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| 1 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 2 | Arsenic and heavy metals innative plants at tailings impoundments in Queretaro, Mexico显示文摘 | Jose S J Alejandrina C R Jose H C | 2012 | Physicsand Chemistry of the Earth2012，3739，： | 1 |
| 3 | Targeting aurora2 kinase in oncogenesis:a structural Bioinformatics approach to target validation and rational drug design显示文摘 | Vankayalapati H Bearss D J Jose W | 2003 | Mol Cancer Therap2003，2，3： | 1 |
| 4 | Simultaneous photocatalytic Cr (VI) reduction and dye oxidation in a TiO2 slurry reactor 显示文摘 | Schrank S G Jose H J Moreira R F P M | 2002 | J Photochem Photobiol A: Chemistry2002，147，1： | 1 |
| 5 | Maintenance strategy based on a multicriterion classification of equipments 显示文摘 | C G L H Felix J R C Jose | 2006 | Reliability Engineering and System Safety2006，，91： | 1 |
| 6 | Effect of Indigofera aspalathoides against Dalton's ascitic lymphoma显示文摘 | Christina A J M Alwin Jose M Robert S J H | 2003 | Fitoterapia2003，74，3： | 1 |
| 7 | Reduction of ketones and aldehydes to alcohols with magnesium-aluminium mixed oxide and 2-propanol 显示文摘 | Jose R R Cesar J S Julia M H | 2006 | Journal of Molecular Catalysis A : Chemical2006，246，： | 1 |
| 8 | Meerwein-Ponndorf-Verley reaction of acetophenones with 2-propanol over MgA1 mixed oxide: the substituent effect 显示文摘 | Jose R R Cesar J S Julia M H | 2007 | Catalysis Communications2007，，8： | 1 |
| 9 | The Olsen-P method as an agronomic and environmental test for predicting phosphorus release from acid soils显示文摘 | Maria D C H Jose J | 2007 | Nutrient Cycling of Agroecosystem2007，77，： | 1 |
| 10 | Reduction of heterocyclic carboxaldehydes via Meerwein-Ponndorf-Verley reaction 显示文摘 | Cesar J S Julia M H Jose R R | 2006 | Applied Catalysis A : General2006，303，： | 1 |
| 11 | Treatment of textile wastewater by heterogeneous Fenton process using a new composite Fe2O3/carbon 显示文摘 | Dantas T L P Mendonca V P Jose H J | 2006 | Chemical Engineering Journal2006，118，5： | 1 |
| 12 | 显示文摘 | Moreira R F P M Jose H J Rodrigues A E | 2001 | Carbon2001，39，： | 1 |
| 13 | Kineticsof photocatalytic degradation of reactive dyes in a Ti02slurry reactor 显示文摘 | SAUER T CESCONETO G JOSE H J | 2002 | J Photochem Photo : A : Chem2002，149，： | 1 |
| 14 | Treatment of textile wastewater by heterogeneous Fenton process using a new composite Fe203/carbon显示文摘 | DANTAS T L P MENDONCA V P JOSE H J | 2006 | Chemical Engineering Journal2006，118，12： | 1 |
| 15 | The plant ionome revisited by the nutrient balance concept 显示文摘 | PARENT S H PARENT L E JOSE EGOZCUE J | 2013 | Frontiers in plant science2013，，： | 1 |
| 16 | Treatment of textile wastewater by heterogeneous Fenton process using a new composite Fe2O3/carbon 显示文摘 | Dantas T L P Mendonca V P Jose H J | 2006 | Chemical Engineering Journal2006，118，12： | 1 |
| 17 | Comparison of different advanced oxidation process to reduce toxicity and mine ralisation of tannery wastewater 显示文摘 | Schrank S G Jose H J Moreira R F P M | 2004 | Water Sci Technol2004，50，5： | 1 |
| 18 | Ring opening of decalin and tetralin on HY and Pt HY zeolite catalysts 显示文摘 | MALEE S JOSE E H SIRIPORN J | 2004 | Journal of Catalysis2004，228，1： | 1 |
| 19 | Applicability of fenton and H2O2/UV reactions in the treatment of tannery wastewater 显示文摘 | Schrank S G Jose H J Moreira R F P M | 2005 | Chemosphere2005，60，5： | 1 |
| 20 | A multiphase harmonic load flow solution technique显示文摘 | Jose J R Dommel H W | 1991 | IEEE Transaction on Power Systems1991，6，2： | 1 |
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