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| 1 | Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease显示文摘AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty liver disease(NAFLD) models.METHODS: Male C57BL/6J mice were classified according to control or high fat diet(HFD) with or without PPAR-δ agonist(GW) over period of 12 wk [control, HFD, HFD + lipopolysaccharide(LPS), HFD + LPS + GW group]. Hep G2 cells were exposed to palmitic acid(PA) and/or LPS in the absence or presence of GW.RESULTS: HFD caused glucose intolerance and hepatic steatosis. In mice fed an HFD with LPS, caspase-1 and interleukin(IL)-1β in the liver were significantly increased. Treatment with GW ameliorated the steatosis and inhibited overexpression of pro-inflammatory cytokines. In Hep G2 cells, PA and LPS treatment markedly increased m RNA of several nucleotide-binding andoligomerization domain-like receptor family members(NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1β. PA and LPS also exaggerated reactive oxygen species production. All of the above effects of PA and LPS were reduced by GW. GW also enhanced the phosphorylation of AMPK-α.CONCLUSION: PPAR-δ agonist reduces fatty acidinduced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-δ agonist may have therapeutic implication for NAFLD. | Hyun Jung Lee Jong Eun Yeon Eun Jung Ko Eileen L Yoon Sang Jun Suh Keunhee Kang Hae Rim Kim Seoung Hee Kang Yang Jae Yoo Jihye Je Beom Jae Lee Ji Hoon Kim Yeon Seok Seo Hyung Joon Yim Kwan Soo Byun | 2015 | World Journal of Gastroenterology2015，21，45： | 9 |
| 2 | Risk of inflammatory bowel disease in patients with chronic obstructive pulmonary disease: A nationwide, population-based study显示文摘BACKGROUND There is a growing evidence regarding an increased risk of inflammatory bowel disease(IBD)among patients with airway diseases.AIM To investigate the influence of chronic obstructive pulmonary disease(COPD)on the risk of IBD.METHODS A nationwide,population-based study was conducted using data from the National Health Insurance Service database.A total of 1303021 patients with COPD and 6515105 non-COPD controls were identified.The COPD group was divided into the severe and the mild COPD group according to diagnostic criteria.The risk of IBD in patients with COPD compared to controls was analyzed by Cox proportional hazard regression models.The cumulative incidences of IBD were compared between the groups.RESULTS The COPD group had higher incidences of IBD compared to non-COPD controls(incidence rate,9.98 vs 7.18 per 100000 person-years,P<0.001).The risk of IBD in the COPD group was increased by 1.38(adjusted hazard ratio(HR);95%CI:1.25-1.52).The incidence rate of IBD was higher in the severe COPD group than in the mild COPD group(12.39 vs 9.77 per 100000 person-year,P<0.001).The severity of COPD was associated with an increased risk of IBD(adjusted HR 1.70 in severe COPD,95%CI:1.27-2.21 and adjusted HR 1.35 in mild COPD,95%CI:1.22-1.49)CONCLUSION The incidences of IBD were significantly increased in COPD patients in South Korea and the risk of developing IBD also increased as the severity of COPD increased. | Jooyoung Lee Jong Pil Im Kyungdo Han Seona Park Hosim Soh Kukhwan Choi Jihye Kim Jaeyoung Chun Joo Sung Kim | 2019 | World Journal of Gastroenterology2019，25，42： | 7 |
| 3 | 苹果多酚-壳寡糖微胶囊的制备表征及释放特性显示文摘为了有效提高未熟苹果多酚(ApplePolyphenols,APP)和壳寡糖(Chitooligosaccharides,COS)多功能协调效应,该研究采用喷雾干燥法研制未成熟的苹果多酚-壳寡糖微胶囊(Apple Polyphenols-Chitooligosaccharides Microcapsule,APCM),并测定了APCM的微胶囊粒度和分布,以及结构表征,并评价了模拟胃肠道消化模型对总多酚(Total Phenolic Content,TPC)释放和健康益处功能的影响。激光粒度分析结果表明,APCM的平均粒径为32.98μm。跨度值最小为1.19,这意味着APCM比COS和APP更均匀、颗粒度更小。APP在1 237和1 194 cm^(-1)处观察到了清晰的峰形,在APCM中同一位置处未观察到。但是,APCM与APP具有相似的吸收带,这意味着APP与COS也可能通过范德华力和分子间氢键的方式形成APCM。模拟胃肠消化模型结果表明,APCM中多酚的释放发生在60min以内。在模拟胃液消化系统(SimulatedGastricFluid,SGF)处理中,APCM释放的TPC从25.6%到76.5%不等,而在模拟肠液消化系统(Simulated Intestinal Fluid,SIF)持续处理中,TPC释放量达到31.3%到97.6%。体外抗氧化活性和活性氧(Reactive Oxygen Species,ROS)清除活性结果表明,相比与APP和COS,APCM对抗氧化能力指数、清除DPPH自由基、铁离子还原抗氧化力、·OH清除活性、O_2^(·-)清除活性和H_2O_2清除活性表现出更出色的清除自由基活性。此外,与APP或COS相比,APCM不仅表现出更高的糖还原酶抑制活性(P<0.05),而且具有更好的血管紧张素I转换酶(Angiotensin I Converting Enzyme,ACE)抑制活性(P<0.05)。结果表明,APCM今后可在功能性食品或药物领域更大的研发潜力。 | 郑虎哲 Choi Jihye Seong Giun Chung Shinkyo | 2020 | 农业工程学报2020，36，14： | 6 |
