| 1 | Inhibition of furin by bone targeting superparamagnetic iron oxide nanoparticles alleviated breast cancer bone metastasis显示文摘Breast cancer bone metastasis poses significant challenge for therapeutic strategies.Inside the metastatic environment,osteoclasts and tumor cells interact synergistically to promote cancer progression.In this study,the proprotein convertase furin is targeted due to its critical roles in both tumor cell invasion and osteoclast function.Importantly,the furin inhibitor is specifically delivered by bone targeting superparamagnetic iron oxide(SPIO)nanoparticles.Our in vitro and in vivo data demonstrate that this system can effectively inhibit both osteoclastic bone resorption and breast cancer invastion,leading to alleviated osteolysis.Therefore,the bone targeting&furin inhibition nanoparticle system is a promising therapeutic and diagnostic strategy for breast cancer bone metastasis. | Yichuan Pang Li Su Yao Fu Fan Jia Chenxi Zhang Xiankun Cao Wenxin He Xueqian Kong Jiake Xu Jie Zhao An Qin | 2021 | Bioactive Materials2021，6，3： | 2 |
| 2 | Preparation of HNS microspheres by rapid membrane emulsification显示文摘In order to improve the dispersibility and loading efficiency of 2,2',4,4',6,6'-hexanitrostilbene(HNS),HNS microspheres were prepared by rapid membrane emulsification method with nitrocellulose(NC)as binder.The effects of NC solution concentration,stirring speed and polyvinyl alcohol(PVA)solution concentration on microspheres were investigated.It was characterized by scanning electron microscope(SEM),X-ray diffractometer(XRD),differential thermal analysis(DTA)and angle of repose analyzer.The results show that the HNS microspheres prepared with 5 wt%NC solution concentration,stirring speed of 100 rpm and 2 wt%PVA solution concentration have better regular morphology,higher sphericity,unchanged crystalline shape,increased activation energy and significantly improved dispersibility compared with the refined HNS.Rapid membrane emulsification has a series of advantages such as green,low cost and easy scale up,which provides a better way to prepare microspheres of energy materials. | Hongbiao Huo Baoyun Ye Yuhuai Shi Chenhe Feng Jiechao Wang Minjie Li Jiake Fan Lianqiang Li Jingyu Wang Chongwei An | 2023 | Particuology2023，，8： | 0 |
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