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| 1 | Novel concepts in radiation-induced cardiovascular disease显示文摘Radiation-induced cardiovascular disease(RICVD) is the most common nonmalignant cause of morbidity and mortality among cancer survivors who have undergone mediastinal radiation therapy(RT).Cardiovascular complications include effusive or constrictive pericarditis,cardiomyopathy,valvular heart disease,and coronary/vascular disease.These are pathophysiologically distinct disease entities whose prevalence varies depending on the timing and extent of radiation exposure to the heart and great vessels.Although refinements in RT dosimetry and shielding will inevitably limit future cases of RICVD,the increasing number of long-term cancer survivors,including those treated with older higher-dose RT regimens,will ensure a steady flow of afflicted patients for the foreseeable future.Thus,there is a pressing need for enhanced understanding of the disease mechanisms,and improved detection methods and treatment strategies.Newly characterized mechanisms responsible for the establishment of chronic fibrosis,such as oxidative stress,inflammation and epigenetic modifications,are discussed and linked to potential treatments currently under study.Novel imaging modalities may serve as powerful screening tools in RICVD,and recent research and expert opinion advocating their use is introduced.Data arguing for the aggressive use of percutaneous interventions,such as transcutaneous valve replacement and drug-eluting stents,are examined and considered in the context of prior therapeutic approaches.RICVD and its treatment options are the subject of a rich and dynamic body of research,and patients who are at risk or suffering from this disease will benefit from the care of physicians with specialty expertise in the emerging field of cardiooncology. | Jason R Cuomo Gyanendra K Sharma Preston D Conger Neal L Weintraub | 2016 | World Journal of Cardiology2016，8，9： | 17 |
| 2 | Methods for the development and assessment of atrial fibrillation and heart failure dog models显示文摘与动物的发展报导 Medtronic 经验的目的用为 AF 模型,的为 CHF.Methods 的为 AF 和 microemboli 的高率的踱步为 atrial 纤维性颤动( AF )和长期的心失败( CHF )当模特儿一根 atrial 皮带被纳入 Medtronic 协同作用 neurostimulator ,它被规划在开关责任 cycle.Atrial natnuretic 肽( ANP )在 50 Hz 刺激,大脑 natriuretic 肽( BNP )和N终端职业人员大脑 natriuretic 肽( NT-proBNP )皮脂腺囊瘤;在精选时间 points.For CHF 模型,的 assayed 在 62,400 beads/mL 的 90 m 聚苯乙烯 microspheres 的连续注射( Polybead , Polysciences 公司)被执行导致全球局部缺血,有每周监视的任何一个和 embolization 时间表(集团 1 , n = 25 )或与监视的双周刊和 emboliation 时间表(集团 2 , n36 ) .Echocardiograms 每周与 ventriculograms 和磁性的回声成像扫描一起被使用估计心脏的功能和 ANP , BNP 和 NT-proBNP 是为 AF 模型的 monitored.Results ,为 CHF 模型,遇见 CHF 端点的日子在集团 2 .For 在集团 1 和 89 是 116 AF 和 CHF 模型, NT-proBNP 与在为动物的搜索的研究人员为估计基于设备的治疗的安全和功效建模的我们为 AF 和 CHF 狗模型的发展和评价的经验可以帮助的疾病 states.Conclusion 的发展相关很好。 | Jon F Urban Renee L Gerhart Jason R Krzeszak Corey R Leet Linnea R Lentz Carolyn B McClay | 2011 | Journal of Geriatric Cardiology2011，8，3： | 3 |
| 3 | Optimization and implementation of periodic cruise for a hypersonic vehicle 显示文摘 | Chen Robert H Williamson Walton R Speyer Jason L | 2006 | Journal of Guidance Control and Dynamics2006，29，5： | 1 |
| 4 | Combing new technologies for determination of phytoplankton community structure in the northern gulf of Mexico显示文摘 | JASON H S LISA C TAMMI L R | 2005 | Journal Plankton2005，41，： | 1 |
| 5 | Chronic fatigue syndrome,chronic fatigue,and psychiatric disorders: pre- dictors of functional status in a national nursing sample 显示文摘 | Wagner L I Jason L A Ferrari J R | 1999 | J Occup Health Psychol1999，4，1： | 1 |
| 6 | The interactions of multiple cytokines control NK cell maturation 显示文摘 | Jason Brady Sebastian Carotta Thong R P L | 2010 | J Immunol2010，185，11： | 1 |
| 7 | Ipilimumab forpatients with advanced mucosal melanoma 显示文摘 | Michael A P Jason J L Ma r k J B | 2013 | Oncologist2013，18，6： | 1 |
| 8 | The molecular basis for apoptotic defects in patients with CD95 (Fas/APO-1) mutations显示文摘 | AKSHAY K V JASON R O JIA L C | 1999 | J Clin Invest1999，103，： | 1 |
| 9 | Homing missile guidance and estimation under agile target acceleration 显示文摘 | CHEN R H JASON L S | 2007 | Journal of Guidance Control and Dynamic2007，30，6： | 1 |
| 10 | Chemical manipulation of glucose metabolism in porcine oocytes: effects on nuclear and cytoplasmic maturation in vitro 显示文摘 | Jason R Amber M Rebecca L | 2006 | Reprod2006，131，2： | 1 |
| 11 | The contemporary physical and chemical flux of aeolian dust:A synthesis of direct measurements of dust deposition显示文摘 | COREY R L JASON C | 2009 | Chemical Geology2009，267，1： | 1 |
| 12 | control: a general problem formation and selected solutions显示文摘 | Jason R Wells Brett Selective harmonic M Nee Patrick L Chapman | 2005 | IEEE Transactions on Power Electronics2005，20，6： | 1 |
| 13 | Role of disinfectant concentration and pH in the inactivation kinetics of Cryptosporidium parvum oocysts with ozone and monochloramlne 显示文摘 | Jason L R Jae H K Benito C V | 2001 | Environmental Science and Technology2001，35，13： | 1 |
| 14 | Daptomycin显示文摘 | Aarti R Jason L John L | | 0，，02： | 1 |
| 15 | Fatigue rating scales: an empirical comparison 显示文摘 | Taylor R Jason L Torres A | 2000 | Psychol Med2000，30，4： | 1 |
| 16 | Metformin hydrochloride in the treatment of type 2 diabetes mellitus: A clinical review with a focus on dual therapy 显示文摘 | Stephen M Setter J L Jason T R | 2003 | Clin Therapeutics2003，25，12： | 1 |
| 17 | Phosphodiesterase Al, a Regulator of Cellulose Synthesis in Acetobacter xylinum, Is a Heme-Based Sensor显示文摘 | Alan L Chang Jason R Tuckerman Gonzalo Gonzalez | 2001 | Biochemistry2001，40，： | 1 |
| 18 | Chronic fatigue syndrome,chronic fatigue,and psychiatric disorders:predictors of functional status in a national nursing sample显示文摘 | WAGNER-RAPHAEL L I JASON L A FERRARI J R | | 0，，01： | 1 |
| 19 | STATl-dependent and STATl-independent gene expression in murine immune cells following stimulation with interfer on-alpha显示文摘 | Gregory B L Michael D R | 2007 | Cancer Immunol Immunother2007，56，： | 1 |
| 20 | SCR catalyst performance in flue gases derived from subbituminous and lignite coals 显示文摘 | STEVEN A B JASON D L CHARLENE R C | 2005 | Fuel Processing Technology2005，86，： | 1 |
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