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| 1 | 急性病毒性心肌炎的药物治疗观察显示文摘目的 全国十二家大型医院协作观察中西医结合治疗急性病毒性心肌炎疗效。方法 对 10 2 8例临床诊断为急性病毒性心肌炎患者随机各分两组 ,治疗组 60 2例 ,用中西医结合 (黄芪、牛磺酸、泛葵利酮、抗心律失常药等)治疗 ;对照组 4 2 6例 ,用常规 (极化液、抗心律失常药等 )治疗。结果 中西医结合治疗组临床症状改善、外周血肠道病毒阴转、心电图ST T改变及房室传导阻滞、阵发性心房颤动、窦房传导阻滞等恢复均优于对照组(P <0 .0 1、0 .0 5 ) ;对早搏及心功能改善两组间无统计学差异(P <0 .0 5 )。结论 在目前对急性病毒性心肌炎无特效药物治疗的情况下 ,采用中西医结合治疗可作为一种治疗手段。 | Collaborative Group of “Key National Medical Projects for the Ninth Five Year Plan Research” (Correspondence: YANG Yingzhen, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital,Shanghai Medical University,Shanghai 200032) | 1999 | 中华心血管病杂志1999，27，6： | 94 |
| 2 | Thermal-responsive genetic and epigenetic regulation of DAM cluster controlling dormancy and chilling requirement in peach floral buds显示文摘The Dormancy-associated MADS-box(DAM)gene cluster in peach serves as a key regulatory hub on which the seasonal temperatures act and orchestrate dormancy onset and exit,chilling response and floral bud developmental pace.Yet,how different temperature regimes interact with and regulate the six linked DAM genes remains unclear.Here,we demonstrate that chilling downregulates DAM1 and DAM3–6 in dormant floral buds with distinct patterns and identify DAM4 as the most abundantly expressed one.We reveal multiple epigenetic events,with tri-methyl histone H3 lysine 27(H3K27me3)induced by chilling specifically in DAM1 and DAM5,a 21-nt sRNA in DAM3 and a ncRNA induced in DAM4.Such induction is inversely correlated with downregulation of their cognate DAMs.We also show that the six DAMs were hypermethylated,associating with the production of 24-nt sRNAs.Hence,the chilling-responsive dynamic of the different epigenetic elements and their interactions likely define distinct expression abundance and downregulation pattern of each DAM.We further show that the expression of the five DAMs remains steadily unchanged or continuously downregulated at the ensuing warm temperature after chilling,and this state of regulation correlates with robust increase of sRNA expression,H3K27me3 and CHH methylation,which is particularly pronounced in DAM4.Such robust increase of repressive epigenetic marks may irreversibly reinforce the chillingimposed repression of DAMs to ensure flower-developmental programming free from any residual DAM inhibition.Taken together,we reveal novel information about genetic and epigenetic regulation of the DAM cluster in peach,which will be of fundamental significance in understanding of the regulatory mechanisms underlying chilling requirement and dormancy release,and of practical application for improvement of plasticity of flower time and bud break in fruit trees to adapt changing climates. | Hong Zhu Pao-Yang Chen Silin Zhong Chris Dardick Ann Callahan Yong-Qiang An Steve van Knocker Yingzhen Yang Gan-Yuan Zhong Albert Abbott Zongrang Liu | 2020 | Horticulture Research2020，7，1： | 9 |
| 3 | Two Poplar Glycosyltransferase Genes, PdGATL 1.1 and PdGATL1.2, Are Functional Orthologs to PARVUS/AtGATL 1 in Arabidopsis显示文摘包括 PARVUS/AtGATL1,在 Arabidopsis 的几基因在木聚糖合成被含有。然而,在这多糖是木头的一个主要部件的地方,在木质的植物的木聚糖的生合成糟糕被理解。这里,我们描绘二 Populus 基因, PdGATL1.1 和 PdGATL1.2,最靠近的 orthologs 到 Arabidopsis PARVUS/GATL1 基因关于他们在白杨的基因表示,他们在 Arabidopsis 补充 parvus 变化的亚 cellular 本地化,和他们的能力。包括词法变化,在缺点的救的大多数由 parvus 变化引起了的 parvus 异种的二白杨基因的 Overexpression 折叠木部,并且改变了房间墙 monosaccharide 作文。量的 RTPCR 证明 PdGATL1.1 在开发白杨的木部最强烈被表示。相反, PdGATL1.2 在叶,射击尖端,外皮,韧皮部,和木部更一致地被表示,并且 PdGATL1.2 的抄本水平是比在检验的所有纸巾的 PdGATL1.1 的低得多的。亚 cellular 本地化实验证明这二蛋白质对局部性嗯并且与到这些亚 cellular 分隔空间的标记蛋白质居民比较的 Golgi。我们的数据显示 PdGATL1.1 和 PdGATL1.2 是 PARVUS/GATL1 的功能的 orthologs 并且能在木聚糖合成起一个作用,但是可以也在另外的墙聚合物的合成有角色。 | Yingzhen Kong Gongke Zhou Utku Avci Xiaogang Gu Chelsea Jones Yanbin Yin Ying Xu Michael G. Hahn | 2009 | Molecular Plant2009，2，5： | 6 |
