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| 1 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 2 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 3 | Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians显示文摘 | Getchell Jane P Wroblewski Kelly E DeMaria Alfred Bean Christine L Parker Monica M Pandori Mark Dufour D Robert Busch Michael P Brecher Mark E Meyer William A Pesano Rick L Teo Chong-Gee Beckett Geoffrey A Araujo Aufra C Branson Bernard M D | 2013 | MMWR. Morbidity and Mortality Weekly Report2013，，18： | 3 |
| 4 | Hematopoietic AMPK [Beta]1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity显示文摘 | Galic Sandra Fullerton Morgan D Schertzer Jonathan D Sikkema Sarah Marcinko Katarina Walkley Carl R Izon David Honeyman Jane Chen Zhi-Ping van Denderen Bryce J Kemp Bruce E Steinberg Gregory R | 2011 | Journal of Clinical Investigation2011，，12： | 2 |
| 5 | Spinal cord injury with-out radiographic abnormalities in children显示文摘 | Pang D Janes E Wicberger J | 1987 | Pediatrics1987，57，1： | 1 |
| 6 | Regulatory role of SGTI in early R Gene-Mediated plant defenses显示文摘 | Mark J Paul M Katherine K Bart J Jonathan D G Jane E | 2002 | Science2002，295，15： | 1 |
| 7 | Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction 显示文摘 | JAMES L JANUZZI JR MD SHAFIQ U REHMAN M D ASIM A MOHAMMED M D ANJU BHARDWAJ M D LINDA BARAJAS R N JUSTINE BARAJAS HAN-NA KIM M D MPH AARON L BAGGISH M D RORY B WEINER M D ANNABEL CHEN-TOURNOUX MD JANE E MARSHALL RDCS STEPHANIE A MOORE M D WILLIAM D CARLSON M D GREGORY D LEWIS M D JORDAN SHIN M D DOROTHY SULLIVAN ANP KIMBERLY PARKS D O THOMAS J WANG M D SHAWN A GREGORY M D SHANMUGAM UTHAMALINGAM M D MARC J SEMIGRAN M D | 2011 | J Am Coll Cardiol2011，58，18： | 1 |
| 8 | Spinal cord injury without radio graphic abnormalities in children显示文摘 | Pang D Janes E Wicberger J | 1987 | Neurosurg1987，57，1： | 1 |
| 9 | Co-administration of ABT-737 and SAHA induces apoptosis, mediated by Noxa upreg- ulation, Bax activation and mitochondrial dysfunction in PTEN- intact malignant human glioma cell lines 显示文摘 | Foster K Jane E Premkumar D | 2014 | J Ncurooncol2014，120，3： | 1 |
| 10 | The mass media and American adolescents health 显示文摘 | Jane D Brown E Witherspoon M | 2002 | Journal of Adolescent Health2002，31，： | 1 |
| 11 | Spinal cord in jury without radiographic abnom alities in children 显示文摘 | Pang D Janes E Wicberger J | 1987 | Neuro Sury1987，57，1： | 1 |
| 12 | Improved alignment method for noisy high resolution ECG and Hoher records using multiscale cross correlation显示文摘 | Laciar E Jane R Brooks D H | 2003 | IEEE Trans Biomed2003，50，3： | 1 |
| 13 | Differential protein expression of two photosystem II subunits,PsbO and PsbP,in an albino mutant of Bambusa edulis with chloroplast DNA aberration显示文摘 | Lin C S Liu N T Liao D C Yu J S Tsao H Lin C H Sun C W Jane W N Tsay H S Chen J J W Lai E M Lin N S Chang W C Lin C C | 2008 | AMER SOC Horticulture Science2008，133，2： | 1 |
| 14 | Dynamics of the $1S2 glutamate binding domain of GluR2 measured u- singIUFNMRspectroscopy显示文摘 | Ahmed A H Loh A P Jane D E etal | 2007 | J BiolChem2007，282，17： | 1 |
| 15 | Extrasynaptic NR2D-con- taining NMDARs are recruited to the synapse during LTP of NMDAR-EPSCs显示文摘 | Harney S C Jane D E Anwyl R | 2008 | J Neurosci2008，28，11： | 1 |
| 16 | Spinal cord injury without radio graphic abnormalities in children显示文摘 | Pang D Janes E Wicberger J | 1987 | J Neurosurg1987，57，1： | 1 |
| 17 | Biodegradation of protein/starch based plastics显示文摘 | K E Spence S Wang A Pometto J Jane A L Allen J M Mayer D L Kaplan | 1994 | Polym prepr1994，35，2： | 1 |
| 18 | Uptake and effects of six rare earth elements(REEs) on selected native and crop species growing in contaminated soils显示文摘 | CARPENTER D BOUTIN C JANE E | 2015 | PLoS ONE2015，10，01： | 1 |
| 19 | Pharmacological agents acting at subtypes of metabotropic glutamate receptors显示文摘 | SCHOEPP D D JANE D E MONN J A | 1999 | Neuropharmacology1999，38，： | 1 |
| 20 | Threat rigidity effects in organizational behavior: a multilevel analysis 显示文摘 | BARRY M S LANCE E S JANE E D | 1981 | Administrative Science Quarterly1981，26，4： | 1 |
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