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| 1 | Hyperhomocysteinemia-mediated DNA Hypomethylation and its Potential Epigenetic Role in Rats显示文摘Hyperhomocysteinemia (HHcy ) 它是为动脉粥样硬化,基因表达的力量原因 dysregulation,而是特征和关键连接的一个独立风险因素在它的病原的机制包含了仍然糟糕被理解。学习是在 DNA methylation 和人半胱氨酸(Hcy ) 的内在的机制上调查 HHcy 的效果的礼品的目的导致了 DNA methylation.HHcy 在 4 星期一本低、中等或高的蛋氨酸食谱以后在 Sprague-Dawley 老鼠被导致。全部的人半胱氨酸的层次,S-腺苷甲硫氨酸( AdoMet ) andS-adenosylhomocysteine ( AdoHcy )被基因的高效的液体 chromatography.Theexpression 层次检测,S-腺苷高半胱氨酸水疗院的蛋白质放射激光, DNA methyltransferaseand methyl-CpG-binding 领域 2 被即时反向的抄写聚合酶链反应和蛋白质印迹 analysis.A 检测高产量的量的 methylation 试金 基于usingfluorescence 的即时聚合酶链反应被采用决定 DNAmethylation.The 结果的层次显示 HHcy 导致了 AdoHcy 集中的举起, AdoMet 集中的衰落, AdoMet/AdoHcy 和 RNA 和蛋白质表示 ofS-adenosylhomocysteine 水疗院的比率放射激光并且 methyl-CpG-binding 领域 2 ,以及 DNAmethyltransferase 的增加活动。与不同 methylation 依赖的限制 endonucleases,异常 demethylation 被发现喜欢 CCGG 序列而不是 CpG 岛。在 B1 重复元素的 HHcysignificantly 增加的染色体 hypomethylation 的增加的层次。HHcy 的不同层次的影响证明 HHcy 的改变的有害效果能通过不同机制被归因于不同集中。在温和、中等的 HHcy, Hcy 可能首先通过 transferringmethyl 组新陈代谢的干扰影响基因表达的 epigenetic 规定。在高 Hcy 集中,然而,影响可能通过氧化应力, apoptosis 和发炎是更有害的。 | Yideng JIANG Tao SUN Jiantuan XIONG Jun CAO Guizhong LI Shuren WANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，9： | 16 |
| 2 | Ligands of Peroxisome Proliferator-activated Receptor Inhibit Homocysteineinduced DNA Methylation of Inducible Nitric Oxide Synthase Gene显示文摘高半胱氨酸(Hcy ) 是为动脉粥样硬化的一个风险因素。可诱导的氮的氧化物合酶(i NOS ) 是在脉管的疾病的规定的关键酶,这通常被接受。现在的学习的目的是在人的单核白血球面对 Hcy 在 i NOS 上调查激活 peroxisomeproliferator 的受体 ligands 的效果。Foamcells,导致了由氧化低密度脂蛋白(ox-LDL ) 和 phorbol 十四酸盐醋酸盐(PMA ) 面对在人的单核白血球 for4 d 的 Hcy, clofibrate 和 pioglitazone 的不同集中,被染色的油红 O 检验。i NOS 的活动被 real-timequantitative 颠倒抄写聚合酶链反应和蛋白质印迹分析检测。DNA methylation 的 Thecapability 被 assaying 测量内长的 C5 DNA 甲基转移酶(C5MTase ) 活动,和 i NOS 倡导者 methylation 水平被量的 MethyLight 试金决定。结果显示 Hcy 增加了 C5MTase 的活动和 i NOS 基因 DNAmethylation 的水平,导致 i NOS 表示的减少。Clofibrate 和 pioglitazone 能通过 DNA methylation 在 i NOS 表示上反对 hcy 效果,导致变细 ofiNOS 抄写。这些调查结果建议 Hcy 减少了由 elevatingiNOS DNA methylation 的 i NOS 的表示铺平一些基因的抄写,它能镇压。激活 Peroxisomeproliferator 的受体 alpha/gamma ligands 装下面调整 i NOS DNA methylation,并且能为由镇压阻止导致 Hcy 的动脉粥样硬化有用 i NOS 表示。 | Yideng JIANG Jianzhong ZHANG Jiantuan XIONG Jun CAO Guizhong LI Shuren WANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，5： | 9 |
| 3 | miR-30a-5p promotes glomerular podocyte apoptosis via DNMT1-mediated hypermethylation under hyperhomocysteinemia显示文摘Abnormal elevation of homocysteine(Hcy)level is closely related to the development and progression of chronic kidney disease(CKD),with the molecular mech2anisms that are not fully elucidated.Given the demonstration that miR-30a-5p is specifically expressed in glomerular podocytes,in the present study we aimed to investigate the role and potential underlying mechanism of miR-30a-5p in glomerular podocyte apoptosis induced by Hcy.We found that elevated Hcy downregulates miR-30a-5p expression in the Cbs^(+/-)-mice and Hcy-treated podocytes,and miR-30a-5p directly targets the 3′-untranslated region(3′-UTR)of the forkhead box A1(FOXA1)and overexpression of miR-30a-5p inhibits FOXA1 expression.By nMS-PCR and MassARRAY quantitative methylation analysis,we showed the increased DNA methylation level of miR-30a-5p promoter both in vivo and in vitro.Meanwhile,dual-luciferase reporter assay showed that the region between--1400 and--921 bp of miR-30a-5p promoter is a possible regulatory element for its transcription.Mechanistic studies indicated that DNA methyltransferase enzyme 1(DNMT1)is the key regulator of miR-30a-5p,which in turn enhances miR-30a-5p promoter methylation level and thereby inhibits its expression.Taken together,our results revealed that epigenetic modification of miR-30a-5p is involved in glomerular podocyte injury induced by Hcy,providing a diagnostic marker candidate and novel therapeutic target in CKD induced by Hcy. | Ning Ding Lin Xie Fei Ma Shengchao Ma Jiantuan Xiong Guanjun Lu Huiping Zhang Yideng Jiang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，1： | 4 |
| 4 | Homocysteine- mediated PPARa, g DNA methylationand its potential pathogenic mechanism in monocytes显示文摘 | YIDENG J ZHIHONG L JIANTUAN X | 2008 | DNA Cell Biol2008，27，3： | 1 |
| 5 | New Bipolar Electrocoagulation - electroflotation Process for the Treatment of Laundry Wastewater 显示文摘 | Ge Jiantuan | 2004 | Separation and Purification Technology2004，36，： | 1 |
