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| 1 | Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection显示文摘The coronavirus disease 2019(COVID-19)pandemic is caused by infection with the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which is spread primary via respiratory droplets and infects the lungs.Currently widely used cell lines and animals are unable to accurately mimic human physiological conditions because of the abnormal status of cell lines(transformed or cancer cells)and species differences between animals and humans.Organoids are stem cell-derived selforganized three-dimensional culture in vitro and model the physiological conditions of natural organs.Here we showed that SARS-CoV-2 infected and extensively replicated in human embryonic stem cells(hESCs)-derived lung organoids,including airway and alveolar organoids which covered the complete infection and spread route for SARS-CoV-2 within lungs.The infected ceils were ciliated,club,and alveolar type 2(AT2)cells,which were sequentially located from the proximal to the distal airway and terminal alveoli,respectively.Additionally,RNA-seq revealed early cell response to virus infection including an unexpected downregulation of the metabolic processes,especially lipid metabolism,in addition to the well-known upregulation of immune response.Further,Remdesivir and a human neutralizing antibody potently inhibited SARS-CoV-2 replication in lung organoids.Therefore,human lung organoids can serve as a pathophysiological model to investigate the underlying mechanism of SARS-CoV-2 infection and to discover and test therapeutic drugs for COVID-19. | Rongjuan Pei Jianqi Feng Yecheng Zhang Hao Sun Lian Li Xuejie Yang Jiangping He Shuqi Xiao Jin Xiong Ying Lin Kun Wen Hongwei Zhou Jiekai Chen Zhili Rong Xinwen Chen | 2021 | Protein & Cell2021，12，9： | 7 |
| 2 | Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients显示文摘Dear Editor,In 2019,a zoonotic coronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was identified as the causative agent of Coronavirus Disease 2019(COVID-19).As of 8 June 2020,the World Health Organization(WHO)has reported 6,912,751 globally confirmed cases with 400,469 deaths.Although generally causes mild disease,SARS-CoV-2 infection can result in serious outcomes,including acute lung injury(ALI)and acute respiratory distress syndrome(ARDS),the leading cause of mortality in patients with comorbidities.Recent autopsy studies of COVID-19 patients revealed mononuclear infiltration and excessive production of mucus in the infected lung,especially in the damaged small airways and alveoli(Bian and Team,2020;Liu et al.,2020). | Jiangping He Shuijiang Cai Huijian Feng Baomei Cai Lihui Lin Yuanbang Mai Yinqiang Fan Airu Zhu Huang Huang Junjie Shi Dingxin Li' Yuanjie Wei Yueping Li Yingying Zhao’ Yuejun Pan He Liu Xiaoneng Mo Xi He Shangtao Cao FengYu Hu Jincun Zhao Jie Wang Nanshan Zhong Xinwen Chen Xilong Deng Jiekai Chen | 2020 | Protein & Cell2020，11，9： | 7 |
| 3 | Vertical Distribution of Soil Carbon, Nitrogen, and Phosphorus in Typical Chinese Terrestrial Ecosystems显示文摘Characterization of the vertical distribution of soil organic carbon(C), nitrogen(N), and phosphorus(P) may improve our ability to accurately estimate soil C, N, and P storage. Based on a database of 21 354 records in 74 long-term monitoring plots from 2004 to 2013 in the Chinese Ecosystem Research Network(CERN), we built fitting functions to quantify the vertical distribution of soil C, N, and P(up to 100 cm depth) in the typical Chinese terrestrial ecosystems. The decrease of soil C, N, and P content with depth can be well fitted with various mathematical functions. The fitting functions differed greatly between artificial(agriculture) and natural(desert, forest, and grassland) ecosystems, and also differed with respect to soil C, N, and P content. In both the artificial and natural ecosystems, the best fitting functions were exponential functions for C, quadratic functions for N, and quadratic functions for P. Furthermore, the stoichiometric ratios of soil C, N, and P were ranked in descending order: grassland > forest > agriculture > desert, and were also associated with climate. This study is the first to build the fitting functions for the profile distribution of soil C, N, and P in China at a national scale. Our findings provide a scientific basis to accurately assess the storage of C, N, and P in soils at a large scale, especially for the integrative analysis of historical data. | CHAI Hua YU Guirui HE Nianpeng WEN Ding LI Jie FANG Jiangping | 2015 | Chinese Geographical Science2015，25，5： | 7 |
