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| 1 | Columbianetin acetate inhibits the occurrence and development of pancreatic cancer cells by down-regulating the expression of Meiotic nuclear divisions 1显示文摘Columbianetin acetate(CE)is one of the effective components of Angelica pubescens.So far,the specific role and molecular mechanism of CE in pancreatic cancer are not clear.Thus,this study aimed to explore the specific mechanism of CE on pancreatic cancer.The target genes combined with CE were predicted through the PharmMapper database and the 3D molecular structure of CE.Then,the Cancer Genome Atlas(TCGA)and Cistrome data browser(DB)databases were used to screen Meiotic nuclear divisions 1(MND1)-related genes,transcription factors,and transcription factor data sets,and the intersection of the above data sets.The“limma”package in the R and gene expression profiling interactive analysis(GEPIA)databases were used to analyze the correlation and survival difference between the target genes and MND1 to predict the degree of association between CE and MND1.Western blotting and RT-PCR experiments revealed the regulatory relationship among CE,E2F1,and MND1 at the cellular level.The specific effects of CE on pancreatic cancer cells were explored through CCK8,wound healing,migration,and flow cycle experiments.E2F1,also the predictive transcription factor of MND1,was also the predictive target protein of CE.At the same time,E2F1 and MND1 were closely related in pancreatic tissue.In the cell function experiment,CE and interference with E2F1 expression could reduce the gene and protein expression of MND1,which was closely associated with cell proliferation,migration,and cycle development.Similarly,interfering with the expression of mnd1 can also inhibit the further development of tumor cells.CE may inhibit the development of pancreatic cancer cells by reducing the expression of MND1.This implies that CE may be a potential novel agent for the treatment of pancreatic cancer. | KANG SUN DONGQIN WANG ZHIQIANG ZHANG YINLONG HUANG XIAOFU LIAN JIALE HUA JING ZHANG CHAOQUN LIAN | 2023 | BIOCELL2023，47，2： | 1 |
| 2 | Design of hierarchical and mesoporous FeF_(3)/rGO hybrids as cathodes for superior lithium-ion batteries显示文摘Iron fluoride(FeF_(3)) is considered as a promising cathode material for Li-ion batteries(LIBs)due to its high theoretical capacity(712 mAh/g)with a 3 e-transfer.Herein,we have designed a strategy of hierarchical and mesoporous FeF_(3)/rG O hybrids for LIBs,where the hollow Fe F_(3) nanospheres are the main contributor to the specific capacity and the 2 D r GO nanosheets are the matrix elevating the electronic conductivity and buffering the volume expansion.The unique FeF_(3)/rGO hybrid can be rationally synthesized by a nonaqueous in-situ precipitation method,offering the merits of large specific surface area with rich active sites,fast transport channels for lithium ions,effective alleviation of volume expansion during cycles,and accelerating the electrochemical reaction kinetics.The Fe F_(3)/r GO hybrid electrode possesses a high initial discharge capacity of 553.9 m Ah/g at a rate of 0.5 C with 378 m Ah/g after 100 cycles,acceptable rate capability with 168 m Ah/g at 2 C,and feasible high-temperature operation(320 m Ah/g at 70℃).The superior electrochemical behaviors presented here demonstrates that the FeF_(3)/rGO hybrid is a potential electrode for LIBs,which may open up a new vision to design high-efficiency energy-storage devices such as LIBs based on transition metal fluorides. | Jiale Lian Yang Wu Yichuan Guo Zhenyun Zhao Qinghua Zhang Yang Hou Lingxiang Chen Bin Lu Xinhua Pan Zhizhen Ye Jianguo Lu | 2022 | Chinese Chemical Letters2022，33，8： | 0 |
| 3 | Application and Challenge of Blockchain Technology in Medical Field显示文摘Due to its unique security,blockchain technology is widely used in the financial field.Under the background of the rapid development of information technology and the rapid improvement of medical level,it is also a general trend to integrate blockchain technology into the medical field.According to the characteristics of blockchain and the research contents of many scholars on the application of blockchain in the medical field,this paper analyzes and summarizes the problems existing in the current development of blockchain,puts forward corresponding solutions,and looks forward to the further application of blockchain technology in the medical field. | Kaifeng Zhang Zhao Qiu Gengquan Xie Jiale Lin Tingting Zhang Yingsheng Lian Tao Chen Yunlong He Yu Yang | 2022 | Journal of Cyber Security2022，4，2： | 0 |
| 4 | Regulating adsorption ability toward polysulfides in a porous carbon/Cu_(3)P hybrid for an ultrastable high-temperature lithium-sulfur battery显示文摘Lithium-sulfur batteries(LSBs)can work at high temperatures,but they suffer from poor cycle life stability due to the“shuttle effect”of polysulfides.In this study,pollen-derived porous carbon/cuprous phosphide(PC/Cu_(3)P)hybrids were rationally synthesized using a one-step carbonization method using pollen as the source material,acting as the sulfur host for LSBs.In the hybrid,polar Cu_(3)P can markedly inhibit the“shuttle effect”by regulating the adsorption ability toward polysulfides,as confirmed by theoretical calculations and experimental tests.As an example,the camellia pollen porous carbon(CPC)/Cu_(3)P/S electrode shows a high capacity of 1205.6 mAh g^(−1) at 0.1 C,an ultralow capacity decay rate of 0.038%per cycle after 1000 cycles at 1 C,and a rather high initial Coulombic efficiency of 98.5%.The CPC/Cu_(3)P LSBs can work well at high temperatures,having a high capacity of 545.9 mAh g^(−1) at 1 C even at 150℃.The strategy of the PC/Cu_(3)P hybrid proposed in this study is expected to be an ideal cathode for ultrastable high-temperature LSBs.We believe that this strategy is universal and worthy of in-depth development for the next generation energy storage devices. | Yichuan Guo Rabia Khatoon Jianguo Lu Qinggang He Xiang Gao Xiaopeng Yang Xun Hu Yang Wu Jiale Lian Zhoupeng Li Zhizhen Ye | 2021 | Carbon Energy2021，3，6： | 0 |
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