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| 1 | Parishin C's prevention of Aβ_(1–42)-induced inhibition of long-term potentiation is related to NMDA receptors显示文摘The rhizome of Gastrodia elata(GE), a herb medicine, has been used for treatment of neuronal disorders in Eastern Asia for hundreds of years. Parishin C is a major ingredient of GE. In this study, the i.c.v. injection of soluble Aβ1–42oligomers model of LTP injury was used. We investigated the effects of parishin C on the improvement of LTP in soluble Aβ1–42oligomer–injected rats and the underlying electrophysiological mechanisms. Parishin C(i.p. or i.c.v.) significantly ameliorated LTP impairment induced by i.c.v. injection of soluble Aβ1–42oligomers. In cultured hippocampal neurons,soluble Aβ1–42oligomers significantly inhibited NMDAR currents while not affecting AMPAR currents and voltage-dependent currents. Pretreatment with parishin C protected NMDA receptor currents from the damage induced by Aβ. In summary, parishin C improved LTP deficits induced by soluble Aβ1–42oligomers. The protection by parishin C against Aβ-induced LTP damage might be related to NMDA receptors. | Zhihui Liu Weiping Wang Nan Feng Ling Wang Jiangong Shi Xiaoliang Wang | 2016 | Acta Pharmaceutica Sinica B2016，6，3： | 25 |
| 2 | Glucosylated caffeoylquinic acid derivatives from the flower buds of Lonicera japonica显示文摘Three new glucosylated caffeoylquinic acid isomers(1–3),along with six known compounds,have been isolated from an aqueous extract of the flower buds of Lonicera japonica.Structures of the new compounds were determined by spectroscopic and chemical methods as()-4-O-(4-O-β-D-glucopyranosylcaffeoyl)quinic acid(1),()-3-O-(4-O-β-D-glucopyranosylcaffeoyl)quinic acid(2),and()-5-O-(4-O-β-D-glucopyranosylcaffeoyl)quinic acid(3),respectively.In the preliminary in vitro assays,two known compounds methyl caffeate and 2?-O-methyladenosine showed inhibitory activity against Coxsackie virus B3 with IC50 values of 3.70 μmol/L and 6.41 μmol/L and SI values of 7.8 and 12.1,respectively. | Yang Yu Zhibo Jiang Weixia Song Yongchun Yang Yuhuan Li Jiandong Jiang Jiangong Shi | 2015 | Acta Pharmaceutica Sinica B2015，5，3： | 23 |
| 3 | 4-Hydroxybenzyl-substituted amino acid derivatives from Gastrodia elata显示文摘Seven new 4-hydroxybenzyl-substituted amino acid derivatives(1-7), together with 11 known compounds, were isolated from an aqueous extract of the rhizomes of Gastrodia elata Blume.Their structures were determined by spectroscopic and chemical methods. Compounds 1-3 are pyroglutamate derivatives containing 4-hydroxybenzyl units at the N atom and 4-7 are the first examples of natural products with the 4-hydroxybenzyl unit linked via a thioether bond to 2-hydroxy-3-mercaptopropanoic acid(4-6) and 2-hydroxy-4-mercaptobutanoic acid(7), which would be biogenetically derived from cysteine and homocysteine, respectively. The structures of 1 and 2 were verified by synthesis, while the absolute configurations of 4, 5 and 7 were assigned using Mosher's method based on the MPA determination rule of ΔδRS values. The known compound 4-(hydroxymethyl)-5-nitrobenzene-1,2-diol(8) exhibited activity against Fe^(2+)-cysteine induced rat liver microsomal lipid peroxidation with IC_(50) values of 9.99×10^(-6) mol/L. | Qinglan Guo Yanan Wang Sheng Lin Chenggen Zhu Minghua Chen Zhibo Jiang Chengbo Xu Dan Zhang Huailing Wei Jiangong Shi | 2015 | Acta Pharmaceutica Sinica B2015，5，4： | 18 |
