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| 1 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 2 | Enhancement of optical re- mote sensing images by subband-decomposed multi- scale Retinex with hybrid intensity transfer Function 显示文摘 | Jae H J Sung D K Jong B | 2011 | IEEE Geoscience and Remote Sensing Letters2011，8，5： | 1 |
| 3 | New hybrid method for simultaneousimprovement of tensile and impact properties of carbon fiber reinforcedcomposites显示文摘 | Seong Y K Soo J B Jae R Y | 2011 | Carbon2011，49，15： | 1 |
| 4 | A new process for the synthesis of diphenyl carbonate from dimethyl carbonate and phenol over heterogeneous catalysts显示文摘 | Won B K Jae S L | 1999 | Catalyst Letter1999，59，1： | 1 |
| 5 | Adsorption,sequestration,and bioaccessibility of As(V)in soils显示文摘 | JAE K Y MARK O B PHILIP M J | 2002 | EnvironSci Technol2002，36，21： | 1 |
| 6 | Effect of liquidity on firms' R&D spending显示文摘 | Hao K Y Jae A B | 1993 | Economics of Innovation and New Technology1993，2，4： | 1 |
| 7 | Vanadosilicate mesoporous SBA-15 molecular sieves incorporated with N-alkylphenothiazines显示文摘 | Zhao H L Jae Y B Larry k | 2000 | Chem Mater2000，12，10： | 1 |
| 8 | Deposition of ZnO thin films by magnetron sputtering for a film bulk acoustic resonator显示文摘 | Jae B L Hyeong J K Soo G K etc | 2003 | Thin Solid Films2003，435，： | 1 |
| 9 | On determining minimal spectrally arbitrary patterns 显示文摘 | Cavers M S Kim In - Jae Shader B L Vander Meulen K N | 2005 | Electronic Journal of Linear Algebra2005，13，： | 1 |
| 10 | Controlled release of donepezil intercalated in smectite clays 显示文摘 | Jin K P Young B C Jae M O | 2008 | Int J Pharm2008，359，5： | 1 |
| 11 | Synthesis and antibacterial activity of oxazolidinones containing pyridine substituted with heteroaromatic ring 显示文摘 | YEONG W J WEON B I JAE K R | 2004 | Bioorg Med Chem2004，12，22： | 1 |
| 12 | Controlled release of donepezil intercalated in smectite clays显示文摘 | Jin K P Young B C Jae M O | 2008 | Int J Pharm2008，359，5： | 1 |
| 13 | Expression and function of the P2X (7) receptor in rat C6 glioma cells显示文摘 | Wei Wei Jae K Ryu Hyun B Choi | 2008 | Cancer Lett2008，260，12： | 1 |
| 14 | Business group and tunneling:evidence from private securities offerings by korean ehaebols 显示文摘 | JAE - SEUNG B JUN - KOO K INMOO L | 2006 | Journal of Finance2006，61，5： | 1 |
| 15 | Preparation of core-shell BaTiO3 particles coated with MgO显示文摘 | Jae N K Tae S B Chang S K | 2005 | J Chem Eng Jap2005，，38： | 1 |
| 16 | New hybrid method for simuhaneousimprovement of tensile and impact properties of carbon fiber reinforced composites 显示文摘 | SEONG Y K SO0 J B JAE R Y | 2011 | Carbon2011，49，15： | 1 |
| 17 | Electron microscopic study on the integumentary epidermis of the paot fish, Opelgnathus fasciatus, Korean显示文摘 | JAE W K GUN W B HEA J B | 2004 | Journal of Electron Microscopy2004，43，： | 1 |
| 18 | Left ventricular diastolic dysfunction as a predictor of the first diagnosed nonvalvular atrial fibrillation in 840 elderly men and women显示文摘 | Teresa S.M Tsang Bernard J Gersh Christopher P Appleton A.Jamil Tajik Marion E Barnes Kent R Bailey Jae K Oh Cynthia Leibson Samantha C Montgomery James B Seward | 2002 | Journal of the American College of Cardiology2002，，： | 1 |
| 19 | 显示文摘 | Jae Y S Sang W P Hong K B | 1997 | Thin Solid Films1997，，292： | 1 |
| 20 | Adipocyte differen- tiation:a transcriptional regulatory cascade显示文摘 | Regina P B Jae B K Hu E D | 1996 | Current Opinion in Cell Biology1996，8，6： | 1 |
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