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| 1 | Gut microbiota imbalance and colorectal cancer显示文摘The gut microbiota acts as a real organ. The symbiotic interactions between resident micro-organisms and the digestive tract highly contribute to maintain the gut homeostasis. However, alterations to the microbiome caused by environmental changes(e.g., infection, diet and/or lifestyle) can disturb this symbiotic relationship and promote disease, such as inflammatory bowel diseases and cancer. Colorectal cancer is a complex association of tumoral cells, non-neoplastic cells and a large amount of micro-organisms, and the involvement of the microbiota in colorectal carcinogenesis is becoming increasingly clear. Indeed, many changes in the bacterial composition of the gut microbiota have been reported in colorectal cancer, suggesting a major role of dysbiosis in colorectal carcinogenesis. Some bacterial species have been identified and suspected to play a role in colorectal carcinogenesis, such as Streptococcus bovis, Helicobacter pylori, Bacteroides fragilis, Enterococcus faecalis, Clostridium septicum, Fusobacterium spp. and Escherichia coli. The potential pro-carcinogenic effects of these bacteria are now better understood. In this review, we discuss the possible links between the bacterial microbiota and colorectal carcinogenesis, focusing on dysbiosis and the potential pro-carcinogenic properties of bacteria, such as genotoxicity and other virulence factors, inflammation, host defenses modulation, bacterial derived metabolism, oxidative stress and anti-oxidative defenses modulation. We lastly describe how bacterial microbiota modifications could represent novel prognosis markers and/or targets for innovative therapeutic strategies. | Johan Gagnière Jennifer Raisch Julie Veziant Nicolas Barnich Richard Bonnet Emmanuel Buc Marie-Agnès Bringer Denis Pezet Mathilde Bonnet | 2016 | World Journal of Gastroenterology2016，22，2： | 76 |
| 2 | Results of percutaneous sclerotherapy and surgical treatment in patients with symptomatic simple liver cysts and polycystic liver disease显示文摘AIM: To evaluate the results of the treatment of simple liver cysts (solitary and multiple) and polycystic liver disease (PLD) using percutaneous sclerotherapy and/or surgical procedures in a single tertiary referral centre. METHODS: Retrospective analysis of 54 patients referred for evaluation and possible treatment of simple liver cysts (solitary and multiple) and PLD, from January 1997 to July 2006. RESULTS: Simple liver cysts were treated in 41 pts (76/) with a mean size of 12.6 cm. The most common reason for referral was abdominal pain or discomfort (85/). Percutaneous sclerotherapy was performed as initial treatment in 30 pts, showing cyst recurrence in 6 pts (20/). Surgical treatment was initially performed in 11 pts with cyst recurrence in 3 pts (27/). PLD was treated in 13 pts (24/) with a mean size of the dominant cyst of 13 cm. Percutaneous sclerotherapy for PLD was performed in 9 pts with recurrence in 7 pts (77.8/). Surgical treatment for PLD was undertaken in 4 pts (30.8/) with recurrence in all. Eventually, 2 pts with PLD in the presence of polycystic kidney disease underwent liver-and kidney transplantation because of deterioration of liver and kidney function. CONCLUSION: The majority of patients with simple liver cysts and PLD are referred for progressive abdominal pain. As initial treatment, percutaneous sclerotherapy is appropriate. Surgical deroofing is indicated in caseof cyst recurrence after percutaneous sclerotherapy. However, the results of percutaneous sclerotherapy and surgical treatment for PLD are disappointing. Partial liver resection is indicated when there is suspicion of a pre-malignant lesion. | Deha Erdogan Otto M van Delden Erik AJ Rauws Olivier RC Busch Johan S Lameris Dirk J Gouma Thomas M van Gulik | 2007 | World Journal of Gastroenterology2007，13，22： | 15 |
| 3 | Microbial markers in colorectal cancer detection and/or prognosis显示文摘Colorectal cancer(CRC) is the second leading cause of cancer worldwide. CRC is still associated with a poor prognosis among patients with advanced disease. On the contrary, due to its slow progression from detectable precancerous lesions, the prognosis for patients with early stages of CRC is encouraging. While most robust methods are invasive and costly, actual patient-friendly screening methods for CRC suffer of lack of sensitivity and specificity. Therefore, the development of sensitive, non-invasive and cost-effective methods for CRC detection and prognosis are necessary for increasing the chances of a cure. Beyond its