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| 1 | Clinical scenarios for the use of S100β as a marker of hepatic encephalopathy显示文摘AIM: To evaluate the association between serum concentrations of S100β in patients with cirrhosis and the presence of low grade hepatic encephalopathy(HE).METHODS: This was a cross-sectional study. The population was categorized into four groups healthy subjects, cirrhosis without HE, cirrhosis with covert hepatic encephalopathy(CHE) and cirrhosis with overt HE. Kruskal-Wallis, Mann Whitney's U with Bonferroni adjustment Spearman correlations and area under the ROC were used as appropriate.RESULTS: A total of 61 subjects were included, 46 cirrhotic patients and 15 healthy volunteers. S100β values were different among all groups, and differences remained significant between groups 1 and 2(P < 0.001), and also between groups 2 and 3(P = 0.016), but not between groups 3 and 4. In cirrhotic patients with HE S100β was higher than in patients without HE [0.18(0.14-0.28) ng/m L vs 0.11(0.06-0.14) ng/m L, P < 0.001]. There was a close correlation between serum concentrations of S100β and psychometric hepatic encephalopathy score in patients with cirrhosis without HE compared to the patients with cirrhosis with CHE(r =-0.413, P = 0.019). ROC curve analysis yielded > 0.13 ng/m L as the best cutoff value of S100β for the diagnosis of HE(sensitivity 83.3%, specificity 63.6%).CONCLUSION: Serum concentrations of S100β are higher in patients with cirrhosis than in healthy volunteers, and are further increased in the presence of hepatic encephalopathy. The results suggest that serum biomarkers such as S100β could help in the correct characterization of incipient stages of HE. | Andrés Duarte-Rojo Astrid Ruiz-Margáin Ricardo U Macias-Rodriguez Francisco Javier Cubero José Estradas-Trujillo Rosa Ma Munoz-Fuentes Aldo Torre | 2016 | World Journal of Gastroenterology2016，22，17： | 4 |
| 2 | Unexplained liver laceration after metastasis radiofrequency ablation显示文摘Many studies have established the role of radiofrequency (RF) ablation as a minimally invasive treatment for liver metastases. Although relatively safe, several complications have been reported with the increased use of RF ablation. We describe here a case of unexplained liver laceration after a RF procedure. A woman who presented a solitary metachronous liver metastasis underwent RF ablation treatment for this lesion. Six hours later the patient displayed fatigue and pallor. Emergency blood tests showed a haemoglobin level of < 7 g/dL and markedly elevated transaminase levels. A computed tomography examination revealed two areas of liver laceration with haematoma, one of them following the path of the needle and the other leading away from the f irst. Following a blood transfusion, the patient was haemodynamically stable and completely recovered 24 h later. The patient remained in bed for 1 wk. No surgical intervention was required, and she was discharged 1 wk later. | Esther Ua Javier Trueba Jose Manuel Montes | 2009 | World Journal of Gastroenterology2009，15，40： | 3 |
| 3 | Integration of multi-body systems in mechatronic simulation environments of any kind 显示文摘 | Javier U | 2002 | International Journal of vehicle design (S873L-D068)2002，28，123： | 1 |
| 4 | Control of Dis-tributed Uninterrupted Power Supply System显示文摘 | GUERRERO J M LI Junhang JAVIER U | 2008 | IEEE Trans-actions on Industrial Electronics2008，55，8： | 1 |
| 5 | Reconstruction of Particle-size Distributions form Light-scattering Patterns Using Three Inversion Methods 显示文摘 | JAVIER V U AGUILAR J F DAVID M G | 2007 | Applied Optics2007，46，1： | 1 |
| 6 | Accessibility in the European Union: The impact of the trans-European road network显示文摘 | JAVIER G PALOMA U | 1996 | Journal of Transport Geography1996，4，1： | 1 |
| 7 | Integration of multi - body systems in meehatrorde simulation environments of any kind 显示文摘 | U Javier | 2002 | International Journal of vehicle design ( S873L - D068 )2002，28，123： | 1 |
| 8 | Single-stranded antisense siRNAs guide target RNA cleavage in RNAi显示文摘 | Javier M Agnieszka P Henning U | 2002 | Cell2002，110，5： | 1 |
| 9 | Integration of multi-body systems in mechatronic simulation environments of any kind 显示文摘 | Javier U | 2002 | /nternational Journal of vehicle design (S873L-D068)2002，28，123： | 1 |
| 10 | Simulation and thermoeconomic analysis of different configurations of gas turbine (GT)-based dual-purpose power and desalination plants (DPPDP) and hybrid plants (HP)显示文摘 | THIBAUT R JAVIER U LUIS S | 2007 | Energy2007，32，： | 1 |
| 11 | Selenium modulates oxidative stress-induced cell apoptosis in human myeloid HL-60 cells through regulation of calcium release and caspase-3 and -9 activities显示文摘 | Abd u lhadi CU Mustafa N Javier E | 2009 | J Membr Biol2009，232，： | 1 |
| 12 | Reconstruction of particle-size distributions from light scattering patterns using three inversion methods显示文摘 | Javier V U Aguilar J F David M G | 2007 | Applied Optics2007，46，1： | 1 |
| 13 | Molecularly imprinted polymers as antibody mimics in automated on-line fluorescent competitive assays 显示文摘 | Javier L U Uillermo O G Andrew J H | 2007 | Anal Chem2007，79，13： | 1 |
| 14 | Accessibility in the European Union: the impact of the transeuropean road network显示文摘 | Javier G Paloma U | 1996 | Journal of Transport Geography1996，4，15： | 1 |
| 15 | Complications of continuous renal replacement therapy in critically ill children: A prospective observational evaluation study 显示文摘 | Maria J Jesus L Javier U | 2009 | Crit Care2009，13，6： | 1 |
| 16 | Rapid quantification of murine endothelin-1 and vasoactive intestinal contractor gene expression levels by a real-time PCR system 显示文摘 | Tsuyoshi U A Javier S Kaname | 2000 | Journal of Biotechnology2000，84，： | 1 |
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