| 4 | Sesquiterpene glycosides from the roots of Codonopsis pilosula显示文摘Three new sesquiterpene glycosides,named codonopsesquilosides A C(1 3),were isolated from an aqueous extract of the dried roots of Codonopsis pilosula.Their structures including absolute configurations were determined by spectroscopic and chemical methods.These glycosides are categorized as C_(15) carotenoid(1),gymnomitrane(2),and eudesmane(3)types of sesquiterpenoids,respectively.Compound 1 is the first diglycoside of C_(15) carotenoids to be reported.Compound 2 represents the second reported example of gymnomitrane-type sesquiterpenoids from higher plants.The absolute configurations were supported by comparison of the experimental circular dichroism(CD)spectra with the calculated electronic CD(ECD)spectra of 13,their aglycones,and model compounds based on quantummechanical time-dependent density functional theory.The influences of the glycosyls on the calculated ECD spectra of the glycosidic sesquiterpenoids,as well as some nomenclature and descriptive problems with gymnomitrane-type sesquiterpenoids are discussed. | Yueping Jiang Yufeng Liu Qinglan Guo Chengbo Xu Chenggen Zhu Jiangong Shi | 2016 | Acta Pharmaceutica Sinica B2016，6，1： | 16 |
| 5 | Acetylenes and fatty acids from Codonopsis pilosula显示文摘Four new acetylenes(1–4) and one new unsaturated ω-hydroxy fatty acid(5),together with 5known analogues,were isolated from an aqueous extract of Codonopsis pilosula roots.Their structures were determined by spectroscopic and chemical methods.The new acetylenes are categorized as an unusual cyclotetradecatrienynone(1),tetradecenynetriol(2),and rare octenynoic acids(3 and 4),respectively,and 3 and 4 are possibly derived from oxidative metabolic degradation of 1 and/or 2.The absolute configuration of 1 was assigned by comparison of the experimental circular dichroism(CD)spectrum with the calculated electronic circular dichroism(ECD) spectra of stereoisomers based on the quantum-mechanical time-dependent density functional theory,while the configuration of 2 was assigned by using modified Mosher's method based on the MPA determination rule of ΔδRSvalues for diols. | Yueping Jiang Yufeng Liu Qinglan Guo Zhibo Jiang Chengbo Xu Chenggen Zhu Yongchun Yang Sheng Lin Jiangong Shi | 2015 | Acta Pharmaceutica Sinica B2015，5，3： | 15 |
| 6 | Indole alkaloid sulfonic acids from an aqueous extract of Isatis indigotica roots and their antiviral activity显示文摘Six new indole alkaloid sulfonic acids(1–6), together with two analogues(7 and 8) that were previously reported as synthetic products, were isolated from an aqueous extract of the Isatis indigotica root. Their structures including the absolute configurations were determined by spectroscopic data analysis, combined with enzyme hydrolysis and comparison of experimental circular dichroism and calculated electronic circular dichroism spectra. In the preliminary assay, compounds 2 and 4 showed antiviral activity against Coxsackie virus B3 and influenza virus A/Hanfang/359/95(H3N2), respectively. | Lingjie Meng Qinglan Guo Yufeng Liu Minghua Chen Yuhuan Li Jiandong Jiang Jiangong Shi | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 14 |
| 7 | 8,4′-Oxyneolignane glucosides from an aqueous extract of“ban lan gen”(Isatis indigotica root)and their absolute configurations显示文摘Three pairs of glycosidic 8,4′-oxyneolignane diastereoisomers, named isatioxyneolignosides A-F(1–6), were isolated from an aqueous extract of Isatis indigotica roots. Their structures and absolute configurations were elucidated by comprehensive spectroscopic data analysis and enzyme hydrolysis. The validity of Δδ_(C8-C7) values to distinguish threo and erythro aryl glycerol units and Cotton effects at 235±5 nm to determine absolute configurations at C-8 in 1–6 and their aglycones(1a–6a) are discussed. | Lingjie Meng Qinglan Guo Yufeng Liu Jiangong Shi | 2017 | Acta Pharmaceutica Sinica B2017，7，6： | 13 |
