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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Design of a solar concentrator combining paraboloidal and hyperbolic mirrors using ray tracing method 显示文摘 | Chen C F Lin C H Jan H T | 2009 | Optics Communications2009，282，： | 1 |
| 3 | Structural analysis and proteolytic processing of recombinant G domain of mouse laminin α2 chain显示文摘 | Jan F T Karlheinz Yoshihiko Y | 1998 | FEBS letters1998，426，： | 1 |
| 4 | A solar concentratorwith two reflection mirrors designed by using a ray trac-ing method显示文摘 | CHEN CH F LIN CH H JAN H T | 2010 | Optik2010，121，11： | 1 |
| 5 | Effect of exposure to long photoperiod during the rearing period on the age at first egg and the subsequent reproductive performance in geese显示文摘 | WANG S D JAN D F YEH L T | 2002 | Animal Reproduction Science2002，73，34： | 1 |
| 6 | The effect on the lipid metabolism of Tsaiya ducks when high levels of choline or methionine are added to the duck's diet显示文摘 | Lien T F Jan D F | 1999 | Asian Australasian J Animal Sci1999，12，7： | 1 |
| 7 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 8 | An optimum die fillet design for minimizing the difference in extruded fin lengths of straight-fin heat sink extrusion显示文摘 | Kwan C T Jan F S Lee W C | 2008 | Journal of Materials Processing Technology2008，201，： | 1 |
| 9 | Topological optimization of a communication network subject to a reliability constraint显示文摘 | R H JAN F J HWANG S T CHENG | | 0，，03： | 1 |
| 10 | Arsenite induces apoptosis in Chinese hamster ovary cells by generation of reactive oxygen species显示文摘 | Wang T S Kuo C F Jan K Y | 1996 | J Cell Physiol1996，169，2： | 1 |
| 11 | Clinical studies of mucin producing cholangiocellular carcinoma显示文摘 | Chen M F Jan Y Y Chen T C | 1998 | Ann Surg1998，1，： | 1 |
| 12 | Necrosis of a large hepatic tumor after hemorrhage and subsequent selective arterial embolization显示文摘This case report describes a young female patient presenting with acute intra-abdominal hemorrhage originating from a large tumor in the liver, most likely a hepatocellular adenoma. The bleeding was stopped by selective embolization of right hepatic artery branches. Subsequently, partial hepatectomy was performed after 6 mo. Macro- and microscopic examination showed complete necrosis and absence of tumorous tissue. The patient was discharged without complications, and subsequent follow-up until 22 mo after resection did not reveal any new lesions in the liver. This case emphasizes the signifi cance of selective arterial embolization in the management of bleeding liver tumors and questions the need for (partial) hepatectomy after this procedure in selective cases. | Volkert AL Huurman Jan HMB Stoot Edwin van der Linden Alexander F M Schaapherder Onno T Terpstra Alexander FM Schaapherder | 2006 | World Journal of Gastroenterology2006，12，37： | 1 |
| 13 | Conceptualizing and Measur- ing Environmentally Responsible Behaviors from the Per- spective of Community-based Tourists 显示文摘 | Lee T H Jan F H Yang C C | 2013 | Tourism Man- agement2013，36，： | 1 |
| 14 | Topological optimization of a communication network subject to a reliability constraint显示文摘 | R H Jan F J Hwang S T Cheng | 1993 | IEEE Trans Reliability1993，42，1： | 1 |
| 15 | The effect on the lipid metabolism of tsaiya ducks when high levels of choline or methionine are added to the duck's diet显示文摘 | LIEN T F JAN D F | 1999 | Asian Australasian Journal of Animal Science1999，12，7： | 1 |
| 16 | Fabrication and magnetic properties of nickel nanowires 显示文摘 | LIN S W CHANG S C LIU R S FlU S F JAN N T | 2004 | Journal of Magnetism and Magnetic Materials2004，282，： | 1 |
| 17 | A high-performance lattice Boltzmann implementation to model flow in porous media 显示文摘 | Chongxun Pan Jan F Prins Cass T Miller | 2004 | Computer Physics Communications (S0010-4655)2004，158，2： | 1 |
| 18 | Selective catalytic reduction of nitrogen oxides by ammonia on iron oxide catalysts显示文摘 | APOSTOLESCU N GEIGER B HIZBULLAH K JAN M T KURETI S REICHERT D SCHOTF F WEISWEILER W | 2006 | Appl Catal B2006，62，12： | 1 |
| 19 | Peperomins A,B and C,novel secolignans from Peperomia japonica显示文摘 | CHEN C M JAN F Y CHEN M T | 1989 | Heterocycles1989，29，3： | 1 |
| 20 | Alkaloids of some Asian sedum species显示文摘 | Jeong Hee Kim Henk T Hart Jan F Stenvens | 1996 | Phyto Chemistry1996，41，5： | 1 |
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