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| 1 | 中国妇女妊娠前后单纯服用叶酸对神经管畸形的预防效果显示文摘目的 评价妇女在妊娠前后服用单纯 40 0 μg叶酸增补剂对胎 /婴儿神经管畸形 (NTDs)的预防效果。方法 1993~ 1995年在中国北方的NTDs高发地区和南方的NTDs低发地区妇女增补叶酸的推广项目中 ,共募集从孕前或孕后任何时间开始服药的妇女 130 142名 ,未服药的妇女 1176 89名 ;设计的服药方法从婚检时开始到孕满 3个月为止 ,每天服用单纯叶酸片 40 0 μg ;最后对妇女的分娩结局进行监测并进行预防效果的对比评价研究。结果 服药组妇女生育的胎婴儿中共发现 10 2例NTDs ,对照组胎婴儿中共发现 173例NTDs。末次月经前募集的未服药妇女在孕 2 0周以后分娩的胎婴中NTDs发生率 ,北方为 4 8‰ (16 / 3 318) ,南方为 1 0‰ (2 8/ 2 82 6 5 ) ,而妊娠前后服药妇女组则分别为1 0‰ (13/ 13 0 12 )和 0 6‰ (34/ 5 86 38)。与末次月经前募集的未服药妇女组相比 ,北方服药妇女NTDs发生率明显降低 ,其中依从性大于 80 %的服药组妇女预防率达 85 % (95 %CI为 6 2 %~ 94% ) ,南方地区服叶酸的预防率为 41% (95 %CI为 3 %~ 6 4% )。结论 妇女在妊娠前后每天服用单纯叶酸 40 0 | 李竹 RobertJ Berry 李松 J David Erickson 王红 Cynthia A Moore 赵平 Joseph Mulinare 洪世欣 Lee-Yang C Wong 呼和牧人 Jacqueline Gindler 郝玲 Adolfo Correa 朱慧萍 Elaine Gunter | 2000 | 中华医学杂志2000，80，7： | 185 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | International NeuroAIDS: prospects of HIV-1 associated neurological com-plications显示文摘Neurological complications associated with HIV-1/AIDS are being recognized with a high frequency that parallels the increased number of AIDS cases. The early infiltration by HIV-1 into the nervous system can cause primary and/or secondary neurological complications. The most common neurocognitive disorder is AIDS Dementia Complex (ADC). In developing countries of Asia the three most opportunistic infections are tuberculosis (TB), cryptococcosis, and Pneumocystis carinii pneumonia. Therefore, it is expected that secondary neurological complications due to TB and cryptococcosis will be the most common cause of morbility and mortality in HIV-1/AIDS cases in China. Research of NeuroAIDS in China is necessary to understand the impact and the biology of HIV-1 in the nervous system. Future studies would include, the molecular epidemiology and the description of opportunistic infections associated to HIV-1; the neuropathological description of primary and secondary HIV-1 complications in different groups; the HIV-1 neurot- ropism and immune response studies for China’s unique HIV-1 strains and recombinant forms derived from the nervous system, including experimental models such as the use of transgenic rats; and the study of potential resistant virus, primarily when the anti-retroviral therapy (ART) has not full access in the brain. | J Roberto TRUJILLO Gilberto JARAMILLO-RANGEL Marta ORTEGA-MARTINEZ Augusto C PENALVA de OLIVEIRA Jose E VIDAL Joseph BRYANT Robert C GALLO | 2005 | Cell Research2005，15，11： | 4 |
| 4 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 5 | Is Ulnar Nerve Transposition Beneficial During Open Reduction Internal Fixation of Distal Humerus Fractures?显示文摘 | Ryan C Chen David J Harris Stephane Leduc Joseph J Borrelli Paul Tornetta William M Ricci | 2010 | Journal of Orthopaedic Trauma2010，，7： | 2 |
| 6 | Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery显示文摘 | Mary C Corretti Todd J Anderson Emelia J Benjamin David Celermajer Francois Charbonneau Mark A Creager John Deanfield Helmut Drexler Marie Gerhard-Herman David Herrington Patrick Vallance Joseph Vita Robert Vogel | 2002 | Journal of the American College of Cardiology2002，，： | 2 |
