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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | 浙江蝮蛇蛇毒对鹌鹑动脉粥样硬化的影响显示文摘用DEAE-cellulose DE-52柱层析分离浙江蝮蛇蛇毒,用其中一组份给已经发生动脉粥样硬化的鹌鹑做静脉注射(隔日1次)。7周后发现此组份可使血清胆固醇含量下降,凝血时间延长,并降低肝脂肪化程度。此组份含二种主要蛋白,分子量为63000和51000,后者有精氨酸酯酶活性,二者均有纤溶酶活性。 | 孙黎光 郝文学 Jason C H shih | 1990 | 中国医科大学学报1990，19，5： | 5 |
| 3 | 紫杉醇局部治疗抑制猪静脉桥新生内膜形成和增厚的实验研究显示文摘目的 :局部药物治疗是一个很好的防治静脉桥病变的策略。本研究用抗细胞增殖药物紫杉醇处理大隐静脉桥后植入猪的颈动脉 ,以观察紫杉醇的抗细胞增殖作用在抑制静脉桥内膜平滑肌细胞增殖、迁移导致内膜形成和增厚的效果。方法 :将 10头猪的 2 0只大隐静脉桥分为两组。治疗组 :将大隐静脉桥 10只置于含有 10 μmol/L浓度的紫杉醇溶液中 (先用该溶液灌洗 )浸泡 1h后植入猪的颈动脉 ,紫杉醇是溶解在 2 5 μl/L的无水酒精中 ,对照组 10只大隐静脉桥置于单纯的酒精中浸泡。 4周后取开放的静脉桥进行组织学分析。结果 :①治疗组静脉桥新生内膜面积 (1 5 9± 0 95 )mm2 ,对照组新生内膜面积高达 (2 43± 1 3 5 )mm2 ,治疗组显著低于对照组 ,两组比较有非常显著的差异 ,P <0 0 1;②治疗组内膜平滑肌细胞密度均值为 (3 681± 193 5 ) /mm2 ,对照组为 (4 60 7± 1993 ) /mm2 ,两组比较有显著性差异 ,P <0 0 5 ;中膜平滑肌细胞密度均值治疗组 (2 13 9± 73 4) /mm2 ,对照组(3 62 9± 3 2 0 7) /mm2 ,两组比较有显著性的差异 ,P <0 0 5。结论 :紫杉醇可显著抑制静脉桥内膜、中膜平滑肌细胞的增殖 ,抑制新生内膜的形成 ,证明紫杉醇可在防治静脉桥闭塞方面发挥独特作用。 | 吴隐雄 Martin H Chamberlain Thomas Johnson Jason L Johnson Andrew C Newby Gianni D Angelin Martin Oberhoff Karl K Karsch | 2003 | 中国循环杂志2003，18，6： | 2 |
| 4 | A biomechanical comparison of calf versus cadaver lumbar spine models 显示文摘 | Lee H Jason C Hiroguki Yoshida | 2004 | Spine2004，29，11： | 1 |
| 5 | Combing new technologies for determination of phytoplankton community structure in the northern gulf of Mexico显示文摘 | JASON H S LISA C TAMMI L R | 2005 | Journal Plankton2005，41，： | 1 |
| 6 | Optimal finite thrust orbit transfers with large numbers of burns显示文摘 | Troy G Jason C H John H | 1999 | Journal of Guidance Control and Dynamics1999，22，1： | 1 |
| 7 | A study of storage assignmentproblem for an order picking line in a pick-and-pass w are-housing system显示文摘 | JASON C H P WU M H | 2008 | Computers&Industrial Engineering2008，，57： | 1 |
| 8 | A Study of an ecnomic production-shipment policy for a single-buyer systerm 显示文摘 | Pan C H Jason Yang J S | 2000 | European Journal of Operational Research2000，121，： | 1 |
| 9 | Circulat- ing and dietary magnesium and risk of cardiovascular disease:A systematic review and meta-analysis of pro- spective studies 显示文摘 | Liana C D G Fumiaki I Jason H Y W | 2013 | Am J Clin Nutr2013，98，1： | 1 |
| 10 | Possible role of climate in the collapse of classic Maya civilization 显示文摘 | David A H Jason H C Mark B | 1995 | Nature1995，375，： | 1 |
| 11 | Loss of INI 1 expression is characteristic of both conventional and proximal-type epithelioid sarcoma显示文摘 | Jason H L Paola D C Christopher F D M | 2009 | Am J Surg Pathol2009，33，4： | 1 |
| 12 | Climate variability on the Yucatan peninsula (Mexico) during the past 3500 years, andimplications for Maya cultural evolution 显示文摘 | Jason H C Danvid A H | 1996 | Quaternary Research1996，46，： | 1 |
| 13 | ' Marketmore 97' :A monoecious slicing cucumber inbred with multiple disease and insect resistances 显示文摘 | JASON C GEORGE M MARK H | 2007 | Hortscience2007，42，3： | 1 |
| 14 | Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localised primary gastrointestinal stromal tumour: a retrospective analysis显示文摘 | Jason S Gold Mithat G?nen Antonio Gutiérrez Javier Martín Broto Xavier García-del-Muro Thomas C Smyrk Robert G Maki Samuel Singer Murray F Brennan Cristina R Antonescu John H Donohue Ronald P DeMatteo | 2009 | Lancet Oncology2009，，11： | 1 |
| 15 | The importance of preoperative Hemoglobin Evaluation in large volume liposuction 显示文摘 | Umar H C Petr H Jason L | 2008 | Ann Plast Surg2008，61，3： | 1 |
| 16 | 查看详情显示文摘 | Leila H Jason W H Danni C | | 0，，1： | 1 |
| 17 | Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons显示文摘 | HOA H L EMILY M C JASON P C | 2008 | Toxicology Letters2008，176，2： | 1 |
| 18 | Increased production of Bacillus keratinase by chromosomal integration of multiple copies of the kerA Gene显示文摘 | Wang Jeng-Jie Kawan Rojanatavorn Shih Jason C H | 2004 | Biotechnology and Bioengineering2004，，4： | 1 |
| 19 | Role of disinfectant concentration and pH in the inactivation kinetics of Cryptosporidium parvum oocysts with ozone and monochloramlne 显示文摘 | Jason L R Jae H K Benito C V | 2001 | Environmental Science and Technology2001，35，13： | 1 |
| 20 | Filter backwash and start-up strategies for enhanced particulate removal显示文摘 | JASON F C PETER H CAROLINE S B | 1996 | Water Research1996，30，10： | 1 |
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