| 4 | Channel morphologic processes of a highly sinuous bend approaching neck cutoff by bank erosion in the middle Yangtze River显示文摘The distal reach of the Lower Jingjiang River(LJR)in the middle of the Yangtze River consists of five adjacent bends,among which the Qigongling Bend is a U-shaped meander with a mean sinuosity of 2.2 and the narrowest neck 525 m in width.This bend is slowly approaching neck cutoff owing to progressive bank erosion.An abnormal phenomenon has occurred in this bend since the Three Gorges Reservoir(TGR)began to operate in 2003 which is erosion in the inner bank zone and deposition in the outer bank zone.This problem has not been fully understood because of the interplay of changes in water-sediment,bank erosion,and artificial bank revetment.In this study,aerial and remote sensing images,hydrological data,channel topography,and an existing bank erosion model are used to reveal channel morphodynamics of this bend and the trend of the potential neck cutoff induced by bank erosion.The study results show that the clear water released from the TGR has provided by forcefully eroded the point bar of inner bank but failed to scour the outer bank due to the protection of bank revetment since the 1990 s.Thus far,the outer bank zone near the bend apex has increasingly widened in conjunction with the formation of 2 emerging sand bars.Consequently,the thalweg of the main channel has laterally shifted toward the inner bank by roughly 800 m.More severely,the rate of bank retreat on the upstream side of the bend neck was about 4.5 m/yr in 2010-2019,but the downstream side of this neck was experienced slight deposition.Bank erosion could be accelerated by progressively increasing erosion and eventually trigger the occurrence of neck cutoff in the next few decades,thereby significantly altering the quasi-equilibrium regime of channel morphodynamics in the LJR. | Zhiwei Li Hanyuan Yang Junqiang Xia Meirong Zhou Shanshan Deng Yingzhen Wang | 2021 | International Journal of Sediment Research2021，36，4： | 5 |
| 5 | 隧道数字化火灾预警系统的在线量化评估显示文摘为检查和评价隧道及地下空间火灾预警系统的实际功能,需要一套可行的在线评估手段。根据近年来国内外全尺寸隧道火灾发展曲线的试验结果,提出隧道火情的定义依据;引用运营隧道内准分布式光纤光栅感温火灾探测器的实测数据,证明运营中隧道报警系统的个性化现象;提出合格的数字化报警系统应存在一个在统计学意义上使漏报率和误报率同时达到期望值的合理阈值取值区间;建议以该区间的尺度作为该系统功能完好性的评估指标;对日常隧道运行温度数据的统计分析可估计合理阈值取值区间的下限,对规定条件下的现场点火试验温度数据分析可估计合理阈值取值区间的上限。在隧道运营期该区间尺度可实时在线自动更新。 | 赵浩 张光 LI Yingzhen 杜新民 | 2019 | 隧道建设(中英文)2019，39，S02： | 4 |
| 6 | Osteoclasts are not a source of SLIT3显示文摘The axon guidance cue SLIT3 was identified as an osteoanabolic agent in two recent reports. However, these reports conflict in their nomination of osteoblasts versus osteoclasts as the key producers of skeletal SLIT3 and additionally offer conflicting data on the effects of SLIT3 on osteoclastogenesis. Here, aiming to address this discrepancy, we found no observable SLIT3 expression during human or mouse osteoclastogenesis and the only modest SLIT3-mediated effects on osteoclast