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| 1 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 2 | Adherence to NICE guidance on glucagon-like peptide-1 receptor agonists among patients with type 2 diabetes mellitus:an evaluation using the Clinical Practice Research Datalink显示文摘 | Jameson K D'Oca K Leigh P | 2016 | Curr Med Res Opin2016，32，1： | 1 |
| 3 | Association of vitamin D status with knee pain and radiographic knee osteoarthritis 显示文摘 | Muraki S Dennison E Jameson K et d | 2011 | Osteoarthritis Cartilage2011，19，11： | 1 |
| 4 | 6-Bis(N-Pyrazolyl)pyridines,the convenient synthesis of a family of planar tridentate N3 ligand that are terpyridine analogues显示文摘 | Jameson D L Agoldsby K | 1990 | J Org Chem1990，55，17： | 1 |
| 5 | Absence of the interstitial ceils of Cajal in patients with clinical findings显示文摘 | Jameson F Ivan D Zhiyue L | 2005 | J Gastroen- terol Surg2005，9，3： | 1 |
| 6 | Fluorescence anisotropy ap- plied to biomolecular interactions显示文摘 | Jameson D M Sawyer W H | 1995 | Methods in Enzy- mology1995，246，： | 1 |
| 7 | Tera- hertz imaging and spectroscopy of large-area single-layer graphene 显示文摘 | Tomaino J L Jameson A D Kevek J W | 2011 | Optics Express2011，19，1： | 1 |
| 8 | Absence of the interstitial of Cajal in patients with gastroparesis and correlation with clinical findings 显示文摘 | Jameson F Ivan D Zhiyue L | 2005 | J Gastroenterol Surg2005，9，1： | 1 |
| 9 | Chlorpyrifos affects phenotypic outcomes in a model of mammalian neuro development: critical stages targeting differentiation in PC12 cells显示文摘 | Jameson R R Seidler F J Qiao D | 2006 | Environmental Health Perspectives2006，114，5： | 1 |
| 10 | Advances in the study of high intensity conditioning as a means of improving mineral flotation performance 显示文摘 | ENGEL M D MIDDLEBROOK P D JAMESON G J | 1997 | Minerals Engineering1997，10，1： | 1 |
| 11 | Mitogen-activated protein kinase kinase activity is required for the G(2)/M transition of the cell cycle in mammalian fibroblasts显示文摘 | Wright J H Munar E Jameson D R | 1999 | Proc Natl Acad Sci U S A1999，96，11： | 1 |
| 12 | Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor 显示文摘 | GEHM B D CHIEN P Y JAMESON J L | 1997 | Proc Natl Acad Sci1997，94，14： | 1 |
| 13 | Absence of the interstitial cells of Cajal in patients with clinical findings 显示文摘 | Jameson F Ivan D Zhi yue L | 2005 | J Gastroenterol Surg2005，9，3： | 1 |
| 14 | Absence of the interstitial cells of Cajal in patients with clinical findings显示文摘 | Jameson F Ivan D Zhi yue L | 2005 | J Gastroenterol Surg2005，9，3： | 1 |
| 15 | Advances in the study of high intensity conditioning as-ameans of improving mineral flotation performance 显示文摘 | Engel M D Middlebrook Jameson G J | 1997 | Minerals Engineering1997，10，1： | 1 |
| 16 | Xyloglucan and hemicelluloses in the cell wall during apple fruit development and ripening 显示文摘 | PERCY A E MELTON L D JAMESON P E | 1997 | Plant Science1997，125，1： | 1 |
| 17 | Improving Resectability and Survival in Patients With primary Duodenal Carcinoma显示文摘 | James H Jameson F | 1993 | Am J Surg1993，166，12： | 1 |
| 18 | Fluorescent measurement of mieroalgal neutral lipids显示文摘 | Elsey D Jameson D Raleigh B | 2009 | Journal of Microbiological Methods2009，68，： | 1 |
| 19 | Kidney transplantation and the ageing immune system显示文摘 | McKay D Jameson J | | 0，，12： | 1 |
| 20 | Multigrid solution of the Navier-Stokes equations on triangular meshes 显示文摘 | Mavriplis D J Jameson A | 1990 | AIAA J1990，28，8： | 1 |
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