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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | Improvement of Regeneration of Jycopersicon Pennelli Protoplasts by Decreasing Ethylene Production显示文摘 | Jansen C E Snel E A M | 1991 | Plant Cell Report1991，9，： | 1 |
| 4 | Non-perturbative renormalization of moments of parton distribution functions显示文摘 | A Shindler M Guagnelli K Jansen | 2004 | Nuclear Physics B-Proceedings Supplements2004，，： | 1 |
| 5 | Thyroid hormone regulates earnitine pahnitoyl transferase I a gene expression through elements in the promoter and first intron 显示文摘 | Jansen M S Cook G A Song S L | 2000 | J Biol Chem2000，275，34： | 1 |
| 6 | Light dosimetry for photodynamic therapy by whole bladder wall irradiation 显示文摘 | W M Star J P A Marijnissen H Jansen | 1987 | Photochem Photobiol1987，46，： | 1 |
| 7 | Managing traceability information in manufacture显示文摘 | Jansen Vullers M H van Dorp C A Beuens A J M | 2003 | International Journal of Information Management2003，，23： | 1 |
| 8 | Mitochondrial DNA and the origins of the domestic horse显示文摘 | JANSEN T FORSTER P LEVINE M A | 2002 | Proc Natl Acad Sci USA2002，99，10： | 1 |
| 9 | Analysisand control of proteolysis of a fusion protein in Pichia pastoris fed-batch processes显示文摘 | Jahic M Gustavsson M Jansen A K | 2003 | J Biotechnol2003，102，1： | 1 |
| 10 | Reproducibility of pulse wave velocity and augmentation index measured by pulse wave analysis显示文摘 | Wilkinson I B Fuchs S A Jansen I M | | 0，，12： | 1 |
| 11 | Mutation scanning of the p53 tumor suppressor gene in renal and liver transplant patients in Hungary 显示文摘 | Sarvary E Nagy P Benjamin A Szoke M Remport A Jansen J | 2005 | Transpl Proc2005，37，： | 1 |
| 12 | Veep insight study,a speculative methed for ingrown toenail显示文摘 | Bossers A M Jansen I M Eggink-W F | 1992 | Kanslawel Plastic Beligum1992，58，3： | 1 |
| 13 | Liquid chromatography-mass spectrometric analysis of buprenorphine and its N-dealkylated metabolite norbuprenorphine in ran brain tissue and urine显示文摘 | Yue J Borenstein M R Jansen S A | 2005 | J Pharm ToxicolMethods2005，52，： | 1 |
| 14 | Characteristics and therapy of premenopansal patients with early - onset breast cancer in Germany显示文摘 | Banz - Jansen C Heinrichs A Hedderich M | 2012 | Arch Gynecol Obstet2012，4，11： | 1 |
| 15 | Damage control resuscitation for patients with major trauma显示文摘 | Jansen J O Thomas R Loudon M A | 2009 | BMJ2009，338，： | 1 |
| 16 | Dimerization of molecular phosphorus oxides显示文摘 | Tellenbach A Jansen M | | 0，，： | 1 |
| 17 | Psychological contract breach and job attitudes:A meta-analysis of age as a moderator 显示文摘 | Bal P M De Lange A H Jansen P G W Der Velde M E G V | 2008 | Journal of Vocational Behavior2008，72，1： | 1 |
| 18 | Modelling the influence of human behaviour on the spread of infectious diseases: a review显示文摘 | FUNK S SALATH6 M JANSEN V A A | 2010 | J R S oc Interface2010，7，50： | 1 |
| 19 | Abdominal compartment syndrome:significance,diagnosis and treatment显示文摘 | Schachtrupp A Jansen M Bertram P | 2006 | Anaesthesist2006，55，6： | 1 |
| 20 | Temper- ature dependence of friction at the nanoseale: when the unexpected turns normal显示文摘 | Barel I Urbakh M Jansen L Schirmeisen A | 2010 | Tribology Letters2010，39，3： | 1 |
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