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| 1 | Macrophage polarization in response to wear particles in vitro显示文摘全部的联合代替是为有停用关节炎和联合机能障碍的病人的治疗的一个高度成功的外科的过程。随着时间的过去,与活动的高水平和关节的用法,然而植入穿粒子从明白表示的表面被产生。这些穿粒子能在 implant (periprosthetic osteolysis ) 附近导致煽动性的反应,和随后的骨头再吞的激活。单核白血球 / 巨噬细胞系的房间安排这长期的煽动性的回答,它被支持 inflammatory (M1 ) 统治巨噬细胞显型而非一反煽动性的支持织物的愈合(M2 ) 巨噬细胞显型。当它被显示出时,那 interleukin-4 (IL-4 ) 有选择地极化向支持骨头愈合的 M2 反煽动性的显型的巨噬细胞,而非发炎,很少对这在通过 IL-4 的极化在哪个是很有效的在发生或调节的时间功课被知道。这个工作的目标是与 polymethyl methacrylate (PMMA ) 的联合响应挑战学习鼠科的巨噬细胞极化和 cytokine 版本的时间功课粒子, lipopolysaccharide (LPS ) 和在 vitro 的 IL-4。有 IL-4 的质问粒子的单核白血球 / 巨噬细胞的处理导致了支持 inflammatory cytokines 和可诱导的氮的氧化物 synthase (iNOS ) 的起始的抑制生产和随后的极化进 M2 反煽动性的显型。当 IL-4 在 PMMA 粒子挑战前被交付时,这结果被优化,到 M1 显型而非到未遂(M0 ) 巨噬细胞。这极化的效果在一堂 5 天的时间功课上被支撑。进 M2 显型的 M1 巨噬细胞的极化可以是策略减轻穿粒子联系 periprosthetic osteolysis。 | Joseph K Antonios Zhenyu Yao Chenguang Li Allison J Rao Stuart B Goodman | 2013 | Cellular & Molecular Immunology2013，10，6： | 10 |
| 2 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Joseph P Costantino Takamaru Ashikaga Donald L Weaver Eleftherios P Mamounas Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Norman Wolmark | 2010 | Lancet Oncology2010，，10： | 3 |
| 3 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 4 | Effect of weekend admission on geriatric hip fractures显示文摘BACKGROUND The care discrepancy for patients presenting to a hospital on the weekend relative to the work week is well documented.With respect to hip fractures,however,there is no consensus about the presence of a so-called“weekend effect”.This study sought to determine the effects,if any,of weekend admission on care of geriatric hip fractures admitted to a large tertiary care hospital.It was hypothesized that geriatric hip fracture patients admitted on a weekend would have longer times to medical optimization and surgery and increased complication and mortality rates relative to those admitted on a weekday.AIM To determine if weekend admission of geriatric hip fractures is associated with poor outcome measures and surgical delay.METHODS A retrospective chart review of operative geriatric hip fractures treated from 2015-2017 at a large tertiary care hospital was conducted.Two cohorts were compared:patients who arrived at the emergency department on a weekend,and those that arrived at the emergency department on a weekday.Primary outcome measures included mortality rate,complication rate,transfusion rate,and length of stay.Secondary outcome measures included time from emergency department arrival to surgery,time from emergency department arrival to medical optimization,and time from medical optimization to surgery.RESULTS There were no statistically significant differences in length of stay(P=0.2734),transfusion rate(P=0.9325),or mortality rate(P=0.3460)between the weekend and weekday cohorts.Complication rate was higher in patients who presented on a weekend compared to patients who presented on a weekday(13.3%vs 8.3%;P=0.044).Time from emergency department arrival to medical optimization(22.7 h vs 20.0 h;P=0.0015),time from medical optimization to surgery(13.9 h vs 10.8 h;P=0.0172),and time from emergency department arrival to surgery(42.7 h vs 32.5 h;P<0.0001)were all significantly longer in patients who presented to the hospital on a weekend compared to patients who presented to the hospital on a weekday.CONCLUSION This study provided insight into the“weekend effect”for geriatric hip fractures and found that day of presentation has a clinically significant impact on delivered care. | Jordan B Pasternack Matthew L Ciminero Michael Silver Joseph Chang Ronald J Simon Kevin K Kang | 2020 | World Journal of Orthopedics2020，11，9： | 2 |
