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| 1 | Melatonin reduces traumatic brain injury-induced oxidative stress in the cerebral cortex and blood of rats显示文摘Free radicals induced by traumatic brain injury have deleterious effects on the function and antioxidant vitamin levels of several organ systems including the brain. Melatonin possesses antioxidant effect on the brain by maintaining antioxidant enzyme and vitamin levels. We investigated the effects of melatonin on antioxidant ability in the cerebral cortex and blood of traumatic brain injury rats. Results showed that the cerebral cortex β-carotene, vitamin C, vitamin E, reduced glutathione, and erythrocyte reduced glutathione levels, and plasma vitamin C level were decreased by traumatic brain injury whereas they were increased following melatonin treatment. In conclusion, melatonin seems to have protective effects on traumatic brain injury-induced cerebral cortex and blood toxicity by inhibiting free radical formation and supporting antioxidant vitamin redox system. | Nilgün Senol Mustafa Naziroglu | 2014 | Neural Regeneration Research2014，9，11： | 5 |
| 2 | Effects of tyrosine kinase inhibitor E7080 and eNOS inhibitor L-NIO on colorectal cancer alone and in combination显示文摘Objective:To investigate the effects of E7080 and N5-(1-iminoethyl)-L-ornithine dihydrochloride(L-NIO)on colorectal cancer alone and in combination.Methods:HT29 colorectal cancer cell line from Sap Institute was used.Real-time cell analysis(xCELLigence system)was performed to determine the effects of E7080 and L-NIO on colorectal cell proliferation.While apoptosis was determined with Annexin V staining,and the effect of agents on angiogenesis was determined with chorioallantoic membrane(CAM)model.Results:We found that E7080 has a strong antiproliferative effect with an half maximum inhibition of concentration(IC50)value of 5.60×10–8mol/L.Also it has been observed that E7080 showed antiangiogenic and apoptotic effects on HT29 colorectal cancer cells.Antiangiogenic scores of E7080 were 1.2,1.0 and 0.6for 100,10 and 1 nmol/L E7080 concentrations,respectively.Furthermore,apoptosis has been detected in71%of HT29 colorectal cancer cells after administration of 100 nmol/L E7080 which may indicate strong apoptotic effect.Meanwhile administration of L-NIO alone did not show any effect,but the combination of E7080 with L-NIO increased the antiproliferative,antiangiogenic and apoptotic effects of E7080.Conclusions:Results of this study indicate that E7080 may be a good choice in treatment of colorectal tumors.Furthermore the increased effects of E7080 when combined with L-NIO raise the possibility to use a lower dose of E7080 and therefore avoid/minimize the side effects observed with E7080. | Ahmet Altun Tijen Kaya Temiz Ezgi Balc Zübeyde Ak n Polat Mustafa Turan | 2013 | Chinese Journal of Cancer Research2013，25，5： | 4 |
| 3 | Patients with Inflammatory Bowel Disease Have a Lower Response Rate to HBV Vaccination Compared to Controls显示文摘 | Mustafa Erhan Altun?z Ebubekir ?enate? Atakan Ye?il Turan ?alhan Ay?e Oya Kurda? ?vün? | 2012 | Digestive Diseases and Sciences2012，，4： | 3 |
| 4 | Mesenchymal stem cell therapy in patients with small bowel transplantation:Single center experience显示文摘AIM:To study the effects of mesenchymal stem cell(MSC) therapy on the prevention of acute rejection and graft vs host disease following small bowel transplantation.METHODS: In our transplantation center, 6 isolated intestinal transplants have been performed with MSC therapy since 2009. The primary reasons for transplants were short gut syndrome caused by surgical intestine resection for superior mesenteric artery thrombosis(n = 4), Crohn's disease(n = 1) and intestinal aganglionosis(n = 1). Two of the patients were children. At the time of reperfusion, the first dose of MSCs cultured from the patient's bone marrow was passedinto the transplanted intestinal artery at a dose of 1000000 cells/kg. The second and third doses of MSCs were given directly into the mesenteric artery through the arterial anastomosis using an angiography catheter on day 15 and 30 post-transplant.RESULTS: The median follow-up for these patients was 10.6 mo(min: 2 mo-max: 30 mo). Three of the patients developed severe acute rejection. One of these patients did not respond to bolus steroid therapy. Although the other two patients did respond to antirejection treatment, they developed severe fungal and bacterial infections. All of these patients died in the 2nd and 3rd months post-transplant due to sepsis. The remaining patients who did not have acute rejection had good quality of life with no complications observed during the follow-up period. In addition, their intestinal grafts were functioning properly in the 13th, 25th and 30th month post-transplant. The patients who survived did not encounter any problems related to MSC transplantation.CONCLUSION: Although this is a small case series and not a randomized study, it is our opinion that small bowel transplantation is an effective treatment for intestinal failure, and MSC therapy may help to prevent acute rejection and graft vs host disease following