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| 1 | Clinical implications of fatty pancreas:Correlations between fatty pancreas and metabolic syndrome显示文摘AIM:To investigate the clinical implications of lipid deposition in the pancreas(fatty pancreas). METHODS:The subjects of this study were 293 patients who had undergone abdominal computed tomography(CT)and sonography.Fatty pancreas was diagnosed by sonographic findings and subdivided into mild,moderate,and severe fatty pancreas groups comparing to the retroperitoneal fat echogenicity. RESULTS:Fatty pancreas was associated with higher levels for visceral fat,waist circumference,aspartate aminotransferase(AST),alanine aminotransferase (ALT),total cholesterol,triglyceride,high density lipoprotein,free fatty acid,γ-GTP,insulin,and the homeostasis model assessment of insulin resistance (HOMA-IR)than the control group(P<0.05).HOMAIR,visceral fat,triglyceride,and ALT also tended to increase with the degree of fat deposition in the pancreas on sonography.In a multivariate logistic regression analysis,HOMA-IR,visceral fat,and ALT level were independently related to fatty pancreas after adjustment for age,body mass index,and lipid profile.The incidence of metabolic syndrome in the fatty pancreas group was significantly higher than in the control group,and the numbers of metabolic syndrome parameters were significantly higher in the fatty pancreas group(P<0.05).CONCLUSION:Sonographic fatty pancrease showed higher insulin resistance,visceral fat area,triglyceride, and ALT levels than normal pancreases.Fatty pancreas also showed a strong correlation with metabolic syndrome. | Jun Seok Lee Sang Heum Kim Dae Won Jun Jee Hye Han Eun Chul Jang Ji Young Park Byung Kwan Son Seong Hwan Kim Yoon Ju Jo Young Sook Park Yong Soo Kim | 2009 | World Journal of Gastroenterology2009，15，15： | 40 |
| 2 | Effect of tellurium on the microstructure and mechanical properties of Fe-14Cr oxide-dispersion-strengthened steels produced by additive manufacturing显示文摘Conventionally,Te has primarily been used to improve the machinability of steel and its alloys.In this work,Te was used to refine the grains of an oxide-dispersion-strengthened(ODS)steel produced by additive manufacturing(AM)with fixed processing parameters.Addition of Te to the raw powder produced an ODS steel with a fine-grained microstructure,in contrast to the ODS steel manufactured without Te.Moreover,the addition of Te resulted in superior yield strength and ultimate tensile strength,which was attributed to the combined effects of grain refinement and the finer nanoparticles(NPs)composed of Terich composite NPs and Cr-rich NPs.For the first time,the AM technique was used to obtain grain and nanoparticle sizes of~3.4μm and 6 nm,respectively,from the Te-added ODS steel. | Barton Mensah Arkhurst Jee Hwan Bae Min Young Na Hye Jung Chang Hyun Gil Kim Il Hyun Kim Ho Jin Ryu Jeoung Han Kim | 2021 | Journal of Materials Science & Technology2021，，36： | 3 |
| 3 | 来自一项艾日布林联合吉西他滨对比紫杉醇联合吉西他滨作为HER2阴性转移性乳腺癌的一线化疗的Ⅱ期、多中心、随机试验的包含神经病变相关量表的生活质量结果:韩国癌症研究组试验(KCSG BR13-11)显示文摘背景与目的一项比较艾日布林联合吉西他滨(eribulin plus gemcitabine,EG)或紫杉醇联合吉西他滨(paclitaxel plus gemcitabine,PG)作为转移性乳腺癌(metastatic breast cancer,MBC)患者一线化疗方案的II期临床试验发现,EG方案的神经毒性较低,但疗效与PG方案相似。在本研究中,我们分析了该临床实验中的癌症患者生命质量测评量表–紫杉烷(functional assessment of cancer therapy-taxane,FACT-Taxane)问卷评分以确定他们的生活质量(quality of life,QoL)。方法使用韩国版的FACT-Taxane问卷评估QoL。在评估基线之后,前12个疗程中每2个疗程评估1次QoL,之后每3个疗程评估1次QoL。使用线性混合模型评估EG组和PG组QoL的差异。结果在118例入组患者中,117例在基线时回复了FACT-Taxane问卷,PG组中有1例患者没有回复。EG组和PG组之间的基线QoL评分没有差异。在治疗期间,除了第11个疗程外,在第2–13个化疗疗程后,PG组紫杉烷亚量表评分显著高于EG组(均P<0.05)。神经病变特异性分析显示PG组患者的神经病症状比EG组患者更早出现且更严重(P<0.001)。结论在我们的QoL分析中,与PG方案相比,EG方案延迟并减少神经病变的发生。因此,艾日布林是MBC一线化疗药物紫杉醇的合理替代品。 | Ji‑Yeon Kim Seri Park Seock‑Ah Im Sung‑Bae Kim Joohyuk Sohn Keun Seok Lee Yee Soo Chae Ki Hyeong Lee Jee Hyun Kim Young‑Hyuck Im Tae‑Yong Kim Kyung‑Hun Lee Jin‑Hee Ahn Gun Min Kim In Hae Park Soo Jung Lee Hye Sook Han Se Hyun Kim Kyung Hae Jung Yeon Hee Park Korean Cancer Study Group | 2019 | 癌症2019，38，8： | 2 |
