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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Sequence-based screening for putative polyketide synthase gene-harboring clones from a soil metagenome library 显示文摘 | JI S C KIM D YOON J H | 2006 | J Microbiol Biotechnol2006，16，： | 1 |
| 3 | Rapid multimodality registration based on MM-SURF 显示文摘 | ZHAO D YANG Y JI ZH H | 2014 | Neurocomputing2014，131，5： | 1 |
| 4 | A retrospective study of continuous renal replacement therapy versus intermittent hemodialysis in severe acute renal failure显示文摘 | Ji D Gong D Xie H | 2001 | Chin Med J (Engl)2001，114，： | 1 |
| 5 | TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis显示文摘 | Pettit AR Ji H Vonstechal D | 2001 | Am J Pathol2001，159，5： | 1 |
| 6 | Sexual dimorphism and reproduction in the grass lizard, Talo, dromus septentn'onalis显示文摘 | Ji X Zhou W H Zhang X D | 1998 | Russian Journal of Herpetology1998，5，1： | 1 |
| 7 | Direct catalytic conversion of cellulose into ethylene glycol using nickel-promoted tungsten carbide catalysts显示文摘 | JI N ZHANG T ZHENG M Y WANG A Q WANG H WANG X D CHENG J G | 2008 | Angew Chem2008，120，44： | 1 |
| 8 | A real maximum power point tracking method for mismatching compensation in PV array under partially shaded conditions显示文摘 | Ji Y H Jung D Y Kim J G | 2011 | IEEE Transactions on Power Electronics2011，26，4： | 1 |
| 9 | Sexual dimorphism and reproduction in the grass lizard Takydromus septentrionalis 显示文摘 | JI X ZI-IOU W H ZHANG X D | 1995 | Russ J Herpetol1995，5，： | 1 |
| 10 | LKB1 modulates lung cancer diferentiation and metastasis显示文摘 | JI H RAMSEY M R HAYES D N | 2007 | Nature2007，448，7155： | 1 |
| 11 | Magnetic-field-induced twin boundary motion in magnetic shape memory alloys 显示文摘 | Chopra H D Ji C | 2000 | Physical Review B2000，61，14： | 1 |
| 12 | Anaerobic baffled reactor (ABR) for treating heavy oil produced water with high concentrations of salt and poor nutrient显示文摘 | Ji G D Sun T H Ni J R | 2009 | Bioresource Technology2009，，11： | 1 |
| 13 | Controllability, stabilizablity, and continous-time Markovian jump linear quadratic control显示文摘 | Ji Y D Chizeck H J | 1990 | IEEE Transactions on Automatic Control1990，35，7： | 1 |
| 14 | Adakites from continental collision zones: Melting of thickened lower crust beneath southern Tibet 显示文摘 | Chung S L Liu D Y Ji J Q Chu M F Lee H Y Wen D J Lo C H Lee T Y Qian Q Zhang Q | 2003 | Geology2003，31，11： | 1 |
| 15 | Thermus thermophilus proteins that are differentially expressed in response to growth temperature and their implication in thermoadaptation 显示文摘 | LI H B JI X L ZHOU Z D | 2010 | J Proteome Res2010，9，： | 1 |
| 16 | Combustion synthesis and photoluminescence of Ce^3+-activated MHfO3 (M =Ba, Sr, or Ca)显示文摘 | JI Y M JIANG D Y WU Z H FENG T SHI J L | 2005 | Materials Research Bulletin2005，40，： | 1 |
| 17 | Anaerobic baffled reactor (ABR) for treating heavy oil produced water with high concentrations of salt and poor nutrient 显示文摘 | Ji G D Sun T H Ni J R | 2009 | Bioresource Technology2009，，100： | 1 |
| 18 | Minimally invasive percutaneous plate osteosynthesis (MIPPO) technique applied in the treatment of humeral shaft distal fractures through a lateral approach显示文摘 | Ji F Tong D Tang H | 2009 | Int Orthop2009，33，2： | 1 |
| 19 | Block Copolymer Micelles with Acid - Labile Ortho Ester Side- Chains : Synthesis, Char- acterization, and Enhanced Drug Delivery to Human Glioma Cells显示文摘 | Tang R Ji W H Panus D | 2011 | Journal of Controlled Release2011，151，1： | 1 |
| 20 | Efficiency droop due to electron spill-over and limited hole injection in Ⅲ-nitride visible light-emitting diodes employing lattice-matched InAlN electron blocking layers显示文摘 | Choi S Ji M H Kim J Kim H J Satter M M Yoder P D Ryou J H Dupuis R D Fischer A M Ponce F A | | 0，，16： | 1 |
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