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| 1 | Antidiabetic effect of an engineered bacterium Lactobacillus plantarum-pMG36e-GLP-1 in monkey model显示文摘Glucagon-like peptide-1(GLP-1)reduces postprandial hyperglycaemia,but its short half-life inhibits clinical application.The aim of the current study was to evaluate the treatment efforts of an engineered strain,Lactobacillus plantarum-pMG36e-GLP-1(L.plantarum-pMG36e-GLP-1),that continuously expresses GLP-1 in spontaneous type 2 diabetes mellitus(T2DM)monkeys.After 7 weeks of oral supplementation with L.plantarum-pMG36e-GLP-1,the fasting blood glucose(FPG)of monkeys was significantly(p<0.05)reduced to a normal level and only a small amount of weight was lost.The results of metagenomic sequencing showed that L.plantarum-pMG36e-GLP-1 caused a substantial(p<0.05)reduction in the intestinal pathogen Prevotella and marked enhancement of butyrate-producing Alistipes genera.According to the functional analysis using Kyoto Encyclopaedia of Genes and Genomes(KEGG)pathways,19 metabolism-related pathways were significantly enriched in T2DM monkeys after treatment with L.plantarum-pMG36e-GLP-1.LC-MS faecal metabolomics analysis found 41 significant differential metabolites(11 higher and 30 lower)in monkeys after treatment pathways linked to the metabolism of cofactors and vitamins were the most relevant.The present study suggests that L.plantarum-pMG36e-GLP-1 had an impact on the gut microbial composition and faecal metabolomic profile in spontaneous T2DM monkeys and may be a novel candidate for diabetes treatment. | Jie Luo Hongfei Zhang Jiachen Lu ChaoLin Ma Tingtao Chen | 2021 | Synthetic and Systems Biotechnology2021，6，4： | 3 |
| 2 | Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future directions显示文摘With the improved understanding of driver mutations in non-small cell lung cancer (NSCLC), expanding the targeted therapeutic options improved the survival and safety. However, responses to these agents are commonly temporary and incomplete. Moreover, even patients with the same oncogenic driver gene can respond diversely to the same agent. Furthermore, the therapeutic role of immune-checkpoint inhibitors (ICIs) in oncogene-driven NSCLC remains unclear. Therefore, this review aimed to classify the management of NSCLC with driver mutations based on the gene subtype, concomitant mutation, and dynamic alternation. Then, we provide an overview of the resistant mechanism of target therapy occurring in targeted alternations (“target-dependent resistance”) and in the parallel and downstream pathways (“target-independent resistance”). Thirdly, we discuss the effectiveness of ICIs for NSCLC with driver mutations and the combined therapeutic approaches that might reverse the immunosuppressive tumor immune microenvironment. Finally, we listed the emerging treatment strategies for the new oncogenic alternations, and proposed the perspective of NSCLC with driver mutations. This review will guide clinicians to design tailored treatments for NSCLC with driver mutations. | Jia Zhong Hua Bai Zhijie Wang Jianchun Duan Wei Zhuang Di Wang Rui Wan Jiachen Xu Kailun Fei Zixiao Ma Xue Zhang Jie Wang | 2023 | Frontiers of Medicine2023，17，1： | 2 |
| 3 | Local spatial properties based image interpolation scheme using SVMs显示文摘Image interpolation plays an important role in image process applications. A novel support vector machines (SVMs) based interpolation scheme is proposed with increasing the local spatial properties in the source image as SVMs input patterns. After the proper neighbor pixels region is selected, trained support vectors are obtained by training SVMs with local spatial properties that include the average of the neighbor pixels gray values and the gray value variations between neighbor pixels in the selected region. The support vector regression machines are employed to estimate the gray values of unknown pixels with the neighbor pixels and local spatial properties information. Some interpolation experiments show that the proposed scheme is superior to the linear, cubic, neural network and other SVMs based interpolation approaches. | Ma Liyong Shen Yi Ma Jiachen | 2008 | Journal of Systems Engineering and Electronics2008，19，3： | 2 |
