Responses after implantation were characterized by an at least 20% decrease in CEA and/or CA 19-9 in75% of patients. Fluorodeoxyglucose(FDG)-positive lesions(phase I, 39; 2 a, 82) were detected in 37/48 evaluable patients, with 35% stable volume and stable or decreased SUV(10) plus four with necrosis; 10, increased tumor volume, SUV. LDH levels remained stable and low in Responders(R)(d 0–60, 290.4–333.9), but increased steadily in Non-responders(NR)(d 0–60, 382.8–1,278.5)(d 60, P=0.050). Responders to RMBs, indicated by the changes in the above markers, correlated with OS(R mean OS=10.76 months; NR mean OS=4.9 months; P=0.0006).Conclusions: The correlations of the tumor marker, tumor volume and SUV changes on PET-CT, and LDH levels themselves, and with OS, support the concept of a biological response to RMB implantation and the validity of the biological-systems approach to m CRC. A phase III clinical trial is planned. | Barry H.Smith Lawrence S.Gazda Thomas J.Fahey Angelica Nazarian Melissa A.Laramore Prithy Martis Zoe P.Andrada Joanne Thomas Tapan Parikh Sudipta Sureshbabu Nathaniel Berman Allyson J.Ocean Richard D.Hall David J.Wolf | 2018 | Chinese Journal of Cancer Research2018，30，1： | 2 |
| 14 | A single administration of fish oil inhibits the acute inflammatory response in rats显示文摘Objective: To investigate the antiinflammatory effects of a single administration of fish oil(FO) on the acute inflammatory response. Methods: The paw edema and pleurisy models were used to evaluate the effects of FO dissolved in olive oil(FOP) orally administered in a single dose in rats. Nitric oxide(NO) concentrations in the pleural exudate were performed according to the Griess method and the cytokine concentrations were determined by Luminex bead-based multiplex assay. Results: FOP treatment(30 and 300 mg/kg) significantly reduced paw edema. FOP treatment at 18.75, 37.5, 75.0, 150.0, and 300 mg/kg decreased both the volume of pleural exudate and cellular migration into the pleural cavity and each of these doses presented the same effectiveness. Treatment with FOP(300 mg/kg) reduced NO, TNF-α, IL-1β, and IL-6 concentrations in the pleural exudate. Conclusions: The present data provide evidence that FO has inhibitory effects on the acute inflammatory response when administered in a single dose in rats. This effect might be attributable to a direct inhibitory effect of FO on the production or release of inflammatory mediators that are involved in the pathological processes evaluated herein. | Laura Licia Milani de Arruda Franciele Queiroz Ames Damila Rodrigues de Morais Renata Grespan Ana Paula Maziero Gil Maria Angelica Raffaini Covas Pereira Silva Jesui Vergilio Visentainer Roberto Kenji Nakamura Cuman Ciomar Aparecida Bersani-Amado | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，8： | 2 |
| 15 | 肝切除术治疗结直肠癌肝转移的患者选择显示文摘1简介
结直肠癌最常见的血行转移器官为肝脏。大约有一半的患者在结直肠癌病程中发展为肝转移癌[1]。针对肝转移病灶,肝切除术仍是唯一可能的根治性治疗,其5年生存率约50%[2],10年治愈率接近20%[3]。此外,有效的系统和局部化疗结合手术切除可以达到在未治愈的情况下使患者长期存活[4]。因此, | Matthew J.Weiss Michael I.D'Angelica 夏发达 姜晖 | 2013 | 中国普通外科杂志2013，22，7： | 2 |
| 16 | ERCC1 predicts outcome in patients with gastric cancer treated with adjuvant cisplatin-based chemotherapy显示文摘 | Sara Dosso Elena Zanellato Martina Nucifora Renzo Boldorini Angelica Sonzogni Roberto Biffi Nicola Fazio Eraldo Bucci Ottavio Beretta Stefano Crippa Piercarlo Saletti Milo Frattini | 2013 | Cancer Chemotherapy and Pharmacology2013，，1： | 2 |
| 17 | Volumetric Analysis Predicts Hepatic Dysfunction in Patients Undergoing Major Liver Resection显示文摘 | Margo Shoup Mithat Gonen Michael D’Angelica William R Jarnagin Ronald P DeMatteo Lawrence H Schwartz Scott Tuorto Leslie H Blumgart Yuman Fong | 2003 | Journal of Gastrointestinal Surgery2003，，3： | 2 |
| 18 | Operative Drainage Following Pancreatic Resection: Analysis of 1122 Patients Resected Over 5 Years at a Single Institution显示文摘 | Camilo Correa-Gallego Murray F. Brennan Michael D?Angelica Yuman Fong Ronald P. DeMatteo T. Peter Kingham William R. Jarnagin Peter J. Allen | 2013 | Annals of Surgery2013，，6： | 2 |
| 19 | s-BLM修饰电极对组胺电化学传感行为的研究显示文摘研究了以抗组胺剂修饰的固体支撑双层类脂膜 (s BLM)分子器件体系对组胺的电化学传感行为 .结果表明 ,在s BLM膜中镶嵌抗组胺剂 ,体系对组胺的电化学响应强烈 ,并随着组胺浓度的增加而加大 ,这主要是由于组胺与抗组胺剂的特异性对抗效应引起的 .在接近通常的生理条件下 (pH =7.5 ) ,响应电流与组胺的浓度在 3.0~ 6 0 .0 μg/L呈良好的线性关系 ,相关系数为 0 .9878,表现出较高的灵敏度、选择性及良好的稳定性 .该体系可以在 - 2 0 0mV下用伏安法检测组胺的浓度 。 | 蔡红 张占军 王斌 李裕辉 蔡生民 H.Ti Tien Angelica Ottova | 2004 | Chinese Journal of Chemical Physics2004，17，2： | 2 |
| 20 | Volumetric analysis predicts hepatic dysfunction in patients undergoing major liver resection显示文摘 | Margo Shoup M.D. Mitbat Gonen Ph.D. Michael D'Angelica M.D. William R. Farnagin M.D. Ronald P. DeMatteo M.D. Lawrence H. Schwartz M.D. Scott Tuorto Leslie H. Blumgart M.D. Yuman Fong M.D | 2003 | Journal of Gastrointestinal Surgery2003，，3： | 2 |
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