| 8 | Mechanism and control of water seepage of vertical feeding borehole for solid materials in backflling coal mining显示文摘To solve the problem of water seepage of vertical feeding borehole for solid materials,we established the fluid-solid coupling dynamic model of groundwater flowing in rock mass adjacent to the vertical feeding borehole.Combining with the engineering geological conditions,we built a numeral model to study the influence rule of the aquifer hydraulic pressure and seepage location of feeding borehole on the amount of seepage with fnite element numerical method.The results show that the nonlinear relationship is presented among the amount of seepage,the seepage location and aquifer hydraulic pressure.The higher the aquifer hydraulic pressure is,the closer the distance between seepage location and aquifer is,and the faster the harmful levels of aquifer will grow.In practice,we calculated the allowable seepage of feeding borehole by the optimum moisture content and natural moisture content of backflling materials,and then determined the protection zone of feeding borehole,so the moisture content of backflling materials can be controlled within the scope of optimum moisture content. | Zhou Yuejin Guo Hongzeng Cao Zhengzheng Zhang Jiangong | 2013 | International Journal of Mining Science and Technology2013，23，5： | 12 |
| 9 | Analysis for retrieval and validation results of FY-3 Total Ozone Unit (TOU)显示文摘Retrieval experiment was made for global total column ozone using the first year measurements of Total Ozone Unit (TOU) on board the second generation polar orbiting meteorological satellite of China, FY-3/A. The retrieval results were analyzed and validated by comparison with AURA/OMI, Meteop/GOME-2 global ozone products and ground-based ozone measurement data. The qualititative comparisons over the globe especially over Antarctica and the Tibetan Plateau show that the spatial and temporal distribution characteristics are consistent with OMI and GOME-2 products. The quantitative comparisons with ground-based measurements and AURA/OMI ozone product were made over 74 stations, the TOU total ozone retrieval has a 3% rms relative error compared with AURA/OMI ozone product and 4.2% rms relative error with ground-based measurements. The maximum difference between satellite retrieval and ground-based measurements was found in the Antarctica ozone hole. The TOU global ozone product is operational and distributed to all users. | WANG WeiHe ZHANG XingYing AN XingQin ZHANG Yan HUANG FuXiang WANG YongMei WANG YingJian ZHANG ZhongMou LU JianGong FU LiPing JIANG Fang LIU GuoYang | 2010 | Chinese Science Bulletin2010，55，26： | 12 |
| 10 | Three pairs of alkaloid enantiomers from the root of Isatis indigotica显示文摘Three pairs of enantiomerically pure alkaloids with diverse structure features, named isatindigoticoic acid A and epiisatindigoticoic acid A [(—)-1 and(+)-1], phaitanthrin A and epiphaitanthrin A [(—)-2 and(+)-2], and isatindopyrromizol A and epiisatindopyrromizol A [(—)-3and(+)-3], respectively, were isolated from an aqueous extract of the roots of Isatis indigotica. Racemic and scalemic mixtures of these enantiomers were separated by HPLC on a chiral semi-preparative column.Their structures including absolute configurations were determined by extensive spectroscopic analysis in conjunction with the calculation of electronic circular dichroism(ECD) spectra. The enantiomer pairs possess parent structures of 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid, indolo[2,1-b]quinazolinone, and 3-thioxohexahydro-1H-pyrrolo[1,2-c]imidazol-1-one, respectively. Except for phaitanthrin A[(—)-2] which the configuration was previously undetermined, these compounds are new enantiomeric natural products. | Yufeng Liu Xiaoliang Wang Minghua Chen Sheng Lin Li Li Jiangong Shi | 2016 | Acta Pharmaceutica Sinica B2016，6，2： | 12 |