| 4 | Cybertwin-Assisted Mode Selection in Ultra-Dense LEO Integrated Satellite-Terrestrial Network显示文摘Ultra-dense low earth orbit(LEO)integrated satellite-terrestrial network(ULISTN)has become an emerging paradigm to support massive access of Internet of things(IoT)in beyond fifth generation mobile networks(B5G).In ULISTN,there are two communication modes:cellular mode and satellite mode,where IoT users assessing terrestrial small base stations(TSBSs)and terrestrial-satellite terminals(TSTs)respectively.However,how to optimize the network performance and guarantee self-interests of the operator and IoT users in ULISTN is a challenging issue.In this paper,we propose a cybertwin-assisted joint mode selection and dynamic pricing(JMSDP)scheme for effective network management in ULISTN,where cybertwin serves as the intelligent agent.In JMSDP,the operator determines optimal access prices of TSBSs and TSTs,while each user selects the access mode according to access prices.Specifically,the operator conducts the Stackelberg game aiming at maximizing average throughput depending on the mode selection results of IoT users.Meanwhile,IoT users as followers adopt the evolutionary game to choose an access mode based on the access prices provided by the operator.Simulation results show that the proposed JMSDP can improve the average throughput and reduce the delay effectively,comparing with random access(RA)and maximum rate access. | Xin Zhang Bo Qian Xiaohan Qin Ting Ma Jiachen Chen Haibo Zhou Xuemin(Sherman)Shen | 2022 | Journal of Communications and Information Networks2022，7，4： | 1 |
| 5 | Determination of Multiple Pesticide Residues in Honey Using Gas Chromatography-Electron Impact Ionization-Mass Spectrometry显示文摘 | Zhen JIN Zhuguang LIN Meiyu CHEN Yu MA Jun TAN Yulan FAN Jiachen WEN Zhaobin CHEN Fengzhang TU | 2006 | Chinese Journal of Chromatography2006，，5： | 1 |
| 6 | Constructing nanocomposites with robust covalent connection between nanoparticles and polymer for high discharged energy density and excellent tensile properties显示文摘High discharged energy density and excellent flexible properties in dielectric materials are significantly sought to meet the rapid advancements in the electronics industry. In this study, covalent bonds are constructed between poly(vinylidene fluoride-chlorotrifluoroethylene), which contains olefinic bonds, and thiol-modified BaTiO_(3) at the interface before the nanocomposite films are fabricated. The presence of the covalent bonds is proved to promote the dispersibility of the modified BaTiO_(3) and enhance the interfacial adhesion between the modified BaTiO_(3) and the polymer, followed by a remarkably positive effect in suppressing the dielectric loss(tanδ) and increasing the breakdown strength(Eb) of the nanocomposite films. In addition, the cross-linking treatment in the preparation process is found to be favourable for improving the mechanical properties of the nanocomposite films, which benefits the enhancement of Eb. Furthermore, at 400% elongation, the stretched nanocomposite film doped with 5 vol% modified BaTiO_(3) exhibits an Eb15.6% greater than that of the unstretched film, and the discharged energy density reaches 11.4 J/cm^(3) with a high discharge energy efficiency of 84.5%. This study provides a novel strategy for preparing flexible nanocomposites with powerful interfacial adhesion at high filler content to achieve high discharged energy density. | Jiachen Ma Yabin Zhang Yan Zhang Luqing Zhang Shuxiang Zhang Xuchuan Jiang Hong Liu | 2022 | Journal of Energy Chemistry2022，31，5： | 1 |
| 7 | Structural Damage Identification System Suitable for Old Arch Bridge in Rural Regions: Random Forest Approach显示文摘A huge number of old arch bridges located in rural regions are at the peak of maintenance.The health monitoring technology of the long-span bridge is hardly applicable to the small-span bridge,owing to the absence of technical resources and sufficient funds in rural regions.There is an urgent need for an economical,fast,and accurate damage identification solution.The authors proposed a damage identification system of an old arch bridge implemented with amachine learning algorithm,which took the vehicle-induced response as the excitation.A damage index was defined based on wavelet packet theory,and a machine learning sample database collecting the denoised response was constructed.Through comparing three machine learning algorithms:Back-Propagation Neural Network(BPNN),Support Vector Machine(SVM),and Random Forest(R.F.),the R.F.damage identification model were found to have a better recognition ability.Finally,the Particle Swarm Optimization(PSO)algorithm was used to optimize the number of subtrees and split features of the R.F.model.The PSO optimized R.F.model was capable of the identification of different damage levels of old arch bridges with sensitive damage index.The proposed framework is practical and promising for the old bridge’s structural damage identification in rural regions. | Yu Zhang Zhihua Xiong Zhuoxi Liang Jiachen She Chicheng Ma | 2023 | Computer Modeling in Engineering & Sciences2023，，7： | 1 |
