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| 1 | Pancreaticoduodenectomy: a comparison of superior approach with classical Whipple's technique显示文摘BACKGROUND: Pancreaticoduodenectomy (PD) is the standard procedure for resecting tumors arising from the periampullary area and the pancreatic head. Nevertheless this procedure is inherently difficult and associated with high morbidity and mortality. Besides, the technique applied for exposing the portal and superior mesenteric veins is time-consuming, difficult and associated with the risk of major venous injury. Recently we have introduced a modified approach for making this part of the procedure quick, safe and bloodless, which constitutes the subject of this study. METHODS: Patients who underwent pylorus preserving pancreaticoduodenectomy (PPPD) either by superior approach technique (group 1) or by classical Whipple's technique (group 2) were retrospectively identified. Age-sex composition, body mass index (BMI), total operative time, operative blood loss, intraoperative blood transfusion requirement, morbidity, mortality and length of hospital stay were compared between the two groups. RESULTS: Between January 1997 and December 2011, 72 patients underwent PPPD by the superior approach technique (group 1) and 38 underwent PPPD by the classical Whipple's technique (group 2) at our institution. Statistically significant differences were observed in operative time (208.1±46.3 minutes in group 1 vs 322.0±33.8 minutes in group 2), operative blood loss (601.0±250.3 mL in group 1 vs 1371.5±471.8 mL in group 2), and intraoperative blood transfusion requirement [10 (13.9%) patients in group 1 and 24 (63.2%) in group 2]. Among 18 (16.4%) obese patients, significant differences in operativetime, operative blood loss and intraoperative blood transfusion requirement were observed between groups 1 and 2. There was no significant inter-group difference in complication rate among obese patients, but comparing obese patients with normal weight patients revealed higher rates of complications like pancreatic fistula (27.8% vs 6.5%), delayed gastric emptying (16.7% vs 5.4%), and infective complications like wound infection and intra abdominal collection (44.4% vs 5.4%). CONCLUSIONS: On the basis of analytical data, we conclude that the superior approach technique is effective for PD compared with the classical Whipple's technique. It allows fast, safe and virtually bloodless dissection for exposure of the superior mesenteric and portal veins during early steps of PD. PD is normally a difficult and tedious procedure carrying a remote risk of major venous injury leading to substantial blood loss. | Omar Javed Shah Mushtaq A Gagloo Irfan Jan Khan Rayees Ahmad Saleema Bano | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，2： | 8 |
| 2 | Potentially harmful metals,and health risk evaluation in groundwater of Mardan,Pakistan:Application of geostatistical approach and geographic information system显示文摘This study investigates the values of pH,total dissolved solids(TDS),elevation,oxidative reduction potential(ORP),temperature,and depth,while the concentrations of Br,and potentially harmful metals(PHMs)such as Cr,Ni,Cd,Mn,Cu,Pb,Co,Zn,and Fe in the groundwater samples.Moreover,geographic information system(GIS),XLSTAT,and IBM SPSS Statistics 20 software were used for spatial distribution modeling,principal component analysis(PCA),cluster analysis(CA),and Quantile-Quantile(Q-Q)plotting to determine groundwater pollution sources,similarity index,and normal distribution reference line for the selected parameters.The mean values of pH,TDS,elevation,ORP,temperature,depth,and Br were 7.2,322 mg/L,364 m,188 mV,29.6℃,70 m,0.20 mg/L,and PHMs like Cr,Ni,Cd,Mn,Cu,Pb,Co,Zn,and Fe were 0.38,0.26,0.08,0.27,0.36,0.22,0.04,0.43 and 0.86 mg/L,respectively.PHMs including Cr(89%),Cd(43%),Mn(23%),Pb(79%),Co(20%),and Fe(91%)exceeded the guideline values set by the world health organization(WHO).The significant R^(2)values of PCA for selected parameters were also determined(0.62,0.67,0.78,0.73,0.60,0.87,-0.50,0.69,0.70,0.74,-0.50,0.70,0.67,0.79,0.59,and-0.55,respectively).PCA revealed three geochemical processes such as geogenic,anthropogenic,and reducing conditions.The mineral phases of Cd(OH)_(2),Fe(OH)_(3),FeOOH,Mn_(3)O_(4),Fe_(2)O_(3),MnOOH,Pb(OH)_(2),Mn(OH)_(2),MnO_(2),and