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| 1 | Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk显示文摘AIM: To examine the relationships between pre-diagnostic biomarkers and colorectal cancer risk and assess their relevance in predictive models.METHODS: A nested case-control study was designed to include all first primary incident colorectal cancer cases diagnosed between inclusion in the SUpplémentation en VItamines et Minéraux AntioXydants cohort in 1994 and the end of follow-up in 2007. Cases (n = 50) were matched with two randomly selected controls (n = 100). Conditional logistic regression models were used to investigate the associations between pre-diagnostic levels of hs-CRP, adiponectin, leptin, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1, E-selectin, monocyte chemoattractant protein-1 and colorectal cancer risk. Area under the receiver operating curves (AUC) and relative integrated discrimination improvement (RIDI) statistics were used to assess the discriminatory potential of the models. RESULTS: Plasma adiponectin level was associated with decreased colorectal cancer risk (P for linear trend = 0.03). Quartiles of sVCAM-1 were associated with increased colorectal cancer risk (P for linear trend = 0.02). No association was observed with any of the other biomarkers. Compared to standard models with known risk factors, those including both adiponectin and sVCAM-1 had substantially improved performance for colorectal cancer risk prediction (P for AUC improvement = 0.01, RIDI = 26.5%). CONCLUSION: These results suggest that pre-diagnostic plasma adiponectin and sVCAM-1 levels are associated with decreased and increased colorectal cancer risk, respectively. These relationships must be confirmed in large validation studies. | Mathilde Touvier Léopold Fezeu Namanjeet Ahluwalia Chantal Julia Nathalie Charnaux Angela Sutton Caroline Méjean Paule Latino-Martel Serge Hercberg Pilar Galan Sébastien Czernichow | 2012 | World Journal of Gastroenterology2012，18，22： | 15 |
| 2 | Shoaling in white cloud mountain minnows,Tanichthys albonubes:Effects of predation risk and prey hunger显示文摘 | Richardson Jean M L | 1994 | Animal Behaviour1994，48，3： | 2 |
| 3 | Normal Spinal Bone Marrow in Adult:Dynamic Gadolinium-enhanced MR Imaging显示文摘 | Jean M Marine D Eric L | 2003 | Radiology2003，229，： | 1 |
| 4 | In vivo growth inhibitory effect of iterative wild-type p53 gene transfer in human head and neck carcinoma xenografts using glucosylated polyethylenimine nonviral vector显示文摘 | GILLES D JEAN L M MRIEL B H | 2002 | Cancer Gene Ther2002，，9： | 1 |
| 5 | Oligonucleotide - Modified Gold Nanoparticles for Intracellular Gene Regulation 显示文摘 | Rosi N L Giljohann D A Thaxton S C Lytton -Jean A K Han M S Mirkin C A | 2006 | Science2006，312，5776： | 1 |
| 6 | Thirteen week feeding study withtransgenic maize grain containing event DAS-157-1 in Sprague-Dawley rats显示文摘 | Susan A M Ian L Jean S | 2007 | Food and Chemical Toxicology2007，45，4： | 1 |
| 7 | Production, oxidation and consumption of methane by soils: A review显示文摘 | Jean L M Pierre R | 2001 | Eur JSoil Biol2001，37，： | 1 |
| 8 | High-pressure liquid chromatographic analysis of penicillin G potassium and its degradation products显示文摘 | JEAN M B ADELBERT M K STANLEY L H | 1975 | Journal of Pharmaceutical Sciences1975，64，8： | 1 |
| 9 | Involvement of Nramp1 from Arabidopsis thaliana in iron transport显示文摘 | CUIE C ALONSOL J M JEAN M L | 2000 | Biochem J2000，347，： | 1 |
| 10 | Solutions for a Quasilinear Schr(o)dinger Equations:a Dual Approach显示文摘 | COLIN M JEAN JEAN L | 2004 | Nonlinear Anal TMA2004，56，： | 1 |
| 11 | Effective primary isolation of wild-type Canine distemper virus in MDCK, MV1 Lu and Vero cells without nucleotide sequence changes within the entire haemagglutinin protein gene and in subgenomic sections of the fusion and phospho protein genes显示文摘 | John A Lednicky Thomas P Meehan Michael J Kinsel Jean Dubach Laura L Hungerford Nicolene A Sarich Kelley E Witecki Michael D Braid Casandra Pedrak Christiane M Houde | 2004 | Journal of Virological Methods2004，，2： | 1 |
| 12 | Electrical Contacts on Nickel-Plated Aluminum:The state of the Art显示文摘 | Jean G Richard M | 1991 | IEE Transactions on Components Hybrids and Manofacturing Technology1991，14，1： | 1 |
| 13 | J,Chem Int Ed显示文摘 | Gilat Sylvain L Adronov Alex and Fréchet Jean M | 1999 | 38 (10):1422-14271999，38，10： | 1 |
| 14 | Comparing two approaches to land use/cover change modeling and their implications for the assessment of bio-diversity loss in a deciduous tropical forest显示文摘 | AZUCENA P V JEAN F M ARIKA L Z | 2012 | Environmental Modeling and Software2012，29，1： | 1 |
| 15 | Efficacy of a cognitive training programme for mild cognitive impairment:results of a randomised controlled study显示文摘 | JEAN L SIMARD M WIEDERKEHR S | 2010 | Neuropsychological Rehabilitation2010，20，3： | 1 |
| 16 | A loss-of function mutatinn in AtYSL1 reveal its role in iron and nicotianamine seedloading显示文摘 | Jean M L Schikora A Marl M | 2005 | Plant J2005，44，： | 1 |
| 17 | 显示文摘 | Denis D Mira F Jean C L Francuoise M W | 2002 | Bioconjugate Chem2002，13，： | 1 |
| 18 | Catalytic direct arylation with aryl chlorides, bromides and io- dides:Intramolecular studies leading to new intermo- lecular reactions 显示文摘 | Campeau L C Parisien M Jean A | 2006 | Journal of American Chemical Society2006，128，： | 1 |
| 19 | Degradation of explosives-related compounds using nickel catalysts显示文摘 | MARK E F CHARLES E S JEAN M L | 2007 | Chemosphere2007，，67： | 1 |
| 20 | Magnetically induced hyperthermia: size-dependent heating power of γ-Fe2O3 nanoparticles 显示文摘 | Michael L Claire W Jean M S | 2008 | J Phys: Condens Matter2008，，： | 1 |
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