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| 1 | 前列腺癌调强放疗计划等效均匀剂量法优化研究显示文摘目的评价等效均匀剂量(EUD)优化法在前列腺癌调强放疗计划优化中的应用价值。方法随机抽取10例已接受调强放疗的前列腺癌病例,其治疗计划均基于剂量一体积(DV)优化法得到。将直肠、膀胱、小肠的约束条件改为EUD约束,其他优化条件不变。比较新旧治疗计划的剂量学差异并行配对t检验。结果EUD优化比DV优化对靶区的适形度好(1.00±0.04:0.94±0.04,t=3.80,P=0.04),对危及器官降低了直肠D53(24.4±2.7:25.5±2.6,t=一3.82,P=0.004)、D30(34.1±4.3:39.1±2.1,t=一3.80,P=0.004)、Dl。。3(51.4±1.0:51.8±0.9,t=一2.42,P=0.039)和膀胱V10(92.2±6.2:99.4±1.1,t=一4.28,P:0.002)、V20(70.7±5.7:78.7±6.3,t=一3.10,P=0.013),以及小肠V100(62.2±30.2:74.7±30.0,t=一4.18,P=0.002)、V20(34.3±26.3:46.5±30.9,t=一5.46,P=0.000)、V30(17.1±17.0:25.1±22.6,t=一3.52,P=0.007)、V40(10.6±11.5:15.6±16.1,t=一2.64,P=0.030)。结论EUD优化对靶区适形度好,并能有效降低直肠、膀胱及小肠受照剂量。 | 廖雄飞 Jack Yang 黎杰 王培 | 2013 | 中华放射肿瘤学杂志2013，22，2： | 12 |
| 2 | 等效均匀剂量优化法在肺癌调强放疗计划优化中的应用显示文摘目的:评估等效均匀剂量(EUD)优化法在肺癌调强放疗计划优化中的作用。方法:随机抽取10例治疗计划基于剂量-体积优化法得到,且已完成调强放射治疗的肺癌病例,将治疗计划中的危及器官全肺、心脏以及脊髓的约束条件改为EUD约束,保持其它优化条件不变,设计出新的治疗计划,比较新旧治疗计划的剂量学差异。结果:在靶区剂量分布没有差别甚至更好的情况下,基于EUD优化能够使全肺的V_(20)和D_(mean)分别降低2.1%、1.0Gy,心脏的D_(33)和D_(mean)分别降低2.2Gy、1.9Gy,脊髓的D_(1cc)降低6Gy,经配对t检验,差异均有统计学意义(P<0.05)。结论:EUD优化能够有效降低全肺、心脏以及脊髓的受照剂量,这对于降低肺癌患者放射治疗并发症具有重大意义,同时也为进一步提高肿瘤靶区剂量,提高肿瘤局部控制率提供了可能。 | 廖雄飞 Jack Yang Yie Chen 黎杰 王培 | 2012 | 肿瘤预防与治疗2012，25，6： | 9 |
| 3 | Optimized quantitative angiographic and intravascular ultrasound parameters predicting the functional significance of single de novo lesions in the left anterior descending artery显示文摘 | Tak W. Kwan YANG Song XU Bo Jack Chen XU Tian YE Fei ZHANG Jun-jie TIAN Nai-liang LIU Zhi-zhong CHEN Shao-liang | 2012 | Chinese Medical Journal2012，，23： | 8 |
| 4 | 调强放疗计划多目标优化算法比较研究显示文摘目的探讨多目标优化(MCO)算法在调强放疗计划优化中的应用。方法随机抽取已接受治疗的10例前列腺癌和10例肺癌患者的调强治疗计划,这些计划都是基于直接子野优化算法进行优化的。在射野方向等设置条件不变前提下,改用MCO算法重新优化治疗计划。比较两种优化算法得到的剂量体积直方图参数、计划优化时间和机器跳数,并行配对t检验。结果两种优化算法得到的调强计划均满足临床要求。与DMPO算法相比,在靶区剂量分布无差别下MCO算法使得前列腺癌计划中的直肠、膀胱及小肠受量均有不同程度降低,计划优化时间减少58%,机器跳数平均增加32%;在肺癌计划中肺、心脏和脊髓受量均有不同程度降低,计划优化时间减少59%,机器跳数平均增加11%。结论与DMPO算法相比,MCO算法可显著降低危及器官受照剂量、缩短计划优化时间。 | 廖雄飞 Jack Yang Yie Chen 黎杰 肖明勇 王培 | 2013 | 中华放射肿瘤学杂志2013，22，4： | 8 |
| 5 | Mechanisms and clinical significance of quality of final kissing balloon inflation in patients with true bifurcation lesions treated by crush stenting technique显示文摘背景为吻的出现负责的机制未得到满足(KUS ) 在古典压碎 stenting 以后结果仍然保持不清楚。现在的学习瞄准了分析机制和 KUS 的临床的意义。有真分叉损害的 213 个病人与古典压碎 stenting 和最后的吻汽球通货膨胀( FKBI )对待的方法根据分支给视觉评价换新电线由估计了的方面的位置被分到上面、中间、更低的组,量的冠的分析( QCA )和 intravascular 超声( IVUS )。Angiographic 后续在 12 months.Results 被索引上面的组被 55.53 的一个更大的分叉角度描绘吗? | ZHANG Jun-jie CHEN Shao-liang YE Fei YANG Song KAN Jing LIU Yue-qiang ZHOU Yong SUN Xue-wen ZHANG Ai-ping WANG Xin CHEN Jack | 2009 | Chinese Medical Journal2009，，18： | 8 |
| 6 | 人类端粒酶逆转录酶hTERT Ki-67及p27^(kip1)在嗜铬细胞瘤组织的表达及意义研究显示文摘目的研究人端粒酶逆转录酶(hTERT)、Ki-67及p27kip1的表达在嗜铬细胞瘤发生与发展中的作用和作为预测生物学行为标志物的价值。方法采用免疫组织化学方法检测hTERT、Ki-67及p27kip1在2000—2004年广西医科大学第一附属医院病理科的45例嗜铬细胞瘤和神经节细胞瘤及9例正常肾上腺组织中的表达。结果hTERT蛋白的表达在良性(3/31例)和可疑恶性(6/7例)以及良性与恶性肿瘤(5/7例)间的差异均有统计学意义(P<0.01)。31例良性肿瘤中26例未检测到Ki-67,而恶性肿瘤和可疑恶性肿瘤均为阳性;Ki-67与hTERT的表达呈正相关性(r=0.544,P<0.01)。恶性和可疑恶性肿瘤中未检测到p27kip1,5例良性肿瘤为阳性,所有正常肾上腺髓质标本均可检测到p27kip1的表达。p27kip1与hTERT的表达无相关性。结论端粒酶的激活在恶性嗜铬细胞瘤和神经节细胞瘤的发生发展中起着重要作用,在细胞周期调控中端粒酶可能存在不同的激活途径。hTERT和Ki-67的检测可作为鉴别良恶性嗜铬细胞瘤的手段。 | 李健玲 罗佐杰 秦映芬 韦敏怡 梁杏欢 冼晶 卢德成 沈昱 何志恒 Jack Y.YANG Mary Qu YANG | 2006 | 中国实用内科杂志:临床前沿版2006，26，11： | 2 |