| 11 | C_(19)-Diterpenoid alkaloid arabinosides from an aqueous extract of the lateral root of Aconitum carmichaelii and their analgesic activities显示文摘Eight new C_(19)-diterpenoid alkaloid arabinosides, named aconicarmichosides E–L(1–8), were isolated from an aqueous extract of the lateral roots of Aconitum carmichaelii(Fu Zi). Their structures were determined by spectroscopic and chemical methods including 2D NMR experiments and acid hydrolysis. Compounds 1–8, together with the previously reported four neoline 14-O-arabinosides from the same plant, represent the only examples of glycosidic diterpenoid alkaloids so far. At a dose of 1.0 mg/kg(i.p.), as compared with the black control, compounds 1, 2, and 4–6 exhibited analgesic effects with 465.6% inhibitions against acetic acid-induced writhing of mice. Structure–activity relationship was also discussed. | Qinglan Guo Huan Xia Xianhua Meng Gaona Shi Chengbo Xu Chenggen Zhu Tiantai Zhang Jiangong Shi | 2018 | Acta Pharmaceutica Sinica B2018，8，3： | 12 |
| 12 | FY-3 satellite Ultraviolet Total Ozone Unit显示文摘FY-3 satellites are Chinese second-generation polar orbit meteorological satellite series. Ultraviolet Total Ozone Unit (TOU) is one of the main payloads on FY-3 satellite and the first instrument for daily global coverage of total ozone monitoring in China. The main purpose of TOU is to measure the Earth backscatter ultraviolet radiation for retrieving daily global map of atmospheric ozone. TOU will provide the important parameters for environmental monitoring, climate forecasting and global climate changing research. At present, the in-orbit testing of TOU has accomplished and won a consummation, and it will be delivered to National Satellite Meteorological Center for the operational phase of the project. In this paper we introduce the instrument of TOU and its measuring principle, in general. We also analyze the recent working status of the instrument, including the sensitivity, measuring precision of solar irradiance, diffuser degradation and wavelength drift. The inversion results show that TOU can provide good global ozone maps, and a comparison with the OMI total ozone product shows that their RMS deviation is about 5%. It is indicated that the satisfied global distribution of total ozone can be obtained through TOU observational data and self-developed inversion method. | WANG YongMei WANG YingJian WANG WeiHe ZHANG ZhongMou LU JianGong FU LiPing JIANG Fang CHEN Ji WANG JiHong GUAN FengJun HUANG FuXiang ZHANG XingYing | 2010 | Chinese Science Bulletin2010，55，1： | 9 |
| 13 | A Novel Method for Making NiO Nanofibres via An Electrospinning Technique显示文摘Thin PVA/nickel acetate composite fibres were prepared by using sol-gel processing and electrospinning technique. After calcination of the above precursor fibres, NiO nanofibres with a diameter of 50-150 nm could be successfully obtained. The fibres were characterized by SEM, FT-IR, WAXD, respectively. | ChangLuSHAO HongYuGUAN ShangBinWEN BinCHEN XingHuaYANG JianGONG | 2004 | Chinese Chemical Letters2004，15，3： | 8 |
| 14 | Correction of Observation Interference on Z component of Geomagnetic Field From DC Power Lines显示文摘为减小直流输电线路对地磁场观测的干扰,采用数学计算的方法精确求解了线路对地磁Z分量的干扰水平。以观测点为原点建立了地磁仪器观测点坐标系,推导了观测点坐标系各坐标轴在地心坐标系中的单位矢量表达式。根据空间矢量点积的定义,得到了空间电流磁场矢量投影到地磁Z分量方向的求解公式。利用推导的公式和直流线路电流磁场三维计算模型,最终求得直流线路对地磁Z分量观测的干扰水平。由此,开发了"直流线路对地磁观测干扰校正系统",并开展了地磁台站和野外联合地磁观测干扰实验。结果表明,直流线路和地磁观测台站距离不超过10km时,提出的数学模型和计算方法误差不超过5%。 | TANG Bo ZHANG Jiangong MENG Suimin LIU Xingfa DENG Changzheng | 2012 | 中国电机工程学报2012，32，30： | 8 |
| 15 | Aromatic compounds from an aqueous extract of “ban lan gen” and their antiviral activities显示文摘A pair of new diphenyl glycerol ether enantiomers(-)-l and(+)-l and two new methyl benzamidobenzoates 2 and 3,named(-)-(R)-and(+)-(S)-isatindigotrioic acid[(-)-l and(+)-l]and isatindigoticamides A(2) and B(3),respectively,were isolated from an aqueous decoction of the roots of Isatis indigotica(ban lan gen).Their structures were elucidated by spectroscopic data analysis including2 D NMR experiments.The absolute configurations of(-)-l and(+)-l were assigned based on the CD exciton chirality method.Compounds 2 and 3 exhibited antiviral activities against HSV-1 with IC_(50)values of 4.87 and 25.87μmol/L,respectively.Compound 2 was also found active against Coxsackie virus B3 and LPS-induced NO production. | Yufeng Liu Minghua Chen Qinglan Guo Yuhuan Li Jiandong Jiang Jiangong Shi | 2017 | Acta Pharmaceutica Sinica B2017，7，2： | 8 |
