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| 1 | Arabidopsis thaliana histone deacetylase1(AtHD1)is localized in euchromatic regions and demonstrates histone deacetylase activity in vitro显示文摘Arabidopsis thaliana 嘘一 deacetylase 1 (AtHD1 或 AtHDA19 ) ,酵母 RPD3 的一个相当或相同的事物,是在植物的许多生理、发展的过程的一个全球管理者。尽管有为在植物基因规定和开发的 AtHD1 的一个角色的基因证据, AtHD1 的生物化学、细胞的性质糟糕被理解。这里,我们在 vivo 报导 AtHD1 的细胞的本地化模式并且嘘在 vitro 的一项 deacetylase 活动。绿荧光灯的蛋白质(GFP ) 的短暂、稳定的表示在洋葱房间标注了 AtHD1 并且分别地,在转基因的 Arabidopsis 的根,种子和叶子表明 AtHD1 在 euchromatic 区域大概在原子核是局部性的并且从核排除。AtHD1 的本地化模式与涉及核形成和 transgenes 的 silencing 并且分别地重复了 DNA 元素的 AtHD2 和 AtHDA6 的那些不同。另外,一 hist 一 deacetylase 活动试金证明在细菌生产的 recombinant AtHD1 示威了一特定嘘在 vitro 的一项 deacetylase 活动。数据建议 AtHD1 是原子蛋白质并且拥有嘘为对植物生长和开发重要的全球 transcriptional 规定负责的一项 deacetylase 活动。 | Paulus M Fong Lu Tian Z Jeffrey Chen | 2006 | Cell Research2006，16，5： | 6 |
| 2 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 3 | An Integrated Genetic,Physical and Transcript Map of Homoeologous Chromosomes 12 and 26 in Upland Cotton(Gossypium hirsutum L.)显示文摘While Upland cotton(Gossypium hirsutum L.) represents 95% of the world production,its genetic improvement is hindered by the shortage of effective genomic tools and resources.The | KOHEL Russell J CHO Jaemin TOMKINS Jeffrey YU John Z | 2008 | 棉花学报2008，20，S1： | 2 |
| 4 | CFRM concept for vehicle thermal system显示文摘 | Yang Zhi gang Bozeman Jeffrey Shen Fred Z | 2002 | SAE Paper2002，，： | 1 |
| 5 | Treatment of hydrolysates of the high explosives hexahydro-1,3,5-trinitro-1,3,5-triazine and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine using biological denitification显示文摘 | Kyung D Z Jeffrey I | 1999 | Water Environment Reseach1999，71，2： | 1 |
| 6 | Mapping soil micronutrients显示文摘 | Jeffrey G W Robert J Z | 1999 | Field Crops Research1999，60，： | 1 |
| 7 | Lysozyme enhancement of tumor cell immunoprotection in a murine fibrosarcoma显示文摘 | Jeffrey S W John J R Bruce S Z | 1981 | Cancer Research1981，41，5： | 1 |
| 8 | Treatment of hydrolysates of the high explisives hex-ahydro-1,3,5-trinitro-1,3,5-triazine and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine using biological denitification显示文摘 | Kyung-Duk Z Jeffrey I D John P K | | 0，，02： | 1 |
| 9 | Contextual influences on the corporate entrepreneurship-performance relationship:A longitudinal analysis 显示文摘 | SHAKER A Z JEFFREY G C | 1995 | Journal of Business Venturing1995，10，1： | 1 |
| 10 | Present-day crustal deformation in China constrained by global positioning system measurements显示文摘 | Wang Q Zhang P Z Jeffrey T F | 2001 | Science2001，294，： | 1 |
| 11 | Thermal-velocity coupling in vehicle thermal system calculations 显示文摘 | Zhigang Yang Jeffrey Bozeman Shen F Z | 2002 | SAE paper2002，，： | 1 |
| 12 | Studies of pentlandite leaching in mixed oxygenated acidic-chloride sulfate solutions 显示文摘 | Lu Z Y Jeffrey M I | 2000 | Hydrometallurgy2000，56，： | 1 |
| 13 | Escalation of commitment to an ineffective course of action:The effect of feedback having negative implications for self-identity显示文摘 | Joel Brockner Robert Houser Gregg Birnbaum Kathy Lloyd Janet Deitcher Sinaia Nathanson Jeffrey Z Rubin | 1986 | Administrative Science Quarterly1986，，： | 1 |
| 14 | An electrochemical study of the effect of chloride ions on the dissolution of chalcopyrite in acidic solutions显示文摘 | Jeffrey M I Lawson F | 2000 | Hydrometallurgy2000，56，： | 1 |
| 15 | The effect of chloride ions on the dissolution of chalcopyrite in acidic solutions显示文摘 | Jeffrey M I Lawson F | 2000 | Hydrometallurgy2000，56，： | 1 |
| 16 | Paraneoplastic anti–N‐methyl‐D‐aspartate receptor encephalitis associated with ovarian teratoma显示文摘 | JosepDalmau ErdemTüzün Hai‐yanWu JaimeMasjuan Jeffrey E.Rossi AlfredoVoloschin Joachim M.Baehring HaruoShimazaki ReijiKoide DaleKing WarrenMason Lauren H.Sansing Marc A.Dichter Myrna R.Rosenfeld David R.Lynch | 2007 | Ann Neurol2007，，1： | 1 |
| 17 | Importance of diarrhea as a presenting symptom of appendicitis in very young children显示文摘 | Jeffrey R Horwit Z Mustafa Gursoy | | 0，，： | 1 |
| 18 | An Electrochemical Study of the Effect of Chloride Ions on the Dissolution of Chalcopyrite in Acidic Solutions 显示文摘 | Lu Z Y Jeffrey M I Lawson F | 2000 | Hydrometallurgy2000，56，2： | 1 |
| 19 | The optimal group consensusdeviation measure for multiplicative preference relations显示文摘 | Gong Z W Jeffrey F Zhao Y | 2012 | Expert Systems with Applications2012，39，11： | 1 |
| 20 | An electrochemical study of the effect of chloride ions on the dissolution of chalcopyrite in acidic solutions显示文摘 | Lu Z Y Jeffrey M I Lawson F | 2000 | Hydrometallurgy2000，56，2： | 1 |
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