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您的检索式：作者名="Longze Pan"
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| 1 | Inhibiting collagen Ⅰ production and tumor cell colonization in the lung via miR-29a-3p loading of exosome-/liposome-based nanovesicles显示文摘The lung is one of the most common sites for cancer metastasis.Collagens in the lung provide a permissive microenvironment that supports the colonization and outgrowth of disseminated tumor cells.Therefore,down-regulating the production of collagens may contribute to the inhibition of lung metastasis.It has been suggested that mi R-29 exhibits effective anti-fibrotic activity by negatively regulating the expression of collagens.Indeed,our clinical lung tumor data shows that mi R-29 a-3 p expression negatively correlates with collagen I expression in lung tumors and positively correlates with patients’outcomes.However,suitable carriers need to be selected to deliver this therapeutic mi RNA to the lungs.In this study,we found that the chemotherapy drug cisplatin facilitated mi R-29 a-3 p accumulation in the exosomes of lung tumor cells,and this type of exosomes exhibited a specific lung-targeting effect and promising collagen down-regulation.To scale up the preparation and simplify the delivery system,we designed a lung-targeting liposomal nanovesicle(by adjusting the molar ratio of DOTAP/cholesterol-mi RNAs to 4:1)to carry mi R-29 a-3 p and mimic the exosomes.This liposomal nanovesicle delivery system significantly down-regulated collagen I secretion by lung fibroblasts in vivo,thus alleviating the establishment of a pro-metastatic environment for circulating lung tumor cells. | Yan Yan Cancan Du Xixi Duan Xiaohan Yao Jiajia Wan Ziming Jiang Zhongyu Qin Wenqing Li Longze Pan Zhuoyu Gu Fazhan Wang Ming Wang Zhihai Qin | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 7 |
| 2 | Stability Comparison Between Grid-forming and Grid-following Based Wind Farms Integrated MMC-HVDC显示文摘Grid-forming(GFM)control based high-voltage DC(HVDC)systems and renewable energy sources(RESs)provide support for enhancing the stability of power systems.However,the interaction and coordination of frequency support between the GFM-based modular multilevel converter based HVDC(MMC-HVDC)and grid-following(GFL)based RESs or GFM-based RESs have not been fully investigated,which are examined in this study.First,the detailed AC-and DC-side impedances of GFM-based MMC-HVDC are analyzed.The impedance characteristics of GFL-and GFM-based wind turbines are next analyzed.Then,the influences of GFL-and GFM-based wind farms(WFs)on the DC-and AC-side stabilities of WF-integrated MMC-HVDC systems are compared and evaluated.The results show that the GFM-based wind turbine performs better than the GFL-based wind turbine.Accordingly,to support a receiving-end AC system,the corresponding frequency supporting strategies are proposed based on the GFM control for WF-integrated MMC-HVDC systems.The GFM-based WF outperforms the GFL-based WF in terms of stability and response time.Simulations in PSCAD/EMTDC demonstrate the DC-and AC-side stability issues and seamless grid support from the RESs,i.e.,WFs,to the receiving-end AC system. | Rongcai Pan Dong Liu Shan Liu Jie Yang Longze Kou Guangfu Tang | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，4： | 0 |
| 3 | Natural long-chain saturated fatty acids doped LNPs enabling spleen selective mRNA translation and potent cancer immunotherapy显示文摘Rationally tailored lipid nanoparticles(LNPs)with efficient and tunable delivery of mRNA in vivo are crucial for mRNA vaccines.Selective expression of antigenic protein in lymphoid tissues/organs could improve the immunostimulatory efficacy and safety of LNPs-based mRNA vaccines.Inspired by the metabolic behavior that long-chain saturated fatty acids tending to enter lymphoid tissue rather than the liver,we developed fatty acid-doped LNPs capable of mediating differential protein expressions in the liver and spleen when administered intravenously.When the molar ratio of saturated fatty acid located 60%–70%,the doped LNPs achieved the spleen selective mRNA translation.The mechanism could be attributed to the different cellular uptake behaviors of saturated fatty acids in hepatocytes.Immunization with a model antigen(ovalbumin)mRNA-loaded spleen selective LNPs,we observed enhanced antigen-specific T cell immune responses,and potent immunotherapeutic and immunoprophylactic efficacy in the mouse lymphoma model.Our natural long-chain saturated fatty acids metabolic characteristics-inspired design of LNPs for spleen-selective mRNA vaccines delivery will provide references for designing mRNA vaccines with high efficacy and safety for tumor immunotherapy. | Fazhan Wang Meng Zhang Meiling Tian Jia Lou Longze Pan Xiaoke Gao Lijing Zhang Xiaohan Lou Linyu Zhu Yuqiao Sheng Ming Wang Rui Xue Wenjing Deng Shuai Shao Zhihai Qin | 2024 | Nano Research2024，17，3： | 0 |
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