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| 1 | Optimizing hepatitis C virus treatment through pharmacist interventions: Identification and management of drug-drug interactions显示文摘AIM To quantify drug-drug-interactions(DDIs) encountered in patients prescribed hepatitis C virus(HCV) treatment, the interventions made, and the time spent in this process.METHODS As standard of care, a clinical pharmacist screened for DDIs in patients prescribed direct acting antiviral(DAA) HCV treatment between November 2013 and July 2015 at the University of Colorado Hepatology Clinic. HCV regimens prescribed included ledipasvir/sofosbuvir(LDV/SOF), paritaprevir/ritonavir/ombitasvir/dasabuvir(OBV/PTV/r + DSV), simeprevir/sofosbuvir (SIM/SOF), and sofosbuvir/ribavirin (SOF/RBV). This retrospective analysis reviewed the work completed by the clinical pharmacist in order to measure the aims identified for the study. The number and type of DDIs identified were summarized with descriptive statistics.RESULTS Six hundred and sixty four patients(83.4% Caucasian, 57% male, average 56.7 years old) were identified; 369 for LDV/SOF, 48 for OBV/PTV/r + DSV, 114 for SIM/SOF, and 133 for SOF/RBV. Fifty-one point five per cent of patients were cirrhotic. Overall, 5217 medications were reviewed (7.86 medications per patient) and 781 interactions identified (1.18 interactions per patient). The number of interactions were fewest for SOF/RBV (0.17 interactions per patient) and highest for OBV/PTV/r + DSV (2.48 interactions per patient). LDV/SOF and SIM/SOF had similar number of interactions (1.28 and 1.48 interactions per patient, respectively). Gastric acid modifiers and vitamin/herbal supplements commonly caused interactions with LDV/SOF. Hypertensive agents, analgesics, and psychiatric medications frequently caused interactions with OBV/PTV/r + DSV and SIM/SOF. To manage these interactions, the pharmacists most often recommended discontinuing the medication (28.9%), increasing monitoring for toxicities (24.1%), or separating administration times (18.2%). The pharmacist chart review for each patient usually took approximately 30 min, with additional time for more complex patients. CONCLUSION DDIs are common with HCV medications and management can require medication adjustments and increased monitoring. An interdisciplinary team including a clinical pharmacist can optimize patient care. | Jacob A Langness Matthew Nguyen Amanda Wieland Gregory T Everson Jennifer J Kiser | 2017 | World Journal of Gastroenterology2017，23，9： | 5 |
| 2 | Random and site -specific immobilization of catalytic antibodies 显示文摘 | Spitznagel T M Jacobs J W Clark D S | 1993 | Enzyme Microbial Technol1993，15，： | 1 |
| 3 | Loss of tumor mark er-immunostaining intensity on stored paraffin slides of hreast cancer显示文摘 | Jacobs T W Prioleau J E Schnitt S J | 1996 | NatlCancer Inst1996，88，15： | 1 |
| 4 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 5 | Foam processing of poly ( ethylene - co - vinyl acetate ) rubber using supereritical carbon dioxide 显示文摘 | JACOBS M A KEMMERE M F KEURENTJES J T | 2004 | Polymer2004，45，： | 1 |
| 6 | The role of ClC-3 in volume-activated chloride currents and volume regulation in bovine epithelial cells demonstrated by antisense inhibition显示文摘 | Wang L Chen L Jacob T J | 2000 | J Physiol2000，524，： | 1 |
| 7 | MALDITOF MS of phosphorylated lipids in biological fluids using immobilized metal affinity chromatography and a solid ionic crystal matrix显示文摘 | HAM B M JACOB J T COLE R B | 2005 | Analytical Chemistry2005，77，14： | 1 |
