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| 1 | Cooling rate controlled basal precipitates and age hardening response of solid-soluted Mg-Gd-Er-Zn-Zr alloy显示文摘The precipitation and age hardening response of the solid-soluted Mg–10Gd–1Er–1Zn–0.6Zr(wt.%)alloy performed by water-quenching(QC),air-cooling(AC)and furnace-cooling(FC)in terms of the volume fraction of precipitates and tensile properties were investigated in present paper.Results indicated the solid-soluted alloy contained stacking faults(SFs)and long period stacking ordered(LPSO)phase on the basal planes regardless of the cooling rate,but a larger volume fraction of the LPSO phase was formed with decreasing in the cooling rate.After aging,βandβ1 phases precipitated on the prismatic planes,and their number density decreased but mean particle size increased with decreasing in the cooling rate.The solid-soluted alloys(QC,AC and FC samples)showed no apparent difference in yield strength(YS),but their correspondent peak-aged alloys exhibited sharp difference in hardening response.The strongest hardening response took place in the QC sample and showed 82MPa enhancement in YS,which was much larger than that of AC(+26MPa)and FC samples(+5MPa).The reason lies in that the higher cooling rate promotes the precipitation and reduces the average size ofβprecipitate.A novel cooling-rate controlled precipitation model with respect to the correlation of precipitates on basal and prismatic planes was established.From this model,the basal precipitates showed a restrictive effect on the growth and/or coarsening ofβprecipitate,and composite precipitates containing theβphase with fine size as well as high area-number density and lower volume fraction of the LPSO phase are preferred to strengthen the Mg–10Gd–1Er–1Zn–0.6Zr alloy. | Jinlong Fu Wenbo Du Linyue Jia Yunfeng Wang Xunming Zhu Xian Du | 2021 | Journal of Magnesium and Alloys2021，9，4： | 3 |
| 2 | Design and Validity Study on Oral English Assessment in Graduate Students显示文摘To explore the adoption of formative assessment in oral English test Validity study of oral test scores was performed in PhD candidates of 2011.Through linear relevance analysis,it is concluded that the relevance coefficient between oral score and overall score is 0.751 (P <0.001),the relevance coefficient between oral score and listening score is 0.530 (P <0.001),and the results indicate overall score and listening score have a positive relevancy with oral score.The result showed a positive correlation of oral test scores with written examination scores.Questionnaires modeled with the 5-point Likert Scale revealed a moderate supportive attitude of students on this formative assessment.The results are:80.1% of students indicated they feel satisfied and very satisfied with such oral English evaluation form,77.9% of students consider this oral score reflects their real oral English proficiency.This indicates that most students feel satisfied about the form and score in this oral exam.Through effective combination between formative evaluation method and summative evaluation method,it can effectively coordinate the relation between teaching and learning in oral English teaching practice,stimulate students'study initiative,and play a positive role in improving students'overall oral English proficiency. | Zhang Yan Jia Linyu Hu Jiyue | 2013 | 学术界2013，，2： | 2 |
| 3 | SARS-CoV-2 immunity and functional recovery of COVID-19 patients 1-year after infection显示文摘The long-term immunity and functional recovery after SARS-CoV-2 infection have implications in preventive measures and patient quality of life.Here we analyzed a prospective cohort of 121 recovered COVID-19 patients from Xiangyang,China at 1-year after diagnosis.Among them,chemiluminescence immunoassay-based screening showed 99%(95%CI,98–100%)seroprevalence 10–12 months after infection,comparing to 0.8%(95%CI,0.7–0.9%)in the general population.Total anti-receptor-binding domain(RBD)antibodies remained stable since discharge,while anti-RBD IgG and neutralization levels decreased over time.A predictive model estimates 17%(95%CI,11–24%)and 87%(95%CI,80–92%)participants were still 50%protected against detectable and severe re-infection of WT SARS-CoV-2,respectively,while neutralization levels against B.1.1.7 and B.1.351 variants were significantly reduced.All non-severe patients showed normal chest CT and 21%reported COVID-19-related symptoms.In contrast,53%severe patients had abnormal chest CT,decreased pulmonary function or cardiac involvement and 79%were still symptomatic.Our findings suggest long-lasting immune protection after SARS-CoV-2 infection,while also highlight the risk of immune evasive variants and long-term consequences for COVID-19 survivors. | Yan Zhan Yufang Zhu Shanshan Wang Shijun Jia Yunling Gao Yingying Lu Caili Zhou Ran Liang Dingwen Sun Xiaobo Wang Zhibing Hou Qiaoqiao Hu Peng Du Hao Yu Chang Liu Miao Cui Gangling Tong Zhihua Zheng Yunsheng Xu Linyu Zhu Jin Cheng Feng Wu Yulan Zheng Peijun Liu Peng Hong | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 0 |
| 4 | Natural long-chain saturated fatty acids doped LNPs enabling spleen selective mRNA translation and potent cancer immunotherapy显示文摘Rationally tailored lipid nanoparticles(LNPs)with efficient and tunable delivery of mRNA in vivo are crucial for mRNA vaccines.Selective expression of antigenic protein in lymphoid tissues/organs could improve the immunostimulatory efficacy and safety of LNPs-based mRNA vaccines.Inspired by the metabolic behavior that long-chain saturated fatty acids tending to enter lymphoid tissue rather than the liver,we developed fatty acid-doped LNPs capable of mediating differential protein expressions in the liver and spleen when administered intravenously.When the molar ratio of saturated fatty acid located 60%–70%,the doped LNPs achieved the spleen selective mRNA translation.The mechanism could be attributed to the different cellular uptake behaviors of saturated fatty acids in hepatocytes.Immunization with a model antigen(ovalbumin)mRNA-loaded spleen selective LNPs,we observed enhanced antigen-specific T cell immune responses,and potent immunotherapeutic and immunoprophylactic efficacy in the mouse lymphoma model.Our natural long-chain saturated fatty acids metabolic characteristics-inspired design of LNPs for spleen-selective mRNA vaccines delivery will provide references for designing mRNA vaccines with high efficacy and safety for tumor immunotherapy. | Fazhan Wang Meng Zhang Meiling Tian Jia Lou Longze Pan Xiaoke Gao Lijing Zhang Xiaohan Lou Linyu Zhu Yuqiao Sheng Ming Wang Rui Xue Wenjing Deng Shuai Shao Zhihai Qin | 2024 | Nano Research2024，17，3： | 0 |
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