| 16 | Sulfur-enriched alkaloids from the root of Isatis indigotica显示文摘Five new sulfur-enriched alkaloids isatithioetherins A–E(1–5), and two pairs of scalemic enantiomers(t)-and( à)-isatithiopyrin B(6 a and 6 b) and isoepigoitrin and isogoitrin(7 a and 7 b), along with the known scalemic enantiomers epigoitrin and goitrin(8 a and 8 b), were isolated and characterized from an aqueous extract of the Isatis indigotica roots. Their structures were determined by extensive spectroscopic data analysis, including 2 D NMR and theoretical calculations of electronic circular dichroism(ECD) spectra based on the quantum-mechanical time-dependent density functional theory(TDDFT). Compounds 1–5 represent a novel group of sulfur-enriched alkaloids, biogenetically originating from stereoselective assemblies of epigoitrin-derived units. Isolation and structure characterization of 6 a and 6 b support the postulated biosynthetic pathways for the diastereomers 9 a and 9 b via a rare thio-Diels–Alder reaction. Compounds 2 and 4 showed antiviral activity against the influenza virus A/Hanfang/359/95(H3 N2, IC500.60 and 1.92 μmol/L) and the herpes simplex virus 1(HSV-1, IC503.70 and 2.87 μmol/L), and 2 also inhibited Coxsackie virus B3(IC500.71 μmol/L).& 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license(http://gffzzeb6f7f563f66445dhp00b90ocp9wk6bvw.ffgz.tsg.suse.edu.cn/licenses/by-nc-nd/4.0/). | Qinglan Guo Chengbo Xu Minghua Chen Sheng Lin Yuhuan Li Chenggen Zhu JiANDong Jiang Yongchun Yang Jiangong Shi | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 8 |
| 17 | Isatindolignanoside A, a glucosidic indole-lignan conjugate from an aqueous extract of the Isatis indigotica roots显示文摘A glucosidic indole-lignan conjugate with a novel carbon skeleton, named isatindolignanoside A(1), was isolated from an aqueous extract of the Isatis indigotica roots 'ban lan gen'. Its structure was elucidated by comprehensive analysis of spectroscopic data, including J-and NOESY correlation-based configurational analysis, circular dichroism(CD) data, enzyme hydrolysis, and theoretical ECD calculation. In a preliminary assay, compound 1 showed antiviral activity against Coxsackie virus B3. This compound is the first example of natural product having a structural feature of conjugation between indole and lignan units, and its biosynthetic pathway is postulated. | Lingjie Meng Qinglan Guo Minghua Chen JiANDong Jiang Yuhuan Li Jiangong Shi | 2018 | Chinese Chemical Letters2018，29，8： | 7 |
| 18 | Effect of Yiqihuoxue prescription on myocardial energy metabolism after myocardial infarction via cross talk of liver kinase B1-depen-dent Notch1 and adenosine 5'-monophosphate-activated protein kinase显示文摘OBJECTIVE: To investigate the effect of Yiqihuoxue prescription(YQHX) from Traditional Chinese Medicine(TCM) on myocardial glucose and lipid metabolism after myocardial infarction via the cross talk between the liver kinase B1(LKB1)-dependent Notch1 and adenosine 5'-monophosphate(AMP)-activated protein kinase(AMPK). YQHX was prepared with substances with properties that benefit, to activate blood circulation based on the TCM theory.METHODS: Animal models of myocardial infarction were established by ligating Sprague Dawley rats' left anterior descending coronary arteries. The animals were randomly divided into a myocardial infarction(MI) group, a YQHX group, a perindopril group, a γ-secretase inhibitor, Notch signal inhibitor(DAPT) group, a DAPT+YQHX group and a sham group. The related drugs were administered on the second day after operation, and changes in the relevant indexes were examined on weeks 1 and 4.Changes in cardiac structure and function were examined by echocardiography. The glucose and free fatty