| 4 | Multi-proxy evidence of environmental change related to collapse of the Liangzhu Culture in the Yangtze Delta,China显示文摘The Liangzhu Culture(5300–4300 cal.a BP)has been regarded as the culmination of the Neolithic Age in the Yangtze Delta and as an archaic state.However,the reason behind the collapse of the Liangzhu Culture remains controversial.Some scholars attributed it to social conflicts or foreign invasions,while others suggested that environmental deterioration,such as cold episodes,inundation and palaeo-typhoon events,disrupted the civilization.Notably,the yellowish silty sediments widely overlying the Liangzhu group sites have been presumed to be one of the vital clues to resolving these issues.The process and cause of their formation are key to understanding the decline in the Liangzhu Culture.In this study,two typical profiles composed of the Liangzhu cultural layer and yellowish silty sediments were collected in Liangzhu Ancient City.Multiple proxies,including pollen,phytoliths and diatoms,along with radiocarbon and optically stimulated luminescence dating and synthesized geochemical evidence from different sediments,were applied to reconstruct ecological and hydrological changes and discuss their linkage to cultural collapse.The regional ecology was typical freshwater wetlands during 4800–4400 cal.a BP,which facilitated rice farming and large-scale architectural engineering in Liangzhu Ancient City.Evidence from microfossils and dating of the yellowish silty sediments indicated that Liangzhu Ancient City was significantly affected by seawater after abandonment during 4300–3400 cal.a BP.Furthermore,geochemical evidence,including trace element and Sr-Nd isotopic compositions,suggested that the primary provenance of the yellowish silt was a mixture of sediments from the Qiantang River,East China Sea,Yangtze River and Yellow River,which had been transported to Liangzhu Ancient City by the Yellow Sea Coastal Current and a marine transgression.Therefore,based on evidence from archaeological sites and numerical simulation in the Yangtze Delta,it was supposed that the short-term accelerated relative sea-level rise at approximately 4400 cal.a BP caused a marine transgression around Taihu Lake,formed a large range of yellowish silty sediments,destroyed rice farming production,and ultimately led to the collapse of the Liangzhu Culture. | Keyang HE Houyuan LU Guoping SUN Xiang JI Yonglei WANG Kaikai YAN Xinxin ZUO Jiangping ZHANG Bin LIU Ningyuan WANG | 2021 | Science China Earth Sciences2021，64，6： | 3 |
| 5 | In situ preparation of poly (ethylene terephthalate)-SiO2 nanocomposites显示文摘 | Jiangping He Huaming Li Xiayu Wang | 2006 | European Polymer Journal2006，42，： | 1 |
| 6 | Struc- ture of InSb (100) Surface 显示文摘 | Dawid Toton Jiangping He Crzegorz Goryl | 2010 | J Phys: Condens mat- ter2010，22，26： | 1 |
| 7 | Osteoclast stimulatory transmembrane protein induces a phenotypic switch in macrophage polarization suppressing an M1 pro-inflammatory state显示文摘 | Huimin Yuan Jiangping He Guangya Zhang Dandan Zhang Xiangxin Kong Fengling Chen | 2017 | Acta Biochimica et Biophysica Sinica2017，49，10： | 1 |
| 8 | miR-141 regulates TGF-β1-induced epithelial-mesenchymal transition throughrepression of HIPK2 expression in renal tubular epithelial cells显示文摘 | Yuanhang Huang Junrong Tong Feng He Xinpei Yu Liming Fan Jing Hu Jiangping Tan Zhengliang Chen | 2015 | International Journal of Molecular Medicine2015，，2： | 1 |
| 9 | Microstructure and properties of epoxy foams prepared by microwave 显示文摘 | Zhong Fachun He Jiangping Wang Xiaochuan | 2009 | J Appl Polym Sci2009，112，： | 1 |
| 10 | Irrigation scheduling based on CERES-Wheat model for spring wheat production in the Minqin Oasis in Northwest China显示文摘 | Jianqiang He Huanjie Cai Jiangping P ai | 2013 | Agricultural Water Management2013，128，： | 1 |
| 11 | Irrigation scheduling based on CERES-Wheat model for spring wheat production in the Minqin Oasis in Northwest China显示文摘 | Jianqiang He Huanjie Cai Jiangping Bai | 2013 | Agricultural Water Management2013，，： | 1 |
| 12 | KDM2B能够依赖其招募PRC1.1复合物的功能调控体细胞重编程显示文摘文章简介PRC1(Polycomb Repressive Complex 1)复合物在发育过程中起着非常重要的作用,很多复合物成分的缺失或者异常都能直接导致胚胎发育的异常。最近的研究发现PRC1包含多种变体,但是其对细胞命运调控的具体机制并不十分清楚。 | Zhiwei Zhou Xuejie Yang Jiangping He Jing Liu Fang Wu Shengyong Yu Yuting Liu Runxia Lin He Liu Yuanbin Cui Chunhua Zhou Xiaoshan Wang Jian Wu Shangtao Cao Lin Guo Lihui Lin Tao Wang Xiaozhong Peng Boqing Qiang Andrew P.Hutchins 裴端卿 陈捷凯 | 2018 | 科学新闻2018，0，4： | 0 |