| 7 | Carbon-based bifunctional electrocatalysts for oxygen reduction and oxygen evolution reactions:Optimization strategies and mechanistic analysis显示文摘Electrocatalysts are one of the essential components for the devices of high-efficiency green energy storage and conversion,such as metal-air cells,fuel cells,and water electrolysis systems.While catalysts made from noble metals possess high catalytic performance in both oxygen reduction reaction(ORR)and oxygen evolution reaction(OER),their scarcity and expensiveness significantly limit large-scale applications.In this regard,metal-free/non-noble metal carbon-based catalysts have become competitive alternatives to replace catalysts made of noble metals.Nevertheless,low catalytic ORR/OER performance is the challenge of carbon-based catalysts for the commercial applications of metal-air batteries.To solve the problem of poor catalytic performance,two strategies have been proposed:(1)controlling the microstructure of the catalysts to expose more active sites as the channels of rapid mass and electron transfer;and(2)reducing the reaction energy barrier by optimizing the electronic structures of the catalysts via surface engineering.Here,we review different types of bifunctional ORR/OER electrocatalysts with the activated surface sites.We focus on how the challenge can be overcome with different methods of material synthesis,structural and surface characterization,performance validation/optimization,to outline the principles of surface modifications behind catalyst designs.In particular,we provide critical analysis in the challenges that we are facing in structural design and surface engineering of bifunctional ORR/OER catalysts and indicate the possible solution for these problems,providing the society with clearer ideas on the practical prospects of noble-metal-free electrocatalysts for their future applications. | Huidong Xu Jack Yang Riyue Ge Jiujun Zhang Ying Li Mingyuan Zhu Liming Dai Sean Li Wenxian Li | 2022 | Journal of Energy Chemistry2022，31，8： | 2 |
| 8 | An fMRI study of somatosensoryimplicated acupuncture points in stable somatosensory stroke patients显示文摘 | Li G Jack CR Jr Yang ES | 2006 | J Magn Reson Imaging2006，24，5： | 1 |
| 9 | The K domain mediates heterodimerization of the Arabidopsis floral organ identity proteins ,APETALA3 and PISTILLATA 显示文摘 | YANG Y FANNING L JACK T | 2003 | Plant J2003，33，1： | 1 |
| 10 | Application of atmospheric pressure ionization time-of-flight mass spectrometry coupled with liquid chromatography for the characterization of in vitro drug metabolites显示文摘 | Jack Henion Yi YANG | 2000 | Anal Chem2000，72，： | 1 |
| 11 | Defining subdomains of the K domain important for protein–protein interactions of plant MADS proteins显示文摘 | Yingzhen Yang Thomas Jack | 2004 | Plant Molecular Biology2004，，1： | 1 |
| 12 | The drug/metabolite transporter superfamily显示文摘 | Jack DL Yang NM Saier MH | 2001 | Eur J Biochem2001，268，13： | 1 |
