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| 1 | Application of heat shock protein expression for detecting natural adaptation and exposure to stress in natural populations显示文摘Heat-shock proteins (HSPs) play an undisputed role for maintaining cellular functioning under environmental challengesand protein denaturing conditions. Compelling evidence points to an evolutionary important role of HSPs and a strict evolutionarycontrol of these proteins as a balance between benefits and costs. While there is a great potential for using HSP expressionfor detecting natural adaptation and exposure to stress in natural populations, some obstacles and key issues await investigation.From an ecological perspective these key issues needs to be resolved in order to fully appreciate the complex responses andadaptations to stress and to increase our understanding of HSPs and other molecular chaperones for stress adaptation and potentialuse as biomarkers. Here, the current knowledge and understanding of HSPs is reviewed and a number of key issues including theinterpretation of elevated HSP levels, the complications of extrapolating between laboratory and field conditions, the effects ofchoice of traits and methodology and the larger intra-and extracellular networks of interactions that HSPs participate in are | Jesper Givskov SφRENSEN | 2010 | Current Zoology2010，56，6： | 6 |
| 2 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 3 | Antifungal 3 - hydroxyfatty acids from Lactobacillus planetarium MiLAB - 14 显示文摘 | Jorgen S Jesper M Anders B | 2003 | Applied and Environmental Microbiology2003，69，12： | 1 |
| 4 | Butyltin compounds in human liver显示文摘 | Jesper BN Jakob S | 2002 | Environ Res2002，88，2： | 1 |
| 5 | Hemodynamics and vasopressor support in therapeutic hypothermia after cardiac arrest: Prognostic implications显示文摘 | John Bro-Jeppesen Jesper Kjaergaard Helle S?holm Michael Wanscher Freddy K. Lippert Jacob E. M?ller Lars K?ber Christian Hassager | 2013 | Resuscitation2013，，： | 1 |
| 6 | Modeling of macropore flow and transport processes at catchment scale显示文摘 | Jesper S C Metre T | 2004 | Journal of Hydrology2004，299，： | 1 |
| 7 | Gain- switched holmium-doped fiber laser 显示文摘 | WU K S OTTAWAY D JESPER MUNCH | 2009 | Optics ExPress2009，17，20： | 1 |
| 8 | Study of the nature of recognition in molecularly imprinted polymers Ⅱ,Influence of monomer template ratio and sample load on retention and selectivity显示文摘 | Jesper G K Sergey A | 1999 | Journal of Chromatography A1999，848，： | 1 |
| 9 | Three-Dimensional Re- construction of the Mouse Nephron显示文摘 | Xiao-Yue Zhai Jesper S T Henrik B | 2006 | Journal of the American Society of Nephrology2006，，： | 1 |
| 10 | Lactobacillus coryniformis subsp, coryniformis strain Si3 produces a broad-spectrum protein- aceous antifungal compound 显示文摘 | Jesper M Johan S | 2001 | App Environ Microbiol2001，67，1： | 1 |
| 11 | Mixing oil and water? Using hybrid input-output tables in a structural decomposition analysis显示文摘 | Erik D Jesper S | 2006 | Economic Systems Research2006，18，1： | 1 |
| 12 | RNA aptamerbased electrochemical biosensor for selective and label-free analysis of dopamine显示文摘 | ELAHEH F RUI C JESPER S N | 2013 | Anal Chem2013，85，1： | 1 |
| 13 | Simics-a full system simulation platform显示文摘 | Peter S Magnusson Magnus Christensson Jesper Eskilson | 2002 | IEEE Computer2002，35，2： | 1 |
| 14 | The economic impacts of tourism in Botswana, Namibia and South Africa: is poverty subsiding显示文摘 | Edwin M Jesper S | 2013 | Natural Resources Forum2013，37，2： | 1 |
| 15 | Simics: A full system simulation platform 显示文摘 | Peter S M Magnus C Jesper E | 2002 | Computer2002，35，2： | 1 |
| 16 | Synthesis显示文摘 | Klaus B Niels S Jesper L | 1996 | : 407 - 4161996，，： | 1 |
| 17 | Reform Drivers and Reform Obstacles in Natural Resource Management: The Northeast Atlantic Fisheries from 1945 to the Present 显示文摘 | Stig S Gezelius Jesper Raakj r etc | 2010 | Human Ecology2010，38，4： | 1 |
| 18 | Periprocedural complications and one-year outcomes after catheter ablation for treatment of atrial fibrillation in elderly patients:a nationwide Danish cohort study显示文摘OBJECTIVES To investigate complications within 30-days following first-time ablation for atrial fibrillation(AF),including a composite of cardiac tamponade,hematoma requiring intervention,stroke or death,in patients≥75 years of age,compared to pa-tients aged 65−74 years.In addition,one-year all-cause mortality and AF relapse were compared.METHODS&RESULTS All patients receiving their first catheter ablation for AF between 2012 and 2016 were identified us-ing Danish nationwide registries.Patients aged 65−74 years served as the reference group for patients≥75 years.Relapse of AF within one year was defined as cardioversion following a three-month blanking period,re-ablation or confirmed relapse within follow-up.The composite complication outcome did not differ between the two age groups,with 39/1554(2.8%)in patients 65−74 years of age,versus 5/199(2.5%)in older patients(adjusted HR=0.94),95%CI:0.37−2.39,P=0.896).Patients≥75 years or older had no increased hazard of death within 30 days after the procedure,with an incidence of 3/1554(0.2%)in younger pa-tients and 2/199(1.0%)in patients≥75 years of age(adjusted HR=4.71,95%CI:0.78−28.40,P=0.091).There was no difference in relapse of AF after one year between age groups(≥75 years adjusted HR=1.00,95%CI:0.78-1.26,P=0.969).CONCLUSION In patients≥75 years of age selected for catheter ablation for AF,the incidence of periprocedural complica-tions,as well as one-year freedom from AF showed no statistical difference,when compared to patients 65−74 years of age. | Jesper Nielsen Kristian Hay Kragholm Sofie Brix Christensen Arne Johannessen Christian Torp-Pedersen Steen Buus Kristiansen Peter Karl Jacobsen Peter Steen Hansen Mogens Stig Djurhus Christoffer Polcwiartek Peter Søgaard Anna Margrethe Thøgersen Uffe Jakob Ortved Gang Ole Dan Jørgensen Filip Lyng Lindgren Sam Riahi | 2021 | Journal of Geriatric Cardiology2021，18，11： | 1 |
| 19 | Simulation of wear in gears with flank interference—a mixed FE and analytical approach显示文摘 | Jesper Brauer S?ren Andersson | 2003 | Wear2003，，11： | 1 |
| 20 | Guiding the selection of human antibodies from phage display repertoires to a single epitope of an antigen 显示文摘 | Jespers L S Robertsa Mahler S M | 1994 | Bio Technology1994，12，： | 1 |
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