Zn(OH)_(2)(-3.7,3.75,9.7,-5.8,8.9,-3.6,2.2,-4.6,-7.7,-0.9,and 0.003,respectively)showed super-saturation and under-saturation conditions.Health risk assessment(HRA)values for PHMs were also calculated and the values of hazard quotient(HQ),and hazard indices(HI)for the entire study area were increased in the following order:Cd>Ni>Cu>Pb>Mn>Zn>Cr.Relatively higher HQ and HI values of Ni,Cd,Pb,and Cu were greater than one showing unsuitability of groundwater for domestic,agriculture,and drinking purposes.The long-term ingestion of groundwater could also cause severe health concerns such as kidney,brain dysfunction,liver,stomach problems,and even cancer. | Abdur Rashid Muhammad Ayub Asif Javed Sardar Khan Xubo Gao Chengcheng Li Zahid Ullah Tariq Sardar Juma Muhammad Shahla Nazneen | 2021 | Geoscience Frontiers2021，12，3： | 2 |
| 3 | Development of bis-thiobarbiturates as successful urease inhibitors and their molecular modeling studies显示文摘Bis-thiobarbiturate derivatives 1–15 have been synthesized, characterized by1 HNMR and EI-MS and screened for urease inhibition. All compounds showed various degree of urease inhibitory activity with IC_(50) values ranging 7.45 0.12 74.24 0.81 mmol/L while the standard thiourea behaved normally(IC_(50) = 21.10 0.12). Compounds 1(IC_(50) = 7.45 0.12 μmol/L), 9(IC_(50) = 18.17 1.03 μmol/L) and 13(IC_(50) = 8.61 0.45 μmol/L) showed excellent urease inhibitory activity in the series. Molecular modeling studies were performed to understand the binding site with the bimetallic nickel center of the enzyme.Structure-activity relationship has also been established for these compounds. This study identified bisthiobarbiturate as a novel class of urease inhibitors. | Fazal Rahim Muhammad Ali Shifa Ullah Umer Rashid Hayat Ullah Muhammad Taha Muhammad Tariq Javed Wajid Rehman Aftab Ahmad Khan Obaid Ur Rahman Abid Muhammad Bilal | 2016 | Chinese Chemical Letters2016，27，5： | 2 |
| 4 | Efficient UAV Communications: Recent Trends and Challenges显示文摘Unmanned Ariel Vehicles(UAVs)are flying objects whose trajectory can be remotely controlled.UAVs have lot of potential applications in the areas of wireless communications,internet of things,security,traffic management,monitoring,and smart surveying.By enabling reliable communication between UAVs and ground nodes,emergency notifications can be efficiently and quickly disseminated to a wider area.UAVs can gather data from remote areas,industrial units,and emergency scenarios without human involvement.UAVs can support ubiquitous connectivity,green communications,and intelligent wireless resource management.To efficiently use UAVs for all these applications,important challenges need to be investigated.In this paper,we first present a detailed classification of UAVs based on factors such as their size,communication range,weight,and flight altitude.We also explain the hardware system configuration and uses of these UAVs.We present a brief overview of recent work done related to three major challenges in UAVs.These challenges include trajectory control,energy efficiency and resource allocation.We also present three open challenges and future opportunities for efficient UAV communications.These include use of learning algorithms for resource allocation and energy efficiency in UAVs,intelligent surfaces-based communications for enhanced reliability in UAVs,and security algorithms to combat malicious attacks against UAVs. | Abdulfattah Noorwali Muhammad Awais Javed Mohammad Zubair Khan | 2021 | Computers, Materials & Continua2021，，4： | 2 |
| 5 | HCV genotype distribution and possible transmission risks in Lahore, Pakistan显示文摘AIM: To investigate the prevalence of hepatitis C virus (HCV) genotypes and their association with possible transmission routes in the general population of Lahore, as the data exclusively related to this city is limited. METHODS: Complete data regarding patient's history, possible route of infection and biochemical tests was collected from the public hospital for 1364 patients. SPSS version 16 windows software was used for data analysis by univariate and multivariate techniques. RESULTS: Age range ≤ 40 years showed high prevalence of HCV infection. HCV genotype 3a was dominant (55.9%), followed by 1a (23.6%), 4a (12.5%), 3b (3.2%), untypable (2.5%), 4b (1.2%) and mixed type (1.2%). Blood transfusion, dental