differentiation. Conditional deletion of SLIT3 in cathepsin K(CTSK)-positive cells, including osteoclasts, had no effect on the number of osteoclast progenitors, in vitro osteoclast differentiation, overall bone mass, or bone resorption/formation parameters. Similar results were observed with the deletion of SLIT3 in Lys M-positive cells, including osteoclast lineage cells. Consistent with this finding, bone marrow chimeras made from Slit3-/-donors that lacked SLIT3 expression at all stages of osteoclast development displayed normal bone mass relative to controls. Taken in context, multiple lines of evidence were unable to identify the physiologic function of osteoclast-derived SLIT3,indicating that osteoblasts are the major source of skeletal SLIT3. | Na Li Kazuki Inoue Jun Sun Yingzhen Niu Sarfaraz Lalani Alisha Yallowitz Xu Yang Chao Zhang Rong Shen Baohong Zhao Ren Xu Matthew B.Greenblatt | 2020 | Bone Research2020，8，2： | 4 |
| 7 | Characteristics of the Late Quaternary right-lateral strike-slip movement of Bolokenu-Aqikekuduk fault in northern Tianshan Mountains,NW China显示文摘The characteristics of the Bolokenu-Aqikekuduk(Bo-A) fault,a right-lateral strike-slip fault that runs for more than 700 km long and obliquely cuts North Tianshan Mountains,are evaluated here based on remote sensing data,and through an analysis of the results from field investigations as well as climate-geomorphic events. The fault is composed of a western segment with a NW strike and an eastern segment with a NWW strike.The western segment is nearly 250 km long,extending northwestward into Kazakhstan with a right-lateral strike-slip rate of 5 mm/a.This domain consists of 4-5 rupture sections,with 3-4 deformation belts,caused by ancient or historical earthquakes,and suggesting the potential for the occurrence of further strong earthquakes(with M≈7.5) in future. The eastern segment of the fault shows a right-lateral strike-slip rate of 1-1.4 mm/a,with the development of 3-4 deformation belts caused by ancient or historical earthquakes,and with a potential for future strong earthquake with M≈7.0. A typical strain partitioning style in the compression area has developed between the intermontane BoA fault and the piedmont thrust structures of Northern Tianshan Mountains,under the effect of oblique compression,as indicated by the piedmont thrust structure and the strike-slip fault in the mountains. | Jun Shen Yipeng Wang Yingzhen Li | 2011 | Geoscience Frontiers2011，2，4： | 4 |
| 8 | Telomere-to-telomere and gap-free reference genome assembly of the kiwifruit Actinidia chinensis显示文摘Kiwifruit is an economically and nutritionally important fruit crop with extremely high contents of vitamin C.However,the previously released versions of kiwifruit genomes all have a mass of unanchored or missing regions.Here,we report a highly continuous and completely gap-free reference genome of Actinidia chinensis cv.