| 5 | Status and direction of communication technologies SiGe BiCMOS and RFCMOS 显示文摘 | Joseph A J Harame D L Jagannathan B | 2005 | Proc the IEEE2005，93，9： | 1 |
| 6 | The effectsof end-point internal cooking tempomtures on meat quality at-tributes of selected Nigerian poultry meat显示文摘 | JOSEPH J K WOSANYA B A ADENIRANA T | 1997 | Food Qualityand Preference1997，，1： | 1 |
| 7 | U- Pb zircon and geochemical evidence for bimodal mid-Paleozoic magmatism and syngenetic base-metal mineralization in the Yukon-Tanana terrane,Alaska显示文摘 | Cynthia D B Joseph L W Melanie J H | | 0，，7： | 1 |
| 8 | Vibrio parahaemo- lyticus and related halophilic Vibrios显示文摘 | joseph S-W Coiwell'R R Kaper J B | 1982 | Crit Rev Micro- biol1982，10，： | 1 |
| 9 | Activation of nuclear factor-B during doxorubiocin-induced apoptosis in endothelial cell and myocytes is pro-apoptotic:the role of hydrogen peroxide显示文摘 | Wang S Kotamraju S Konoter E Kalivendi S Joseph J Kalyanaraman B | 2002 | Biochem J2002，367，3： | 1 |
| 10 | A standardized method for measuring intraeranial arterial stenosis显示文摘 | Samuels O B Joseph G J Lynn M J | 2000 | AJNR Am J Neuroradiol2000，21，4： | 1 |
| 11 | Effect of surfactant addition on phenanthrene biodegradation in sediments显示文摘 | Harry J T Joseph B H Michelle T J | 1995 | Environ Toxicol Chem1995，14，6： | 1 |
| 12 | Thermal degradation and flammability characteristics of some polystyrenes and poly(methyl methacrylate)s chemically modified with silicon-containing groups 显示文摘 | EBDON J R HUNT B J JOSEPH P | 2004 | Polymer Degradation and Stability2004，83，1： | 1 |
| 13 | Diet as a factor in behavioral radiation protection following exposure to heavy particles显示文摘 | Rabin BM Shukitt-Hale B Joseph J | 2005 | Gravit Space Biol Bull2005，18，： | 1 |
| 14 | Annual Energy Out- look 2012, DOE/EIA-0383 显示文摘 | John J C Paul D H Joseph A B | 2012 | Energy Information Admin- istration2012，6，： | 1 |
| 15 | Evaluation of anti-pyretic and analgesic activity of Emblica officinalis Gaertn显示文摘 | Perianayagam J B Sharma S Joseph A Chistina A J M | 2004 | Journal of Ethnopharmacology2004，95，1： | 1 |
| 16 | Expression of inhibitor of apoptosis proteins in small - and non - small - cell lung carcinoma cells显示文摘 | Ekedahl J Joseph B Grigoriev MY | 2002 | Exp Cell Res2002，279，： | 1 |
| 17 | Lipid and fatty acid composition of the endogenous energy sources of striped bass (Moronic saxatilis ) eggs 显示文摘 | Eldridge M B Joseph J D Taberski K M | 1983 | Lipids1983，18，： | 1 |
| 18 | On the shortest spanning subtree of a graph and the travelling salesman problem 显示文摘 | Joseph B Kruskal J R | 1956 | Proceedings of the American Mathematical Society1956，7，1： | 1 |
| 19 | Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation 显示文摘 | JOSEPH J A SHUKITT-HALE B DENISOVA N A | 1999 | The Journal of Neuroscience1999，19，18： | 1 |
| 20 | Calculating fragment impact velocity from penetration data 显示文摘 | JOSEPH B J CLAY J N | 2010 | International Journal of Impact Engineering2010，37，： | 1 |
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