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		题名	作者	年代	出处	被引量
	1	Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients显示文摘AIM: To determine the composition of both fecal and duodenal mucosa-associated microbiota in irritable bowel syndrome (IBS) patients and healthy subjects using molecular-based techniques. METHODS: Fecal and duodenal mucosa brush samples were obtained from 41 IBS patients and 26 healthy subjects. Fecal samples were analyzed for the composition of the total microbiota using fluorescent in situ hybridization (FISH) and both fecal and duodenal brush samples were analyzed for the composition of bif idobacteria using real-time polymerase chain reaction. RESULTS: The FISH analysis of fecal samples revealed a 2-fold decrease in the level of bifidobacteria (4.2 ± 1.3 vs 8.3 ± 1.9, P < 0.01) in IBS patients compared to healthy subjects, whereas no major differences in other bacterial groups were observed. At the species level, Bifidobacterium catenulatum levels were significantly lower (6 ± 0.6 vs 19 ± 2.5, P < 0.001) in the IBS patients in both fecal and duodenal brush samples than in healthy subjects.CONCLUSION: Decreased bifidobacteria levels in both fecal and duodenal brush samples of IBS patients compared to healthy subjects indicate a role for microbiotic composition in IBS pathophysiology.	Angèle PM Kerckhoffs Melvin Samsom Michel E van der Rest Joris de Vogel Jan Knol Kaouther Ben-Amor Louis MA Akkermans	2009	World Journal of Gastroenterology2009，15，23：	33
	2	Influence of fermented milk products, prebiotics and probiotics on microbiota composition and health显示文摘	Corina Ceapa Harm Wopereis Lahcene Reza?ki Michiel Kleerebezem Jan Knol Raish Oozeer	2013	Best Practice & Research Clinical Gastroenterology2013，，1：	1
	3	Quantitative Real-Time PCR Analysis of Fecal Lactobacillus Species in Infants Receiving a Prebiotic Infant Formula显示文摘		2006	Applied and Environmental Microbiology2006，，4：	1
	4	Colon Microflora in Infants Fed Formula with Galacto-and Fructo-Oligosaccharides: More Like Breast-Fed Infants 显示文摘	Knol Jan Scholtens Petra Kafka Corinna	2005	J of Pediatric Gastroenterology & Nutrition2005，40，1：	1
	5	Altered gut microbiota and activity in a murine model of autism spectrum disorders显示文摘	Caroline G.M. de Theije Harm Wopereis Mohamed Ramadan Tiemen van Eijndthoven Jolanda Lambert Jan Knol Johan Garssen Aletta D. Kraneveld Raish Oozeer	2013	Brain Behavior and Immunity2013，，：	1
	6	Bifidogenic Effects of Solid Weaning Foods With Added Prebiotic Oligosaccharides: A Randomised Controlled Clinical Trial显示文摘	Petra A.M.J. Scholtens Martine S. Alles Jacques G. Bindels Esmeralda G.M. van der Linde Jules J.M. Tolboom Jan Knol	2006	Journal of Pediatric Gastroenterology and Nutrition2006，，5：	1

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