‘Hongyang’,named Hongyang v4.0,which is the first to achieve two de novo haploid-resolved haplotypes,HY4P and HY4A.HY4P and HY4A have a total length of 606.1 and 599.6 Mb,respectively,with almost the entire telomeres and centromeres assembled in each haplotype.In comparison with Hongyang v3.0,the integrity and contiguity of Hongyang v4.0 is markedly improved by filling all unclosed gaps and correcting some misoriented regions,resulting in∼38.6–39.5 Mb extra sequences,which might affect 4263 and 4244 protein-coding genes in HY4P and HY4A,respectively.Furthermore,our gap-free genome assembly provides the first clue for inspecting the structure and function of centromeres.Globally,centromeric regions are characterized by higher-order repeats that mainly consist of a 153-bp conserved centromere-specific monomer(Ach-CEN153)with different copy numbers among chromosomes.Functional enrichment analysis of the genes located within centromeric regions demonstrates that chromosome centromeres may not only play physical roles for linking a pair of sister chromatids,but also have genetic features for participation in the regulation of cell division.The availability of the telomere-to-telomere and gap-free Hongyang v4.0 reference genome lays a solid foundation not only for illustrating genome structure and functional genomics studies but also for facilitating kiwifruit breeding and improvement. | Junyang Yue Qinyao Chen Yingzhen Wang Lei Zhang Chen Ye Xu Wang Shuo Cao Yunzhi Lin Wei Huang He Xian Hongyan Qin Yanli Wang Sijia Zhang Ying Wu Songhu Wang Yi Yue Yongsheng Liu | 2023 | Horticulture Research2023，10，2： | 4 |
| 9 | A key‘foxy’aroma gene is regulated by homologyinduced promoter indels in the iconic juice grape‘Concord’显示文摘‘Concord’,the most well-known juice grape with a parentage of the North American grape species Vitis labrusca L.,possesses a special‘foxy’aroma predominantly resulted from the accumulation of methyl anthranilate(MA)in berries.This aroma,however,is often perceived as an undesirable attribute by wine consumers and rarely noticeable in the common table and wine grape species V.vinifera.Here we discovered homology-induced promoter indels as a major genetic mechanism for species-specific regulation of a key‘foxy’aroma gene,anthraniloyl-CoA:methanol acyltransferase(AMAT),that is responsible for MA biosynthesis.We found the absence of a 426-bp and/or a 42-bp sequence in AMAT promoters highly associated with high levels of AMAT expression and MA accumulation in‘Concord’and other V.labrusca-derived grapes.These promoter variants,all with direct and inverted repeats,were further confirmed in more than 1,300 Vitis germplasm.Moreover,functional impact of these indels was validated in transgenic Arabidopsis.Superimposed on the promoter regulation,large structural changes including exonic insertion of a retrotransposon were present at the AMAT locus in some V.vinifera grapes.Elucidation of the AMAT genetic regulation advances our understanding of the‘foxy’aroma trait and makes it genetically trackable and amenable in grapevine breeding. | Yingzhen Yang JoséCuenca Nian Wang Zhenchang Liang Honghe Sun Benjamin Gutierrez Xiaojun Xi Jie Arro YiWang Peige Fan Jason Londo Peter Cousins Shaohua Li Zhangjun Fei Gan-Yuan Zhong | 2020 | Horticulture Research2020，7，1： | 3 |
| 10 | A new method to solve the damped nonlinear Klein-Gordon equation显示文摘This paper discusses a damped nonlinear Klein-Gordon equation in the reproducing kernel space and provides a new method for solving the damped nonlinear Klein-Gordon equation based on the reproducing kernel space.Two numerical examples are given for illustrating the feasibility and accuracy of the method. | LIN YingZhen CUI MingGen | 2008 | Science China Mathematics2008，51，2： | 3 |