surgery and barber shops were the main risk factors for HCV transmission. Genotype prevalence was independent of age (P = 0.971) and gender (P = 0.122) while risk factors showed a significant association with age (P = 0.000) and genotypes (P = 0.000). We observed an independent association of risk factors and genotype 3a, while patients with genotype 1 and 4 were mostly infected due to dental surgery blood transfusion and barber shops. Risk factors of intravenous drug use and sexual exposure were exclusively found in ≤ 40 years age group. CONCLUSION: An increase in genotypes 1a and 4a suggest migration of people, possibly from Balochistan and the northern war-zone area. Government should focus on public education regarding infection routes. | Waqar Ahmad Bushra Ijaz Fouzia Tahir Javed Shah Jahan Imran Shahid Fawad Mumtaz Khan Sajida Hassan | 2010 | World Journal of Gastroenterology2010，16，34： | 2 |
| 6 | Edaravone ameliorates oxi- dative stress associated eholinergic dysfunction and limits apoptotic response following focal cerebral ischemia in rat显示文摘 | Abmad A Khan MM Javed H | 2012 | Mol Cell Bio- ehem2012，367，12： | 1 |
| 7 | Zinc oxide nanoparticles selectively induce apoptosis in human cancer cells through reactive oxygen species显示文摘 | Maqusood Ahamed Alrokayan Ahmad Majeed Khan Kumar Javed Akhtar | 2012 | International Journal of Nanomedicine . 2012 (defa)2012，，： | 1 |
| 8 | Effect of Zn doping on electronic structure and optical properties zincblende GaN(A DFT+U insight)显示文摘The development of new materials,having exceptional properties in comparison to existing materials is highly required for bringing advancement in electronic and optoelectronic technologies.Keeping this fact,we investigated structural,electronic,and optical properties of zincblende GaN doped with selected Zn concentrations(6.25%,12.50%,and 18.70%),using the first-principle calculations based on density functional theory with GGA+U.We conducted the entire study using the WIEN2K code.In this study,we calculated various significant parametric quantities such as cohesive energies,formation energies,bulk moduli,and lattice constants along with the study of optical and electronic properties by substituting Ga atoms with Zn atoms in 1×2×2 supercell.The structural stability is confirmed by studying the phonon dispersion curves which suggest that Zn:GaN material is stable against the 6.25%and 18.70%Zn concentrations while for 12.50%,it shows instability.The Hubbard values U=0,2,4,6 eV were added to GGA and the electronic properties were improved with the U=6 eV.Optical absorption was blue shifted while the refractive index and dielectric constant were increased with increasing the Zn concentrations.Electronic properties are enhanced due to the prime contribution of cations(Zn)3ri states.The optical and electronic properties are further discussed in detail in the entire study. | Muhammad Junaid Iqbal Khan Zarfishan Kanwal Masood Yousaf Hamid Ullah Javed Ahmad Abid Latif Yong-Han Shin Ata Ur Rahman Khalid | 2021 | Communications in Theoretical Physics2021，73，3： | 1 |
| 9 | Non-surgical management of urinary stress incontinence 显示文摘 | Zeenat Eva Khan Javed Rizvi | 2005 | Review in Gynaecological Practice2005，5，： | 1 |
| 10 | Rutin prevents cog- nitiv impairments by ameliorating oxidative stress and neu- roinflammation in rat model of sporadic dementia of Alzheimer typd显示文摘 | JAVED H KHAN M M AHMAD A | 2012 | Journal of Neuroscienee2012，210，： | 1 |
| 11 | Williamson流体在黏性耗散和均匀磁场作用下四次自催化化学反应的熵优化(英文)显示文摘阐述了可伸缩的旋转盘对非牛顿磁流体动力学(MHD)的影响。两个圆盘以不同的角速度和不同的伸缩率旋转。在能量表达式中考虑黏性耗散,利用热力学第二定律分析熵的生成,文中首次介绍了熵产生的化学过程(多相和均相)。采用边界层方法建立模型,引入变量对控制系统进行无量纲化。通过高度非线性表达式的计算,得到同伦过程解的收敛性。用图解法描述了各种因素对热场、速度场和溶质场的影响特征。此外,以表格形式给出了工程质量包括表面摩擦系数、Nusselt数的计算结果。结果证实了因Weissenberg(We)(韦斯森伯格)和Eckert(Ec)(埃克特)数而导致的温度梯度分布的增加。 | M. IJAZ KHAN Sania JAVED Tasawar HAYAT M. WAQAS Ahmed ALSAEDI | 2019 | Journal of Central South University2019，26，5： | 1 |
| 12 | Edaravone amel- iorates oxidative stress associated cholinergic dysfunction and limits apoptotic response following focal cerebral ischemia in rat 显示文摘 | Ahmad A Khan M M Javed H | 2012 | Mol Cell Biochem2012，367，12： | 1 |
| 13 | Synergistic effect of a fun- gus, Fusarium semitectum , and a nematode, Tylenchulus semi- penetrans, on citrus decline 显示文摘 | Safdar A Javed N Khan S A | 2013 | Pakistan Journal of Zoology2013，45，3： | 1 |
