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| 1 | Near-diffraction-limited linearly polarized narrow-linewidth random fiber laser with record kilowatt output显示文摘In this paper, we propose and experimentally investigate a linearly polarized narrow-linewidth random fiber laser(RFL) operating at 1080 nm and boost the output power to kilowatt level with near-diffraction-limited beam quality using a master oscillation power amplifier. The RFL based on a half-opened cavity, which is composed of a linearly polarized narrow-linewidth fiber Bragg grating and a 500 m piece of polarization-maintained Ge-doped fiber, generates a 0.71 W seed laser with an 88 pm full width at half-maximum(FWHM) linewidth and a 22.5 dB polarization extinction ratio(PER) for power scaling. A two-stage fiber amplifier enhances the seed laser to the maximal 1.01 k W with a PER value of 17 dB and a beam quality of M_x^2=1.15 and M_y^2=1.13. No stimulated Brillouin scattering effect is observed at the ultimate power level, and the FWHM linewidth of the amplified random laser broadens linearly as a function of the output power with a coefficient of about 0.1237 pm∕W.To the best of our knowledge, this is the first demonstration of a linearly polarized narrow-linewidth RFL with even kilowatt-level near-diffraction-limited output, and further performance scaling is ongoing. | JIANGMING XU LONG HUANG MAN JIANG JUN YE PENGFEI MA JINYONG LENG JIAN WU HANWEI ZHANG PU ZHOU | 2017 | Photonics Research2017，5，4： | 20 |
| 2 | Three-dimensional-printed individualized porous implants:A new“implant-bone”interface fusion concept for large bone defect treatment显示文摘Bone defect repairs are based on bone graft fusion or replacement.Current large bone defect treatments are inadequate and lack of reliable technology.Therefore,we aimed to investigate a simple technique using three-dimensional(3D)-printed individualized porous implants without any bone grafts,osteoinductive agents,or surface biofunctionalization to treat large bone defects,and systematically study its long-term therapeutic effects and osseointegration characteristics.Twenty-six patients with large bone defects caused by tumor,infection,or trauma received treatment with individualized porous implants;among them,three typical cases underwent a detailed study.Additionally,a large segmental femur defect sheep model was used to study the osseointegration characteristics.Immediate and long-term biomechanical stability was achieved,and the animal study revealed that the bone grew into the pores with gradual remodeling,resulting in a long-term mechanically stable implant-bone complex.Advantages of 3D-printed microporous implants for the repair of bone defects included 1)that the stabilization devices were immediately designed and constructed to achieve early postoperative mobility,and 2)that osseointegration between the host bone and implants was achieved without bone grafting.Our osseointegration method,in which the“implant-bone”interface fusion concept was used instead of“bone-bone”fusion,subverts the traditional idea of osseointegration. | Teng Zhang Qingguang Wei Hua Zhou Zehao Jing Xiaoguang Liu Yufeng Zheng Hong Cai Feng Wei Liang Jiang Miao Yu Yan Cheng Daoyang Fan Wenhao Zhou Xinhong Lin Huijie Leng Jian Li Xinyu Li Caimei Wang Yun Tian Zhongjun Liu | 2021 | Bioactive Materials2021，6，11： | 9 |
| 3 | Tandem pumping architecture enabled high power random fiberlaser with near-diffraction-limited beam quality显示文摘In this contribution, we present the tandem pumping avenue leveraged performance scaling of random fiber laser to record 3 kW level with inherent temporal stability and near-diffraction-limited beam quality. The high power system employs a four-stage master oscillator power amplifier chain. The master oscillator is a half-opened cavity structured random distributed feedback fiber laser centered at 1080 nm and pumped by incoherent amplified spontaneous emission source. Narrowband random laser seed is selected by employing a spectral filtering module with a maximum output power of 1.08 W, full width at half maximum linewidth of 0.47 nm and spectral optical-signal-to-noise