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| 1 | Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis显示文摘BACKGROUND Hepatitis C virus(HCV)infection is responsible for a chronic liver inflammation,which may cause end-stage liver disease and hepatocellular carcinoma.Apolipoprotein E(protein:ApoE,gene:APOE),a key player in cholesterol metabolism,is mainly synthesized in the liver and APOE polymorphisms may influence HCV-induced liver damage.AIM To determine whether APOE alleles affect outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation(OLT).METHODS This was a cohort study in which 179 patients,both genders and aged 34-70 years,were included before or after(up to 10 years follow-up)OLT.Liver injury severity was assessed using different criteria,including METAVIR and models for endstage liver disease.APOE polymorphisms were analyzed by quantitative real-time polymerase chain reaction.RESULTS The APOE3 allele was the most common(67.3%).In inflammation severity of biopsies from 89 OLT explants and 2 patients in pre-transplant,the degree of severe inflammation(A3F4,0.0%)was significantly less frequent than in patients with minimal and moderate degree of inflammation(≤A2F4,16.2%)P=0.048,in patients carrying the APOE4 allele when compared to non-APOE4.In addition,a significant difference was also found(≤A2F4,64.4%vs A3F4,0.0%;P=0.043)and(A1F4,57.4%vs A3F4,0.0%;P=0.024)in APOE4 patients when compared to APOE3 carriers.The fibrosis degree of the liver graft in 8 of 91 patients and the lack of the E4 allele was associated with more moderate fibrosis(F2)(P=0.006).CONCLUSION Our results suggest that the E4 allele protects against progression of liver fibrosis and degree of inflammation in HCV-infected patients. | José Carlos Rodrigues Nascimento Lianna C Pereira Juliana Magalhães C Rêgo Ronaldo P Dias Paulo Goberlânio B Silva Silvio Alencar C Sobrinho Gustavo R Coelho Ivelise Regina C Brasil Edmilson F Oliveira-Filho James S Owen Pierluigi Toniutto Reinaldo B Oriá | 2021 | World Journal of Gastroenterology2021，27，11： | 1 |
| 2 | Activation of platelet-rich plasma using thrombin receptor agonist peptide 显示文摘 | Regina L Andrea B David P | 2005 | Oral Maxillofac Surg2005，63，4： | 1 |
| 3 | Reduction of SO2 on different carbons 显示文摘 | Eduardo Humeres Moreira Regina F P M Peruch Maria da Oliria B | 2002 | Carbon2002，40，： | 1 |
| 4 | Effects of stareh synthase IIa gene dosage on grain, protein and starch in endosperm of wheat 显示文摘 | Konik-Rose C Thistleton J Chanvrier H Tan I Halley P Gidley hi Kosar-Hashemi B Wang H Larroque O Ikea J McMaugh S Regina A Rahman S Morell M Li Z | 2007 | Theoretical and Ap- plied Genetics2007，115，8： | 1 |
| 5 | Adipocyte differen- tiation:a transcriptional regulatory cascade显示文摘 | Regina P B Jae B K Hu E D | 1996 | Current Opinion in Cell Biology1996，8，6： | 1 |
| 6 | Green tea (-)epigallocatechin-3-gallate reverses oxidative stress and reduces acetylcholinesterase activity in a streptozotocin-induced model of dementia 显示文摘 | Regina B Ana C T Ana P C | 2013 | Behavioural Brain Research2013，236，1： | 1 |
| 7 | Novel composite polymeric electrolytes with surface-modified inorganic fillers 显示文摘 | Jaroslaw S Regina B Kamil P | 2007 | Journal of Power Sources2007，173，23： | 1 |
| 8 | Assessment of aroma impact compounds in a cashew apple-based alcoholic beverage by GC - MS and GC - olfactometry 显示文摘 | Deborah S Maria Regina B Maria Aparecida A P | 2006 | Food Science and Technology2006，39，4： | 1 |
| 9 | Reduction of SO2 on deferent carbons显示文摘 | Eduardo Humeres Moreira Regina F P M Peruch Mariada Gliria B | 2002 | Carbon2002，40，： | 1 |
| 10 | Computational fluid dynamics simulations of inspira tory airflow in the human nose and nasopharynx显示文摘 | RAVI P SUBRAMANIA M REGINA B | 1998 | Inhal Toxicol1998，10，： | 1 |
| 11 | Mutational analysis of CYP21 gene in Slovak patients with 21-hydroxylase deficiency and comparison with other European popula- tions显示文摘 | Regina W Zuzana P Regina B | 2004 | Biologia2004，59，6： | 1 |
| 12 | Assessment of aroma impact compounds in a cashew apple-based alcoholic beverage by GC-MS and GC-olfactometry 显示文摘 | Deborah S Garruti Maria Regina B Franco Maria Aparecida A P da Silva | 2006 | Lebensmittel-Wissenschaft und Technologie2006，39，4： | 1 |
| 13 | Vitamin D deficiency,functional status,and balance in older adults with osteoarthritis显示文摘BACKGROUND Low vitamin D levels are associated with a more severe case of knee osteoarthritis(OA).However,there are few published reports concerning an association between vitamin D deficiency and functional status of individuals with OA and no reports about postural balance in this population.AIM To analyze the relationship between vitamin D deficiency and severity,functional status,and balance in elderly patients with OA.METHODS In this cross-sectional study,105 elderly patients with hip and knee OA were included.The severity was assessed by the Kellgren-Lawrence criteria.The functional status was assessed with the Lequesne index.Postural balance was assessed using a force platform,and center-of-pressure parameters(velocity at anteroposterior and mediolateral axis)were used as the balance outcomes.Serum 25(OH)vitamin D levels were measured using a chemiluminescence method.RESULTS Most of the patients(mean age:70.6±6.5 years)were female(n=78,74.3%).In the group with vitamin D deficiency,43 patients(56.6%)had severe OA,while 33 patients(43.4%)had mild or moderate OA(χ^(2) test,P=0.04).Patients with vitamin D deficiency showed a higher Lequesne index score(Mann-Whitney test,P=0.04),indicating a worse functional impairment when compared to individuals with normal vitamin D levels.Additionally,patients with vitamin D deficiency had worse postural balance according to the Mann-Whitney test(P=0.03).CONCLUSION Vitamin D deficiency is associated with worse severity,functional status,and postural balance in patients with OA. | Cláudia N Montemor Marcos Tadeu P Fernandes Audrey S Marquez Regina Célia Poli-Frederico Rubens Alexandre da Silva Karen B P Fernandes | 2021 | World Journal of Clinical Cases2021，9，31： | 0 |
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