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| 1 | Recurrence and rejection in liver transplantation for primary sclerosing cholangitis显示文摘Primary sclerosing cholangitis (PSC) is a chronic progressive inflammatory disease affecting the bile ducts, leading to f ibrosis and eventually cirrhosis in most patients. Its etiology is unknown and so far no effective medical therapy is available. Liver transplantation (LTX) is the only curative treatment and at present PSC is the main indication for LTX in the Scandinavian countries. Close to half of the PSC patients experience one or more episodes of acute cellular rejection (ACR) following transplantation and approximately 1/5 of the transplanted patients develop recurrent disease in the graft. In addition, some reports indicate that ACR early after LTX for PSC can infl uence the risk for recurrent disease. For these important post-transplantation entities affecting PSC patients, we have reviewed the current literature on epidemiology, pathogenesis, treatment and the possible infl uence of rejection on the risk of recurrent disease in the allograft. | Bjarte Fosby Tom H Karlsen Espen Melum | 2012 | World Journal of Gastroenterology2012，18，1： | 8 |
| 2 | Genetic epidemiology of primary sclerosing cholangitis显示文摘The aetiology of primary sclerosing cholangitis (PSC) is not known. A more than 80-fold increased risk of PSC among first-degree relatives emphasizes the importance of genetic factors. Genetic associations within the human leukocyte antigen (HLA) complex on chromosome 6p21 were detected in PSC 25 years ago. Subsequent studies have substantiated beyond doubt that one or more genetic variants located within this genetic region are important. The true identities of these variants,however,remain to be identified. Several candidate genes at other chromosomal loci have also been investigated. However,according to strict criteria for what may be denominated a susceptibility gene in complex diseases,no such gene exists for PSC today. This review summarises present knowledge on the genetic susceptibility to PSC,as well as genetic associations with disease progression and clinical subsets of particular interest (inflammatory bowel disease and cholangiocarcinoma). | Tom H Karlsen Erik Schrumpf Kirsten Muri Boberg | 2007 | World Journal of Gastroenterology2007，13，41： | 7 |
| 3 | Autoantibodies in primary sclerosing cholangitis显示文摘The aetiology of primary sclerosing cholangitis (PSC) is not known and controversy exists as to whether PSC should be denominated an autoimmune disease. A large number of autoantibodies have been detected in PSC patients,but the specifi city of these antibodies is generally low,and the frequencies vary largely between different studies. The presence of autoantibodies in PSC may be the result of a nonspecifi c dysregulation of the immune system,but the literature in PSC points to the possible presence of specifi c antibody targets in the biliary epithelium and in neutrophil granulocytes. The present review aims to give an overview of the studies of autoantibodies in PSC,with a particular emphasis on the prevalence,clinical relevance and possible pathogenetic importance of each individual marker. | Johannes Roksund Hov Kirsten Muri Boberg Tom H Karlsen | 2008 | World Journal of Gastroenterology2008，14，24： | 7 |
| 4 | Hydrocarbon composition of authigenic inclusions: application to elucidation of petroleum reservoir filling history显示文摘 | Karlsen D A Nedkvitne T Larter S R | 1993 | Geochimica et Comochimca Acta1993，57，： | 2 |
| 5 | Review article: controversies in the management of primary biliary cirrhosis and primary sclerosing cholangitis显示文摘 | T. H. Karlsen M. Vesterhus K. M. Boberg | 2014 | Aliment Pharmacol Ther2014，，3： | 2 |
| 6 | The Genetics of Complex Cholestatic Disorders显示文摘 | Gideon M. Hirschfield Roger W. Chapman Tom H. Karlsen Frank Lammert Konstantinos N. Lazaridis Andrew L. Mason | 2013 | Gastroenterology2013，，7： | 2 |
| 7 | No difference in portal and hepatic venous bacterial DNA in patients with cirrhosis undergoing transjugular intrahepatic portosystemic shunt insertion显示文摘 | Christian Mortensen Stine Karlsen Henning Gr?nb?k Dennis T. Nielsen Susanne Frevert Jens O. Clemmesen S?ren M?ller J?rgen S. Jensen Flemming Bendtsen | 2013 | Liver Int2013，，9： | 2 |
| 8 | Update on primary sclerosing cholangitis genetics显示文摘 | Eva K.K. Henriksen Espen Melum Tom H. Karlsen | 2014 | Current Opinion in Gastroenterology2014，，3： | 2 |
| 9 | The dynamics of regional specialization and cluster formation: Dividing trajectories of maritime industries in two Norwegian regions显示文摘 | KARLSEN A | 2005 | Entrepreneurship & Regional Development2005，，17： | 1 |
| 10 | Digital marine bioprospecting: mining new neurotoxin drug candidates from the transcriptomes of cold-water sea anemones 显示文摘 | Urbarova I Karlsen B O Okkenhaug S | 2012 | Mar Drugs2012，10，10： | 1 |
| 11 | Construction proposals for Vital ium prostheses显示文摘 | Karlsen K Owal B | | 0，，02： | 1 |
| 12 | Relationship between reservoir diagenetic evolution and petroleum emplacement in the Ula field, North Sea 显示文摘 | Nedkvitne T Karlsen D A Bjrykke K | 1993 | Marine and Petroleum Geology1993，10，3： | 1 |
| 13 | Light hydro carbon redistribution in a shallow core from the Ravnefjeld formation on the Wegener Halvo, East Greenland显示文摘 | Karlsen D A Leythaeuser D Schaefer R G | 1988 | Or- ganic Geochemistry1988，13，88： | 1 |
| 14 | Relationship between reservoir diagenetic evolution and petroleum emplacement in the Ula Field, North Sea显示文摘 | Nedkvitne T Karlsen D Bjrykke K Larter S | 1993 | Mar Petrol Geol1993，10，3： | 1 |
| 15 | Psychosocial group intervention for patients with primary breast cancer: A randomised trial 显示文摘 | Boesen EH Karlsen R Christensen J | 2011 | Eur J Cancer2011，，： | 1 |
| 16 | Rock-slope failure in norway : type, geometry, deformation mechanisms a-nd stability显示文摘 | Braathen A Blikra L H Karlsen S S | 2004 | Norweigian Journal of Geology2004，84，： | 1 |
| 17 | Hydrocarbon composition of authigenic inclusions : Application to elucidation of petroleum reservoir filling history 显示文摘 | Karlsen D A Nedkvitne T Larter S R | 1993 | Geochim Cosmochim Acta1993，57，： | 1 |
| 18 | Effects of a group--based coun selling programme on diabetes-- related stress, coping, psychological well-- being and metabolic control in adults with type i or type 2 di- abetes显示文摘 | Karlsen B Idsoe T Dirdal I | 2004 | Patient Educ Couns2004，53，3： | 1 |
| 19 | Evaluation of HFA, CA125, risk of ovarian malignancy algorithm (ROMA) and risk of malignancy index (RMI) as diagnostic tools of epithelial ovarian cancer in patients with a pelvic mass 显示文摘 | KARLSEN MA SANDHU N HOGDALL C | 2012 | Gynecol Oncol2012，127，2： | 1 |
| 20 | Aprimary screen of thebovine genome for quantitative trait loci affecting twinning rate 显示文摘 | Astrid Karlsen Gunnar Klemetsdal | 2000 | Mamm Genome2000，11，： | 1 |
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