ratio of about 42 dB. As to the main amplification stage, for given 104 W pre-amplified random laser seed and 3.61 kW pump laser, an ultimate output power of 3.03 kW can be obtained,corresponding to an optical-to-optical conversion efficiency of 81.05%. Nearly single-transverse-mode amplified random laser can be achieved even at full power level for inherent high thermal modal instability threshold enabled by tandem pumping and inducing bending loss for high-order transverse-mode. Further performance scaling of this high power random laser system, such as power boosting, operation wavelength tuning and linewidth alteration, is the next goal. | XU JiangMing YE Jun ZHOU Pu LENG JinYong XIAO Hu ZHANG HangWei WU Jian CHEN JinBao | 2019 | Science China(Technological Sciences)2019，62，1： | 8 |
| 4 | MATRIEX imaging:multiarea two-photon real-time in vivo explorer显示文摘Two-photon laser scanning microscopy has been extensively applied to study in vivo neuronal activity at cellular and subcellular resolutions in mammalian brains.However,the extent of such studies is typically confined to a single functional region of the brain.Here,we demonstrate a novel technique,termed the multiarea two-photon real-time in vivo explorer(MATRIEX),that allows the user to target multiple functional brain regions distributed within a zone of up to 12mm in diameter,each with a field of view(FOV)of ~200μm in diameter,thus performing two-photon Ca2+imaging with single-cell resolution in all of the regions simultaneously.For example,we demonstrate real-time functional imaging of single-neuron activities in the primary visual cortex,primary motor cortex and hippocampal CA1 region of mice in both anesthetized and awake states.A unique advantage of the MATRIEX technique is the configuration of multiple microscopic FOVs that are distributed in three-dimensional space over macroscopic distances(>1 mm)both laterally and axially but that are imaged by a single conventional laser scanning device.In particular,the MATRIEX technique can be effectively implemented as an add-on optical module for an existing conventional single-beam-scanning two-photon microscope without requiring any modification to the microscope itself.Thus,the MATRIEX technique can be readily applied to substantially facilitate the exploration of multiarea neuronal activity in vivo for studies of brain-wide neural circuit function with single-cell resolution. | Mengke Yang Zhenqiao Zhou Jianxiong Zhang Shanshan Jia Tong Li Jiangheng Guan Xiang Liao Bing Leng Jing Lyu Kuan Zhang Min Li Yan Gong Zhiming Zhu Junan Yan Yi Zhou Jian K Liu Zsuzsanna Varga Arthur Konnerth Yuguo Tang Jinsong Gao Xiaowei Chen Hongbo Jia | 2019 | Light(Science & Applications)2019，8，1： | 4 |
| 5 | Phase Ⅱ open-label study of recombinant circularly permuted TRAIL as a single-agent treatment for relapsed or refractory multiple myeloma显示文摘Background: Despite the recent development of new therapies, multiple myeloma(MM) remains an incurable disease. Thus, new, efective treatments are urgently needed, particularly for relapsed or refractory MM(RRMM). In an earlier phase I study, a novel form of recombinant human Apo2L/tumor necrosis factor-related apoptosis-inducing ligand(TRAIL) that is currently in clinical development for the treatment of hematologic malignancies, i.e., circularly permuted TRAIL(CPT), was well tolerated at a dose of 2.5 mg/kg per day and showed promising preliminary activity in patients with RRMM. This phase II, open-label, multicenter study further investigated the eicacy and safety of 2.5-mg/kg per day CPT as single-agent therapy for patients with RRMM.Methods: Patients with RRMM were treated once daily with CPT(2.5 mg/kg, intravenously) for 14 consecutive days for each 21-day cycle. Clinical response and toxicity were assessed after each treatment cycle.Results: Twenty-seven patients received CPT. Using the European Group for Blood and Marrow Transplantation criteria, we calculated the overall response rate of 33.3% with 1 near-complete response(n CR) and 8 partial responses(PRs). The clinical beneit rate(48.1%) included 1 nCR, 8 PRs, and 4 minimal responses. The most