intestinal transplantation. | Sait Murat Do?an Sel?uk K?l?n? Eyüp Kebap?? Cem Tu?men Mustafa ?lmez Cezmi Karaca Alp Gürkan Ma?allah Baran Yusuf Kurtulmu? | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 5 | Delaying surgery after neoadjuvant chemoradiotherapy improves prognosis of rectal cancer显示文摘AIM To investigate the prognostic effect of a delayed interval between neoadjuvant chemoradiotherapy(CRT) and surgery in locally advanced rectal cancer.METHODS We evaluated 87 patients with locally advanced mid-or distal rectal cancer undergoing total mesorectal excision following an interval period after neoadjuvant CRT at ?i?li Hamidiye Etfal Training and Research Hospital,Istanbul between January 2009 and January 2014.Patients were divided into two groups according to the intervalbefore surgery: < 8 wk(group Ⅰ) and ≥ 8 wk(group Ⅱ).Data related to patients,cancer characteristics and pathological examination were collected and analyzed.RESULTS When the distribution of timing between group Ⅰ(n = 45) and group Ⅱ(n = 42) was viewed,comparison of interval periods(median ± SD) of groups showed a significant difference of as 5 ± 1.28 wk in group Ⅰ and 10.1 ± 2.2 wk in group Ⅱ(P < 0.001).The median follow-up period for all patients was 34.5(9.9-81) mo.group Ⅱ had significantly higher rates of pathological complete response(p CR) than group Ⅰ had(19% vs 8.9%,P = 0.002).Rate of tumor regression grade(TRG) poor response was 44.4% in group Ⅰ and 9.5% in group Ⅱ(P < 0.002).A poor pathological response was associated with worse disease-free survival(P = 0.009).The interval time did not show any association with local recurrence(P = 0.79).CONCLUSION Delaying the neoadjuvant CRT-surgery interval may provide nodal down-staging,improve p CR rate,and decrease the rate of TRG poor response. | Mehmet Mihmanli Esin Kabul Gürbulak Ismail Ethem Akgün Mustafa Fevzi Celayir Pinar Yazici Deniz Tuncel Tuba Tülin Bek Ayhan Oz Sinan Omeroglu | 2016 | World Journal of Gastrointestinal Oncology2016，8，9： | 3 |
| 6 | Left‐sided hepatic resection for hepatolithiasis: a longitudinal study of 110 patients显示文摘 | Omar Javed Shah Irfan Robbani Parveen Shah Showkat Ali Zargar Gul Javaid Ghulam N Yattoo Altaf Shah Farhat Mustafa | 2012 | HPB2012，，11： | 2 |
| 7 | Clinical evaluation of submucosal colonic lipomas: Decision making显示文摘甚至脂肪瘤是胃肠道的最普通的间充质的良性瘤,征兆的结肠的表示是稀罕的。此处,我们评估了受不了结肠的脂肪瘤的各种各样的尺寸的四个病人并且由不同治疗学的形式来临了。 | Oge Tascilar Güldeniz Karadeniz Cakmak Banu Dogan Gün Bülent Hamdi U(?)an Hakan Balbaloglu Ali Cesur Ali Ugur Emre Mustafa Comert Lütfü Oktay Erdem Selim Aydemir | 2006 | World Journal of Gastroenterology2006，12，31： | 2 |
| 8 | Devel- opment of wide area monitoring anf control applications in Malaysia显示文摘 | MUSTAFA M A YUSUF N S N TERZIJIA V V | 2009 | lEEE Power and Energy Society General Meeting2009，，： | 1 |
| 9 | Adaptive zero-phase error-tracking controllers with advance learning显示文摘 | MUSTAFA M M YAACOB N R MOHAMED N A Nik | 2004 | Control and Intelligent Systems2004，32，2： | 1 |
| 10 | 'Pass the ball!'simultaneous flexible nephroscopy and retrograde intrarenal surgery for large residual upper-pole staghorn stone显示文摘 | Undre S Olsen S Mustafa N | 2004 | J Endourolo2004，18，9： | 1 |
| 11 | Lipid vesicles for skin delivery of drugs : Reviewing three decades of re- search 显示文摘 | MUSTAFA M A E OSSAMA Y A V1VIANE F N | 2007 | Int JPharm2007，332，12： | 1 |
| 12 | Metabolomics:back to basics显示文摘 | VERPOORTE R CHOI Y MUSTAFA N etal | 2008 | PhytochemistryReviews2008，7，3： | 1 |
| 13 | Vulvar syringoma exacerbated during pregnancy显示文摘 | Cem Turan Mustafa Ugur Lale Kutluay Selahattin Kükner Tülin Dabakoglu Tugrul Aydogdu Yusuf Ergün Omer Cobanoglu | 1996 | European Journal of Obstetrics and Gynecology1996，，1： | 1 |
| 14 | Near-linear time approximation algorithms for curve simplification 显示文摘 | AGARWAL P K HAR-PELED S MUSTAFA N H | 2005 | Algorithmica2005，42，34： | 1 |
| 15 | Detection of Y chromosome-specific DNA in the plasma and urine of pregnant women using nested polymerase chain reaction显示文摘 | A1-Yatama M K Mustafa A S Ali S Abraham S Khan Z Khaja N | 2001 | Prenat Diagn2001，21，： | 1 |
| 16 | Sol-gel synthesized of nanocomposite palladium-alumina ceramic membrane for H-2 permeability: Preparation and characterization 显示文摘 | Ahmad A L Mustafa N N N | 2007 | INT J HYDROGEN ENERG2007，32，： | 1 |
| 17 | Systematic reviews and meta-analyses of benefits and harms of cryotherapy, LEEP, and cold knife conization to treat cervical intraepithelial neoplasia 显示文摘 | Santesso N Mustafa RA Wiercioch W | 2015 | Int J Gynaecol Obstet2015，132，3： | 1 |
| 18 | Data Aggregation in Wireless Sensor Networks-Exact and Approximate Algorithms显示文摘 | Jamal N Karaki Raza Mustafa Ahmed E Kamal | 2004 | IEEE2004，，： | 1 |
| 19 | Evaluation on Antibacterial Activity of Lactobacillus acidophilus Strains Isolated from Honey 显示文摘 | Mustafa A M Hassan Z Mohd N H | 2012 | American Journal of Applied Sciences2012，9，6： | 1 |
| 20 | Dynamic Simplification and Visualization of Large Maps显示文摘 | KRISHMAN S VARADHAN G | 2006 | International Journal of Geographical Information Science2006，20，3： | 1 |
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