acids(FFA) were examined by ELISA. The expression of Notch, LKB1 and AMPK m RNA was examined by a real-time fluorescence quantitative method. The expression of glucose transporter 4(GLUT4), and the expression of total acetyl-Co A carboxylase(ACC) and its phosphorylation were examined by western blotting.RESULTS: Compared with the sham group, the expression of Notch, LKB1 and AMPK m RNA in the MI group was lower. Compared with the MI group, the expression of these m RNAs in the YQHX and perindopril groups was higher, and their expression in the DAPT group was lower. At all time points, the protein expression of GLUT4 and p ACC decreased in the MI group. On week 1, the expression of p ACC protein was higher. In the DAPT group, the expression of p ACC protein decreased. Compared with the YQHX group, the expression of p ACC protein in the DAPT + YQHX group was lower. On week 4,compared with the MI group, the expression of GLUT4 protein in the YQHX group and the perindo-pril group was higher. The expression of GLUT4 protein in the DAPT group decreased. Compared with the YQHX group, the expression of GLUT4 protein in the DAPT+YQHX group was lower. There was no significant difference in the expression of ACC protein between the groups.CONCLUSION: YQHX promoted cross talk between the LKB1-dependent Notch1 and AMPK in myocardial tissue after myocardial infarction. Furthermore,it regulated the glucose and lipid metabolism of cardiomyocytes at different time points, thereby ameliorating the cardiac energy metabolism via different mechanisms and protecting the heart. | Wu Jiangong Chen Xi Guo Shuwen Liu Wenchen Zhang Lu Li Fanghe Wu Jiani Huang Xiaolou Cai Qian Tan Xiaobo Wang Hui | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 7 |
| 19 | (+)-/(-)-Angelignanine,a pair of neolignan enantiomers with an unprecedented carbon skeleton from an aqueous extract of the Angelica sinensis root head显示文摘A pair of neolig nan enan tiomers with an unprecedented carb on skelet on,(+)-/(-)-angeligna nine[(+)-/(-)-1].was isolated as minor components of an aqueous extract of the Angelica sinensis root heads(guitou).Their structures were determined by spectroscopic data analysis and the absolute configurations were assigned by the circular dichroism(CD)exciton chirality method as well as electronic CD quantum calculations.The enantiomers represent the first 2,7/-cyclo-8,9z-neolignans,of which biosynthetic pathways originating from precursors ferulic acid and coniferyl alcohol is proposed.In an in vivo test,both the enantiomers showed significant hypnotic effects at a dose of 10 mg/kg(i.g.). | Youzhe Chen Qinglan Guo Chengbo Xu Chenggen Zhu Jianjun Zhang Jiangong Shi | 2021 | Chinese Chemical Letters2021，32，5： | 7 |
| 20 | Effect of NH_4F and Nano-SiO_2 on Morphological Control of α-Al_2O_3 Platelets via Solid-state Reaction显示文摘Alpha-alumina(α-Al_2O_3) platelets were prepared via solid-state reaction using pseudo-boehmite as the starting material, while NH_4F and nano-SiO_2 were used as additives, and nitric acid was used as the binder. The effect of these additives on properties of the alumina platelets was determined via scanning electron microscopy, X-ray diffraction, and measurements of the surface area and silicon content. A mechanism governing their role in the synthesis process was proposed. The results indicated that NH_4F could promote the formation of highly crystalline platelets. Addition of nano-SiO_2 could lead to increase in the diameter and reduction in the thickness of the platelets, and could also prevent their transformation to α-Al_2O_3. This addition weakened the effect of NH_4F because of the reaction of nano-SiO_2 with F-species and the formation of volatile SiF_4. | Miao Zhuang Shi Jiangong Zhang Wenping Zhang Minhong | 2016 | China Petroleum Processing & Petrochemical Technology2016，18，4： | 7 |
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