5篇
您的检索式：作者名="Olfert Landt"
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| 1 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | Tropical calcific pancreatitis: Strong association with SPINK1 trypsin inhibitor mutations显示文摘 | Eesh Bhatia Gourdas Choudhuri Sadiq S. Sikora Olfert Landt Andreas Kage Michael Becker Heiko Witt | 2002 | Gastroenterology2002，，4： | 1 |
| 3 | Peptide nucleic acid-mediated PCR clamping as a use ful supplement in the determination of microbial diversity显示文摘 | Friedrich von Wintzingerode Olfert Landt Angelika Ehrlich | 2000 | Appl Envir Microbiol2000，66，2： | 1 |
| 4 | Guideline to reference gene selection for quantitative real-time PCR显示文摘 | Aleksandar Radoni? Stefanie Thulke Ian M Mackay Olfert Landt Wolfgang Siegert Andreas Nitsche | 2003 | Biochemical and Biophysical Research Communications2003，，4： | 1 |
| 5 | Tropical calcific pancreatitis: Strong association with SPINK1 trypsin inhibitor mutations显示文摘 | Eesh Bhatia Gourdas Choudhuri Sadiq S. Sikora Olfert Landt Andreas Kage Michael Becker Heiko Witt | 2002 | Gastroenterology2002，，4： | 1 |
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