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| 1 | Liver stiffness and perfusion changes for hepatic sinusoidal obstruction syndrome in rabbit model显示文摘BACKGROUND Hepatic sinusoidal obstruction syndrome(SOS)is caused by damage to hepatic sinusoidal endothelial cells that results in fibrous obliteration of intrahepatic venules and necrosis of hepatocytes.Currently the diagnosis is primarily based on nonspecific clinical features and invasive liver biopsy.Therefore,noninvasive imaging methods are required for the early diagnosis and severity assessment of hepatic SOS.AIM To determine the effectiveness of supersonic shear wave imaging(SSI)and dual energy computed tomography(DECT)for diagnosing hepatic SOS using a rabbit model.METHODS Among nine New Zealand white rabbits(3-4 kg,male),three in control group ingested normal saline for 20 d and six in the SOS group ingested 6-thioguanine(5 mg/kg/d)for 20 d.Liver stiffness was measured using SSI on days 0,3,10,and 20.On the same days,liver perfusion was evaluated from virtual monochromatic images of 55 keV and iodine map using DECT.Morphologic changes in the liver were assessed using CT.Final pathology scores were compared between the two groups.Liver stiffness and perfusion parameters were compared according to the groups,days,and pathology scores.RESULTS Final pathology scores were significantly higher in the SOS than the control group(median 22 vs 2,P=0.024).No gross morphologic changes were seen in livers.Liver stiffness,Hounsfield Unit values,and iodine concentrations were higher in the SOS compared to the control group on days 10 and 20(all,P≤0.007).Compared to day 0,liver stiffness and perfusion parameters were higher on day 20 in the SOS group(all,P≤0.001).Correlation coefficients for liver stiffness(r=0.635),Hounsfield Unit values(r=0.587),and iodine concentration(r=0.611)with final pathology scores were positive without significance(all,P>0.05).CONCLUSION Liver stiffness and perfusion parameters were significantly increased in the livers of a rabbit SOS model.SSI and DECT might aid in early diagnosis of hepatic SOS. | Jaeseung Shin Haesung Yoon Yoon Jin Cha Kyunghwa Han Mi-Jung Lee Myung-Joon Kim Hyun Joo Shin | 2020 | World Journal of Gastroenterology2020，26，7： | 3 |
| 2 | Anti-tumor activity of exvivo expanded cytokine-induced killer cells against human hepato- cellular carcinoma 显示文摘 | Hwan MK Jaeseung L Yeo DY | 2007 | Int Immunopharmacol2007，7，13： | 1 |
| 3 | Nonlinear Analysis of the EEG of Schizophrenics with Optimal Embedding Dimension显示文摘 | Jeong Jaeseung Kim Daijin Chae Jeongho | 1998 | Medical Engineering Physics1998，20，： | 1 |
| 4 | Antitumor activity of cytokine-induced killer cell against human lung cancer显示文摘 | Hwan Mook Kim Jaeseung Lira Song-Kyu Park | 2007 | Int Immunopharmacol2007，24，5： | 1 |
| 5 | Adaptive interference suppression in CDMA systems with large processing gain 显示文摘 | Jaeseung Yoor John F Doherty | 1998 | IEEE MILCOM1998，，98： | 1 |
| 6 | Application of the viscoelastic continuum damage model to the indirect tension test at a single temperature 显示文摘 | JAESEUNG K RANDY C W | 2010 | Journal of Engineering Mechanics2010，36，4： | 1 |
| 7 | Application of The Viscoelastic Con- tinuum Damage Model to The Indirect Tension Test at A Single Temperature 显示文摘 | Kim Jaeseung West Randy C | 2010 | Journal of Engineering Mechanics2010，36，4： | 1 |
| 8 | Antitumor activity of cytokine-induced killer cells in nude mouse xenograft model显示文摘 | Hwan Mook Kim Jong Soon Kang Jaeseung Lim Jee Youn Kim Yeon Jin Kim Soo Jae Lee Sukgil Song Jin Tae Hong Youngsoo Kim Sang-Bae Han | 2009 | Archives of Pharmacal Research2009，，5： | 1 |
| 9 | Mutual information analysis of the EEG in patients with Alzheimer's disease显示文摘 | JAESEUNG J JOHN C G BRADLEY S P | 2001 | Clinical Neurophysiology2001，，112： | 1 |
| 10 | Wireless Authentication Protocol Preserving User Anonymity显示文摘 | Jaeseung Go Kawangjo Kim | 2001 | SCIS 2001 Japan January 23-262001，，： | 1 |
| 11 | Multiplex RT-PCR assay for the detection of Applestem grooving virus and Apple chlorotic leaf spot virusin infected Korean apple cultivars显示文摘 | Honglyeol Park Jaeseung Yoon Hyunran Kim | 2006 | Plant Pathol J2006，22，2： | 1 |
| 12 | Electrical and Optical Properties of Cu2Zn Sn S4Thin Films Prepared by RF Magnetron Sputtering Process显示文摘 | Jaeseung S Sangyul L Jaechoon L | 2003 | Solar Energy Materials and Solar Cells2003，75，： | 1 |
| 13 | Wireless Authentication Protocol Preserving User Anonymity显示文摘 | Jaeseung Go Kawangjo Kim | 2001 | SCIS 2001 Japan January 23-262001，，： | 1 |
| 14 | Nonlinear analysis of the EEG of schizophrenics with optimal embedding dimension 显示文摘 | Jeong Jaeseung Kim Dai-Jin Chae Jeong-Ho | 1998 | Medical Engineering &Physics1998，20，： | 1 |
| 15 | An intelligent display scheme of soccer video on mobile devices显示文摘 | Seo Keewon Ko Jaeseung Ahn Ilkoo | 2007 | IEEE Transactions on Circuits and Systems for Video Technology2007，17，10： | 1 |
| 16 | Application of the viscoelastic continuum damage model to the indirect tension test at a single temperature 显示文摘 | Kim Jaeseung West Randy C | 2010 | Journal of Engineering Mechanics2010，36，4： | 1 |
| 17 | The heterogeneous effect of WOM on product sales: why the effect of WOM valence is mixed?显示文摘 | Joonhyuk Yang Wonjoon Kim Naveen Amblee Jaeseung Jeong | 2012 | European Journal of Marketing2012，，11： | 1 |
| 18 | Feed horn antenna including circular-polarizer and straight type mode converter to illuminate shaped reflector at Ka-band显示文摘 | Yun Jaeseung Jeon Sonick Chae Jongsuk | 2004 | IEEEAntennas and Propagation Society Symposium2004，2，6： | 1 |
| 19 | Anti-tumor activity of ex vivo expanded cytokine-induced killer cells against human hepatocellular careinoma显示文摘 | Hwan M K Jaeseung L Yeo D Y | 2007 | International Immunopharmacology2007，，7： | 1 |
| 20 | Anti-tumor activity of ex vivo expanded cytokine-induced killer cells against human hepatocellular carcinoma显示文摘 | Hwan M K Jaeseung L Yeo D Y | 2007 | International Immunopharmacology2007，7，13： | 1 |
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