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| 1 | Extrahepatic complications to cirrhosis and portal hypertension: Haemodynamic and homeostatic aspects显示文摘In addition to complications relating to the liver, patients with cirrhosis and portal hypertension develop extrahepatic functional disturbances of multiple organ systems. This can be considered a multiple organ failure that involves the heart, lungs, kidneys, the immune systems, and other organ systems. Progressive fibrosis of the liver and subsequent metabolic impairment leads to a systemic and splanchnic arteriolar vasodilatation. This affects both the haemodynamic and functional homeostasis of many organs and largely determines the course of the disease. With the progression of the disease, the circulation becomes hyperdynamic with cardiac, pulmonary as well as renal consequences for dysfunction and reduced survival. Infections and a changed cardiac function known as cirrhotic cardiomyopathy may be involved in further aggravation of other complications such as renal failure precipitatingthe hepatorenal syndrome.Patients with end-stage liver disease and related complications as for example the hepatopulmonary syndrome can only radically be treated by liver transplantation.As a bridge to this treatment,knowledge on the mechanisms of the pathophysiology of complications is essential for the choice of vasoactive drugs,antibiotics,drugs with specific effects on fibrogenesis and inflammation,and drugs that target specific receptors. | S?ren M?ller Jens H Henriksen Flemming Bendtsen | 2014 | World Journal of Gastroenterology2014，20，42： | 14 |
| 2 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 3 | Brain changes in diabetes mellitus patients withgastrointestinal symptoms显示文摘Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system(CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal(GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testingmainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes,especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation. | Anne M Drewes Eirik Søfteland Georg Dimcevski Adam D Farmer Christina Brock Jens B Frøkjær Klaus Krogh Asbjørn M Drewes | 2016 | World Journal of Diabetes2016，7，2： | 4 |
| 4 | 一把椅子抵住这时间的洪流显示文摘关于人与物是如何互相影响的,我想一把汉斯·瓦格纳(HANS J.WEGNER)的椅子便能说明这两者间全部的关系。 | msright PP M?bler Mikkel Adsb?l Jens Mourits S?rensen Erik Brahl Rasmus Koch Studio Katja Kejser Kasper Holst Pedersen | 2015 | 设计2015，28，22： | 2 |
| 5 | No difference in portal and hepatic venous bacterial DNA in patients with cirrhosis undergoing transjugular intrahepatic portosystemic shunt insertion显示文摘 | Christian Mortensen Stine Karlsen Henning Gr?nb?k Dennis T. Nielsen Susanne Frevert Jens O. Clemmesen S?ren M?ller J?rgen S. Jensen Flemming Bendtsen | 2013 | Liver Int2013，，9： | 2 |
| 6 | Simulation of Microstructure Development During the Hydration of a Cement Compound 显示文摘 | Jennings H M Johnson S K | 1986 | Journal of the American Ceramic Society1986，69，11： | 1 |
| 7 | Scales to measure perccivcd control developed specifically for people with tablettreated diaberes 显示文摘 | Bradley C Lewis K S Jennings A M | 1990 | Diabet Med1990，7，8： | 1 |
| 8 | Long-term changes in the trophic level of the Celtic Sea fish community and fish market price distribution显示文摘 | PINNEGAR J K JENNINGS S O' BRIEN C M | 2002 | Journal of Applied Ecology2002，39，3： | 1 |
| 9 | An agenda-based framework for multi-issue negotiation显示文摘 | Fatima S S Wooldridge M Jennings N R | 2004 | Artificial Intelligence2004，152，1： | 1 |
| 10 | A multi-technique investigation of the nanoporosity of cement paste显示文摘 | JENNINGS H M THOMAS J J GEVRENOV J S | 2007 | Cement and Concrete Research2007，，37： | 1 |
| 11 | The limits to tree height显示文摘 | KOCHG W SILLETT S C JENNINGS G M | 2004 | Nature2004，428，6985： | 1 |
| 12 | A generalized approach for the determination of yield stress by slump and slump flow显示文摘 | SAAK A W JENNINGS H M SHAH S P | 2004 | Cement and Concrete Research2004，34，3： | 1 |
| 13 | A generalized ap-proach for the determination of yield stress by slump andslump flow显示文摘 | Saak A W Jennings H M Shah S P | 2004 | Cement Concrete Research2004，34，3： | 1 |
| 14 | A crane scheduling problem in a computer integrated manufacturing environment显示文摘 | Hirofumi M Jen S S Robert S S | 1991 | Management Science1991，37，5： | 1 |
| 15 | Cutting edge: constitutive B cell receptor signaling is critical for basal growth of B lympboma显示文摘 | Gururajan M Jennings CD Bondada S | 2006 | J Immunol2006，176，10： | 1 |
| 16 | A multi-technique investigation of the nanoporosity of cement paste 显示文摘 | Jennings H M Thomas J J Gevrenov J S | 2007 | Cement and Concrete Research2007，37，3： | 1 |
| 17 | MR imaging of synovial sarcoma with radiologic-pathologic correlation显示文摘 | Murphey M D Gibson M S Jenning B T | 2006 | Radiologics2006，26，5： | 1 |
| 18 | A Knowledge-based system for stacker crane control in a manufacturing nvironment显示文摘 | Hirofumi M Jen S S Robert S S | 1991 | IEEE Transactions on Systems Man and Cybernetics1991，19，5： | 1 |
| 19 | Randomied trial comparing continuous subcutaneous insulin infusion and conventional insulin therapy in type Ⅱ diabetc patients poortly controlled with sulfonylureos显示文摘 | JENNINGS A M LEWIS K S MURDOCH S | 1991 | Diabetes Care1991，14，8： | 1 |
| 20 | Malignancies after renal transplantation during 33 years at a single center显示文摘 | Gyula Végs? Maria Tóth Márta Hídvégi éva Toronyi Robert Mlanger Elek Dinya András Tóth Ferenc Perner Jen? Járay | 2007 | Pathology & Oncology Research2007，，1： | 1 |
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