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| 1 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 2 | Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients显示文摘AIM To investigate the relationships among diverse metalloproteases(MMPs) and their tissue inhibitors(TIMPs) and non-alcoholic liver fibrosis in human immunodeficiency virus(HIV)-infected patients.METHODS Single nucleotide polymorphisms(SNPs) in MMPs, TNF-α and CCR5 genes, and serum levels of MMPs and TIMPs were determined in HIV-infected individuals with/out hepatitis C virus(HCV) coinfection. A total of 158 patients were included, 57 of whom were HCVcoinfected. All patients drank < 50 g ethanol/day. Diverse SNPs(MMP-1-1607 1G/2G, MMP-8-799C/T, MMP-9-1562 C/T, MMP-13-77A/G, TNF-α-308 G/A,CCR5-?32), and serum levels of MMPs(2, 3, 8, 9 and 10) and TIMPs(1, 2 and 4) were assessed. Liver fibrosis was determined by transient elastometry, although other non-invasive markers of fibrosis were also considered. Significant liver fibrosis(F ≥ 2) was defined by a transient elastometry value ≥ 7.1 kP a.RESULTS A total of 34 patients(21.5%) had liver fibrosis ≥ F2. MMP-2 and TIMP-2 serum levels were higher in patients with liver fibrosis ≥ F2(P = 0.02 and P = 0.03, respectively) and correlated positively with transient elastometry values(P = 0.02 and P = 0.0009, respectively), whereas MMP-9 values were negatively correlated with transient elastometry measurements(P = 0.01). Multivariate analyses showed that high levels of MMP-2(OR = 2.397; 95%CI: 1.191-4.827, P = 0.014) were independently associated with liver fibrosis ≥ F2 in the patients as a whole. MMP-2(OR = 7.179; 95%CI: 1.210-42.581, P = 0.03) and male gender(OR = 10.040; 95%CI: 1.621-62.11, P = 0.013) were also independent predictors of fibrosis ≥ F2 in the HCV-infected subgroup. Likewise, MMP-2, TIMP-2 and MMP-9 were independently associated with transient elastometry values and other non-invasive markers of liver fibrosis. None of the six SNPs evaluated had any significant association with liver fibrosis ≥ F2.CONCLUSION Certain MMPs and TIMPs, particularly MMP-2, seems to be associated with non-alcoholic liver fibrosis in HIVinfected patients with/without HCV coinfection. | Julio Collazos Eulalia Valle-Garay Tomás Suárez-Zarracina Angel-Hugo Montes José A Cartón Víctor Asensi | 2017 | World Journal of Virology2017，6，2： | 3 |
| 3 | Heat shock reduces browning of fresh-cut celery petioles显示文摘 | Julio G L V Mary E Mangrich Reinaldo Campos-Vargas | 2003 | Postharvest Biology and Technology2003，，27： | 1 |
| 4 | Santiago Urcelay,Biosecurity practices on intensive pig production systems in Chile显示文摘 | Pinto C Julio V | | 0，，： | 1 |
| 5 | Heat shock reduces browning of fresh-cut celery petioles 显示文摘 | JULIO G LOAIZA V MARY E | 2006 | Postharvest Biology and Technology2006，27，： | 1 |
| 6 | Determination of partition and diffusion coefficients of components of two rubber adhesives in different multilayer materials显示文摘 | Nerin C Julio G Paula V | | 0，，： | 1 |
| 7 | Assessment of flicker limits compli- ance for wind energy conversion system in the frequency domain 显示文摘 | Carolina V Hortensia A Julio U | 2006 | Renewable Energy2006，31，8： | 1 |
| 8 | Karyotype analysis and polyploidy in Palaua and a comparison with its sister group Fuertesimalva(Malvaceae)显示文摘Palaua(Malveae,Malvaceae)comprises 15 species endemic to the hyperarid coastal desert of Chile and Peru.So far,chromosome counts have been known for two diploid species(2n=2x=10)only.Here we report new chromosome numbers for 12 species of Palaua and four of its sister group Fuertesimalva.Karyotypes including 4,6-diamidino-2-phenylindole dihydrochloride(DAPI)/chromomycin(CMA3)fluorescent banding are presented for selected species representative of each of the main clades of Palaua.An important finding is the discovery of polyploids in one exclusively tetraploid species(P.trisepala)and four species with mixed diploid and tetraploid cytotypes(P.dissecta,P.mollendoensis,P.moschata,and P.tomentosa).The diploid and tetraploid karyotypes are all unimodal,symmetrical and show one or two pairs of satellite chromosomes with their associated CMA+/DAPI- band depending on the cytotype.For some of the tetraploids an autopolyploid origin is suggested. | Julio V SCHNEIDER Marilú L HUERTAS | 2010 | Journal of Systematics and Evolution2010，48，3： | 1 |
| 9 | Adult liver transplantation:an analysis of the early causes of death in 40consecutive cases显示文摘 | Cuervas-Mons V Julio Martinez A Dekker A | 1986 | Hepatology1986，6，： | 1 |
| 10 | Influence of added concrete compressive strength on adhesion to an existing concrete substrate显示文摘 | JULIO E N B S BRANCO F A B SILVA V D | 2006 | Building and Environment2006，41，： | 1 |
| 11 | Integrated Nonlinear Optimization of Bioprocesses via Linear Programming 显示文摘 | Vera Julio Torres N V Moles C G Banga Julio | 2003 | AIChE Journal2003，49，12： | 1 |
| 12 | Assessment of flicker limits compliance for wind energy conversion system in the frequency domain 显示文摘 | CAROLINA V HORTENSIA A JULIO U | 2006 | Renewable Energy2006，31，8： | 1 |
