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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Interleukin-17 signal transduction pathways implicated in inducing matrix metalloproteinase-3, -13 and aggrecanase-1 genes in articular chondrocytes 显示文摘 | Judith S Abdelhamid L Wen QL | 2004 | Cellular Signalling2004，16，： | 1 |
| 3 | Characterization and photo- Fenton treatment of used tires leachate 显示文摘 | Judith S Tomas L Ormad P | 2006 | Journal of Hazardous Materials2006，136，1： | 1 |
| 4 | Contracting and Patterns of Nonprofit Governance显示文摘 | SHARON L H | 1998 | Nonprofit management & leadership1998，8，3： | 1 |
| 5 | Bridging the Gap Between Finance and Clinical Operations with Activity-Based Coet Management显示文摘 | Judith L S | 1996 | JONA 26( 12)1996，，： | 1 |
| 6 | A waste effluent treatment system based on microbial mats for black sea bass Centropristis striata recycled-water mariculture显示文摘 | Judith B Richard L Michael S | 2004 | Aquacult Eng2004，31，12： | 1 |
| 7 | Receptor and ligands implicated human T cell costimulatory process显示文摘 | Judith L Katharina GP Peter S | 2010 | Immunol Lett2010，128，2： | 1 |
| 8 | The analysis of cell images显示文摘 | JUDITH M S P MENDELSOHN M L | 1966 | Annals of the New York Academy of Sciences1966，128，1： | 1 |
| 9 | Characterization and photo-Fenton treatment of used tires leaehate显示文摘 | I Judith S Tomas L Ormad P | 2006 | Journal of Hazanlous Materials2006，136，87： | 1 |
| 10 | The chemistry of fumarate and maleate inbibitors with platinum hydrosilyation catalysts显示文摘 | LARRY N L JUDITH S ROBERT C | 1996 | J Organometallic Chemistry1996，521，： | 1 |
| 11 | The next generation science standards: implications for preservice and inservice science teacher education 显示文摘 | NORMAN G L JUDITH S L | 2014 | Science Teacher Education2014，25，2： | 1 |
| 12 | Effects of heavy metal con- centrations (Cd, Zn and Pb) in agricultural soils near different emis- sion sources on quality, accumulation and food safety in soybean显示文摘 | Marla J S Judith H R Gast6n L N | 2012 | Journal of Hazardous Materials2012，，233234： | 1 |
| 13 | ZnO-nanostruetures, defects, and devices显示文摘 | LUKAS S M JUDITH L | 2007 | Materials today2007，5，1： | 1 |
| 14 | The Role of Surgery in Primary Gastric Lymphoma: Results of a Controlled Clinical Trial显示文摘 | Agustin Avilés M Jesús Nambo Natividad Neri Judith Huerta-Guzmán Ivonne Cuadra Isabel Alvarado Claudia Casta?eda Raúl Fernández Martha González | 2004 | Annals of Surgery2004，，1： | 1 |
| 15 | Study d anionic and nomonic silicone latlices by si NMR Si pectroscopy 显示文摘 | JUDITH S TRACEY M L JOANN F S | 1993 | Journal of Applied Polymer Science1993，47，： | 1 |
| 16 | EGFR inhibition as a therapy for head and neck squamouscell carcinoma expert opin显示文摘 | Judith L Ilona S Georg MS | 2008 | Investig Drugs2008，17，10： | 1 |
| 17 | Receptor and ligands implicated in human Tcell costimulatory process显示文摘 | Judith L Katharina GP Peter S | 2010 | Immunol Lett2010，128，2： | 1 |
| 18 | Effects of diet,bacitracin,and body weight restrictions on the intestine of broiler chicks显示文摘 | Stutz M W Johnson S L Judith F R | 1983 | Poultry science1983，62，8： | 1 |
| 19 | Receptor and ligands implicated in hunman T cell costimulatory process显示文摘 | JUDITH L KATHARINA G P PETER S | | 0，，02： | 1 |
| 20 | In vitro and in vivo evaluartions of the antibioticefrotomycin 显示文摘 | Stutz M W Johnson S L Judith F R | 1983 | Poultry Science1983，62，： | 1 |
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