| 14 | Deep brain stimulation relieves refractory hypertension显示文摘 | Patel NK Javed S Khan S | 2011 | Neurology2011，76，4： | 1 |
| 15 | Deep brain stimulation relieves refractory hypertension显示文摘 | Patel N K Javed S Khan S | | 0，，04： | 1 |
| 16 | Edaravone amel- iorates oxidative stress associated cholinergic dysfunction and limits apoptotic response following focal cerebral is- chemia in rat显示文摘 | Ahmad A Khan M M Javed H | 2012 | Mol Cell Biochem2012，367，12： | 1 |
| 17 | Deep brain stimulation reli- eves refractory hypertension 显示文摘 | Patel N K Javed S Khan S | 2011 | Neurology2011，76，4： | 1 |
| 18 | High frequency stimulation of the mamillothalamie tract for the treatment of resistant seizures associated with hypothalamic hamartoma 显示文摘 | Khan S Wright I Javed S | 2009 | Epilepsia2009，50，6： | 1 |
| 19 | Prevalent fecal contamination in drinking water resources and potential health risks in Swat, Pakistan显示文摘Fecal bacteria contaminate water resources and result in associated waterborne diseases.This study assessed drinking water quality and evaluated their potential health risks in Swat, Pakistan. Ground and surface drinking water were randomly collected from upstream to downstream in the River Swat watershed and analyzed for fecal contamination using fecal indicator bacteria(Escherichia coli) and physiochemical parameters(potential of hydrogen, turbidity, temperature, electrical conductivity, total dissolved solid, color, odor and taste). The physiochemical parameters were within their safe limits except in a few locations, whereas, the fecal contaminations in drinking water resources exceeded the drinking water quality standards of Pakistan Environmental Protection Agency(Pak-EPA),2008 and World Health Organization(WHO), 2011. Multivariate and univariate analyses revealed that downstream urbanization trend, minimum distance between water sources and pit latrines/sewerage systems, raw sewage deep well injection and amplified urban,pastures and agricultural runoffs having human and animal excreta were the possible sources of contamination. The questionnaire survey revealed that majority of the local people using 10–20 years old drinking water supply schemes at the rate of 73% well supply,13% hand pump supply, 11% spring supply and 3% river/streams supply, which spreads high prevalence of water borne diseases including hepatitis, intestinal infections and diarrhea, dysentery, cholera, typhoid fever, jaundice and skin diseases in children followed by older and younger adults. | Kifayatullah Khan Yonglong Lu Mian Abdal Saeed Hazrat Bilal Hassan Sher Hizbullah Khan Jafar Ali Pei Wang Herman Uwizeyimana Yvette Baninla Qifeng Li Zhaoyang Liu Javed Nawab Yunqiao Zhou Chao Su Ruoyu Liang | 2018 | Journal of Environmental Sciences2018，30，10： | 1 |
| 20 | Formation of crystalline particles from phase change emulsion: Influence of different parameters显示文摘Solidification or crystallization of phase change emulsion in the form of fine emulsion drops in a direct contact coolant at temperatures below their freezing point was studied. This work is mainly focused on the size and shape of the generated particles from phase change emulsified fats. Size of the particles is the major or key factor being considered during their formation, however, other factors that govern the particle size and shape were also observed. The operating parameters of the process were optimized in order to obtain particles of smaller size ranges in the window of current operating conditions. The crystallization of complex emulsion matrices is very difficult to control in the bulk at desired requirement. Hence, the emulsion drop to particle formation has advantage in comparison with the bulk solidification or crystallization. The main objective of this work is to achieve spherical emulsion particles in a direct contact cooling system. Parameters like: stability, characterization, viscosity, and the effect of different energy inputs were examined. Moreover, the effects of the capillary size, interfacial tension, temperature of the emulsion on the particle size were also monitored. | Javed Iqbal Zulfiqar Ali Murid Hussain Rizwan Sheikh Khaliq Majeed Asad Ullah Khan Joachim Ulrich | 2016 | Chinese Journal of Chemical Engineering2016，24，7： | 1 |
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