| 13 | Increase in DPP-IV in the intestine, liver and kidney of the rat treated with high fat diet and streptozotocin显示文摘 | Jian Yang Jack Campitelli Gang Hu Yanhe Lin Jin Luo Chun Xue | 2007 | Life Sciences2007，，4： | 1 |
| 14 | Evidence of impaired adipogenesis in insulin resistance显示文摘 | Jansson PA Nagaev I Jack MM Carvalho E Sunnerhagen KS | 2004 | Biochem Biophys Res Commun2004，317，4： | 1 |
| 15 | Oxidative coupling of methane over Na2WO4/CeO2 and related catalysts显示文摘 | Yu Z Q Yang X M Jack H Lunsford | 1995 | J Catal1995，154，： | 1 |
| 16 | Pistillata-5, an Arabidopsis B class mutant with strong defects in petal but not in stamen development显示文摘 | YANG Y XIANG H JACK T | 2003 | Plant J2003，33，： | 1 |
| 17 | The K domain mediates heterodimerization of the Arabidopsis floral organ identity proteins, APETALA3 and PISTILLATA 显示文摘 | Yang Yingzhen Fanning L Jack T | 2003 | Plant J2003，33，： | 1 |
| 18 | The K domain mediates heterodimerization of the Arabidopsis floral organ identity proteins,APETALA3 and PISTILLATA显示文摘 | YANG Y FANNING L JACK T | | 0，，01： | 1 |
| 19 | Defining subdomains of the K domain important for protein-protein interactions of plant MADS proteins显示文摘 | YANG Y JACK T | | 0，，01： | 1 |
| 20 | Molybdenum disulfide(MoS2)-based electrocatalysts for hydrogen evolution reaction:From mechanism to manipulation显示文摘Molybdenum disulfide(MoS_(2))-based materials as the non-noble metal catalysts have displayed the potential capability to drive electrocatalytic hydrogen evolution reaction(HER)for green hydrogen production along with their intrinsic activity,tunable electronic properties,low cost,and abundance reserves,which have attracted intensive attention as alternatives to the low-abundance and high-cost platinum-based catalysts.However,their insufficient catalytic HER activities and stability are the major challenges for them to become practically applicable.Hereby,the MoS_(2)-based electrocatalysts for HER are comprehensively reviewed to explain the fundamental science behind the manipulations of the crystal structure,microstructure,surface,and interface of MoS_(2) in order to enhance its catalytic performance through changing the electrical conductivity,the number of active sites,surface wettability,and the Gibbs free energy for hydrogen adsorption(ΔGH).Recent studies in surface/interface engineering,such as phase engineering,defect engineering,morphology design,and heterostructure construction,are analyzed to reveal the state-of-the-art strategies for designing and preparing the cost-effective and highperformance MoS_(2)-based catalysts through optimizing the charge transfer,surface-active sites,ΔGH,and surface hydrophilicity.Lastly,the perspectives,challenges,and future research directions of HER electrocatalysis are also given to facilitate the further research and development of HER catalysts. | Yao Xu Riyue Ge Jack Yang Jiancheng Li Sean Li Ying Li Jiujun Zhang Jing Feng Bin Liu Wenxian Li | 2022 | Journal of Energy Chemistry2022，31，11： | 1 |
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