| 4 | Fabrication and characterization of 3D scaffold using 3D plotting system显示文摘In this paper, we design and fabricate a 3D scaffold using rapid prototyping (RP) technology for tissue engineering. The scaffold should have a three-dimensional interconnected pore network. We fabricate a polycaprolactone (PCL) scaffold with interconnecting pores and uniform porosity for cell ingrowth using a 3D plotting system. In order to keep the three dimensional shape under mechanical loading while implanted, we design an oscillating nozzle system to increase elastic modulus and yield strength of PCL strand. We characterize the influence of pore geometry, compressive modulus of the scaffold, elastic modulus and yield strength of the strand using SEM, dynamical mechanical analysis (DMA) and Nano-UTM. Finally the cell responses on scaffolds are observed. | LEE Jun-Hee PARK Su-A PARK KoEun KIM Jae-Hyun KIM Kyung-Shik LEE Jihye Kim WanDoo | 2010 | Chinese Science Bulletin2010，55，1： | 2 |
| 5 | Synthesis of indi- um tin oxide (ITO) and fluorine-doped tin oxide (FTO) nano- powder by sol-gel combustion hybrid method显示文摘 | Han Chihwan: Han Sangdo Jihye Gwak | 2007 | Materials Let- ters2007，61，89： | 1 |
| 6 | Age-dependent association between sleep duration and hypertension in the adult Korean population显示文摘 | Jihye Kim Inho Jo | 2010 | Am J Hypertension2010，23，12： | 1 |
| 7 | On-line product presentation: effects on mood, perceived risk, and purchase intention显示文摘 | JIHYE P SHARRON J L LESLIE S | 2005 | Psychology & Marketing2005，22，9： | 1 |
| 8 | Dynamic Force Balance Model for Metal Transfer Analysis in Arc Welding显示文摘 | Choi J H Jihye Lee | 2001 | Journal of Physics D:Applied Physics2001，34，17： | 1 |
| 9 | Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells显示文摘 | Eunhee Kim Misuk Kim Dong-Hun Woo Yongjae Shin Jihye Shin Nakho Chang Young Taek Oh Hong Kim Jingeun Rheey Ichiro Nakano Cheolju Lee Kyeung Min Joo Jeremy N. Rich Do-Hyun Nam Jeongwu Lee | 2013 | Cancer Cell2013，，6： | 1 |
| 10 | Verteporfin synergizes the efflcacy of anti-PD-1 in cholangiocarcinoma显示文摘Background:Cholangiocarcinoma(CCA)is one of the primary hepatobiliary malignant neoplasms with only 10%of 5-year survival rate.Promising immunotherapy with the blockade of immune checkpoints has no clear benefit in CCA.The inhibition of YAP1 signaling by verteporfin has shown encouraging results by inhibiting cell proliferation and inducing apoptosis.This study aimed to evaluate the potential benefit of the combination of verteporfin and anti-programmed cell death 1(PD-1)in CCA mouse model.Methods:We assessed the cytotoxicity of verteporfin in human CCA cell lines in vitro,including both intrahepatic CCA and extrahepatic CCA cells.We examined the in vitro effect of verteporfin on cell proliferation,apoptosis,and stemness.We evaluated the in vivo efflcacy of verteporfin,anti-PD-1,and a combination of both in subcutaneous CCA mouse model.Results:Our study showed that verteporfin reduced tumor cell growth and enhanced apoptosis of human CCA tumor cells in vitro in a dose-dependent fashion.Nevertheless,verteporfin impaired stemness evidenced by reduced spheroid formation and colony formation,decreased numbers of cells with aldehyde dehydrogenase activity and positive cancer stem cell markers(all P<0.05).The combination of verteporfin and anti-PD-1 reduced tumor burden in CCA subcutaneous SB1 tumor model compared to either agent alone.Conclusions:Verteporfin exhibits antitumor effects in both intrahepatic and extrahepatic CCA cell lines and the combination with anti-PD-1 inhibited tumor growth. | Jianyang Fu Nicole A McGrath Jihye Lee Xin Wang Gagandeep Brar Changqing Xie | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，5： | 1 |
