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| 1 | Evaluation of a nondestructive impact sensor to determine online fruit firmness 显示文摘 | Ian H Francisco J C Jaime O C | 2010 | Chilean of Aarieuhural Research2010，70，1： | 1 |
| 2 | Improving the design of sequences for DNA computing:a multiobjective evolutionary approach显示文摘 | CERVANTES-SALIDO V M JAIME O BRIZUELA C A | 2013 | Applied Soft Computing2013，13，12： | 1 |
| 3 | Improving the design of sequences for DNA computing: a multi-objective evolutionary approach显示文摘 | Cervantes-salido V M Jaime O Brizuela C A | 2013 | Applied Soft Computing2013，13，12： | 1 |
| 4 | Studies on the α and β forms of isotactie polypropylene by crystallization in a temperature gradient显示文摘 | Andrew J Lovinger Jaime O Chua Carl C Gryte | 1977 | J Polym Sci1977，15，： | 1 |
| 5 | Hypoxia stimulates human preproendothelin - 1 promoter activity in transgenic mice显示文摘 | Aversa CR Suzanne O Jaime C | 1997 | Am J Physiol1997，273，41： | 1 |
| 6 | Studies on the and 13 forms of isotactic polypropylene by crystallization in a temperature gradient显示文摘 | Lovinger Andrew J Chua Jaime O Gryte Carl C | 1977 | J Polym Sci PolymPhys Ed1977，15，4： | 1 |
| 7 | Studies on the a and β forms of Isotactic Polypropylene by Crystallization in a Temperature Gradient 显示文摘 | Andrew J Lovinger Jaime O Chua Carl C Gryte | 1977 | Journal of Polymer Science: Polymer Physics Edition1977，15，： | 1 |
| 8 | Improving the design of sequences for DNA computing: a multiobjecticve evolutionary approach显示文摘 | Cervantes-Salido V M Jaime O Brizuela C A | 2013 | Applied Soft Computing2013，13，12： | 1 |
| 9 | Lie algebra approach for tracking and 3D motion estimation using monocular vision显示文摘 | EDUARDO B C JAIME O A | 2007 | Image and Vision Computing2007，25，6： | 1 |
| 10 | HPLC-DAD analysis and antifungal effect of Hyptis martiusii Benth(Lamiaceae) against Candida strains显示文摘Objective: To evaluate the anti Candida activity of Hyptis martiusii decoction and its major compound, caffeic acid alone or in the presence of fluconazole, as well as their cytotoxic effect. Methods: The decoction was characterized using high performance liquid chromatography coupled with diode array detector. For the antifungal activity, the minimum inhibitory concentration(MIC) and the potential effect of the decoction with the fluconazole were evaluated by microdilution method using 96-well microtiter trays. The osmotic fragility test was performed using erythrocytes under saline stress. All tests were performed in triplicate. Results: The chemical characterization of the decoction was performed by high performance liquid chromatography and revealed the presence of seven compounds, including caffeic acid as major constituent. The antifungal tests demonstrated that both decoction(DHm) and caffeic acid obtained from Hyptis martiusii presented MIC and MFC ≥4096 μg/mL against Candida albicans and Candida tropicalis strains. However, in the presence of fluconazole, DHm and caffeic acid presented IC_(50) of 2.60 and 2.53 μg/mL respectively, demonstrating significant synergistic effects against Candida strains. The modulator activity of DHm might be due to the presence of caffeic acid. Moreover, DHm and caffeic acid did not cause significant hemolytic effects, indicating that they present low cytotoxicity. Conclusions: These data indicate that DHm potentiates the activity of the fluconazole, without enhancement of the toxicity, encouraging further toxicological, pharmacological and phytochemical studies to provide consistent evidence of the potential of this plant to be used in drug development. | Janaína Esmeraldo Rocha Henrique Douglas Melo Coutinho Cícero Roberto Nascimento Saraiva Antonia Thassya Lucas dos Santos Ant?nio Judson Targino Machado Jo?o Tavares Calixto Júnior Irwin Rose Alencar Menezes José Galberto Martins da Costa Jaime Ribeiro-Filho Aracelio Viana Colares | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，3： | 0 |
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