beneficial functions for the host, increasing evidence suggests that the intestinal microbiota is a key factor associated with carcinogenesis. Many clinical studies have reported a disruption in the gut microbiota balance and an alteration in the faecal metabolome of CRC patients, suggesting the potential use of a microbialbased test as a non-invasive diagnostic and/or prognostic tool for CRC screening. This review aims to discuss the microbial signatures associated with CRC known to date, including dysbiosis and faecal metabolome alterations, andthe potential use of microbial variation markers for noninvasive early diagnosis and/or prognostic assessment of CRC and advanced adenomas. We will finally discuss the possible use of these markers as predicators for treatment response and their limitations. | Romain Villéger Amélie Lopès Julie Veziant Johan Gagnière Nicolas Barnich Elisabeth Billard Delphine Boucher Mathilde Bonnet | 2018 | World Journal of Gastroenterology2018，24，22： | 10 |
| 4 | A National Strategic Change in Treatment Policy for Rectal Cancer—Implementation of Total Mesorectal Excision as Routine Treatment in Norway. A National Audit显示文摘 | Arne Wibe M.D. Bj?rn M?ller M.Sc. Jarle Norstein M.D. Erik Carlsen M.D. Ph.D. Johan N. Wiig M.D. Ph.D. Richard J. Heald F.R.C.S. Fr?ydis Langmark M.D. Helge E. Myrvold M.D. Ph.D. Odd S?reide F.R.C.S | 2002 | Diseases of the Colon & Rectum2002，，7： | 1 |
| 5 | A shapley decomposition of carbon emissionswithout residuals 显示文摘 | Johan A Delphine F Koen S | 2002 | Energy Policy2002，30，： | 1 |
| 6 | Decreasing Time-Trends of Colorectal Cancer in a Large Cohort of Patients With Inflammatory Bowel Disease显示文摘 | Sverre S?derlund Lena Brandt Annika Lapidus Per Karlén Olle Brostr?m Robert L?fberg Anders Ekbom Johan Askling | 2009 | Gastroenterology2009，，5： | 1 |
| 7 | Assembly Root Cause Analysis: A Way to Reduce Dimensional Variation in Assembled Products显示文摘 | Johan S. Carlson Rikard S?derberg | 2003 | International Journal of Flexible Manufacturing Systems2003，，2： | 1 |
| 8 | Journal status显示文摘 | Johan B Marko A R Herbert V S | 2006 | Scientometrics2006，69，3： | 1 |
| 9 | Relationship between human papillomavirus type 16 in the cervix and intraepithelial neoplasia显示文摘 | Bram TH Frank S Johan K | 1999 | Obstet Gyneeol1999，93，： | 1 |
| 10 | Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence显示文摘 | Johan S Lisa S Ralph BDA | 2005 | Hypertension2005，45，1： | 1 |
| 11 | Antifungal effect of dairy propi- onibacteria-contribution of organic acids 显示文摘 | Helen L Hans J Johan S | 2005 | International Journal of Food Microbiology2005，98，： | 1 |
| 12 | The endoxylanases from family 11: computer analysis of protein sequences reveals important structural and phylogenetic relationships显示文摘 | Amalia S Johan W Christophe L | 2002 | Journal of Biotechnology2002，95，2： | 1 |
| 13 | Characteristics of a piezoelectric miniature motor 显示文摘 | Bexell M Johan Sson S | 1999 | Sensor Actuate A sensor- Phys1999，75，2： | 1 |
| 14 | Mineral absorption and excretion as affected by microbial phytase,and their effect on energy metabolism in young piglets 显示文摘 | Arie K K Walter J J G Johan W S | 2005 | J Nutr2005，135，： | 1 |
| 15 | 257 ankle arthroplasties performed in Norway between 1994 and 2005显示文摘 | Bj?rg-Tilde S Fevang Stein A Lie Leif I Havelin Johan G Brun Arne Skredderstuen Ove Furnes | 2007 | Acta Orthopaedica2007，，5： | 1 |
| 16 | Crohn disease-associated adherent-invasive E. coli bacteria target mouse and human Peyer’s patches via long polar fimbriae显示文摘 | Chassaing Benoit Rolhion Nathalie de Vallée Amélie Salim Sa’ad Y Prorok-Hamon Maelle Neut Christel Campbell Batty J S?derholm Johan D Hugot Jean-Pierre Colombel Jean-Frédéric Darfeuille-Michaud Arlette | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 17 | Ridethrough of wind turbines with doubly-fed induction generator during a voltage dip显示文摘 | Johan Morren Haan S W H de | 2005 | IEEE Trans on Energy Conversion2005，20，2： | 1 |
| 18 | A Shapley Decomposi- tion of Carbon Emissions Without Residuals显示文摘 | Johan A Delphine F Koen S | 2002 | En- ergy Policy2002，30，： | 1 |
| 19 | Clinical experience with the use of a shunt with an adjustable valves in children with hydro- cephalus显示文摘 | Goran Z Johan B Peter S | 2003 | J Neurosurg2003，98，3： | 1 |
| 20 | Minor improvement of venous blood specimen collection practices in primary health care after a large-scale educational intervention显示文摘 | Karin B?lenius Johan S?derberg Johan Hultdin Marie Lindkvist Christine Brulin Kjell Grankvist | 2013 | Clinical Chemistry and Laboratory Medicine2013，，2： | 1 |
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