| 8 | 3D pulmonary vessel segmentation based on improved residual attention u-net显示文摘Automatic segmentation of pulmonary vessels is a fundamental and essential task for the diagnosis of various pulmonary vessels diseases.The accuracy of segmentation is suffering from the complex vascular structure.In this paper,an Improved Residual Attention U-Net(IRAU-Net)aiming to segment pulmonary vessel in 3D is proposed.To extract more vessel structure information,the Squeeze and Excitation(SE)block is embedded in the down sampling stage.And in the up sampling stage,the global attention module(GAM)is used to capture target features in both high and low levels.These two stages are connected by Atrous Spatial Pyramid Pooling(ASPP)which can sample in various receptive fields with a low computational cost.By the evaluation experiment,the better performance of IRAU-Net on the segmentation of terminal vessel is indicated.It is expected to provide robust support for clinical diagnosis and treatment. | Jiachen Han Naixin He Qiang Zheng Lin Li Chaoqing Ma | 2023 | Medicine in Novel Technology and Devices2023，，4： | 0 |
| 9 | Progress on the application of graphene-based composites toward energetic materials:A review显示文摘Carbon material is an important additive in energetic materials.Graphene is a monolayer carbon material in which carbon atoms are arranged in two-dimensional honeycomb structure,who has special optical,electrical,and mechanical properties.Recently,the application of graphene-based composites in energetic materials has received extensive attention.This review mainly summarizes the applications of graphene and graphene-based nanomaterials in energetic materials.The effects of these materials on the thermal stability,sensitivity,mechanical property,ignition and combustion of energetic materials were discussed.Furthermore,the progress of functionalized modification of graphene has been summarized,including covalent bonding modification and doping modification.These studies show that graphenebased materials exhibit excellent performances and might emerge as promising candidate for energetic materials. | Ting Zhang Xiaoming Gao Jiachen Li Libai Xiao Hongxu Gao Fengqi Zhao Haixia Ma | 2024 | Defence Technology(防务技术)2024，31，1： | 0 |
| 10 | Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression显示文摘Fibroblast activation protein(Fap)is a serine protease that degrades denatured type I collagen,α2-antiplasmin and FGF21.Fap is highly expressed in bone marrow stromal cells and functions as an osteogenic suppressor and can be inhibited by the bone growth factor Osteolectin(Oln).Fap is also expressed in synovial fibroblasts and positively correlated with the severity of rheumatoid arthritis(RA).However,whether Fap plays a critical role in osteoarthritis(OA)remains poorly understood.Here,we found that Fap is significantly elevated in osteoarthritic synovium,while the genetic deletion or pharmacological inhibition of Fap significantly ameliorated posttraumatic OA in mice.Mechanistically,we found that Fap degrades denatured type II collagen(Col II)and Mmp13-cleaved native Col II.Intra-articular injection of r Fap significantly accelerated Col II degradation and OA progression.In contrast,Oln is expressed in the superficial layer of articular cartilage and is significantly downregulated in OA.Genetic deletion of Oln significantly exacerbated OA progression,which was partially rescued by Fap deletion or inhibition.Intra-articular injection of r Oln significantly ameliorated OA progression.Taken together,these findings identify Fap as a critical pathogenic factor in OA that could be targeted by both synthetic and endogenous inhibitors to ameliorate articular cartilage degradation. | Aoyuan Fan Genbin Wu Jianfang Wang Laiya Lu Jingyi Wang Hanjing Wei Yuxi Sun Yanhua Xu Chunyang Mo Xiaoying Zhang Zhiying Pang Zhangyi Pan Yiming Wang Liangyu Lu Guojian Fu Mengqiu Ma Qiaoling Zhu Dandan Cao Jiachen Qin Feng Yin Rui Yue | 2023 | Bone Research2023，11，1： | 0 |