| 13 | Genome resequencing reveals the evolutionary history of garlic reproduction traits显示文摘The propagation of cultivated garlic relies on vegetative cloves,thus flowers become non-essential for reproduction in this species,driving the evolution of reproductive feature-derived traits.To obtain insights into the evolutionary alteration of reproductive traits in the clonally propagated garlic,the evolutionary histories of two main reproduction-related traits,bolting and flower differentiation,were explored by genome analyses using 134 accessions displaying wide diversity in these two traits.Resequencing identified 272.8 million variations in the garlic genome,198.0million of which represent novel variants.Population analysis identified five garlic groups that have evolved into two clades.Gene expression,single-cell transcriptome sequencing,and genome-wide trait association analyses have identified numerous candidates that correlate with reproductive transition and flower development,some of which display distinct selection signatures.Selective forces acting on the B-box zinc finger protein-encoding Asa2G00291.1,the global transcription factor group E protein-encoding Asa5G01527.1,and VERNALIZATION INSENSITIVE 3-like Asa3G03399.1 appear to be representative of the evolution of garlic bolting.Plenty of novel genomic variations and trait-related candidates represent valuable resources for biological studies of garlic.Numerous selective signatures from genes associated with the two chosen reproductive traits provide important insights into the evolutionary history of reproduction in this clonally propagated crop. | Haiping Wang Einat Shemesh-Mayer Jiangjiang Zhang Song Gao Zheng Zeng Zemao Yang Xueyu Zhang Huixia Jia Yanzhou Wang Jiangping Song Xiaohui Zhang Wenlong Yang Qiaoyun He Amir Sherman Lin Li Rina Kamenetsky Touming Liu | 2023 | Horticulture Research2023，10，11： | 0 |
| 14 | 化学小分子诱导多能干细胞过程染色质可及性动态变化规律显示文摘文章简介尽管化学小分子诱导多能干细胞(CIP)技术有着令人振奋的潜力和应用前景,但仍存在效率低下,机制不明等问题。在本研究中,课题组开发了无需血清、不用重新传代分盘的高效两步CIP技术. | 曹尚涛 余胜勇 李东伟 Jing Ye Xuejie Yang Chen Li Xiaoshan Wang Yuanbang Mai Yue Qin Jian Wu Jiangping He Chunhua Zhou He Liu Bentian Zhao Xiaodong Shu Chuman Wu Ruiping Chen Waiyee Chan Guangjin Pan Jiekai Chen 刘晶 裴端卿 | 2019 | 科学新闻2019，0，2： | 0 |
| 15 | Polydopamine-Assisted Fabrication of Stable Silver Nanoparticles on Optical Fiber for Enhanced Plasmonic Sensing显示文摘We present a facile and effective method for fabrication of the localized surface plasmon resonance(LSPR)optical fiber sensor assisted by two polydopamine(PDA)layers with enhanced plasmonic sensing performance.The first PDA layer was self-polymerized onto the bare optical fiber to provide the catechol groups for the reduction from Ag^(+)to Ag^(o) through chelating and redox activity.As the reduction of Ag^(+)proceeds,Ag nanoparticles(NPs)were grown in-situ on the PDA layer with uniform distribution.The second PDA layer was applied to prevent Ag NPs from oxidating and achieve an improvement of LSPR signal.The PDA/Ag/PDA-based optical fiber sensor has an enhanced LSPR sensitivity of 961 nm/RIU and excellent oxidation resistance.The stable PDA/Ag/PDA-based LSPR sensor with high optical performance is very promising for future application in optical sensing field. | Yiwen TANG Hui YUAN Jiangping CHEN Qiguo XING Rongxin SU Wei QI Zhimin HE | 2020 | Photonic Sensors2020，10，2： | 0 |
| 16 | Balanced and Coordinated Development of Chemistry in China显示文摘Balanced and coordinated development of Chemistry has narrow sense and generalized com- prehension.The former only refers to the balanced layout and coordinated development among'every discipline and specialty in chemistry',and the latter taking the balanced layout of discipline as core and synthetically balancing the talent troop,the region distribution,the national strategy demand as well as the social affect and so on.At the present,the chemistry in China totally represents discipline bal- ance and coordination,and interdisciplinary is obvi- ous. | He Tianping Wang Fei Ding Hong Xing Jiangping | 2007 | Science Foundation in China2007，15，2： | 0 |
| 17 | 诱导多能性干细胞过程中染色质可及性动态变化规律显示文摘文章简介关于体细胞重编程中染色质结构重排的机制一直没有被清晰地研究过。本研究通过采用可在全基因组范围内研究开放染色质的ATAC(Assay for Transposase-Accessible Chromatin)技术。 | 李东伟 刘晶 杨雪洁 Chunhua Zhou Jing Guo Chuman Wu Yue Qin Lin Guo Jiangping He Shenyong Yu He Liu Xiaoshan Wang Fang Wu Junqi Kuang Andrew P.Hutchins 陈捷凯 裴端卿 | 2018 | 科学新闻2018，0，4： | 0 |
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