| 13 | Risk of fracture in celiac disease:Gender,dietary compliance,or both?显示文摘AIM:To determine the incidence of peripheral fractures in patients with celiac disease (CD) and the effect of treatment on fracture risk.METHODS:We compared the incidence and risk of peripheral fractures before and after diagnosis between a cohort of 265 patients who had been diagnosed with CD at least 5 years before study entry and a cohort of 530 age-and sex-matched controls who had been diagnosed with functional gastrointestinal disorders.Data were collected through in-person interviews with an investigator.The overall assessment window for patients was 9843 patient-years (2815 patient-years after diagnosis).RESULTS:Compared with the control group,the CD cohort showed significantly higher incidence rate and risk of first peripheral fracture before diagnosis [adjusted hazard ratio (HR):1.78,95% CI:1.23-2.56,P < 0.002] and in men (HR:2.67,95% CI:1.37-5.22,P < 0.004).Fracture risk was significantly associated with the classic CD presentation with gastrointestinal symptoms (P < 0.003).In the time period after diagnosis,the risk of fractures was comparable between the CD cohort and controls in both sexes (HR:1.08,95% CI:0.55-2.10 for women;HR:1.57,95% CI:0.57-4.26 for men).CONCLUSION:CD patients have higher prevalence of fractures in the peripheral skeleton before diagnosis.This is associated with male sex and classic clinical presentation.The fracture risk was reduced after the treatment. | María Inés Pinto Sánchez Adriana Mohaidle Andrea Baistrocchi Dolores Matoso Horacio Vázquez Andrea González Roberto Mazure Evangelina Maffei Guillermina Ferrari Edgardo Smecuol Adriana Crivelli Juan Andrés de Paula Juan C Gómez Silvia Pedreira Eduardo Maurio Julio César Bai | 2011 | World Journal of Gastroenterology2011，17，25： | 1 |
| 14 | Gluten immunogenic peptide excretion detects dietary transgressions in treated celiac disease patients显示文摘BACKGROUND Life-long removal of gluten from the diet is currently the only way to manage celiac disease(CeD). Until now, no objective test has proven useful to objectively detect ingested gluten in clinical practice. Recently, tests that determine consumption of gluten by assessing excretion of gluten immunogenic peptides(GIP) in stool and urine have been developed. Their utility, in comparison with conventional dietary and analytical follow-up strategies, has not been fully established.AIM To assess the performance of enzyme-linked immunosorbent assay(ELISA) and point-of-care tests(PoCTs) for GIP excretion in CeD patients on gluten-free diet(GFD).METHODS We conducted an observational, prospective, cross-sectional study in patients following a GFD for at least two years. Using the Gastrointestinal Symptom Rating Scale questionnaire, patients were classified at enrollment as asymptomatic or symptomatic. Gluten consumption was assessed twice by 3-d dietary recall and GIP excretion(by ELISA in stool and PoCTs(commercial kits for stool and urine) in two consecutive samples. These samples and dietary reports were obtained 10 day apart one from the other. Patients were encouraged to follow their usual GFD during the study period.RESULTS Forty-four patients were enrolled, of which 19(43.2%) were symptomatic despite being on a GFD. Overall, 83 sets of stool and/or urine samples were collected.Eleven out of 44 patients(25.0%) had at least one positive GIP test. The occurrence of at least one positive test was 32% in asymptomatic patients compared with 15.8% in symptomatic patients. GIP was concordant with dietary reports in 65.9% of cases(Cohen′s kappa: 0.317). PoCT detected dietary indiscretions. Both ELISA and PoCT in stool were concordant(concomitantly positive or negative) in 67 out of 74(90.5%) samples. Excretion of GIP was detected in 7(8.4%) stool and/or urine samples from patients considered to be strictly compliant with the GFD by dietary reports.CONCLUSION GIP detects dietary transgressions in patients on long-term GFD, irrespective of the presence of symptoms. PoCT for GIP detection constitutes a simple homebased method for self-assessment of dietary indiscretions. | Ana Florencia Costa Emilia Sugai María de la Paz Temprano Sonia Isabel Niveloni Horacio Vázquez María Laura Moreno M.Remedios Domínguez-Flores Alba Mu?oz-Suano Edgardo Smecuol Juan Pablo Stefanolo Andrea F González Angel Cebolla-Ramirez Eduardo Mauri?o Elena F Verdú Julio César Bai | 2019 | World Journal of Gastroenterology2019，25，11： | 1 |
| 15 | Organic contanminants in sediments from San Quintin Bay, Baja California, Mexico显示文摘 | EFRAIN A G G JULIO A V C GILBERTO F M | 1996 | Marine Pollution Bulletin1996，32，4： | 1 |
| 16 | Enhanced scaling-free CORDIC 显示文摘 | FRANCISCO J J MIGUEL A S JAVIER H JULIO V EMILIO L Z | 2010 | IEEE Transactions on Circuits and Systems2010，57，7： | 1 |
| 17 | Reactivity of calcium sulfate from FBC systems显示文摘 | AGRIPANEA P IRIBARNE JULIO V | 1997 | Fuel1997，76，4： | 1 |
| 18 | Heat shock reduces browning of fresh-cut celery petioles显示文摘 | JULIO G LOAIZA V MARY E | 2006 | Postharvest Biology and Technology2006，27，： | 1 |
| 19 | Theeffect of active recovery on power performance duringthe bench press exercise显示文摘 | LOPES F A PANISSA V L JULIO U F | 2014 | J Hum Kinet2014，40，8： | 1 |
| 20 | Diversity,relationships,and genetic fingerprinting of the Listadade Gandíaeggplant landrace using genomic SSRs and EST-SSRs显示文摘 | Julio E Munoz-Falcon Santiago V | 2011 | Scientia Horticulturae2011，129，2： | 1 |
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