| 11 | Corrosion behavior of plasma sprayed ceramic and metallic coatings on carbon steel in simulated seawater显示文摘 | Zhe Liu Yanchun Dong Zhenhua Chu Yong Yang Yingzhen Li Dianran Yan | 2013 | Materials and Design2013，，： | 2 |
| 12 | Defining subdomains of the K domain important for protein–protein interactions of plant MADS proteins显示文摘 | Yingzhen Yang Thomas Jack | 2004 | Plant Molecular Biology2004，，1： | 1 |
| 13 | Protective effects of protocatechuic acid on acute lung injury induced by lipopolysaccharide in mice via p38MAPK and NF-κB signal pathways显示文摘 | Xiuli Zhang Chunli Li Jun Li Yingzhen Xu Shui Guan Mingshan Zhao | 2015 | International Immunopharmacology2015，，1： | 1 |
| 14 | Nonlinear numerical analysis in the reproducing kernel space显示文摘 | Minggen C Yingzhen L | 2009 | 2009，，： | 1 |
| 15 | Repre- sentation of the exact solution for a kind of nonlinear partial differential equations显示文摘 | LIN Yingzhen CUI Minggen YANG Lihong | 2006 | Applied Mathematics Letters2006，19，： | 1 |
| 16 | Hydroxyl radical scavenging activity of β-N-oxalyl-L-α, β-diamino propionic acid显示文摘 | Zhou Gongke Kong Yingzhen Cui Kuirong | 2001 | Phytochemistry2001，58，5： | 1 |
| 17 | The relationship between human cytomegalovirus infection and atherosclerosis development显示文摘 | Ruizhen Chen Sidong Xiong Yingzhen Yang Weiguo Fu Yuqi Wang Junbo Ge | 2003 | Molecular and Cellular Biochemistry (-)2003，，1： | 1 |
| 18 | The K domain mediates heterodimerization of the Arabidopsis floral organ identity proteins, APETALA3 and PISTILLATA 显示文摘 | Yang Yingzhen Fanning L Jack T | 2003 | Plant J2003，33，： | 1 |
| 19 | One-Pot Three-Dimensional Printing Robust Self-Supporting MnO_(x)/Cu-SSZ-13 Zeolite Monolithic Catalysts for NH_(3)-SCR显示文摘Honeycomb cordierite coated with Cu-SSZ-13 zeolite is widely used for the selective catalytic reduction of NO_(x) with NH_(3)(NH_(3)-SCR)to reduce pollutants from vehicle emissions.However,conventional honeycomb catalysts fabricated via coating techniques are limited by low zeolite loadings,loss of the deposited zeolites,and complicated preparation processes.Herein,a facile,one-step three-dimensional(3D)printing strategy is developed to construct MnO_(x)/Cu-SSZ-13 monolithic catalysts with excellent catalytic performance for NH_(3)-SCR.Iron-containing halloysite nanotubes(Fe-HNTs)are introduced as printing ink additives to ensure mechanical stability and modulate the NH_(3)-SCR performance of monolithic catalysts in high temperature conditions.In situ incorporation of Mn into the Cu-SSZ-13 zeolite monoliths during the 3D printing process boosts the mechanical strength of the monolithic structures from 2.54 MPa to 4.33 MPa as well as broadens the temperature window(165-550℃)of the catalysts for NH_(3)-SCR with NO_(x) conversion of above 80%.Such robust multicomponent-integrated 3D-printed selfsupporting catalysts not only possess high zeolite loading and excellent catalytic activity,but also avoid complicated manufacturing processes,which contrasts with conventional honeycomb catalysts fabricated by extrusion coupled with coating. | Yingzhen Wei Mengyang Chen Xiaoyu Ren Qifei Wang Jinfeng Han Wenzheng Wu Xiangguang Yang Shuang Wang Jihong Yu | 2022 | CCS Chemistry2022，4，5： | 1 |
| 20 | Polypbenofic composition and content in the ripe berries of wild Vitis species显示文摘 | Liang Zhenchang Yang Yingzhen Cheng Lailiang | 2012 | Food Chemistry2012，132，2： | 1 |
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