| 4 | Neurologic signs in relation to cognitive function in subcortical ischemic vascular dementia: a CREDOS (Clinical Research Center for Dementia of South Korea) study显示文摘 | Seong Hye Choi SangYun Kim Seol-Heui Han Duk L. Na Doh-Kwan Kim Hae-Kwan Cheong Jae-Hong Lee Seong Yoon Kim Chang Hyung Hong So Young Moon Jay C. Kwon Jung Eun Kim Jee H. Jeong Hae Ri Na Kyung Ryeol Cha Sang Won Seo Yong S. Shim Jun-Young Lee Kyung Won Pa | 2012 | Neurological Sciences2012，，4： | 1 |
| 5 | Quality of life outcomes including neuropathy-associated scale from a phase II,multicenter,randomized trial of eribulin plus gemcitabine versus paclitaxel plus gemcitabine as first-line chemotherapy for HER2-negative metastatic breast cancer:Korean Cancer Study Group Trial(KCSG BR13-11)显示文摘Background: A phase II clinical trial of the comparison between eribulin plus gemcitabine (EG) and paclitaxel plus gemcitabine (PG) as first-line chemotherapy for patients with metastatic breast cancer (MBC) found that the EG regimen was less neurotoxic, but was similar in efficacy to the PG regimen. In the present study, we analyzed functional assessment of cancer therapy-taxane (FACT-Taxane) questionnaires from patients in this clinical trial to determine their quality of life (QoL). Methods: QoL was assessed using the Korean version of the FACT-Taxane questionnaires. After baseline assessment, QoL was assessed every 2 cycles for 12 cycles and every 3 cycles thereafter. The linear mixed model was used to evaluate the difference in QoL between the EG and PG arms. Results: Of the 118 enrolled patients, 117 responded to the FACT-Taxane questionnaires at baseline, 1 in the PG arm did not. Baseline QoL scores were not different between the EG and PG arms. During treatment, taxane subscale scores were significantly higher in the PG arm than in the EG arm after 2-13 cycles of chemotherapy (all P < 0.05), except for the 11th cycle. Neuropathy-specific analysis showed that patients in the PG arm had earlier and more severe neuropathic symptoms than those in the EG arm (P < 0.001). Conclusions: In our QoL analysis, the EG regimen delayed and decreased neuropathy as compared with the PG regimen. Therefore, eribulin would be a reasonable substitute for paclitaxel as first-line chemotherapy for MBC. | Ji-Yeon Kim Seri Park Seock-Ah Im Sung-Bae Kim Joohyuk Sohn Keun Seok Lee Yee Soo Chae Ki Hyeong Lee Jee Hyun Kim Young-Hyuck Im Tae-Yong Kim Kyung-Hun Lee Jin-Hee Ahn Gun Min Kim In Hae Park Soo Jung Lee Hye Sook Han Se Hyun Kim Kyung Hae Jung Yeon Hee Park Korean Cancer Study Group | 2019 | Cancer Communications2019，39，1： | 1 |
| 6 | Induction of apoptosis by a stilbene analog involves bax translocation regulated by p38 MAPK and Akt显示文摘 | Kwang Sup So Ji Eun Oh Jee Hye Han Hong Keun Jung Young Suk Lee Sang Hee Kim Young Jin Chun Mie Young Kim | 2008 | Archives of Pharmacal Research2008，，4： | 1 |
| 7 | Pharmacogenetic analysis of adjuvant FOLFOX for Korean patients with colon cancer显示文摘 | Kyung-Hun Lee Hye Jung Chang Sae-Won Han Do-Youn Oh Seock-Ah Im Yung-Jue Bang Sun Young Kim Keun-Wook Lee Jee Hyun Kim Yong Sang Hong Tae Won Kim Young Suk Park Won Ki Kang Sang Joon Shin Joong Bae Ahn Gyeong Hoon Kang Seung-Yong Jeong Kyu Joo Park Jae-Ga | 2013 | Cancer Chemotherapy and Pharmacology2013，，4： | 1 |
| 8 | Transgenie potato expressing Aβ reduce Aβ burden in Alzheimer's disease mouse model 显示文摘 | Jung Won Youm Hee Kim Jee Hye Lo Han | 2005 | FEBS Letters2005，579，： | 1 |
| 9 | Color Doppler Twinkling Artifacts from Gallbladder Adenomyomatosis with 1.8 MHz and 4.0 MHz Color Doppler Frequencies显示文摘 | Mi Hye Yu Jae Young Lee Jeong-Hee Yoon Jee Hyun Baek Joon Koo Han Byung-Ihn Choi | 2012 | Ultrasound in Medicine & Biology2012，，7： | 1 |
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