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| 1 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | Extracorporeal photochemotherapy for treatment of clonal T cell proliferations 显示文摘 | Plumas J Drillat P Jacob MC | 2003 | Bull Cancer2003，90，89： | 1 |
| 3 | Autologous stem cell transplantation for systemic lupus erythematosus显示文摘 | David J Jacob P Alberto M | 2004 | Lupus2004，13，3： | 1 |
| 4 | Protection of experimentally infected pigs by suil- ysin, the thiol-activated haemolysin of Streptococcus suis 显示文摘 | JACOBS A A VAN DEN BERG A J LOEFFEN P L | 1996 | Vet Rec1996，139，10： | 1 |
| 5 | Efficient hydrolytic hydrogenation of cellulose in the presence of Ru-loaded zeolites and trace amounts of mineral acid显示文摘 | GEBOERS J VAN DE VYVER S CARPENTIER K JACOBS P SELS B | 2011 | Catal Commun2011，47，19： | 1 |
| 6 | Measured context-sensitive half-times of remifentanil and alfentanil 显示文摘 | KAPILA A GLASS P S JACOBS J R | 1995 | Anesthesiology1995，83，5： | 1 |
| 7 | Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate显示文摘 | Zhou P Byrne C Jacobs J | 1995 | Genes Dev1995，9，： | 1 |
| 8 | Identification, purification, and characterization of a thiol-activated hemolysin(suilysin) of Streptococcus suis 显示文摘 | JACOBS A A C LOEFFEN P L W BERG A J G | 1994 | Infect Immun1994，62，5： | 1 |
| 9 | The vapour pressure and enthalpy of sublimation of ferrocene显示文摘 | JACOBS M H G VANEKEREN P J DEKRUIF C G | 1983 | The Journal of Chemical Thermodynamics1983，15，7： | 1 |
| 10 | Crystallines microporous phosphates: A family of versatile catalysts and adsorbents 显示文摘 | MARTENS J M JACOBS P A | 1994 | Studies in Surface Science and Catalysis1994，85，： | 1 |
| 11 | A genomewide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer显示文摘 | HUNTER D J KRAFT P JACOBS K B | 2007 | Nature genetics2007，39，7： | 1 |
| 12 | A motion planner for nonholonomic mobile robots 显示文摘 | Laumont J P Jacobs P E Taix M | 1994 | IEEE Transactions on Robotics and Automation1994，10，5： | 1 |
| 13 | Estimation of the void structure and pore dimensions of molecular sieve zeo- lites using the hydroconversion of n-deeane 显示文摘 | Martens J A Tielen M Jacobs P A | 1984 | Zeolites1984，4，2： | 1 |
| 14 | Isomerization and hydrocracking of heptane over bimetallic bifunctional Pt- Pd/H - Beta and PtPd/USY zeolite catalysts 显示文摘 | Blomsma E Martens J A Jacobs P A | 1997 | J Catal1997，165，： | 1 |
| 15 | Percutaneous imaging -guided core breast biopsy:5 years experence in a community hos pital显示文摘 | Margolin F R Leung J W Jacobs R P | 2001 | AmJ Roentgenol2001，177，： | 1 |
| 16 | Cotinine in the serum,sali-va,and urine of nonsmokers,passive smokers,and active smokers显示文摘 | Wall MA Johnson J Jacob P | 1988 | Am J Public Health1988，78，6： | 1 |
| 17 | Metabolism and dis- position kinetic of nicotine 显示文摘 | Hukkanen J Jacob P 3rd Benowitz NL | 2005 | PharmacolRev2005，57，1： | 1 |
| 18 | The Potential and Limitatoins of then-Decane Hydroconversion a Test Reaction for Characteriza- tion of the Void Space of Molecular Sieve Zeolites 显示文摘 | Martens J A Jacobs P A | 1986 | Zeo- lites1986，6，5： | 1 |
| 19 | Automatic target recognition using sequences of high resolution radar profiles 显示文摘 | JACOBS S P OSOLLIVAN J A | 2000 | IEEE Trans of AES2000，36，2： | 1 |
| 20 | Reaction mechanisms of isomerization and cracking of heptane on Pd/H - Beta zeolite显示文摘 | Blomsma E Martens J A Jacobs P A | 1995 | J Catal1995，155，： | 1 |
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