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| 1 | ASAF: altered spontaneous activity fingerprinting in Alzheimer’s disease based on multisite fMRI显示文摘Several monocentric studies have noted alterations in spontaneous brain activity in Alzheimer's disease (AD), although there is no consensus on the altered amplitude of low-frequency fluctuations in AD patients. The main aim of the present study was to identify a reliable and reproducible abnormal brain activity pattern in AD. The amplitude of local brain activity (AM), which can provide fast mapping of spontaneous brain activity across the whole brain, was evaluated based on multisite rs-fMRI data for 688 subjects (215 normal controls (NCs), 221 amnestic mild cognitive impairment (aMCI) 252 AD). Two-sample t-tests were used to detect group differences between AD patients and NCs from the same site. Differences in the AM maps were statistically analyzed via the Stouffer's meta-analysis. Consistent regions of lower spontaneous brain activity in the default mode network and increased activity in the bilateral hippocampus/parahippocampus, thalamus, caudate nucleus, orbital part of the middle frontal gyrus and left fusiform were observed in the AD patients compared with those in NCs. Significant correlations (P? | Jiachen Li Dan Jin Ang Li Bing Liu Chengyuan Song Pan Wang Dawei Wang Kaibin Xu Hongwei Yang Hongxiang Yao Bo Zhou Alexandre Bejanin Gael Chetelat Tong Han Jie Lu Qing Wang Chunshui Yu Xinqing Zhang Yuying Zhou Xi Zhang Tianzi Jiang Yong Liu Ying Han | 2019 | Science Bulletin2019，64，14： | 3 |
| 2 | Three-Dimensional Numerical Simulation of Ice Crystal Melting in Jet Engine显示文摘A method was presented for calculating the melting rate of ice crystals in different axial positions in a compressor. The volume of fluid model and enthalpy-porosity model were used to simulate the melting process of single ice crystal. The result was validated by experimental data from literature. The change of the liquid fraction of the ice crystals with the axial position was obtained when the temperature distribution inside the compressor was introduced into the melting process. The liquid fraction of the spherical ice crystals was fitted with the ice crystal diameter as a variable, and the general distribution function for computing liquid fraction in any axial position in the compressor was obtained. The function of axial position as a variable for non-spherical ice crystal was also got. | ZHU Pengfei ZHANG Jiachen HAN Bingbing ZHANG Lifen LIU Zhenxia | 2019 | Journal of Thermal Science2019，28，5： | 2 |
| 3 | Epigenetic regulation of hematopoietic stem cell homeostasis显示文摘As one of the best characterized adult stem cells,hematopoietic stem cell(HSC)homeostasis is of great importance to hematopoiesis and immunity due to HSC’s abilities of self-renewal and multi-lineage differentiation into functional blood cells.However,excessive self-renewal of HSCs can lead to severe hematopoietic malignancies like leukemia,whereas deficient selfrenewal of HSCs may result in HSC exhaustion and eventually apoptosis of specialized cells,giving rise to abnormalities such as immunodeficiency or anemia.How HSC homeostasis is maintained has been studied for decades and regulatory factors can be generally categorized into two classes:genetic factors and epigenetic factors.Although genetic factors such as signaling pathways or transcription factors have been well explored,recent studies have emerged the indispensable roles of epigenetic factors.In this review,we have summarized regulatory mechanisms of HSC homeostasis by epigenetic factors,including DNA methylation,histone modification,chromatin remodeling,non-coding RNAs,and RNA modification,which will facilitate applications such as HSC ex vivo expansion and exploration of novel therapeutic approaches for many hematological diseases. | Penglei Jiang Hui Wang Jiachen Zheng Yingli Han He Huang Pengxu Qian | 2019 | Blood Science2019，1，1： | 1 |
| 4 | Inhibition of hydrogen sulfide synthesis provides protection for severe acute pancreatitis rats via apoptosis pathway显示文摘 | Gang Wang Bing Han Haoxin Zhou Linfeng Wu Yongwei Wang Guang Jia Jiachen Lv Zhuoxin Cheng Shangha Pan Ji Liu Yinan Zhou Bei Sun | 2013 | Apoptosis2013，，1： | 1 |
