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| 1 | Evaluation of quantitative contrast harmonic imaging to assess malignancy of liver tumors:A prospective controlled two-center study显示文摘AIM: To establish the extent to which contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics facilitates the detection of hepatic tumors. METHODS: One hundred patients with histologically confirmed malignant or benign hepatic tumor (maximum size 5 cm) were analyzed. Contrast-enhanced ultrasound (bolus injection 2.5 mL SonoVue) was carried out with intermittent breath-holding technique using a multifrequency transducer (2.5-4 MHz). Native vascularization was analyzed with power Doppler. The contrast-enhanced dynamic ultrasound investigation was carried out with contrast harmonic imaging in true detection mode during the arterial,portal venous and late phases. Mechanical index was set at 0.15. Perfusion analysis was performed by post-processing of the raw data time intensity curve (TIC) analysis. The cut-off of the gray value differences between tumor and normal liver tissue was established using Receiver Operating Characteristic (ROC) analysis 64-line multi-slice computed tomography served as reference method in all cases. Magnetic resonance tomography was used additionally in 19 cases. RESULTS: One hundred patients with 59 malignant (43 colon,5 breast,2 endocrine metastases,7 hepatocellular carcinomas and 2 kidney cancers) and 41 benign (15 hemangiomas,7 focal nodular hyperplasias,5 complicated cysts,2 abscesses and 12 circumscribed fatty changes) tumors were included. The late venous phase proved to be the most sensitive for classification of the tumor type. Fifty-eight of the 59 malignant tumors were classified as true positive,and one as false negative. This resulted in a sensitivity of 98.3%. Of the 41 benign tumors,37 were classified as true negative and 4 as false negative,which corresponds to a specificity of 90.2%. Altogether,95.0% of the diagnoses were classified as correct on the basis of the histological classification. No investigator-dependency (P = 0.23) was noted. CONCLUSION: The results show the possibility of accurate prediction of malignancy of hepatic tumors with a positive prognostic value of 93.5% using advanced contrast-enhanced ultrasound. Contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics is a valuable tool to discriminate hepatic tumors. | EM Jung DA Clevert AG Schreyer S Schmitt J Rennert R Kubale S Feuerbach F Jung | 2007 | World Journal of Gastroenterology2007，13，47： | 15 |
| 2 | Consecutive fecal calprotectin measurements for predicting relapse in pediatric Crohn's disease patients显示文摘BACKGROUND Asymptomatic children with Crohn's disease(CD) require ongoing monitoring to ensure early recognition of a disease exacerbation.AIM In a cohort of pediatric CD patients, we aimed to assess the utility of serial fecal calprotectin measurements to detect intestinal inflammatory activity and predict disease relapse.METHODS In this prospective longitudinal cohort study, children with CD on infliximab therapy in clinical remission were included. Fecal calprotectin levels were assessed at baseline and at subsequent 2-5 visits. Clinical and biochemical disease activity were assessed using the Pediatric Crohn's Disease Activity Index, Creactive protein and erythrocyte sedimentation rate at baseline and at visits over the following 18 mo.RESULTS 53 children were included and eighteen patients(34%) had a clinical disease relapse during the study. Baseline fecal calprotectin levels were higher in patients that developed symptomatic relapse [median(interquartile range), relapse 723μg/g(283-1758) vs 244 μg/g(61-627), P = 0.02]. Fecal calprotectin levels > 250μg/g demonstrated good predictive accuracy of a clinical flare within 3 mo(area under the receiver operator curve was 0.86, 95% confidence limits 0.781 to 0.937).CONCLUSION Routine fecal calprotectin testing in children with CD in clinical remission is useful to predict relapse. Levels > 250 μg/g are a good predictor of relapse in the following 3 mo. This information is important to guide monitoring standards used in this population. | Alice Jane Foster Matthew Smyth Alam Lakhani Benjamin Jung Rollin F Brant Kevan Jacobson | 2019 | World Journal of Gastroenterology2019，25，10： | 3 |