| 11 | New class of high-entropy pseudobrookite titanate with excellent thermal stability,low thermal expansion coefficient,and low thermal conductivity显示文摘As a type of titanate,the pseudobrookite(MTi_(2)O_(5)/M_(2)TiO_(5))exhibits a low thermal expansion coefficient and thermal conductivity,as well as excellent dielectric and solar spectrum absorption properties.However,the pseudobrookite is unstable and prone to decomposing below 1200℃,which limits the practical application of the pseudobrookite.In this paper,the high-entropy pseudobrookite ceramic is synthesized for the first time.The pure high-entropy(Mg,Co,Ni,Zn)Ti_(2)O_(5) with the pseudobrookite structure and the biphasic high-entropy ceramic composed of the highentropy pseudobrookite(Cr,Mn,Fe,Al,Ga)_(2)TiO_(5) and the high-entropy spinel(Cr,Mn,Fe,Al,Ga,Ti)_(3)O_(4) are successfully prepared by the in-situ solid-phase reaction method.The comparison between the theoretical crystal structure of the pseudobrookite and the aberration-corrected scanning transmission electron microscopy(AC-STEM)images of high-entropy(Mg,Co,Ni,Zn)Ti_(2)O_(5) shows that the metal ions(M and Ti ions)are disorderly distributed at the A site and the B site in high-entropy(Mg,Co,Ni,Zn)Ti_(2)O_(5),leading to an unprecedentedly high configurational entropy of high-entropy(Mg,Co,Ni,Zn)Ti_(2)O_(5).The bulk high-entropy(Mg,Co,Ni,Zn)Ti_(2)O_(5) ceramics exhibit a low thermal expansion coefficient of 6.35×10^(−6) K^(−1) in the temperature range of 25-1400℃ and thermal conductivity of 1.840 W·m^(−1)·K^(−1) at room temperature,as well as the excellent thermal stability at 200,600,and 1400℃.Owing to these outstanding properties,high-entropy(Mg,Co,Ni,Zn)Ti_(2)O_(5) is expected to be the promising candidate for high-temperature thermal insulation.This work has further extended the family of different crystal structures of high-entropy ceramics reported to date. | Jinyu WU Xiaohui MA Xiaoxia HU Liwen YAN Feng HOU Jiachen LIU Anran GUO | 2022 | Journal of Advanced Ceramics2022，11，10： | 0 |
| 12 | Cache-Enabled in Cooperative Cognitive Radio Networks for Transmission Performance显示文摘The proliferation of mobile devices that support the acceleration of data services(especially smartphones)has resulted in a dramatic increase in mobile traffic. Mobile data also increased exponentially, already exceeding the throughput of the backhaul. To improve spectrum utilization and increase mobile network traffic, in combination with content caching, we study the cooperation between primary and secondary networks via content caching. We consider that the secondary base station assists the primary user by pre-caching some popular primary contents.Thus, the secondary base station can obtain more licensed bandwidth to serve its own user. We mainly focus on the time delay from the backhaul link to the secondary base station. First, in terms of the content caching and the transmission strategies, we provide a cooperation scheme to maximize the secondary user’s effective data transmission rates under the constraint of the primary users target rate. Then, we investigate the impact of the caching allocation and prove that the formulated problem is a concave problem with regard to the caching capacity allocation for any given power allocation. Furthermore, we obtain the joint caching and power allocation by an effective bisection search algorithm. Finally, our results show that the content caching cooperation scheme can achieve significant performance gain for the primary and secondary systems over the traditional two-hop relay cooperation without caching. | Jiachen Yang Chaofan Ma Jiabao Man Huifang Xu Gan Zheng Houbing Song | 2020 | Tsinghua Science and Technology2020，25，1： | 0 |
| 13 | Hollow catalysts through different etching treatments to improve active sites and oxygen vacancies for high-performance Li-O_(2)battery显示文摘Li-O_(2)batteries are regarded as one of the most promising next-generation battery systems due to their high theoretical energy density,finding effective cathode catalysts with fine-tuned structure is a key way to improve the performance.Herein,based on the structure of cubic zeolitic imidazolate framework-67(ZIF-67),a series of hollow catalysts were synthesized by different chemical etching treatments.Firstly,from the perspective of metal,nickel nitrate is used for etching,hollow Ni ZIF is obtained through Kirkendall effect.Secondly,hollow TA-ZIF is obtained by adding tannic acid to replace the methylimidazole ligand.Hollow structures have larger surface areas,materials can expose more active sites,which can lead to better performance of Li-O_(2)batteries.On this basis,having more oxygen vacancies can also improve the battery performance.At the same time,further loading noble metal ruthenium on the synthesized cobalt-based catalyst can effectively reduce the overpotential of Li-O_(2)battery and improve the battery performance.For TA-ZIF with more stable hollow structure and more oxygen vacancies,the cycle performance reaches 330 cycles after loading Ru.Compared with the 64 cycles of solid Co_(3)O_(4),it has a great improvement. | Jiachen Qiu Yuran Lin Shuting Zhang Jie Ma Yu Zhang Mengwei Yuan Genban Sun Caiyun Nan | 2023 | Nano Research2023，16，5： | 0 |