common treatmentrelated adverse events(TRAEs) were fever, aspartate aminotransferase elevation, alanine aminotransferase elevation, leucopenia, rash, neutropenia, and thrombocytopenia. We graded toxicity using the Common Toxicity Criteria for Adverse Events, version 3.0, and determined that 37.0% of patients had at least 1 grade 3–4 TRAE.Conclusions: CPT as a single agent can elicit a response in patients with RRMM and is well tolerated. Further clinical investigation is warranted. | Yun Leng Lugui Qiu Jian Hou Yaozhong Zhao Xuejun Zhang Shifang Yang Hao Xi Zhongxia Huang Ling Pan Wenming Chen | 2016 | Chinese Journal of Cancer2016，35，12： | 4 |
| 6 | Passively spatiotemporal gain-modulation-induced stable pulsing operation of a random fiber laser显示文摘Unlike a traditional fiber laser with a defined resonant cavity, a random fiber laser(RFL), whose operation is based on distributed feedback and gain via Rayleigh scattering(RS) and stimulated Raman scattering in a long passive fiber, has fundamental scientific challenges in pulsing operation for its remarkable cavity-free feature. For the time being, stable pulsed RFL utilizing a passive method has not been reported. Here, we propose and experimentally realize the passive spatiotemporal gain-modulation-induced stable pulsing operation of counterpumped RFL. Thanks to the good temporal stability of an employed pumping amplified spontaneous emission source and the superiority of this pulse generation scheme, a stable and regular pulse train can be obtained.Furthermore, the pump hysteresis and bistability phenomena with the generation of high-order Stokes light is presented, and the dynamics of pulsing operation is discussed after the theoretical investigation of the counterpumped RFL. This work extends our comprehension of temporal property of RFL and paves an effective novel avenue for the exploration of pulsed RFL with structural simplicity, low cost, and stable output. | JIANGMING XU JUN YE WEI LIU JIAN WU HANWEI ZHANG JINYONG LENG PU ZHOU | 2017 | Photonics Research2017，5，6： | 4 |
| 7 | Risk Factors for Recurrence of Ovarian Endometriosis in Chinese Patients Aged 45 and Over显示文摘 | Zheng-Xing He Ting-Ting Sun Shu Wang Hong-Hui Shi Qing-Bo Fan Lan Zhu Jin-Hua Leng Da-Wei Sun Jian Sun Jing-He Lang | 2018 | Chinese Medical Journal2018，，11： | 4 |
| 8 | Enhancement of transfection efficiency for HeLa cells via incorporating arginine moiety into chitosan显示文摘Arginine-rich peptides have attracted considerable attention due to their distinct internalization mechanism. It was reported that arginine and guanidino moieties were able to translocate through cell membranes and played a critical role in the process of membrane permeation. In this work, arginine was conjugated to the backbone of chitosan to form a novel chitosan derivative, arginine modified chitosan (Arg-CS). Arg-CS/DNA complexes were prepared according to the method of coacervation process. The physicochemical properties of Arg-CS and Arg-CS/DNA complexes were characterized and the transfection activity and efficiency mediated by Arg-CS/DNA complexes were investigated taking HeLa cells as target cells. Arg-CS was characterized by FTIR and 13C NMR. Arg-CS/DNA polye- lectrolyte complexes were investigated by agarose gel retardation, dynamic light scattering (DLS) and atomic force microscopy (AFM). The results revealed that the Arg-CS/DNA complexes started to form at N/P ratio of 2:1, and the size of particles varied from 100 to 180 nm. The cytotoxicity of Arg-CS and their complexes with plasmid DNA were determined by MTT assay for HeLa cells, and the results suggested that Arg-CS/DNA complexes were slightly less toxic than Arg-CS. Moreover, the derivative alone and their complexes showed significantly lower toxicity than PEI and PEI/DNA complexes, respectively. Taking HeLa cells as target cells and using pGL3-control as reporter gene, the luciferase expression mediated by Arg-CS was greatly enhanced to about 100 folds compared with the luciferase expression mediated by chitosan at different pH media. These results suggest that Arg-CS is a promising candi- date as a safe and efficient vector for gene delivery and transfection. | ZHU DunWan ZHANG HaiLing BAI JinGen LIU WenGuang LENG XiGang SONG CunXian YANG Jian LI XiaoWei JIN Xu SONG LiPing LIU LanXia LI XiuLan ZHANG Yang YAO KangDe | 2007 | Chinese Science Bulletin2007，52，23： | 4 |