| 3 | Limbic and neocortical gliomas associated with intractable seizures: A distictclinicopathological group显示文摘 | Itzhak F Jung HK Dennis DS | 1994 | Neurosurgery1994，34，： | 2 |
| 4 | Coherent destruction of tunneling显示文摘 | Grossmann F Dittrich T Jung P | 1991 | Physical Review Letters1991，67，： | 2 |
| 5 | Anti-CD16/CD30 bispecific antibody treatment for Hodgkin's disease: role of infusion schedule and costimulation with cytokines 显示文摘 | Hartmann F Renner C Jung W ET aI | 2001 | Clinical Cancer Research2001，7，7： | 1 |
| 6 | Development of monocytes, macrophages, and dendritic cells 显示文摘 | Geissmann F Manz MG Jung S | 2010 | Sci2010，327，5966： | 1 |
| 7 | Microbiogical data, but not procalcitonin improve the accuracy of the clinical pulmonary infection score显示文摘 | Jung B Embriaco N Roux F | 2010 | Intensive Care Med2010，36，5： | 1 |
| 8 | Hemorheologic, micro-and macro-circulatory effects of an infusion of 500 mL 6% medium molecular weight hydroxyethyl starch显示文摘 | Jung F Waldhausen P Mrowietz C | 1989 | Infusionstherapie1989，16，： | 1 |
| 9 | Utility of immunochemical techniques for the analysis of pesticides显示文摘 | Jung F Gee S J | 1989 | Pestic Sci1989，26，： | 1 |
| 10 | Precise, automatic andfast method for vanishing point detection显示文摘 | Kalantari M Jung F Guedon J | 2009 | The PhotogrammetricRecord2009，24，127： | 1 |
| 11 | Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression,which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells显示文摘 | Fukuda R Hirota K Fan F Jung YD Ellis LM Semenza GL | | 0，，41： | 1 |
| 12 | State-of-the-art of semiactive control systems using MR fluid dampers in civil engineering applications显示文摘 | Jung H J Spencer B F Jr Ni Y Q | 2004 | Structural Engineering and Mechanics2004，17，34： | 1 |
| 13 | Microcirculation in hyper- tensive patients显示文摘 | Jung F Pindur G Ohlmann P | 2013 | Biorheology2013，50，56： | 1 |
| 14 | Development of a sensitive enzyme-linked immunosrbent aassay for the fungicide fenpropimorph显示文摘 | Jung F Meyer H D Hamm R T | 1989 | J Agric Food Chem1989，37，： | 1 |
| 15 | Dynamic modeling of large-scale magnetorheological damper systems for civil engineering applications 显示文摘 | Yang G Spencer B F Jung H H Carlson J D | 2004 | Journal of Engineering Mechanics2004，130，9： | 1 |
| 16 | Use of immunochemical techniques for the analysis of pesticides 显示文摘 | Jung F Gee S J Harrison R 0 | 1989 | Pestic Sci1989，26，： | 1 |
| 17 | Growth factor-induced phosphoinositide 3-OH kinase/Akt phosphorylation in smooth muscle cells:induction of cell proliferation and inhibition of cell death显示文摘 | Jung F Haendeler J Gaebel C | 2000 | Cardiovasc Res2000，48，： | 1 |
| 18 | A holey-structured metamaterial for acoustic deep-subwavelength imaging显示文摘 | Zhu J Christensen J Jung J Martin-moreno L Yin X Fok L Zhang X Garcia-vidal F J | 2011 | Nature Physics2011，，1： | 1 |
| 19 | Signal recovery from partial information via orthogonal matching pursuit显示文摘 | THEIS F J JUNG A PUNTONET C G | 2007 | IEEE Transactions on Information Theory2007，15，2： | 1 |
| 20 | Development of mon-ocytes, macrophages, and dendritic cells 显示文摘 | Geissmann F Manz MG Jung S | 2010 | Science2010，327，5966： | 1 |
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