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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 3 | Numerical analysis of the noisy Kuramoto-Sivashinsky equation in 2 + 1 dimensions显示文摘 | Drotar Jason T Zhao Y P Lu T M | 1999 | Phys Rev E1999，76，8： | 1 |
| 4 | Recent advance in techniques for hyperspectral image processing显示文摘 | Antonio P Jon A B Joseph W B Jason B Lorenzo B Gustavo C V Jocelyn C Mathieu F Paolo G Anthony G Mattia M James C T Giovanna T | 2009 | Remote Sensing of Environment2009，113，： | 1 |
| 5 | Solvent effects on copper nanoparticle growth behavior in AOT reverse micelle Systems显示文摘 | Joanna P C Michael E M Jason B T | 2001 | Phys ChemB2001，105，12： | 1 |
| 6 | Electronically conductive phospho-olivinos as lithium storage electrodes显示文摘 | Chung S Y Jason T B Chiang Y M | 2002 | Nature Materials2002，1，2： | 1 |
| 7 | The relationship between near-axis hydrothermal cooling and the spreading rate of mi& ocean ridges 显示文摘 | Baker E T Chen Y J Jason P M | 1996 | Earth and Planetary Science Letters1996，142，： | 1 |
| 8 | Compression neuropathies of the median nerve显示文摘 | Jason T Koo MDa Robert M | 2004 | MPH Journal of the American Society for Surgery of the Hand2004，4，3： | 1 |
| 9 | Longitudinal variation in muscle protein expression and contraction kinetics of largenmuth bass axial muscle 显示文摘 | TIERNEY M T JASON M B DAVID J C | 2001 | Journal of Experimental Biology2001，204，24： | 1 |
| 10 | Oil bodies and their associated proteins,oleosin and caleosin显示文摘 | Gitte I F John M Jason T C T | 2001 | Physiologia Plantarum2001，112，3： | 1 |
| 11 | Mycobacterial interspersedrepetitive unit typing of Mycobacterium tuberculosis comparedto IS6110-based restriction fragment length polymorphismanalysis for investigation of apparently clustered cases oftuberculosis显示文摘 | Peter M Grace Smith E Jason T | 2003 | J Clin Microbiol2003，41，8： | 1 |
| 12 | Electronically conductive phospho-olivines as lithium storage electrodes 显示文摘 | Chung S Y Jason T B Chiang Y M | 2002 | Nature Materials2002，1，10： | 1 |
| 13 | A quantitative tool for assessing the integrity of southern coastal California streams 显示文摘 | Peter R O Andrew C R Jason T M | 2005 | Environmental Management2005，35，4： | 1 |
| 14 | Surface roughening in shadowing growth and etching in 2+1 dimensions 显示文摘 | Drotar Jason T Zhao Y P Lu T M | 2000 | Physical Review B2000，62，3： | 1 |
| 15 | Electronically conduc- tive phosphor-olivines as lithium storage electrodes 显示文摘 | Chung S Y Jason T B Chiang Y M | 2002 | Nature Materials2002，10，1： | 1 |
| 16 | Metformin hydrochloride in the treatment of type 2 diabetes mellitus: A clinical review with a focus on dual therapy 显示文摘 | Stephen M Setter J L Jason T R | 2003 | Clin Therapeutics2003，25，12： | 1 |
| 17 | Energy Conservation From Systematie Tire Pressure Regulation显示文摘 | Pearce Jason T Hanlon | 2007 | Energy Policy2007，35，： | 1 |
| 18 | Estrogen receptor p2negatively regulates the transactivation of estrogen receptor ain human breast cancer cells显示文摘 | Chunyan Z Jason M Michel T | 2007 | Cancer Res2007，67，8： | 1 |
| 19 | Solid-supported cyclohexane-1,3-dione (CHD):A' capture and release'reagent for thesynthesis of amides and novel scavenger resin显示文摘 | Cara E H Morag A M E Jason P T et a l | 2003 | Org Lett2003，5，6： | 1 |
| 20 | Prolonged exercise,lymphoeyte apoptosis and isoprostanes显示文摘 | Adam S Jason M Andera T | 2003 | Euro J of Appl Phy2003，87，1： | 1 |
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