| 9 | Vortex random fiber laser with controllable orbital angular momentum mode显示文摘In this paper, we propose and experimentally demonstrate a vortex random fiber laser(RFL) with a controllable orbital angular momentum(OAM) mode. The topological charge of the vortex RFL can range from-50 to 50 with nearly watt-level output power. A triangular toroidal interferometer is constructed to verify the spiral phase structure of the generated vortex random laser with a special coherence property. Vortex RFLs with fractional topological charge are also performed in this work. As the first demonstration of a vortex RFL with a controllable OAM mode(to the best of our knowledge), this work may not only offer a valuable reference on temporal modulation of a vortex beam and optical field control of an RFL but also provide a potential vortex laser source for applications in imaging, sensing, and communication. | XIAOYA MA JUN YE YANG ZHANG JIANGMING XU JIAN WU TIANFU YAO JINYONG LENG PU ZHOU | 2021 | Photonics Research2021，9，2： | 4 |
| 10 | Optical rogue wave in random fiber laser显示文摘The famous demonstration of optical rogue waves(RWs),a powerful tool to reveal the fundamental physics in different laser scenarios,opened a flourishing time for temporal statistics.Random fiber laser(RFL)has likewise attracted wide attention due to its great potential in multidisciplinary demonstrations and promising applications.However,owing to the distinctive cavity-free structure,it is a scientific challenge to achieve temporal localized RWs in RFLs,whose feedback arises from multiple scattering in disordered medium.Here,we report the exploration of RW in the highly skewed,transient intensity of an incoherently pumped RFL for the first time,to our knowledge,and unfold the involved kinetics successfully.The corresponding frequency domain measurements demonstrate that the RW event arises from a crucial sustained stimulated Brillouin scattering process with intrinsic stochastic nature.This investigation highlights a novel path to fully understanding the complex physics,such as photon propagation and localization,in disordered media. | JIANGMING XU JIAN WU JUN YE JIAXIN SONG BAICHENG YAO HANWEI ZHANG JINYONG LENG WEILI ZHANG PU ZHOU YUNJIANG RAO | 2020 | Photonics Research2020，8，1： | 4 |
| 11 | Combining cold sintering and Bi_(2)O_(3)-Activated liquid-phase sintering to fabricate high-conductivity Mg-doped NASICON at reduced temperatures显示文摘The cold sintering process(CSP)and Bi_(2)O_(3)-activated liquid-phase sintering(LPS)are combined to densify Mg-doped NASICON(Na_(3.256)Mg_(0.128)Zr_(1.872)Si_(2)PO_(12))to achieve high densities and conductivities at reduced temperatures.As an example,a cold-sintered specimen with the addition of 1.1wt%Bi_(2)O_(3)sintering additive achieved a high conductivity of 0.91 mS/cm(with~96%relative density)after annealing at 1000℃;this conductivity is>70%higher than that of a cold-sintered specimen without adding the Bi_(2)O_(3)sintering additive,and it is>700%of the conductivity of a dry-pressed counterpart with the same amount of Bi_(2)O_(3)added,all of which are subjected to the same heating profile.The highest conductivity achieved in this study via combining CSP and Bi_(2)O_(3)-activated LSP is>1.5 mS/cm.This study suggests an opportunity to combine the new CSP with the traditional LPS to sinter solid electrolytes to achieve high densities and conductivities at reduced temperatures.This combined CSP-LPS approach can be extended to a broad range of other materials to fabricate the“thermally fragile”solid electrolytes or solid-state battery systems,where reducing the processing temperature is often desirable. | Haoyang Leng Jiuyuan Nie Jian Luo | 2019 | Journal of Materiomics2019，5，2： | 4 |