| 5 | Efficient hydrogenation of ethylene carbonate derived from CO_(2) to synthesize methanol and ethylene glycol over core-shell Cu@GO catalyst显示文摘The synthesis of sustainable methanol and ethylene glycol(EG)via hydrogenation of ethylene carbonate(EC)has caught researchers’growing interests on account of the indirect chemical utilization of CO_(2).Core-shell Cu@GO catalysts with random nanoporous network of graphite oxide(GO)were synthesized via a simple method of ul-trasonic precipitation.Cu@GO catalysts were analyzed systematically by N_(2) physisorption,TGA measurement,XRD,FT-IR,Raman,TEM,SEM,and XPS(XAES).In particular,the mentioned method was confirmed to be effective to fabricate the high dispersity core-shell Cu@GO catalysts through promoting the specific surface area.The as-prepared Cu@GO catalyst was then successfully applied in the hydrogenation of CO_(2)-derived EC to pro-duce methanol and EG.A high TOF of 1526 mg EC g cat^(-1) h^(-1) could be attained in EC hydrogenation at the reaction temperature of 493K.Accordingly,the correlation of catalytic structure and performance disclosed that the synergistic effect between Cu^(+) and Cu^(0) was responsible for achieving high activity of the catalyst.In addition,the reusability of Cu@GO catalyst suggested that graphite oxide shell structure could decrease the aggregation of Cu particles,thus enhance the stability of Cu-based catalysts.DFT calculation results suggested that the involvement of carbon film on Cu was favorable for the stabilization of the active sites.This study is helpful for developing new and stable catalytic system for indirect chemical utilization of CO_(2) to synthesize commodity methanol and EG. | Chanjuan Zhang Liguo Wang Zhuo Han Peng He Yan Cao Jiachen Li Huiquan Li | 2022 | Green Chemical Engineering2022，3，3： | 1 |
| 6 | Designing polyoxometalate-based metal-organic framework for oxidation of styrene and cycloaddition of CO_(2) with epoxides显示文摘A photoactive polyoxometalate-based metal-organic framework (POMOF),NiW-DPNDI,was synthesized by combination of Ni(Ⅱ) ions,[ZnW_(12)O_(40)]^(6–)anions,and N,N’-bis(4-pyridylmethyl)naphthalene diimide(DPNDI) molecules into one single framework.Ni W-DPNDI displays a three-dimensional structure by the strong anion···π interactions between the trapped[ZnW_(12)O_(40)]^(6–)anions and the electron-deficient naphthalenic ring centroids and theπ-πstacking interactions between DPNDI moieties.Ni W-DPNDI displayed a highly efficient hole-electron separation and ordered electron transfer under irradiation,thus ensuing its excellent photocatalysis in oxidation of styrene to produce benzaldehyde.In addition,it gave a high efficiency for styrene oxide under thermocatalytic conditions.Because the carbonic anhydrase (CA)-mimicking Ni sites and the negative electron-enriched[ZnW_(12)O_(40)]^(6–)anions are well aligned in the pores,it can promote the cycloaddition of CO_(2) with epoxides under mild conditions. | Xiaomei Yan Jiangbo Xu Ting Zhang Chen Si Jiachen Jiao Jie Li Qiuxia Han | 2023 | Chinese Chemical Letters2023，34，7： | 0 |
| 7 | 3D pulmonary vessel segmentation based on improved residual attention u-net显示文摘Automatic segmentation of pulmonary vessels is a fundamental and essential task for the diagnosis of various pulmonary vessels diseases.The accuracy of segmentation is suffering from the complex vascular structure.In this paper,an Improved Residual Attention U-Net(IRAU-Net)aiming to segment pulmonary vessel in 3D is proposed.To extract more vessel structure information,the Squeeze and Excitation(SE)block is embedded in the down sampling stage.And in the up sampling stage,the global attention module(GAM)is used to capture target features in both high and low levels.These two stages are connected by Atrous Spatial Pyramid Pooling(ASPP)which can sample in various receptive fields with a low computational cost.By the evaluation experiment,the better performance of IRAU-Net on the segmentation of terminal vessel is indicated.It is expected to provide robust support for clinical diagnosis and treatment. | Jiachen Han Naixin He Qiang Zheng Lin Li Chaoqing Ma | 2023 | Medicine in Novel Technology and Devices2023，，4： | 0 |
