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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | MK-0677, a potent, novel, orally active growth hormone (GH) secretagogue: GH, insulin-like growth factor I, and other hormonal responses in beagles显示文摘 | Jacks T Smith R Judith F | 1996 | Endocrinology1996，137，： | 1 |
| 3 | Predictive models for the effect of storage temperature on Vibrio parahemolyticus viability and counts of total viable bacteria in pacific oysters显示文摘 | Judith F P John P B Tom R | 2011 | Applied and Environmental Microbiology2011，77，24： | 1 |
| 4 | C-erbB-2 oncoprotein, CEA and CA15-3 in patients with breast cancer: prognostic value 显示文摘 | Molina R Judith J Xavier F | 1998 | Breast Cancer Res Treat1998，51，： | 1 |
| 5 | C-erbB-2 oncoprotein, CEA and CA15-3 in patients With breast cancer: prognostic value Breast Cancer Res显示文摘 | Molina R Judith J Xavier F | 1998 | Treat1998，51，： | 1 |
| 6 | C-erbB-2 oncoprotein,CEA and CA153 in patients with breast cancer:prognostic value显示文摘 | Molina R Judith J Xavier F | 1998 | Breast Cancer Res Treat1998，51，3： | 1 |
| 7 | Effects of diet,bacitracin,and body weight restrictions on the intestine of broiler chicks显示文摘 | Stutz M W Johnson S L Judith F R | 1983 | Poultry science1983，62，8： | 1 |
| 8 | Transduction and expression of the human carcinoembryonic antigen in a murine clone carcinoma cell line显示文摘 | Paul F R Judith A K Michael S | 1991 | Cancer Res1991，51，： | 1 |
| 9 | In vitro and in vivo evaluartions of the antibioticefrotomycin 显示文摘 | Stutz M W Johnson S L Judith F R | 1983 | Poultry Science1983，62，： | 1 |
| 10 | Subpopulations of high density lipoproteins in homozygous and heterozygous Tangier disease显示文摘 | Bela F Asztalos Margaret E Brousseau Judith R McNamara Katalin V Horvath Paul S Roheim Ernst J Schaefer | 2001 | Atherosclerosis2001，，： | 1 |
| 11 | Long-term protective immune re,sponse elicited by vaccination with an expression genomic library of Toxoplasma gondii显示文摘 | Alberto F Alexandro R Judith M | 2003 | lnfect Immun2003，71，9： | 1 |
| 12 | Newborn hearing screen- ing what is means for providers of early intervention services显示文摘 | Judith E W Warren R B Richard C F | 2003 | Infants Young Child2003，16，3： | 1 |
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