| 11 | Telepresence and fantasy in online apparel shopping experience显示文摘 | Kun Song Ann Marie Fiore and Jihye Park | 2007 | Journal of Fashion Marketing and Management2007，11，4： | 1 |
| 12 | Hydrother real preparation of carbon microspheres from mono saecha rides and phenolic compounds显示文摘 | Jihye Ryu Young-Woong Suh Dong Jin Suh | 2010 | Carbon2010，48，： | 1 |
| 13 | Enantioseleetive bioeonversion using Escherichia coli cells expressing saccharomyces cerevisiae reductase and bacillus subtilis glucose dehydorgenase显示文摘 | Park Hyun J Jihye J | 2010 | Microbiol Biotech- nol2010，20，9： | 1 |
| 14 | Neuronal Properties, In Vivo Effects, and Pathology of a Huntington’s Disease Patient‐Derived Induced Pluripotent Stem Cells显示文摘 | Iksoo Jeon Nayeon Lee Jia‐Yi Li In‐Hyun Park Kyoung Sun Park Jisook Moon Sung Han Shim Chunggab Choi Da‐Jeong Chang Jihye Kwon Seung‐Hun Oh Dong Ah Shin Hyun Sook Kim Jeong Tae Do Dong Ryul Lee Manho Kim Kyung‐Sun Kang George Q. Daley Patrik Brundin Jihwa | 2012 | STEM CELLS2012，，9： | 1 |
| 15 | On-line Product Presentation:Effects on Mood,Perceived Risk,and Purchase Intention显示文摘 | Jihye Park Sharron J Lennon Leslie Stoel | 2005 | Psychology and Marketing2005，，22： | 1 |
| 16 | Facile fabrication of conducting polymer nanowire?based field effect transistor with controlled shape and position显示文摘 | Jihye Lee | | 0，，： | 1 |
| 17 | Distinct mechanisms of FAK mechanoactivation by different extracellular matrix proteins显示文摘Introduction Cells can sense and respond to the mechanical microenvironment by converting forces into biochemical signals inside the cells,i.e.mechanotransduction[1-3].Focal adhesions are the major sites of interaction between a cell and its extracellular matrix(ECM)microenvironment,thus outside mechanical signals can be sensed at focal adhesions through transmembrane receptor integrins.In particular,it has been shown that matrix elasticity can control the cell fate[4]by modulating the interactions between ECM proteins and their receptor integrins[5,6].For example,different rigidity of polyacrylamide(PA)gels can lead to different density of ECM ancho- | Jihye Seong Arash Tajik Jie Sun Jun-Lin Guan Martin J.Humphries Susan E.Craig Asha Shekaran Andrs J.García Ning Wang Yingxiao Wang | 2013 | 医用生物力学2013，28，S1： | 1 |
| 18 | Investigation of Lymphocyte Gene Expression for Use as Biomarkers for Zinc Status in Humans显示文摘 | Karl BA Jihye K Catherine PK | 2004 | J Nutr2004，134，7： | 1 |
| 19 | Colourimetric redox-polyaniline nanoindicator for in situ vesicular trafficking of intracellular transport显示文摘小囊的 pH 调制许多细胞器的功能并且在象增长和 apoptosis 那样的房间新陈代谢过程起一个枢轴的作用。这里,我们介绍简单比色的 redox-polyaniline nanoindicator,它能检测并且确定有与采用荧光 resonance-energy-transfer 的一个维的刺激的预先的 trafficking 代理人相比的优异敏感的一个更宽广的源於生物的 pH 范围(烦恼) 信号。我们制作了基于 polyaniline 的 nanoprobes,它根据质子层次展出了可改变的转变状态,作为一在里面小囊的运输 pH 的 situ 指示物。硅石涂的 Fe < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 4 -MnO heterometal nanoparticles 是 synthesised 并且作为金属氧化剂利用了到 polymerise 苯胺单体。最后,有吸附的花青染料 fluorophores Cy3 和 Cy7 的硅石涂的 polyaniline nanoparticles (FPSNI < 潜水艇 class= “ a-plus-plus ” > Cy3 和 FPSNI < 潜水艇 class= “ a-plus-plus ” > Cy7 ) 作为质子敏感的 nanoindicators 被制作。由小囊的运输的本地 pH 变化由于选择熄灭导致了, FPSNI < 潜水艇 class= “ a-plus-plus ” > Cy3 和 FPSNI < 潜水艇 class= “ a-plus-plus ” > Cy7 表明了优秀细胞内部的 trafficking 并且提供了极小的质子层次的敏感光指示。 | Eun Bi Choi Jihye Choi Seo Ryung Bae Hyun-Ouk Kim EunjiJang Byunghoon Kang Myeong-Hoon Kim Byeongyoon Kim Jin-Suck Suh Kwangyeol Lee Yong-Min Huh Seungjoo Haam | 2015 | Nano Research2015，8，4： | 1 |
| 20 | Nano-fibrous scaffolding promotes osteoblast differentiation and biomineralization显示文摘 | Kyung Mi Woo Ji-Hae Jun Victor J. Chen Jihye Seo Jeong-Hwa Baek Hyun-Mo Ryoo Gwan-Shik Kim Martha J. Somerman Peter X. Ma | 2006 | Biomaterials2006，，2： | 1 |
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