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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 3 | A comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease显示文摘 | Serruys W P Jaegere D P Kiemeneij F | 1994 | New England Journal of Medicine1994，331，8： | 1 |
| 4 | A comparison of balloon-expandable-stent inplantation with balloon angioplasty in patients with coronary artery disease显示文摘 | Serruys P W Jaegere P D Kiemeneij F | 1994 | New England Journal of Medicine1994，331，8： | 1 |
| 5 | Assessment of iron oxide particles (AMI 227) and a gadolinium complex (Gd-DOTA) in dynamic susceptibility contrast MR imagings (FLASH and EPI) in a tumor model implanted in rats 显示文摘 | Jaegere T D Miao Y | 1999 | Magnetic Resonance Imaging1999，17，： | 1 |
| 6 | A surfactant Co (III) chelate containing two tridentate ligands 显示文摘 | JAEGER D A ZENG X H WANG Y P | 2006 | Colloids Surf A : Physicochem Eng Aspects2006，289，： | 1 |
| 7 | The Impact of Policies on Government Social Media Usage: Issues, Challenges, and Rec- ommendations 显示文摘 | Bertot J C Jaeger P T Hansen D | 2012 | Government Information Quarterly2012，，29： | 1 |
| 8 | Adductor canal block versus femoral nerve block for analgesia after total knee arthroplasty:a randomized,double-blind study显示文摘 | Jaeger P Zaric D Fomsgaard JS | 2013 | Reg Anesth Pain Med2013，38，6： | 1 |
| 9 | Pyrophosphate - based Gemini surfactants 显示文摘 | Jaeger D A Wang Y P Pennington R L | 2002 | Langmuir2002，18，24： | 1 |
| 10 | The Impact of Polices on Gov- ernment Social Media Usage: Issues, Challenges, and Recommen- dations显示文摘 | Bertot J C Jaeger P T Hansen D | 2012 | Government Information Quarterly2012，29，1： | 1 |
| 11 | Polyphoephazenes: synthesis, structures, properties, applications显示文摘 | P H Potin R D Jaeger | 1991 | Eur Polym J1991，27，： | 1 |
| 12 | Integration of spatial and temporal information during floral induction in A rabidopsis 显示文摘 | WIGGE P A KIM M C JAEGER K E BUSCH W SCHMID M LOHMAM J U WEIGEL D | 2005 | Science2005，309，： | 1 |
| 13 | 显示文摘 | Serruys W P Jaegere D P Kiemeneij F | 1994 | N Engl J Med1994，331，： | 1 |
| 14 | Adductor canal block versus femoral nerve block for analgesia after total knee arthroplasty a randomized, double-blind study显示文摘 | Jaeger P Zaric D Fomsgaard JS | 2013 | Reg Anesth Pain Med2013，38，6： | 1 |
| 15 | Surfactant replacement therapy in preterm infants: a European sur- vey显示文摘 | VAN KAAM A H DE JAEGERE A P BORENSZTAJN D | 2011 | Neonatology2011，100，1： | 1 |
| 16 | Angioscopic complex lesions are predominantly compensatory enlarged显示文摘 | SMITS P C PASTERKMP G D E JAEGERE PPT | 1999 | Cardiovasc Res1999，41，： | 1 |
| 17 | Integration of spatial and temporal infor mation during floral induction in Arabidopsis显示文摘 | WIGGE P A KIM M C JAEGER K E BUSCH W SCHMID M LOHMANN J U WEIGEL D | 2005 | Science2005，309，： | 1 |
| 18 | The Impact of Polices on Gov- ernment Social Media Usage: Issues, Challenges, and Recommen- dations 显示文摘 | Bertot J C Jaeger P T Hansen D | 2012 | Government Information Quarterly2012，29，1： | 1 |
| 19 | the Impact of Polices on Gov- ernment Social Media Usage: Issues, Challenges, and Recommen- dations 显示文摘 | Bertot J C Jaeger P T Hansen D | 2012 | Government Information Quarterly2012，29，1： | 1 |
| 20 | Rand-omized comparison of coronary stent implantation under ultrasound or angiographic guidance to reduce stent restenosis(OPTICUS Study)显示文摘 | MUDRA H D I MARIO C D E JAEGERE P | 2001 | Circulation2001，104，： | 1 |
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