| 12 | Analysis of floral scent emitted from Syringa plants显示文摘Syringa is an important aromatic woody angiosperm that is widely planted in gardens. Its dry flowers are traditionally used to manufacture infusions and spices in China. In this study, the floral volatiles emitted from nine different Syringa species and varieties, viz.S. chinensis, S. protolaciniata, S. oblata, S. oblata var.giraldii, S. oblata var. plena, S. vulgaris ‘Mrs Harry Bickle', S. vulgaris ‘Bright Centennial', S. vulgaris ‘White Spires', and S. vulgaris ‘President Lincoln' were collected by the dynamic headspace technique, and then identified by automated thermal desorption–gas chromatography/mass spectrometry. There were significant differences incomponents and corresponding contents of floral scent emitted from the nine Syringa species and varieties.Among the detected components, b-ocimene exhibited the highest content, accounting for more than 70 % of the floral scent of S. protolaciniata, S. oblata var. giraldii, and S. vulgaris ‘Bright Centennial'. A significant daytime variation of floral scent emitted from S. pekinensis was recorded, especially for benzaldehyde, whose content first increased and then decreased. We studied the scent emitted from the in vitro flowers of S. vulgaris ‘Pres Lincoln'during the process of natural drying. Alcohol compounds were released in the greatest content, and the content of 2-ethyl-1-hexanol accounted for about 40 % of the total release amount. The results described the emission pattern and mechanisms of floral scent in Syringa. | Xiaoxia Yang Jing Zhao Jian Zheng Pingsheng Leng Xiaolong Li Zenghui Hu Jianbin Liu Xin Meng | 2016 | Journal of Forestry Research2016，27，2： | 3 |
| 13 | dentification of DW532 as a novel anti-tumor agent targeting both kinases and tubulin显示文摘 | Ting PENG Jian-rui WU Lin-jiang TONG Meng-yuan LI Fang CHEN Yi-xin LENG Rong QU Kun HAN Yi SU Yi CHEN Wen-hu DUAN Hua XIE Jian DING | 2014 | Acta Pharmacologica Sinica2014，35，7： | 3 |
| 14 | Beam test results of high Q CBPM prototype for SXFEL显示文摘In pursuit of high-precision beam position measurements at micrometers or submicrometers for the Shanghai soft X-ray free-electron laser(SXFEL) facility which is under construction in the vicinity of the Shanghai Synchrotron Radiation Facility,a high Q cavity beam position monitor(CBPM) with a resonant frequency of4.7 GHz is developed by the Shanghai Institute of Applied Physics,and the relevant BPM electronics with a dedicated RF front end,and a digital BPM,are completed.The cavity design,cold test,system architecture,and first beam test are performed at the Shanghai deep ultraviolet free-electron laser(Zhao et al.in Nucl Instrum Meth A 528(1-2):591-594,2004.doi:10.1016/j.nima.2004.04.108) facility.Results of the beam experiment show that the performance of the CBPM is consistent with basic expectations,and the beam position resolution can fulfill the requirements for the SXFEL project if the beam conditions are optimized. | Jian Chen Yong-Bin Leng Lu-Yang Yu Long-Wei Lai Ren-Xian Yuan | 2017 | Nuclear Science and Techniques2017，28，4： | 2 |
| 15 | Study of the crosstalk evaluation for cavity BPM显示文摘In order to pursue high-precision beam position measurements for free-electron laser facilities, a cavity beam position monitor(CBPM) is employed to measure the transverse position that can meet the requirement of position resolution at a sub-micrometer or even nanometer scale. However, for the pill-box cavity BPM, crosstalk between the cavities will have an effect on the accurate measurement of beam position. To reduce the effect of crosstalk on CBPM performance and ease the measurement of the isolation between the cavities, the cavities with a slight difference in resonant frequency were designed and applied in the Dalian coherent light source and Shanghai soft X-ray free-electron laser facilities. Furthermore, two methods, the principal component analysis method and the method of harmonic analysis, are proposed in this paper to evaluate the crosstalk. The results demonstrate that the two methods are feasible in evaluating the crosstalk between the cavities. | Jian Chen Yong-Bin Leng Lu-Yang Yu Long-Wei Lai Ren-Xian Yuan | 2018 | Nuclear Science and Techniques2018，29，6： | 1 |
