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| 1 | Floor heave in the west wing track haulage roadway of the Tingnan Coal Mine: Mechanism and control显示文摘Floor heave of a roadway is a dynamic phenomenon that often happens in the roadways of coal mines. It seriously affects safe production in the coal mine. Floor heave has long been one of the most difficult problems to be resolved during coal mining. An analysis of floor heave in the soft rock surrounding the roadway, and the factors influencing it, allowed the deformation mechanism in the west wing double track haulage roadway of the Tingnan Coal Mine to be deduced. Three types of floor heave are observed there: intumescent floor heave, extrusion and mobility floor heave, and compound floor heave. Control measures are proposed that have been adopted during a recent repair engineering project. Control of the floor heave in the west wing track haulage roadway was demonstrated. The reliability and rationality of a combined support technology including floor anchors, an inverted arch, and anchoring of both sides was verified by mine pressure data and the field observations. Waterproofing measures were also under-taken to assist in the control of floor heave. | Wang Jiong | 2012 | International Journal of Mining Science and Technology2012，22，3： | 18 |
| 2 | Edaravone injection reverses learning and memory deficits in a rat model of vascular dementia显示文摘Edaravone 是由禁止 endothelial 损害并且由改善施加 neuroprotective 效果的新奇免费激进的 scavenger 在大脑局部缺血的 neuronal 损坏。最近, edaravone 能减轻病理和 Alzheimers 疾病病人的认知赤字,这被报导。然而,它到脉管的痴呆(VaD ) 的关联不是清楚的。在这研究,我们部分堵塞了老鼠的双边的颈动脉动脉通过手术导致长期的服的 hypoperfusion (CCH ) , VaD 的一个著名老鼠模型。水迷宫和电压降低的禁止的测试被用来评估记忆赤字。superoxide dismutase 的活动 ?( 草皮) 并且喂奶脱氢酶(LDH ) , malondialdehyde 的内容 ?(MDA ) 并且全部的反应的氧种类被测量评估氧化压力水平。西方的污点分析被用来计算 synaptic 蛋白质表达式。有为一个 5 星期的时期的 edaravone 的治疗在有 CCH 的老鼠对空间的颠倒和害怕记忆赤字有能力,这被发现。Edaravone 显著地由增加草皮活动并且减少与 CCH 在老鼠的大脑减少了氧化应力的水平 MDA, LDH,和全部的反应的氧种类的内容。而且, edaravone 处理也与 CCH 在老鼠的海马恢复了多重 synaptic 蛋白质的层次。我们的数据提供在 VaD 支持 edaravone 的 neuroprotective 效果的直接证据。我们建议氧化应力的缓和和 synaptic 蛋白质的恢复在 neuroprotection 起重要作用。 | Xu Li Fen Lu Wei Li Lingzhi Qin Yong Yao Xuerong Ge Qingkai Yu Xinliang Liang Dongmei Zhao Xiaohong Li Jiewen Zhang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，1： | 14 |
| 3 | Comparative efficacy and safety of Chinese herbal injections combined with transcatheter hepatic arterial chemoembolization in treatment of liver cancer: a bayesian network Meta-analysis显示文摘OBJECTIVE: To address the optimal Chinese herbal injections(CHIs) against liver cancer, the present network Meta-analysis is designed to investigate the comparative efficacy and safety of different CHIs.METHODS: Several electronic databases were searched up to June 1 st, 2017. The quality assessment was conducted and network Meta-analysis was performed to compare the efficacy and safety of different CHIs plus transcatheter hepatic arterial chemoembolization(TACE). Primary outcomes were 1-year and 2-year survival rate, the secondary outcomes includes the clinical effective rate, performance status and the adverse reactions(ADRs). Data analysis was applied Stata 13.0 and Win BUGS 1.4 software.RESULTS: A total of 105 randomized controlled trials(RCTs) were identified for inclusion in this analysis, with data for 7683 patients and 13 CHIs. The results suggested that Javanica oil emulsion,Huachansu injection plus TACE were more favorable for 1-year and 2-year survival rate than other CHIs. Kanglaite, Astragalus polysaccharide injection plus TACE showed superiority in the clinical effective rate and performance status over other CHIs.And Shenmai injection plus TACE was superior to reducing ADRs than other CHIs for patients with liver cancer.CONCLUSION: Our findings indicated that receiving CHIs combined with TACE may have therapeutic benefits for patients with liver cancer in improving survival rate, clinical effective rate, the performance status and alleviating the ADRs. | Zhang Dan Wang Kaihuan Zheng Jiewen Wu Jiarui Duan Xiaojiao Ni Mengwei Liu Shuyu Zhang Bing Zhao Yi | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 9 |