| 14 | Vacuum brazing TiAl intermetallic to K4169 alloy using amorphous filler metals Ti_(56.25–x)Zr_(x)Ni_(25)Cu1_(8.75)显示文摘A series of Ti_(56.25-x)Zr_(x)Ni_(25)Cu1_(8.75)(x=0–25,at.%) filler metals were designed based on a cluster-plus-glue-atom model to vacuum braze TiAl intermetallic to K4169 alloy. The impact of Zr content on the interfacial microstructure and shear strength of joints was examined. And the relationship between the interfacial lattice structure and the fracture behavior of the joint was investigated. The findings reveal a sectionalized characteristic with three reaction zones (Zone I, Zone II and Zone III) in the microstructure of the TiAl intermetallic to K4169 alloy joint. As the Zr content in filler metals increased, the diffusion of Ti transitioned from long-distance to short-distance in Zone I, changing the initial composition from TiNi_(3) /TiNi/NiNb/(Cr, Fe, Ni)SS to NiCrFe/(Cr, Fe, Ni)SS /TiNi. In Zone II, the initial composition altered from TiNi_(3) /TiNi to TiNi/Ti_(2) Ni/TiNi_(3) /TiCu/TiNi. The interface between Zones II and III altered from a non-coherent and semi-coherent interface of TiNi/TiAl/Ti_(3) Al with significant residual stress to a semi-coherent interface of TiNi/TiNi_(3) /TiAl_(2) /Ti_(3) Al with a gradient distribution. The shear strength of the joint initially decreased and then increased. When the Zr content of filler metal was 25 at.%, the shear strength of the joint reached 288 MPa. The crack initiation position changed from non-coherent TiNi/TiAl interface with high angle grain boundaries (HAGBs) and lattice mismatch of 65.86 at.% to a semi-coherent Ti3 Al/TiAl2 interface with a lattice mismatch of 20.07 at.% when the Zr content increased. The brittle fracture was present on the fracture surfaces of all brazed joints. | Liangliang Zhang Honggang Dong Peng Li Shuai Li Baosheng Wu Yueting Ma Libing Huang Chao Li Jiachen Li Yuesen Yang | 2023 | Journal of Materials Science & Technology2023，，23： | 0 |
| 15 | Correlation of image textures of a polarization feature parameter and the microstructures of liver fibrosis tissues显示文摘Mueller matrix imaging is emerging for the quantitative characterization of pathological microstructures and is especially sensitive to fibrous structures.Liver fibrosis is a characteristic of many types of chronic liver diseases.The clinical diagnosis of liver fibrosis requires time-consuming multiple staining processes that specifically target on fibrous structures.The staining proficiency of technicians and the subjective visualization of pathologists may bring inconsistency to clinical diagnosis.Mueller matrix imaging can reduce the multiple staining processes and provide quantitative diagnostic indicators to characterize liver fibrosis tissues.In this study,a fibersensitive polarization feature parameter(PFP)was derived through the forward sequential feature selection(SFS)and linear discriminant analysis(LDA)to target on the identification of fibrous structures.Then,the Pearson correlation coeffcients and the statistical T-tests between the fiber-sensitive PFP image textures and the liver fibrosis tissues were calculated.The results show the gray level run length matrix(GLRLM)-based run entropy that measures the heterogeneity of the PFP image was most correlated to the changes of liver fibrosis tissues at four stages with a Pearson correlation of 0.6919.The results also indicate the highest Pearson correlation of 0.9996 was achieved through the linear regression predictions of the combination of the PFP image textures.This study demonstrates the potential of deriving a fiber-sensitive PFP to reduce the multiple staining process and provide textures-based quantitative diagnostic indicators for the staging of liver fibrosis. | Yue Yao Jiachen Wan Fengdi Zhang Yang Dong Lihong Chen Hui Ma | 2023 | Journal of Innovative Optical Health Sciences2023，16，5： | 0 |
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