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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Image quality of sparse -aperture designs for remote sensing显示文摘 | Robert D F Theodore A T Jason R C | 2002 | Optical Engineering2002，41，8： | 1 |
| 3 | Ligand Design and Self-Recognition: A Copper (II) Complex that Dimerizes Via Hydrogen Bonds显示文摘 | Darren J B Jason R T | 2002 | Inorganica Chimica Acta2002，341，： | 1 |
| 4 | Managing supply chain risk and disruption from IT security incidents 显示文摘 | Jason K Deane Cliff T Ragsdale Terry R Rakes Loren Paul Rees | 2009 | Journal of Oper Manag Res2009，，2： | 1 |
| 5 | A quantitative tool for assessing the integrity of southern coastal California streams 显示文摘 | Peter R O Andrew C R Jason T M | 2005 | Environmental Management2005，35，4： | 1 |
| 6 | Toxic activity from cultures of Karlodinium micrum (Gyrodinium galatheanum ) (Dinophyceae)-a dinoflagellate associated with fish mortalities in an estuarine aquaculture facility显示文摘 | Jonathan R D Daniel E T Jason E A | 2002 | Harmful Algae2002，1，： | 1 |
| 7 | Metformin hydrochloride in the treatment of type 2 diabetes mellitus: A clinical review with a focus on dual therapy 显示文摘 | Stephen M Setter J L Jason T R | 2003 | Clin Therapeutics2003，25，12： | 1 |
| 8 | Image quality of sparse-aperture designs for remote sensing显示文摘 | Robert D F Theodore A T Jason R C | 2002 | Optical Engi- neering2002，41，8： | 1 |
| 9 | Regulatory T Cells Reduce Acute Lung Injury Fibroproliferation by Decreasing Fibrocyte Recruitment显示文摘 | Garibaldi Brian T D’Alessio Franco R Mock Jason R Files D Clark Chau Eric Eto Yoshiki Drummond M Bradley Aggarwal Neil R Sidhaye Venkataramana King Landon S | 2013 | American Journal of Respiratory Cell and Molecular Biology2013，，1： | 1 |
| 10 | Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus显示文摘 | Knight Jason S Zhao Wenpu Luo Wei Subramanian Venkataraman O’Dell Alexander A Yalavarthi Srilakshmi Hodgin Jeffrey B Eitzman Daniel T Thompson Paul R Kaplan Mariana J | 2013 | Journal of Clinical Investigation2013，，： | 1 |
| 11 | The effect of uni - axial stretching on the roughness of micmfihration mem- branes显示文摘 | JASON A M DANA L T DOUGLAS R L | 2006 | Journal of Membrane Science2006，280，12： | 1 |
| 12 | PSR J2021+3651:a young radio pulsar coincident with an unidentified EGRET gamma-ray source显示文摘 | Mallory S E R Jason W T H Scott M R | 2002 | The Astrophysical Journal2002，577，： | 1 |
| 13 | Genome relationships in polyploid Poa pratensis and other Poa species inferred from phylogenetic analysis of nuclear and chloroplast DNA sequences显示文摘 | Jason T Patterson Steven R Larson Paul G Johnson | 2005 | Genome2005，48，1： | 1 |
| 14 | High speed cinema to graphy of gas metal atomization 显示文摘 | Jason T Jeffer C Stephen R | 2005 | Materials Science and Engineering:A2005，390，2： | 1 |
| 15 | A quantitative tool for assessing the integrity of Southern Coastal California Streams显示文摘 | Peter R Ode Andrew C Rehn Jason T May | 2005 | Environmental Management2005，35，4： | 1 |
| 16 | Exploring alkaline pre-treatment of microalgal biomass for bioetha- nol production 显示文摘 | R Harun W S Y Jason T Cherrington | 2011 | Applied Energy2011，88，10： | 1 |
| 17 | Coding poten- tial of UL/b' from the initial source of rhesus cytomegalovirus Strain 68-1 显示文摘 | Gill R B Jason Bowman J Krogmann T | 2013 | Virol2013，447，1： | 1 |
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