| 4 | Chimeric antigen receptor T cells in solid tumors: a war against the tumor microenvironment显示文摘Chimeric antigen receptor(CAR) T cell is a novel approach, which utilizes anti-tumor immunity for cancer treatment. As compared to the traditional cell-mediated immunity, CAR-T possesses the improved specificity of tumor antigens and independent cytotoxicity from major histocompatibility complex molecules through a monoclonal antibody in addition to the Tcell receptor. CAR-T cell has proven its effectiveness, primarily in hematological malignancies, specifically where the CD19 CAR-T cells were used to treat B-cell acute lymphoblastic leukemia and B-cell lymphomas. Nevertheless, there is little progress in the treatment of solid tumors despite the fact that many CAR agents have been created to target tumor antigens such as CEA,EGFR/EGFRvIII, GD2, HER2, MSLN, MUC1, and other antigens. The main obstruction against the progress of research in solid tumors is the tumor microenvironment, in which several elements, such as poor locating ability, immunosuppressive cells,cytokines, chemokines, immunosuppressive checkpoints, inhibitory metabolic factors, tumor antigen loss, and antigen heterogeneity, could affect the potency of CAR-T cells. To overcome these hurdles, researchers have reconstructed the CAR-T cells in various ways. The purpose of this review is to summarize the current research in this field, analyze the mechanisms of the major barriers mentioned above, outline the main solutions, and discuss the outlook of this novel immunotherapeutic modality. | Zijun Zhao Xiaoyun Xiao Phei Er Saw Wei Wu Hongyan Huang Jiewen Chen Yan Nie | 2020 | Science China(Life Sciences)2020，63，2： | 7 |
| 5 | An infectious disease of ducks caused by a newly emerged Tembusu virus strain in mainland China显示文摘 | Pixi Yan Youshu Zhao Xu Zhang Dawei Xu Xiaoguang Dai Qiaoyang Teng Liping Yan Jiewen Zhou Xiwen Ji Shumei Zhang Guangqing Liu Yanjun Zhou Yoshihiro Kawaoka Guangzhi Tong Zejun Li | 2011 | Virology2011，，1： | 5 |
| 6 | Reducing relapse and accelerating osteogenesis in rapid maxillary expansion using an injectable mesoporous bioactive glass/fibrin glue composite hydrogel显示文摘Rapid maxillary expansion(RME),as a common treatment for craniomaxillofacial deformity,faces the challenge of high relapse rates and unsatisfactory therapeutic effects.In this study,a standardized Sprague-Dawley(SD)rat RME model was first established with a modified expander as well as retainer design and optimized anterior maxillary expanding force of 100 g which exerted the most synchronized mobility of mid-palatal suture and incisors.Via the standardized model,the high relapse rate was proven to be attributed to insufficient osteogenesis in expanded suture,requiring long-term retainer wearing in clinical situations.To reduce the relapse rate,mesoporous bioactive glass/fibrin glue(MBG/FG)composite hydrogels were developed for an in situ minimal invasive injection that enhance osteogenesis in the expanded palate.The component of 1 wt%MBG was adopted for enhanced mechanical strength,matched degradation rate and ion dissolution,excellent in vitro biocompatibility and osteoinductivity.Effects of 1%MBG/FG composite hydrogel on osteogenesis in expanded mid-palatal sutures with/without retention were evaluated in the standardized model.The results demonstrated that injection of 1%MBG/FG composite hydrogel significantly promoted bone formation within the expanded mid-palatal suture,inhibited osteoclastogenesis and benefited the balance of bone remodeling towards osteogenesis.Combination of retainer and injectable biomaterial was demonstrated as a promising treatment to reduce relapse rate and enhance osteogenesis after RME.The model establishment and the composite hydrogel development in this article might provide new insight to other craniomaxillofacial deformity treatment and design of bone-repairing biomaterials with higher regenerative efficiency. | Hanjiang Zhao Xiangyu Wang Anting Jin Minjiao Wang Zeying Wang Xingtai Huang Jiewen Dai Xudong Wang Dan Lin Steve GF.Shen | 2022 | Bioactive Materials2022，7，12： | 2 |
| 7 | Uncertainties of snow cover extraction caused by the nature of topography and underlying surface显示文摘Manas River,the largest inland river to the north of the Tianshan Mountains,provides important water resources for human production and living.The seasonal snow cover and snowmelt play essential roles in the regulation of spring runoff in the Manas River Basin(MRB).Snow cover is one of the most significant input parameters for obtaining accurate simulations and predictions of spring runoff.Therefore,it is especially important to extract snow-covered area correctly in the MRB.In this study,we qualitatively and quantitatively analyzed the uncertainties of snow cover extraction caused by the terrain factors and land cover types using TM and DEM data,along with the Per(the ratio of the difference between snow-covered area extracted by the Normalized Difference Snow Index(NDSI) method and visual interpretation method to the actual snow-covered area) and