| 7 | Effects of high pressure on meat:a review显示文摘 | Claude C J Joseph C | 1997 | Meat Science1997，46，3： | 1 |
| 8 | Pituitary adenoma:correlation of half-dose gadolinium-enhanced MR imaging with surgical findings in 26 patients显示文摘 | Davis P C Gokhale K A Joseph G J | 1991 | Radiology1991，180，3： | 1 |
| 9 | Effect of dietary fat and cholesterol on the in vitro incorporation of acetate-14C into hen liver and ovarian lipids 显示文摘 | JOSEPH F W EDWARD C N RALPH M J | 1967 | The Journal of Nutrition1967，93，： | 1 |
| 10 | Annual Energy Out- look 2012, DOE/EIA-0383 显示文摘 | John J C Paul D H Joseph A B | 2012 | Energy Information Admin- istration2012，6，： | 1 |
| 11 | Granular cell tumours of the gastrointestinal tract:expression of nestin and clinicopathological evaluation of 11 patients显示文摘 | Parfitt J R McLean C A Joseph M G | 2006 | Histopathology2006，48，： | 1 |
| 12 | Pituitary adenoma:correlation of half-dose gadolinium-enhanced MR imaging with surgical findings in 26 patients显示文摘 | Davis P C Gokhale K A Joseph G J | 1991 | Radiology1991，180，3： | 1 |
| 13 | Posttraumatic Osteoarthritis: A First Estimate of Incidence, Prevalence, and Burden of Disease显示文摘 | Thomas D Brown Richard C Johnston Charles L Saltzman J Lawrence Marsh Joseph A Buckwalter | 2006 | Journal of Orthopaedic Trauma2006，，10： | 1 |
| 14 | Evolution grid computing architecture and grid adoption models显示文摘 | JOSEPH J EMEST M FELLENSTEIN C | 2004 | IBM System Jounals2004，43，4： | 1 |
| 15 | Self-eare and qual- ity of life of heart failure patients at a multidisciplinary heart function clinic显示文摘 | Emily S Kevin J L Joseph A C | 2011 | J Cardiovase Nuts2011，26，5： | 1 |
| 16 | Artificial disc versus fusion 显示文摘 | Rick C Joseph D Robert J | 2007 | Spine2007，26，： | 1 |
| 17 | The effects of a distributor' s attribution of manufacturer influence on the distributor's perceptions of conflict performance and satisfaction 显示文摘 | Joseph C J Baker T | 1993 | Journal of Marketing Channels1993，3，2： | 1 |
| 18 | Use of three- dimensional guglielmi detachable coils in the treatment of wide - necked cerebral aneurysms 显示文摘 | CLOFT H J JOSEPH G J TONG F C | 2000 | Am J Neuroradiol2000，21，： | 1 |
| 19 | Hope or No-HOPE-- Merit-Based College Scholarship Status and Financial Behaviors Among College Students 显示文摘 | JOSEPH W D BRENDA J C | 2008 | Financial Counseling and Planning2008，，1： | 1 |
| 20 | Atrazine and Cancer Incidence Among Pesticide Applicators in the Agricultural Health Study (1994-2007)显示文摘 | Beane Freeman Laura E Rusiecki Jennifer A Hoppin Jane A Lubin Jay H Koutros Stella Andreotti Gabriella Zahm Sheila Hoar Hines Cynthia J Coble Joseph B Barone-Adesi Francesco Sloan Jennifer Sandler Dale P Blair Aaron Alavanja Michael C R | 2011 | Environmental Health Perspectives2011，，9： | 1 |
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