| 6 | New bipolar electrocoagulation-electro-flotation process for the treatment of laundry wastewater显示文摘 | Ge Jiantuan Qu Jiuhui Lei Pengju | 2004 | Journal of Hazardous Materials2004，36，1： | 1 |
| 7 | Ultrasonic irradiation enhanced degradation of azo dye on MnO2显示文摘 | Jiantuan Ge Jiuhui Qu | 2004 | Applied Catalysis B: Environmental2004，47，： | 1 |
| 8 | Degradation of azo dye Acid Red 14 in aqueous solution by electrokinetic and electrooxidation process显示文摘 | Aimin Wang Jiuhui Qu Huijuan Liu Jiantuan Ge | 2004 | Chemosphere2004，55，： | 1 |
| 9 | Degradation of azo dye acid red B on manganese dioxide in the absence and presence of ultrasonic irradiation显示文摘 | Jiantuan Ge Jiuhui Qu | 2003 | Journal of Hazardous Materials B2003，100，： | 1 |
| 10 | Degradation of azo dye acid red B on manganese dioxide in the absence and presence of ultrasonic irradiation显示文摘 | Jiantuan Ge Jiuhui Qu | 2003 | Journal of Hazardous Materials B2003，100，13： | 1 |
| 11 | Changes in the epigenome and transcriptome of rice in response to Magnaporthe oryzae infection显示文摘DNA methylation participates in regulating the expression of coding and non-coding regions in plants. To investigate the association between DNA methylation and pathogen infection, we used whole-genome bisulfite sequencing to survey temporal DNA methylation changes in rice after infection with the rice blast fungus Magnaporthe oryzae. In contrast to previous findings in Arabidopsis, global DNA methylation levels in rice increased slightly after rice blast infection. We identified over 38,000 differentially methylated regions(DMRs), and hypermethylated DMRs far outnumbered hypomethylated DMRs. Most DMRs were located in transposable element regions. Using transcriptome analysis, we identified 8830 differentially expressed genes(DEGs) after 1, 3, and 5 days of infection. Over one-third of DEGs, most of which were CHH-type DMRs, were associated with DMRs. Functional analysis of the CHH DMR-DEGs indicated their involvement in many important biological processes, including cell communication and response to external stimulus. The transcription of many NBS-LRR family genes was affected by changes in DNA methylation, suggesting that DNA methylation plays essential roles in the response of rice to M. oryzae infection. More broadly, the DNA methylation analysis presented here sheds light on epigenomic involvement in plant defense against fungal pathogens. | Na Cui Xiaofeng Chen Yan Shi Meirong Chi Jiantuan Hu Kunlong Lai Zonghua Wang Haifeng Wang | 2021 | The Crop Journal2021，9，4： | 1 |
| 12 | 显示文摘 | Jiantuan Ge Jiuhui Qu Pengju Lei | 2004 | Separation and Purification Technology2004，36，1： | 1 |
| 13 | Homocysteine-mediated PPARalpha, gamma DNA methylation and its potential pathogenic mechanism in monoeytes显示文摘 | Yideng J Zlfilaong L Jiantuan X | 2008 | DNA Cell Biol2008，27，： | 1 |
| 14 | Ultrasonic irradiation enhanced degradation of azo dye on MnO2显示文摘 | GE Jiantuan QU Jiuhui | 2004 | Appliod Catalysis B:Environmental2004，47，2： | 1 |
| 15 | Homocysteine - mediated PPARalpha, gamma DNA methylation and its potential pathogenic mechanism in monocytes 显示文摘 | Yideng J Zhihong L Jiantuan X | 2008 | DNA Cell Biol2008，27，3： | 1 |
| 16 | New bipolar electrocoagulation-electroflotation process for the treatment of laundry wastewater显示文摘 | GE Jiantuan QU Jiuhui LEI Pengju | 2004 | Separation and Purification Technology2004，36，1： | 1 |
| 17 | New bipolar electro- coagulation-electroflotation process for the treatment of laun- dry wastewater显示文摘 | GE Jiantuan QU Jiuhui LEI Pengju | 2004 | Separation and Purification Technology2004，36，1： | 1 |
| 18 | Degradation of azo dye acid red B on manganese dioxide in the absence and presence of ultrasonic irradiation显示文摘 | Jiantuan Ge Jiuhui Qu | 2003 | Journal of Hazardous Materials2003，，1： | 1 |
| 19 | New bipolar electrocoagulation-electroflotation process for the treatment of laundry wastewater显示文摘 | Jiantuan Ge | 2004 | Separation and Purification Technology2004，36，1： | 1 |
| 20 | Degradation of azo dye acid red B on manganese dioxide in the absence and presence of ultrasonic irradiation显示文摘 | Jiantuan Ge Jiuhui Qu | 2003 | Journal of Hazardous Materials B2003，100，： | 1 |
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