| 16 | Characteristics of the Cretaceous Magmatism in Huanghua Depression and Their Relationships with Hydrocarbon Enrichment显示文摘The Huanghua depression located in the hinterland of the Bohai Bay Basin in eastern China is a typical area for the research of multistage magmatic activities with hydrocarbon enrichment,many high-yield wells related to igneous rocks were discovered within the Cretaceous strata in recent years.However,the spatial and temporal distribution of Cretaceous igneous rocks remains unclear,and the relationships among magmatic sequence,lithology,and hydrocarbon enrichment have been poorly studied.In order to solve these problems,core observation,logging analysis,major element analysis,zircon U-Pb chronology,oil-bearing grade statistics and reservoir spaces analysis were used to subdivide the magmatism cycles and to investigate the characteristics of igneous reservoirs.Our results show that the Mesozoic magmatism in Huanghua depression started in 140.1±1.4 Ma and could be divided into two stages including the Early Cretaceous stage and Late Cretaceous stage.The Early Cretaceous magmatism principally developed basic-intermediate rocks in the north zone,and could be subdivided into 3 cycles with their forming ages of 140,125–119,and 118–111 Ma,respectively.By contrast,the late stage mainly developed intermediate-acid rocks centralized in the south zone and formed at 75–70 Ma.The GR and SP curves are good indicators for the contrast of different lithologies,lithofacies and for magmatic sequences division.Intensive magmatism may have an advantage to form reservoirs,since basalt in cycle III in the Early Cretaceous and dacite porphyrite in the Late Cretaceous have great exploration potential.Lithology and tectonic fractures have an important influence on the formation of reservoir spaces and hydrocarbon enrichment.The characteristics of Cretaceous magmatism and igneous reservoirs in Huanghua depression and adjacent areas are summarized,providing important information for igneous reservoirs research and oil-gas exploration in the Cretaceous in related areas. | Fengming Jin Jian Huang Xiugang Pu Changqian Ma Lixin Fu Chongbiao Leng Da Lou Mutian Qin | 2020 | Journal of Earth Science2020，31，6： | 1 |
| 17 | Highly flexible transparent and conductive ZnS/Ag/ZnS multilayer films prepared by ion beam assisted deposition 显示文摘 | Yu Zhinong Leng Jian Xue Wei | 2012 | Appl Surf Sci2012，258，7： | 1 |
| 18 | Clinical Manifestations of Adenomyosis Patients with or without Coexisting Endometriosis显示文摘 | Yun-Wei Li Yu-Ting Liu Shu Wang Hong-Hui Shi Qing-Bo Fan Lan Zhu Jin-Hua Leng Da-Wei Sun Jian Sun Jing-He Lang | 2018 | Chinese Medical Journal2018，，20： | 1 |
| 19 | Gene cloning and expression analysis of limonene synthase in Syringa oblata and S.oblata var.alba显示文摘Syringa species are important ornamentals with strong floral scent,of which monoterpenes are the main component.In this study,a new monoterpene synthase gene,named SoLIM,was collected from the flowers of Syringa oblata and S.oblata var.alba using a homologous cloning method.The full-length cDNA of SoLIM was1746 bp and encoded 581 amino acids.Sequence analysis showed that SoLIM contained the DDxxD and RRx8 W motifs,which are two typical conserved monoterpene synthase motifs,and was thus classified as belonging to the Tpsb subfamily.Using quantitative reverse-transcription PCR,SoLIM was significantly expressed in the petals and pistils of S.oblata and S.oblata var.alba,respectively.SoLIM expression peaked earlier than the D-limonene emissions in the diurnal experiments,but occurred later when D-limonene had peaked during the flowering phase,indicating that differences in SoLIM gene expression and D-limonene emissions existed.The synthesis of floral scent is thus associated with diverse regulatory mechanisms that require further investigation. | Zifei Yan Ying Qin Jian Zheng Pingsheng Leng Zenghui Hu | 2019 | Journal of Forestry Research2019，30，4： | 1 |
| 20 | Recent developments in dynamic advertising research 显示文摘 | Huang Jian Leng Mingming Liang Liping | 2011 | Eu- ropean Journal of Operational Research2011，220，3： | 1 |
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