roughness.The results indicated that the difference of snow-covered area extracted by the two methods was primarily reflected in the snow boundary and shadowy areas.The value of Per varied significantly in different elevation zones.That is,the value generally presented a normal distribution with the increase of elevation.The peak value of Per occurred in the elevation zone of 3,700–4,200 m.Aspects caused the uncertainties of snow cover extraction with the order of sunny slope>semi-shady and semi-sunny slope>shady slope,due to the differences in solar radiation received by each aspect.Regarding the influences of various land cover types on snow cover extraction in the study area,bare rock was more influential on snow cover extraction than grassland.Moreover,shrub had the weakest impact on snow cover extraction. | Jun ZHAO YinFang SHI YongSheng HUANG JieWen FU | 2015 | Journal of Arid Land2015，7，3： | 2 |
| 8 | Brain-derived neurotrophic factor prevents beta-amyloid-induced apoptosis of pheochromocytoma cells by regulating Bax/Bcl-2 expression显示文摘Brain-derived neurotrophic factor was utilized in the present study to treat cell injury models induced by aggregated β-amyloid(25-35).Methylthiazolyldiphenyl-tetrazolium bromide assay and western blot analysis showed that brain-derived neurotrophic factor provided neuroprotection against cellular apoptosis by suppressing the decline in β-amyloid(25-35)-induced cell activity and the increasing ratio of Bax/Bcl-2.After treating pheochromocytoma cells with tyrosine kinase receptor B receptor inhibitor K252a,brain-derived neurotrophic factor reverses the above-mentioned changes.The experimental findings suggested that brain-derived neurotrophic factor prevented β-amyloid peptide-induced cellular apoptosis by modulating Bax/Bcl-2 expression,and this effect was associated with binding to the specific tyrosine kinase receptor B receptor. | Zhikun Sun Xingrong Ma Hongqi Yang Jiahua Zhao Jiewen Zhang | 2012 | Neural Regeneration Research2012，7，5： | 2 |
| 9 | Comparisons of different regressions tools in measurement of antioxidant activity in green tea using near infrared spectroscopy显示文摘 | Quansheng Chen Zhiming Guo Jiewen Zhao Qin Ouyang | 2011 | Journal of Pharmaceutical and Biomedical Analysis2011，，： | 1 |
| 10 | Comparative analyses of apple aroma by a tin-oxide gas sensor array device and GC/MS 显示文摘 | Zou Xiaobo Zhao Jiewen | 2008 | Food Chemistry2008，107，： | 1 |
| 11 | Discrimination of green tea quality using the electronic nose technique and the human panel test, comparison of linear and nonlinear classification tools显示文摘 | Quansheng Chen Jiewen Zhao Zhe Chen Hao Lin De-An Zhao | 2011 | Sensors & Actuators: B Chemical2011，，1： | 1 |
| 12 | Variables selection methods in near-infrared spectroscopy 显示文摘 | Zou Xiaobo Zhao Jiewen Malcolm J W P | 2010 | Analytica Chimica Acta2010，667，12： | 1 |
| 13 | A novel technique for rapid evaluation of fish freshness using colorimetric sensor array 显示文摘 | Huang Xingyi Xin Junwei Zhao Jiewen | 2011 | Journal of Food Engineering2011，105，4： | 1 |
| 14 | Qualitative identification of tea categories by near infrared spectroscopy and support vector machine 显示文摘 | Zhao Jiewen Chen Quansheng Huang Xingyi | 2006 | Journal of Pharmaceutical and Biomedical Analysis2006，41，： | 1 |
| 15 | Selection of the efficient wavelength regions in FT-NIR spectroscopy for determination of SSC of 'Fuji' apple based on BiPLS and FiPLS models显示文摘 | ZOU Xiaobo ZHAO Jiewen LI Yanxiao | 2007 | Vibrational Spectroscopy2007，44，2： | 1 |
| 16 | Simultaneous determination of total polyphenols and caffeine contents of green tea by near-infrared reflectance spectroscopy显示文摘 | Quansheng Chen Jiewen Zhao Xingyi Huang | 2006 | Microchemical Journal2006，，83： | 1 |
| 17 | Variables selection methods in near-infrared spectroscopy显示文摘 | Zou Xiaobo Zhao Jiewen Povey M J W | 2010 | Analytica Chimica Acta2010，667，： | 1 |
| 18 | Variables selection methods in near-infrared spectroscopy显示文摘 | Zou Xiaobo Zhao Jiewen Malcolm J.W. Povey Mel Holmes Mao Hanpin | 2010 | Analytica Chimica Acta2010，，1： | 1 |
| 19 | Selection of the efficient wavelength regions in FT-NIR spectroscopy for determination of SSC of ‘Fuji’ apple based on BiPLS and FiPLS models 显示文摘 | Xiaobo Zou Jiewen Zhao Yanxiao Li | 2007 | Vibrational Spectroscopy2007，44，： | 1 |
| 20 | Determination of total polyphenols content in green tea using FT-NIR spectroscopy and different PLS algorithms 显示文摘 | Chen Quansheng Zhao Jiewen Liu Muhua | 2008 | Journal of Pharmaceutical and Biomedical Analysis2008，46，3： | 1 |
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