| 8 | A Rational Design of Metal–Organic Framework Nanozyme with High‑Performance Copper Active Centers for Alleviating Chemical Corneal Burns显示文摘Metal–organic frameworks(MOFs)have attracted significant research interest in biomimetic catalysis.However,the modulation of the activity of MOFs by precisely tuning the coordination of metal nodes is still a significant challenge.Inspired by metalloenzymes with well-defined coordination structures,a series of MOFs containing halogen-coordinated copper nodes(Cu-X MOFs,X=Cl,Br,I)are employed to elucidate their structure–activity relationship.Intriguingly,experimental and theoretical results strongly support that precisely tuning the coordination of halogen atoms directly regulates the enzyme-like activities of Cu-X MOFs by influencing the spatial configuration and electronic structure of the Cu active center.The optimal Cu–Cl MOF exhibits excellent superoxide dismutase-like activity with a specific activity one order of magnitude higher than the reported Cu-based nanozymes.More importantly,by performing enzyme-mimicking catalysis,the Cu–Cl MOF nanozyme can significantly scavenge reactive oxygen species and alleviate oxidative stress,thus effectively relieving ocular chemical burns.Mechanistically,the antioxidant and antiapoptotic properties of Cu–Cl MOF are achieved by regulating the NRF2 and JNK or P38 MAPK pathways.Our work provides a novel way to refine MOF nanozymes by directly engineering the coordination microenvironment and,more significantly,demonstrating their potential therapeutic effect in ophthalmic disease. | Yonghua Tang Yi Han Jiachen Zhao Yufei Lv Chaoyu Fan Lan Zheng Zhisen Zhang Zuguo Liu Cheng Li Youhui Lin | 2023 | Nano-Micro Letters2023，15，8： | 0 |
| 9 | Rational Manipulation of Intermediates on Copper for CO_(2)Electroreduction Toward Multicarbon Products显示文摘Excess greenhouse gas emissions,primarily carbon dioxide(CO_(2)),have caused major environmental concerns worldwide.The electroreduction of CO_(2)into valuable chemicals using renewable energy is an ecofriendly approach to achieve carbon neutrality.In this regard,copper(Cu)has attracted considerable attention as the only known metallic catalyst available for converting CO_(2)to high-value multicarbon(C_(2+))products.The production of C_(2+)involves complicated C-C coupling steps and thus imposes high demands on intermediate regulation.In this review,we discuss multiple strategies for modulating intermediates to facilitate C_(2+)formation on Cu-based catalysts.Furthermore,several sophisticated in situ characterization techniques are outlined for elucidating the mechanism of C-C coupling.Lastly,the challenges and future directions of CO_(2)electroreduction to C_(2+)are envisioned. | Guangyi Jiang Daliang Han Zishan Han Jiachen Gao Xinyu Wang Zhe Weng Quan-Hong Yang | 2022 | Transactions of Tianjin University2022，28，4： | 0 |
| 10 | Nanoparticles-based phototherapy systems for cancer treatment: Current status and clinical potential显示文摘Remarkable progress in phototherapy has been made in recent decades,due to its non-invasiveness and instant therapeutic efficacy.In addition,with the rapid development of nanoscience and nanotechnology,phototherapy systems based on nanoparticles or nanocomposites also evolved as an emerging hotspot in nanomedicine research,especially in cancer.In this review,first we briefly introduce the history of phototherapy,and the mechanisms of phototherapy in cancer treatment.Then,we summarize the representative development over the past three to five years in nanoparticle-based phototherapy and highlight the design of the innovative nanoparticles thereof.Finally,we discuss the feasibility and the potential of the nanoparticle-based phototherapy systems in clinical anticancer therapeutic applications,aiming to predict future research directions in this field.Our review is a tutorial work,aiming at providing useful insights to researchers in the field of nanotechnology,nanoscience and cancer. | Jiachen Li Shiqi Wang Flavia Fontana Christos Tapeinos Mohammad-Ali Shahbazi Huijie Han Helder A.Santos | 2023 | Bioactive Materials2023，，5： | 0 |
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