| 8 | Composition and morphology of wear debris in failed uncementen total hip replacement 显示文摘 | A S Shanbhag J J Jacobs T T Giant | 1994 | J Bone Joint Surg Br1994，76，1： | 1 |
| 9 | ACC/AHA guideline of percutaneous coronary interventions (revision of the 1993 PTCA guidelines )-executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (committee to revise the 1993 guidelines for percutaneous transluminal coronary angioplasty) 显示文摘 | Smith S C Jr Dove J T Jacobs A K | 2001 | J Am Coll Cardiol2001，37，8： | 1 |
| 10 | Quantum computing using single photons and the Zeno effect 显示文摘 | FRANSON J D JACOBS B C PITTMAN T B | 2004 | Physical Review A2004，70，6： | 1 |
| 11 | Characterization of polyurethane foams from soybean oil显示文摘 | Jacob J Mrinal B Robert B T | 2002 | J Applid Polymer Sci2002，86，： | 1 |
| 12 | Compositionand morphology of wear debris in failed uncemented totalhip replacement显示文摘 | Shanbhag A S Jacobs J J Glant T T | 1994 | J Bone Joint Surg Br1994，76，1： | 1 |
| 13 | Carcinogen exposure during short-term switching from regular to ' light' cigarettes 显示文摘 | BENOWITZ N L JACOB P 3RD BERNERT J T | 2005 | Cancer Epidemiol Biomarkers Prey2005，14，6： | 1 |
| 14 | Prognostic impact of lymph node involvement in pulmonary metastases from colorectal cancer显示文摘 | Welter S Jacobs J Krbek T | | 0，，： | 1 |
| 15 | Roles of volumeactivatedCl- currents and regulatory volume decrease in thecell cycle and proliferation in nasopharyngeal carcinoma cells显示文摘 | Chen L X Zhu L Y Jacob T J | 2007 | Cell Prolif2007，40，2： | 1 |
| 16 | Genome sequence and analysis of the tuber crop potato显示文摘 | Xu X Pan S Cheng S Zhang B Mu D Ni P Zhang G Yang S Li R Wang J Orjeda G Guzman F Tones M Lnzano R Ponce O Martinez D De la Cruz G Chakrabarti S K Patil V U Skryabin K G Kuznetsov B B Ravin N V Kolganova T V Beletsky A V Mardanov A V Di Genova A Bolser D M Martin D M Li G Yang Y Kuang H Hu Q Xiong X Bishop G J Sagredo B Mejia N Zagorski W Gromadka R Gawor J Szczesny P Huang S Zhang Z Liang C He J Li Y He Y Xu J Zhang Y Xie B Du Y Qu D Bonierbale M Ghislain M Herrera Mdel R Giuliano G Pietrella M Perrotta G Faeella P O 'Brien K Feingold S E Barreiro L E Massa G A Diambra L Whitty B R Vaillancourt B Lin H Massa A N Geoffroy M Lundback S DellaPenna D Buell C R Sharma S K Marshall D F Waugh R Bryan G J Destefanis M Nagy I Milbourne D Thomson S J Fiefs M Jacobs J M Nielsen K L Sonderkaer M Iovene M Tortes G A Jiang J Veilleux R E Bachem C W de Boer J Bonn T Kloosterman B van Eck H Datema E Hekkert B Goverse A van Ham R C Visser R G | 2011 | Nature2011，475，7355： | 1 |
| 17 | Carbohydrates, dietary fiber, and incident type 2 diabetes in older women 显示文摘 | Meyer K A Kushi L H Jacobs D R J Slavin J Sellers T A Folsom A R | 2000 | The American Journal of Clinical Nutrition2000，71，4： | 1 |
| 18 | Ladder-type pentaphenylenes and their polymers: Efficient blue-light emitters and electron-accepting materials via a common intermediate显示文摘 | Jacob J Sax S Piok T | 2004 | J Am Chem Soc2004，126，： | 1 |
| 19 | Bladder cancer in 2010:how far have we come显示文摘 | Jacobs B L Lee C T Montie J g | 2010 | CA Cancer J Clin2010，60，： | 1 |
| 20 | Prognostic impact of lymph node involvement in pulmonary metastases from colorectal cancer显示文摘 | Welter S Jacobs J Krbek T | 2007 | Eur J Cardiothorac Surg2007，31，2： | 1 |
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